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Auteur Patrick BOLTON |
Documents disponibles écrits par cet auteur (24)
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[article]
Titre : Is There a Link between Engineering and Autism? Type de document : Texte imprimé et/ou numérique Auteurs : Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Ian M. GOODYER, Auteur Article en page(s) : p.101-109 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism is a severe childhood neuropsychiatric condition with a substantial genetic component. At the cognitive level children with autism are impaired in the development of their folk psychology, seict while they are normal or even superior in the development of their folk physics. We predicted that if their parent shared this cognitive phenotype, then they should be over-represented in engineering as an occupation. This prediction was confirmed. Both fathers and grand-fathers of children with autism were found more than twice as often in the field of engineering, compared with fathers and grandfathers of other children. This link between autism and engineering may throw light not only on autism itself, but ultimately on the genetic basis of two essential human abilities: folk psychology and folk physics. En ligne : http://dx.doi.org/10.1177/1362361397011010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206
in Autism > 1-1 (July 1997) . - p.101-109[article] Is There a Link between Engineering and Autism? [Texte imprimé et/ou numérique] / Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Ian M. GOODYER, Auteur . - p.101-109.
Langues : Anglais (eng)
in Autism > 1-1 (July 1997) . - p.101-109
Index. décimale : PER Périodiques Résumé : Autism is a severe childhood neuropsychiatric condition with a substantial genetic component. At the cognitive level children with autism are impaired in the development of their folk psychology, seict while they are normal or even superior in the development of their folk physics. We predicted that if their parent shared this cognitive phenotype, then they should be over-represented in engineering as an occupation. This prediction was confirmed. Both fathers and grand-fathers of children with autism were found more than twice as often in the field of engineering, compared with fathers and grandfathers of other children. This link between autism and engineering may throw light not only on autism itself, but ultimately on the genetic basis of two essential human abilities: folk psychology and folk physics. En ligne : http://dx.doi.org/10.1177/1362361397011010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206 A longitudinal twin study of the association between childhood autistic traits and psychotic experiences in adolescence / Mark J. TAYLOR in Molecular Autism, (July 2015)
[article]
Titre : A longitudinal twin study of the association between childhood autistic traits and psychotic experiences in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Mark J. TAYLOR, Auteur ; Elise B. ROBINSON, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur ; Daniel FREEMAN, Auteur ; Angelica RONALD, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This twin study investigated whether autistic traits during childhood were associated with adolescent psychotic experiences. En ligne : http://dx.doi.org/10.1186/s13229-015-0037-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (July 2015) . - p.1-11[article] A longitudinal twin study of the association between childhood autistic traits and psychotic experiences in adolescence [Texte imprimé et/ou numérique] / Mark J. TAYLOR, Auteur ; Elise B. ROBINSON, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur ; Daniel FREEMAN, Auteur ; Angelica RONALD, Auteur . - p.1-11.
