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Auteur Daniel Samuel PINE |
Documents disponibles écrits par cet auteur (25)
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Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differences / Michael G. HARDIN in Journal of Child Psychology and Psychiatry, 48-5 (May 2007)
[article]
Titre : Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differences Type de document : Texte imprimé et/ou numérique Auteurs : Michael G. HARDIN, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Elizabeth SCHROTH, Auteur Année de publication : 2007 Article en page(s) : p.446–454 Langues : Anglais (eng) Mots-clés : Saccade inhibition motivation valence salience eye-movement pediatric adolescence anxiety cognition depression development Index. décimale : PER Périodiques Résumé : Developmental changes in cognitive and affective processes contribute to adolescent risk-taking behavior, emotional intensification, and psychopathology. The current study examined adolescent development of cognitive control processes and their modulation by incentive, in health and psychopathology. Predictions include 1) better cognitive control in adults than adolescents, and in healthy adolescents than anxious and depressed adolescents, and 2) a stronger influence of incentives in adolescents than adults, and in healthy adolescents than their depressed and anxious counterparts.
Methods: Antisaccadic eye movement parameters, which provide a measure of cognitive control, were collected during a reward antisaccade task that included parameterized incentive levels. Participants were 20 healthy adults, 30 healthy adolescents, 16 adolescents with an anxiety disorder, and 11 adolescents with major depression. Performance accuracy and saccade latency were analyzed to test both developmental and psychopathology hypotheses.
Results: Development and psychopathology group differences in cognitive control were found. Specifically, adults performed better than healthy adolescents, and healthy adolescents than anxious and depressed adolescents. Incentive improved accuracy for all groups; however, incremental increases were not sufficiently large to further modulate performance. Incentives also affected saccade latencies, pushing healthy adolescent latencies to adult levels, while being less effective in adolescents with depression or anxiety. This latter effect was partially mediated by anxiety symptom severity.
Conclusions: Current findings evidence the modulation of cognitive control processes by incentives. While seen in both healthy adults and healthy adolescents, this modulatory effect was stronger in youth. While anxious and depressed adolescents exhibited improved cognitive control under incentives, this effect was smaller than that in healthy adolescents. These findings suggest differential incentive and/or cognitive control processing in anxiety and depression, and across development. Differences could result from disorder specific, or combined developmental and pathological mechanisms.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01722.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=956
in Journal of Child Psychology and Psychiatry > 48-5 (May 2007) . - p.446–454[article] Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differences [Texte imprimé et/ou numérique] / Michael G. HARDIN, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Elizabeth SCHROTH, Auteur . - 2007 . - p.446–454.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 48-5 (May 2007) . - p.446–454
Mots-clés : Saccade inhibition motivation valence salience eye-movement pediatric adolescence anxiety cognition depression development Index. décimale : PER Périodiques Résumé : Developmental changes in cognitive and affective processes contribute to adolescent risk-taking behavior, emotional intensification, and psychopathology. The current study examined adolescent development of cognitive control processes and their modulation by incentive, in health and psychopathology. Predictions include 1) better cognitive control in adults than adolescents, and in healthy adolescents than anxious and depressed adolescents, and 2) a stronger influence of incentives in adolescents than adults, and in healthy adolescents than their depressed and anxious counterparts.
Methods: Antisaccadic eye movement parameters, which provide a measure of cognitive control, were collected during a reward antisaccade task that included parameterized incentive levels. Participants were 20 healthy adults, 30 healthy adolescents, 16 adolescents with an anxiety disorder, and 11 adolescents with major depression. Performance accuracy and saccade latency were analyzed to test both developmental and psychopathology hypotheses.
Results: Development and psychopathology group differences in cognitive control were found. Specifically, adults performed better than healthy adolescents, and healthy adolescents than anxious and depressed adolescents. Incentive improved accuracy for all groups; however, incremental increases were not sufficiently large to further modulate performance. Incentives also affected saccade latencies, pushing healthy adolescent latencies to adult levels, while being less effective in adolescents with depression or anxiety. This latter effect was partially mediated by anxiety symptom severity.
