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Auteur Katharina DWORZYNSKI |
Documents disponibles écrits par cet auteur (2)
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No major effect of twinning on autistic traits / Sarah CURRAN in Autism Research, 4-5 (October 2011)
[article]
Titre : No major effect of twinning on autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Sarah CURRAN, Auteur ; Katharina DWORZYNSKI, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur ; Patrick BOLTON, Auteur Année de publication : 2011 Article en page(s) : p.377-382 Langues : Anglais (eng) Mots-clés : clinical psychiatry developmental psychology diagnosis epidemiology social cognition Index. décimale : PER Périodiques Résumé : Background: It has been questioned whether the process of twinning might be a risk factor for autism spectrum conditions (ASC) and autistic traits. Aim: We sought to determine whether autistic traits and probable disorder, as measured by the Childhood Autism Spectrum Test (CAST), were more pronounced in twins compared to singletons. Samples: Data were analyzed from two large population-based samples of UK children, twins (n = 5,142 twin pairs, aged 8 years) and singletons (n = 2,805, aged 5–9 years). Results: Distributions of CAST scores in both groups were negatively skewed and scores for twins were more variable than singletons. Mean CAST total scores and standard errors (SE) were not significantly different for twins (5.1; SE 0.04) compared to singletons (4.9; SE 0.08). Moreover, contrary to expectations, the likelihood of scoring above the threshold for possible ASC was significantly lower in the twins than the singletons (OR = 0.69; P = 0.002). Subsidiary analyses of CAST scores according to sex, twin type, and subscale scores representing the subdomains of autism found a few significant differences (P<0.01), but the effect sizes for these differences were small and none exceeded η2 = 0.005. The explanation for these small differences remains obscure, but the very small effect sizes mean they are of little importance. Conclusions: Our results do not provide evidence to support twinning as a risk factor in the development of autistic traits. Autism Res2011,4:377–382. © 2011 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=145
in Autism Research > 4-5 (October 2011) . - p.377-382[article] No major effect of twinning on autistic traits [Texte imprimé et/ou numérique] / Sarah CURRAN, Auteur ; Katharina DWORZYNSKI, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur ; Patrick BOLTON, Auteur . - 2011 . - p.377-382.
Langues : Anglais (eng)
in Autism Research > 4-5 (October 2011) . - p.377-382
Mots-clés : clinical psychiatry developmental psychology diagnosis epidemiology social cognition Index. décimale : PER Périodiques Résumé : Background: It has been questioned whether the process of twinning might be a risk factor for autism spectrum conditions (ASC) and autistic traits. Aim: We sought to determine whether autistic traits and probable disorder, as measured by the Childhood Autism Spectrum Test (CAST), were more pronounced in twins compared to singletons. Samples: Data were analyzed from two large population-based samples of UK children, twins (n = 5,142 twin pairs, aged 8 years) and singletons (n = 2,805, aged 5–9 years). Results: Distributions of CAST scores in both groups were negatively skewed and scores for twins were more variable than singletons. Mean CAST total scores and standard errors (SE) were not significantly different for twins (5.1; SE 0.04) compared to singletons (4.9; SE 0.08). Moreover, contrary to expectations, the likelihood of scoring above the threshold for possible ASC was significantly lower in the twins than the singletons (OR = 0.69; P = 0.002). Subsidiary analyses of CAST scores according to sex, twin type, and subscale scores representing the subdomains of autism found a few significant differences (P<0.01), but the effect sizes for these differences were small and none exceeded η2 = 0.005. The explanation for these small differences remains obscure, but the very small effect sizes mean they are of little importance. Conclusions: Our results do not provide evidence to support twinning as a risk factor in the development of autistic traits. Autism Res2011,4:377–382. © 2011 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=145 Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study / Katharina DWORZYNSKI in Journal of Autism and Developmental Disorders, 39-8 (August 2009)
[article]
Titre : Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study Type de document : Texte imprimé et/ou numérique Auteurs : Katharina DWORZYNSKI, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur Année de publication : 2009 Article en page(s) : p.1197-1210 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorders Symptom-domains Twins Index. décimale : PER Périodiques Résumé : Factor structure and relationship between core features of autism (social impairments, communication difficulties, and restricted, repetitive behaviours or interests (RRBIs)) were explored in 189 children from the Twins Early Development Study, diagnosed with autistic spectrum disorders (ASDs) using the Development and Wellbeing Assessment (DAWBA; Goodman et al. in J Child Psychol Psyc 41:645–655, 2000). A bottom-up approach (analysis 1) used principal component factor analysis of DAWBA items indicating five factors, the first three mapping on the triad. In analysis 2, applying top-down DSM-IV criteria, correlations between domains were modest, strongest between social and communication difficulties. Cross-twin cross-trait correlations suggested small shared genetic effects between RRBIs and other symptoms. These findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0736-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789
in Journal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1197-1210[article] Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study [Texte imprimé et/ou numérique] / Katharina DWORZYNSKI, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur . - 2009 . - p.1197-1210.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1197-1210
Mots-clés : Autism-spectrum-disorders Symptom-domains Twins Index. décimale : PER Périodiques Résumé : Factor structure and relationship between core features of autism (social impairments, communication difficulties, and restricted, repetitive behaviours or interests (RRBIs)) were explored in 189 children from the Twins Early Development Study, diagnosed with autistic spectrum disorders (ASDs) using the Development and Wellbeing Assessment (DAWBA; Goodman et al. in J Child Psychol Psyc 41:645–655, 2000). A bottom-up approach (analysis 1) used principal component factor analysis of DAWBA items indicating five factors, the first three mapping on the triad. In analysis 2, applying top-down DSM-IV criteria, correlations between domains were modest, strongest between social and communication difficulties. Cross-twin cross-trait correlations suggested small shared genetic effects between RRBIs and other symptoms. These findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0736-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789