Langues : Anglais (eng)
in Molecular Autism > (July 2015) . - p.1-11
Index. décimale : PER Périodiques Résumé : This twin study investigated whether autistic traits during childhood were associated with adolescent psychotic experiences. En ligne : http://dx.doi.org/10.1186/s13229-015-0037-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Medical conditions in autism spectrum disorders / Patrick BOLTON in Journal of Neurodevelopmental Disorders, 1-2 (June 2009)
[article]
Titre : Medical conditions in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Patrick BOLTON, Auteur Article en page(s) : p.102-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a behaviourally defined syndrome where the etiology and pathophysiology is only partially understood. In a small proportion of children with the condition, a specific medical disorder is identified, but the causal significance in many instances is unclear. Currently, the medical conditions that are best established as probable causes of ASD include Fragile X syndrome, Tuberous Sclerosis and abnormalities of chromosome 15 involving the 15q11-13 region. Various other single gene mutations, genetic syndromes, chromosomal abnormalities and rare de novo copy number variants have been reported as being possibly implicated in etiology, as have several ante and post natal exposures and complications. However, in most instances the evidence base for an association with ASD is very limited and largely derives from case reports or findings from small, highly selected and uncontrolled case series. Not only therefore, is there uncertainty over whether the condition is associated, but the potential basis for the association is very poorly understood. In some cases the medical condition may be a consequence of autism or simply represent an associated feature deriving from an underlying shared etiology. Nevertheless, it is clear that in a growing proportion of individuals potentially causal medical conditions are being identified and clarification of their role in etio-pathogenesis is necessary. Indeed, investigations into the causal mechanisms underlying the association between conditions such as tuberous sclerosis, Fragile X and chromosome 15 abnormalities are beginning to cast light on the molecular and neurobiological pathways involved in the pathophysiology of ASD. It is evident therefore, that much can be learnt from the study of probably causal medical disorders as they represent simpler and more tractable model systems in which to investigate causal mechanisms. Recent advances in genetics, molecular and systems biology and neuroscience now mean that there are unparalleled opportunities to test causal hypotheses and gain fundamental insights into the nature of autism and its development. En ligne : http://dx.doi.org/10.1007/s11689-009-9021-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341
in Journal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.102-13[article] Medical conditions in autism spectrum disorders [Texte imprimé et/ou numérique] / Patrick BOLTON, Auteur . - p.102-13.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.102-13
Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a behaviourally defined syndrome where the etiology and pathophysiology is only partially understood. In a small proportion of children with the condition, a specific medical disorder is identified, but the causal significance in many instances is unclear. Currently, the medical conditions that are best established as probable causes of ASD include Fragile X syndrome, Tuberous Sclerosis and abnormalities of chromosome 15 involving the 15q11-13 region. Various other single gene mutations, genetic syndromes, chromosomal abnormalities and rare de novo copy number variants have been reported as being possibly implicated in etiology, as have several ante and post natal exposures and complications. However, in most instances the evidence base for an association with ASD is very limited and largely derives from case reports or findings from small, highly selected and uncontrolled case series. Not only therefore, is there uncertainty over whether the condition is associated, but the potential basis for the association is very poorly understood. In some cases the medical condition may be a consequence of autism or simply represent an associated feature deriving from an underlying shared etiology. Nevertheless, it is clear that in a growing proportion of individuals potentially causal medical conditions are being identified and clarification of their role in etio-pathogenesis is necessary. Indeed, investigations into the causal mechanisms underlying the association between conditions such as tuberous sclerosis, Fragile X and chromosome 15 abnormalities are beginning to cast light on the molecular and neurobiological pathways involved in the pathophysiology of ASD. It is evident therefore, that much can be learnt from the study of probably causal medical disorders as they represent simpler and more tractable model systems in which to investigate causal mechanisms. Recent advances in genetics, molecular and systems biology and neuroscience now mean that there are unparalleled opportunities to test causal hypotheses and gain fundamental insights into the nature of autism and its development. En ligne : http://dx.doi.org/10.1007/s11689-009-9021-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures / Jeremy R. PARR in Autism Research, 8-5 (October 2015)