Conclusions: Current findings evidence the modulation of cognitive control processes by incentives. While seen in both healthy adults and healthy adolescents, this modulatory effect was stronger in youth. While anxious and depressed adolescents exhibited improved cognitive control under incentives, this effect was smaller than that in healthy adolescents. These findings suggest differential incentive and/or cognitive control processing in anxiety and depression, and across development. Differences could result from disorder specific, or combined developmental and pathological mechanisms.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01722.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=956 Inhibitory control in anxious and healthy adolescents is modulated by incentive and incidental affective stimuli / Michael G. HARDIN in Journal of Child Psychology and Psychiatry, 50-12 (December 2009)
[article]
Titre : Inhibitory control in anxious and healthy adolescents is modulated by incentive and incidental affective stimuli Type de document : Texte imprimé et/ou numérique Auteurs : Michael G. HARDIN, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Ronald E. DAHL, Auteur ; Sven C. MUELLER, Auteur ; Darcy MANDELL, Auteur Année de publication : 2009 Article en page(s) : p.1550-1558 Langues : Anglais (eng) Mots-clés : Emotion motivation cognitive-control affective-context anxiety-disorders facial-expressions Index. décimale : PER Périodiques Résumé : Background: Anxiety disorders are characterized by elevated, sustained responses to threat, that manifest as threat attention biases. Recent evidence also suggests exaggerated responses to incentives. How these characteristics influence cognitive control is under debate and is the focus of the present study.
Methods: Twenty-five healthy adolescents and 25 adolescents meeting DSM-IV diagnostic criteria for an anxiety disorder were compared on a task of response inhibition. Inhibitory control was assayed with an antisaccade task that included both incentive (monetary reward) and incidental emotion (facial expression) cues presented prior to the execution of inhibitory behavior.
Results: Inhibitory control was enhanced following exposure to threat cues (fear faces) only in adolescent patients, and following exposure to positive cues (happy faces) only in healthy adolescents. Results also revealed a robust performance improvement associated with monetary incentives. This incentive effect did not differ by group. No interaction between incentives and emotional cues was detected.
Conclusions: These findings suggest that biased processing of threat in anxious adolescents affects inhibitory control, perhaps by raising arousal prior to behavioral performance. The absence of normalization of performance in anxious adolescents following exposure to positive emotional cues is a novel finding and will require additional exploration. Future studies will need to more specifically examine how perturbations in positive emotion processes contribute to the symptomatology and the pathogenesis of anxiety disorders.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02121.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=883
in Journal of Child Psychology and Psychiatry > 50-12 (December 2009) . - p.1550-1558[article] Inhibitory control in anxious and healthy adolescents is modulated by incentive and incidental affective stimuli [Texte imprimé et/ou numérique] / Michael G. HARDIN, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Ronald E. DAHL, Auteur ; Sven C. MUELLER, Auteur ; Darcy MANDELL, Auteur . - 2009 . - p.1550-1558.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-12 (December 2009) . - p.1550-1558
Mots-clés : Emotion motivation cognitive-control affective-context anxiety-disorders facial-expressions Index. décimale : PER Périodiques Résumé : Background: Anxiety disorders are characterized by elevated, sustained responses to threat, that manifest as threat attention biases. Recent evidence also suggests exaggerated responses to incentives. How these characteristics influence cognitive control is under debate and is the focus of the present study.
Methods: Twenty-five healthy adolescents and 25 adolescents meeting DSM-IV diagnostic criteria for an anxiety disorder were compared on a task of response inhibition. Inhibitory control was assayed with an antisaccade task that included both incentive (monetary reward) and incidental emotion (facial expression) cues presented prior to the execution of inhibitory behavior.
Results: Inhibitory control was enhanced following exposure to threat cues (fear faces) only in adolescent patients, and following exposure to positive cues (happy faces) only in healthy adolescents. Results also revealed a robust performance improvement associated with monetary incentives. This incentive effect did not differ by group. No interaction between incentives and emotional cues was detected.
