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Détail de l'auteur
Auteur Lauren KRYZAK |
Documents disponibles écrits par cet auteur (2)
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Brief Report: Parental Age and the Sex Ratio in Autism / Alene ANELLO in Journal of Autism and Developmental Disorders, 39-10 (October 2009)
[article]
Titre : Brief Report: Parental Age and the Sex Ratio in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Alene ANELLO, Auteur ; Eric HOLLANDER, Auteur ; Christopher J. SMITH, Auteur ; Lauren KRYZAK, Auteur ; Abraham REICHENBERG, Auteur ; Jeremy M. SILVERMAN, Auteur ; Xiaodong LUO, Auteur ; James SCHMEIDLER, Auteur ; Connor M. PULEO, Auteur Année de publication : 2009 Article en page(s) : p.1487-1492 Langues : Anglais (eng) Mots-clés : Paternal-age Maternal-age Sex-ratio Genetics Genomic-anomalies Copy-number-variants Index. décimale : PER Périodiques Résumé : The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30–34, 35–39, 40–44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children. En ligne : http://dx.doi.org/10.1007/s10803-009-0755-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=840
in Journal of Autism and Developmental Disorders > 39-10 (October 2009) . - p.1487-1492[article] Brief Report: Parental Age and the Sex Ratio in Autism [Texte imprimé et/ou numérique] / Alene ANELLO, Auteur ; Eric HOLLANDER, Auteur ; Christopher J. SMITH, Auteur ; Lauren KRYZAK, Auteur ; Abraham REICHENBERG, Auteur ; Jeremy M. SILVERMAN, Auteur ; Xiaodong LUO, Auteur ; James SCHMEIDLER, Auteur ; Connor M. PULEO, Auteur . - 2009 . - p.1487-1492.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-10 (October 2009) . - p.1487-1492
Mots-clés : Paternal-age Maternal-age Sex-ratio Genetics Genomic-anomalies Copy-number-variants Index. décimale : PER Périodiques Résumé : The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30–34, 35–39, 40–44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children. En ligne : http://dx.doi.org/10.1007/s10803-009-0755-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=840 Familial associations of intense preoccupations, an empirical factor of the restricted, repetitive behaviors and interests domain of autism / Christopher J. SMITH in Journal of Child Psychology and Psychiatry, 50-8 (August 2009)
[article]
Titre : Familial associations of intense preoccupations, an empirical factor of the restricted, repetitive behaviors and interests domain of autism Type de document : Texte imprimé et/ou numérique Auteurs : Christopher J. SMITH, Auteur ; Eric HOLLANDER, Auteur ; Colleen M. LANG, Auteur ; Lauren KRYZAK, Auteur ; Abraham REICHENBERG, Auteur ; Jeremy M. SILVERMAN, Auteur Année de publication : 2009 Article en page(s) : p.982-990 Langues : Anglais (eng) Mots-clés : Developmental-delay family-factors fathers genetics autistic-disorder Index. décimale : PER Périodiques Résumé : Background: Clinical heterogeneity of autism likely hinders efforts to find genes associated with this complex psychiatric disorder. Some studies have produced promising results by restricting the sample according to the expression of specific familial factors or components of autism. Previous factor analyses of the restricted, repetitive behaviors and interest (RRBI) domain of autism have consistently identified a two-factor model that explains a moderate amount of variance. The identification of additional factors may explain more variance in the RRBI domain and provide an additional component of autism that may help in the identification of underlying genetic association.
Methods: We conducted factor analyses of RRBI symptoms with a sample that included verbal subjects meeting full criteria for autism aged 5 to 22 years (n = 245). Among affected sibling pairs (n = 126) we examined the familial aggregation of the identified factors. We also examined the associations of the factors with autism-related personality traits in fathers and mothers (n = 50).
Results: The previously identified two-factor model – insistence on sameness (IS) and repetitive stereotypic motor behaviors (RSMB) – was replicated in our sample. Next, a second factor analysis that included the item for verbal rituals resulted in a four-factor model – IS, 'simple' RSMB, 'complex' RSMB, and a fourth factor including symptoms associated with intense preoccupations (IP). Of these four, both IS and IP were significantly familial among affected siblings, but only IP was significantly correlated with the broader autism phenotype traits of rigidity and aloofness in fathers.
Conclusions: The results support previous evidence for the IS factor, its familiality, and the identification of IP as an additional strong candidate trait for genetic studies of autism.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02060.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788
in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.982-990[article] Familial associations of intense preoccupations, an empirical factor of the restricted, repetitive behaviors and interests domain of autism [Texte imprimé et/ou numérique] / Christopher J. SMITH, Auteur ; Eric HOLLANDER, Auteur ; Colleen M. LANG, Auteur ; Lauren KRYZAK, Auteur ; Abraham REICHENBERG, Auteur ; Jeremy M. SILVERMAN, Auteur . - 2009 . - p.982-990.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.982-990
Mots-clés : Developmental-delay family-factors fathers genetics autistic-disorder Index. décimale : PER Périodiques Résumé : Background: Clinical heterogeneity of autism likely hinders efforts to find genes associated with this complex psychiatric disorder. Some studies have produced promising results by restricting the sample according to the expression of specific familial factors or components of autism. Previous factor analyses of the restricted, repetitive behaviors and interest (RRBI) domain of autism have consistently identified a two-factor model that explains a moderate amount of variance. The identification of additional factors may explain more variance in the RRBI domain and provide an additional component of autism that may help in the identification of underlying genetic association.
Methods: We conducted factor analyses of RRBI symptoms with a sample that included verbal subjects meeting full criteria for autism aged 5 to 22 years (n = 245). Among affected sibling pairs (n = 126) we examined the familial aggregation of the identified factors. We also examined the associations of the factors with autism-related personality traits in fathers and mothers (n = 50).
Results: The previously identified two-factor model – insistence on sameness (IS) and repetitive stereotypic motor behaviors (RSMB) – was replicated in our sample. Next, a second factor analysis that included the item for verbal rituals resulted in a four-factor model – IS, 'simple' RSMB, 'complex' RSMB, and a fourth factor including symptoms associated with intense preoccupations (IP). Of these four, both IS and IP were significantly familial among affected siblings, but only IP was significantly correlated with the broader autism phenotype traits of rigidity and aloofness in fathers.
Conclusions: The results support previous evidence for the IS factor, its familiality, and the identification of IP as an additional strong candidate trait for genetic studies of autism.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02060.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788