[article]
Titre : New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures Type de document : Texte imprimé et/ou numérique Auteurs : Jeremy R. PARR, Auteur ; Maretha V. DE JONGE, Auteur ; Simon WALLACE, Auteur ; Andrew PICKLES, Auteur ; Michael L. RUTTER, Auteur ; Ann S. LE COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; Kerstin WITTEMEYER, Auteur ; Helen MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; Lennart PEDERSEN, Auteur ; Torben ISAGER, Auteur ; Fritz POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; Emma WEISBLATT, Auteur ; Jonathan GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; Gillian BAIRD, Auteur ; Anthony J. BAILEY, Auteur Article en page(s) : p.522-533 Langues : Anglais (eng) Mots-clés : broader autism phenotype informant interview self-report interview interrater reliability retest reliability Index. décimale : PER Périodiques Résumé : Clinical genetic studies confirm the broader autism phenotype (BAP) in some relatives of individuals with autism, but there are few standardized assessment measures. We developed three BAP measures (informant interview, self-report interview, and impression of interviewee observational scale) and describe the development strategy and findings from the interviews. International Molecular Genetic Study of Autism Consortium data were collected from families containing at least two individuals with autism. Comparison of the informant and self-report interviews was restricted to samples in which the interviews were undertaken by different researchers from that site (251 UK informants, 119 from the Netherlands). Researchers produced vignettes that were rated blind by others. Retest reliability was assessed in 45 participants. Agreement between live scoring and vignette ratings was very high. Retest stability for the interviews was high. Factor analysis indicated a first factor comprising social-communication items and rigidity (but not other repetitive domain items), and a second factor comprised mainly of reading and spelling impairments. Whole scale Cronbach's alphas were high for both interviews. The correlation between interviews for factor 1 was moderate (adult items 0.50; childhood items 0.43); Kappa values for between-interview agreement on individual items were mainly low. The correlations between individual items and total score were moderate. The inclusion of several factor 2 items lowered the overall Cronbach's alpha for the total set. Both interview measures showed good reliability and substantial stability over time, but the findings were better for factor 1 than factor 2. We recommend factor 1 scores be used for characterising the BAP. Autism Res 2015, 8: 522–533. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270
in Autism Research > 8-5 (October 2015) . - p.522-533[article] New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures [Texte imprimé et/ou numérique] / Jeremy R. PARR, Auteur ; Maretha V. DE JONGE, Auteur ; Simon WALLACE, Auteur ; Andrew PICKLES, Auteur ; Michael L. RUTTER, Auteur ; Ann S. LE COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; Kerstin WITTEMEYER, Auteur ; Helen MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; Lennart PEDERSEN, Auteur ; Torben ISAGER, Auteur ; Fritz POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; Emma WEISBLATT, Auteur ; Jonathan GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; Gillian BAIRD, Auteur ; Anthony J. BAILEY, Auteur . - p.522-533.
Langues : Anglais (eng)
in Autism Research > 8-5 (October 2015) . - p.522-533
Mots-clés : broader autism phenotype informant interview self-report interview interrater reliability retest reliability Index. décimale : PER Périodiques Résumé : Clinical genetic studies confirm the broader autism phenotype (BAP) in some relatives of individuals with autism, but there are few standardized assessment measures. We developed three BAP measures (informant interview, self-report interview, and impression of interviewee observational scale) and describe the development strategy and findings from the interviews. International Molecular Genetic Study of Autism Consortium data were collected from families containing at least two individuals with autism. Comparison of the informant and self-report interviews was restricted to samples in which the interviews were undertaken by different researchers from that site (251 UK informants, 119 from the Netherlands). Researchers produced vignettes that were rated blind by others. Retest reliability was assessed in 45 participants. Agreement between live scoring and vignette ratings was very high. Retest stability for the interviews was high. Factor analysis indicated a first factor comprising social-communication items and rigidity (but not other repetitive domain items), and a second factor comprised mainly of reading and spelling impairments. Whole scale Cronbach's alphas were high for both interviews. The correlation between interviews for factor 1 was moderate (adult items 0.50; childhood items 0.43); Kappa values for between-interview agreement on individual items were mainly low. The correlations between individual items and total score were moderate. The inclusion of several factor 2 items lowered the overall Cronbach's alpha for the total set. Both interview measures showed good reliability and substantial stability over time, but the findings were better for factor 1 than factor 2. We recommend factor 1 scores be used for characterising the BAP. Autism Res 2015, 8: 522–533. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 New Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure / A. PICKLES in Journal of Autism and Developmental Disorders, 43-9 (September 2013)