Conclusions: These findings suggest that biased processing of threat in anxious adolescents affects inhibitory control, perhaps by raising arousal prior to behavioral performance. The absence of normalization of performance in anxious adolescents following exposure to positive emotional cues is a novel finding and will require additional exploration. Future studies will need to more specifically examine how perturbations in positive emotion processes contribute to the symptomatology and the pathogenesis of anxiety disorders.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02121.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=883 Isolating neural components of threat bias in pediatric anxiety / Jennifer C. BRITTON in Journal of Child Psychology and Psychiatry, 53-6 (June 2012)
[article]
Titre : Isolating neural components of threat bias in pediatric anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer C. BRITTON, Auteur ; Yair BAR-HAIM, Auteur ; Frederick W. CARVER, Auteur ; Tom HOLROYD, Auteur ; Maxine A. NORCROSS, Auteur ; Allison DETLOFF, Auteur ; Ellen LEIBENLUFT, Auteur ; Monique ERNST, Auteur ; Daniel Samuel PINE, Auteur Année de publication : 2012 Article en page(s) : p.678–686 Langues : Anglais (eng) Mots-clés : magnetoencephalography ventrolateral prefrontal cortex attention Index. décimale : PER Périodiques Résumé : Background: Attention biases toward threat are often detected in individuals with anxiety disorders. Threat biases can be measured experimentally through dot-probe paradigms, in which individuals detect a probe following a stimulus pair including a threat. On these tasks, individuals with anxiety tend to detect probes that occur in a location previously occupied by a threat (i.e., congruent) faster than when opposite threats (i.e., incongruent). In pediatric anxiety disorders, dot-probe paradigms detect abnormal attention biases toward threat and abnormal ventrolateral prefrontal cortex (vlPFC) function. However, it remains unclear if this aberrant vlPFC activation occurs while subjects process threats (e.g., angry faces) or, alternatively, while they process and respond to probes. This magnetoencephalography (MEG) study was designed to answer this question.
Methods: Adolescents with either generalized anxiety disorder (GAD, n = 17) or no psychiatric diagnosis (n = 25) performed a dot-probe task involving angry and neutral faces while MEG data were collected. Synthetic Aperture Magnetometry (SAM) beamformer technique was used to determine whether there were group differences in power ratios while subjects processed threats (i.e., angry vs. neutral faces) or when subjects responded to incongruent versus. congruent probes.
Results: Group differences in vlPFC activation during the response period emerged with a 1–30 Hz frequency band. No group differences in vlPFC activation were detected in response to angry-face cues.
Conclusions: In the dot-probe task, anxiety-related perturbations in vlPFC activation reflect abnormal attention control when responding to behaviorally relevant probes, but not to angry faces. Given that motor responses to these probes are used to calculate threat bias, this study provides insight into the pathophysiology reflected in this commonly used marker of anxiety. In addition, this finding may inform the development of novel anxiety-disorder treatments targeting the vlPFC to enhance attention control to task-relevant demands.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02503.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157
in Journal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.678–686[article] Isolating neural components of threat bias in pediatric anxiety [Texte imprimé et/ou numérique] / Jennifer C. BRITTON, Auteur ; Yair BAR-HAIM, Auteur ; Frederick W. CARVER, Auteur ; Tom HOLROYD, Auteur ; Maxine A. NORCROSS, Auteur ; Allison DETLOFF, Auteur ; Ellen LEIBENLUFT, Auteur ; Monique ERNST, Auteur ; Daniel Samuel PINE, Auteur . - 2012 . - p.678–686.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.678–686
Mots-clés : magnetoencephalography ventrolateral prefrontal cortex attention Index. décimale : PER Périodiques Résumé : Background: Attention biases toward threat are often detected in individuals with anxiety disorders. Threat biases can be measured experimentally through dot-probe paradigms, in which individuals detect a probe following a stimulus pair including a threat. On these tasks, individuals with anxiety tend to detect probes that occur in a location previously occupied by a threat (i.e., congruent) faster than when opposite threats (i.e., incongruent). In pediatric anxiety disorders, dot-probe paradigms detect abnormal attention biases toward threat and abnormal ventrolateral prefrontal cortex (vlPFC) function. However, it remains unclear if this aberrant vlPFC activation occurs while subjects process threats (e.g., angry faces) or, alternatively, while they process and respond to probes. This magnetoencephalography (MEG) study was designed to answer this question.
Methods: Adolescents with either generalized anxiety disorder (GAD, n = 17) or no psychiatric diagnosis (n = 25) performed a dot-probe task involving angry and neutral faces while MEG data were collected. Synthetic Aperture Magnetometry (SAM) beamformer technique was used to determine whether there were group differences in power ratios while subjects processed threats (i.e., angry vs. neutral faces) or when subjects responded to incongruent versus. congruent probes.
Results: Group differences in vlPFC activation during the response period emerged with a 1–30 Hz frequency band. No group differences in vlPFC activation were detected in response to angry-face cues.