[article]
Titre : New Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure Type de document : Texte imprimé et/ou numérique Auteurs : A. PICKLES, Auteur ; Jeremy R. PARR, Auteur ; Michael L. RUTTER, Auteur ; M. V. JONGE, Auteur ; S. WALLACE, Auteur ; A. S. COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; K. WITTEMEYER, Auteur ; H. MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; L. PEDERSEN, Auteur ; T. ISAGER, Auteur ; F. POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; E. WEISBLATT, Auteur ; J. GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; A. J. BAILEY, Auteur Article en page(s) : p.2082-2089 Langues : Anglais (eng) Mots-clés : Broader autism phenotype Observer rating Test–retest Factor analysis Social functioning Index. décimale : PER Périodiques Résumé : A 20 item observational measure of social functioning, the Impression of Interviewee rating scale, is one of three measures devised to assess the broader autism phenotype. The sample studied included families containing at least two individuals with autism spectrum disorder; observations were undertaken by the researcher who interviewed the subject. An exploratory factor analysis suggested a single factor was most appropriate (Cronbach’s ? of 0.78). There was a modest but significant retest correlation of 0.42. Correlations between live ratings and blind consensus ratings of vignettes were high (0.93). Correlations with the interview measures were moderate but statistically significant. In conclusion, the observational scale provides a promising start but further work is required before general use can be recommended. En ligne : http://dx.doi.org/10.1007/s10803-013-1810-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212
in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2082-2089[article] New Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure [Texte imprimé et/ou numérique] / A. PICKLES, Auteur ; Jeremy R. PARR, Auteur ; Michael L. RUTTER, Auteur ; M. V. JONGE, Auteur ; S. WALLACE, Auteur ; A. S. COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; K. WITTEMEYER, Auteur ; H. MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; L. PEDERSEN, Auteur ; T. ISAGER, Auteur ; F. POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; E. WEISBLATT, Auteur ; J. GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; A. J. BAILEY, Auteur . - p.2082-2089.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2082-2089
Mots-clés : Broader autism phenotype Observer rating Test–retest Factor analysis Social functioning Index. décimale : PER Périodiques Résumé : A 20 item observational measure of social functioning, the Impression of Interviewee rating scale, is one of three measures devised to assess the broader autism phenotype. The sample studied included families containing at least two individuals with autism spectrum disorder; observations were undertaken by the researcher who interviewed the subject. An exploratory factor analysis suggested a single factor was most appropriate (Cronbach’s ? of 0.78). There was a modest but significant retest correlation of 0.42. Correlations between live ratings and blind consensus ratings of vignettes were high (0.93). Correlations with the interview measures were moderate but statistically significant. In conclusion, the observational scale provides a promising start but further work is required before general use can be recommended. En ligne : http://dx.doi.org/10.1007/s10803-013-1810-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 No major effect of twinning on autistic traits / Sarah CURRAN in Autism Research, 4-5 (October 2011)
PermalinkOutcomes in Adult Life Among Siblings of Individuals with Autism / Patricia HOWLIN in Journal of Autism and Developmental Disorders, 45-3 (March 2015)
PermalinkPervasive Developmental Disorder and Obstetric Complications in Children and Adolescents with Tuberous Sclerosis / Rebecca J. PARK in Autism, 5-3 (September 2001)
PermalinkRegression in autism spectrum disorder: Reconciling findings from retrospective and prospective research / N. PEARSON in Autism Research, 11-12 (December 2018)
PermalinkRelationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study / Katharina DWORZYNSKI in Journal of Autism and Developmental Disorders, 39-8 (August 2009)
PermalinkResponse time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD / Charlotte TYE in Journal of Child Psychology and Psychiatry, 57-12 (December 2016)
PermalinkResting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD / E. SHEPHARD in Journal of Autism and Developmental Disorders, 48-1 (January 2018)
PermalinkScreening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study / James FINDON in Autism Research, 9-12 (December 2016)
PermalinkSelf and informant reports of mental health difficulties among adults with autism findings from a long-term follow-up study / Philippa MOSS in Autism, 19-7 (October 2015)
PermalinkThe CAST (Childhood Asperger Syndrome Test): Preliminary Development of a UK Screen for Mainstream Primary-School-Age Children / Fiona J. SCOTT in Autism, 6-1 (March 2002)
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