Conclusions: In the dot-probe task, anxiety-related perturbations in vlPFC activation reflect abnormal attention control when responding to behaviorally relevant probes, but not to angry faces. Given that motor responses to these probes are used to calculate threat bias, this study provides insight into the pathophysiology reflected in this commonly used marker of anxiety. In addition, this finding may inform the development of novel anxiety-disorder treatments targeting the vlPFC to enhance attention control to task-relevant demands.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02503.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157 Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit / Brendan A. RICH in Journal of Child Psychology and Psychiatry, 49-1 (January 2008)
[article]
Titre : Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit Type de document : Texte imprimé et/ou numérique Auteurs : Brendan A. RICH, Auteur ; Daniel Samuel PINE, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Stephen J. FROMM, Auteur ; Lisa H. BERGHORST, Auteur ; Daniel P. DICKSTEIN, Auteur Année de publication : 2007 Article en page(s) : p.88–96 Langues : Anglais (eng) Mots-clés : Bipolar-disorder children face-perception neural-connectivity amygdala Index. décimale : PER Périodiques Résumé : Background: Pediatric bipolar disorder (BD), a highly debilitating illness, is characterized by amygdala abnormalities, i.e., volume reduction and hyperactivation during face processing. Evidence of perturbed amygdala functional connectivity with other brain regions would implicate a distributed neural circuit in the pathophysiology of BD, and would further elucidate the neural mechanisms associated with BD face emotion misinterpretation.
Methods: Thirty-three BD and 24 healthy age, gender, and IQ-matched subjects completed a functional magnetic resonance imaging (fMRI) task of face emotion identification in which attention was directed to emotional (hostility, fearfulness) and nonemotional (nose width) aspects of faces. Voxel-wise analyses examined whole brain functional connectivity with the left amygdala.
Results: Compared to healthy subjects, BD subjects had significantly reduced connectivity between the left amygdala and two regions: right posterior cingulate/precuneus and right fusiform gyrus/parahippocampal gyrus. Deficits were evident regardless of mood state and comorbid diagnoses.
Conclusions: BD youth exhibit deficient connectivity between the amygdala and temporal association cortical regions previously implicated in processing facial expressions and social stimuli. In conjunction with previously documented volumetric and functional perturbations in these brain regions, dysfunction in this distributed neural circuit may begin to clarify the pathophysiology of the face emotion misperceptions and social deficits seen in BD youth.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01819.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311
in Journal of Child Psychology and Psychiatry > 49-1 (January 2008) . - p.88–96[article] Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit [Texte imprimé et/ou numérique] / Brendan A. RICH, Auteur ; Daniel Samuel PINE, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Stephen J. FROMM, Auteur ; Lisa H. BERGHORST, Auteur ; Daniel P. DICKSTEIN, Auteur . - 2007 . - p.88–96.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-1 (January 2008) . - p.88–96
Mots-clés : Bipolar-disorder children face-perception neural-connectivity amygdala Index. décimale : PER Périodiques Résumé : Background: Pediatric bipolar disorder (BD), a highly debilitating illness, is characterized by amygdala abnormalities, i.e., volume reduction and hyperactivation during face processing. Evidence of perturbed amygdala functional connectivity with other brain regions would implicate a distributed neural circuit in the pathophysiology of BD, and would further elucidate the neural mechanisms associated with BD face emotion misinterpretation.
Methods: Thirty-three BD and 24 healthy age, gender, and IQ-matched subjects completed a functional magnetic resonance imaging (fMRI) task of face emotion identification in which attention was directed to emotional (hostility, fearfulness) and nonemotional (nose width) aspects of faces. Voxel-wise analyses examined whole brain functional connectivity with the left amygdala.
Results: Compared to healthy subjects, BD subjects had significantly reduced connectivity between the left amygdala and two regions: right posterior cingulate/precuneus and right fusiform gyrus/parahippocampal gyrus. Deficits were evident regardless of mood state and comorbid diagnoses.
Conclusions: BD youth exhibit deficient connectivity between the amygdala and temporal association cortical regions previously implicated in processing facial expressions and social stimuli. In conjunction with previously documented volumetric and functional perturbations in these brain regions, dysfunction in this distributed neural circuit may begin to clarify the pathophysiology of the face emotion misperceptions and social deficits seen in BD youth.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01819.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 A primer on brain imaging in developmental psychopathology: What is it good for? / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)
[article]
Titre : A primer on brain imaging in developmental psychopathology: What is it good for? Type de document : Texte imprimé et/ou numérique Auteurs : Daniel Samuel PINE, Auteur Année de publication : 2007 Article en page(s) : p.983–986 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This primer introduces a Special Section on brain imaging, which includes a commentary and 10 data papers presenting applications of brain imaging to questions on developmental psychopathology. This primer serves two purposes. First, the article summarizes the strength and weaknesses of various brain-imaging techniques typically employed in research on developmental psychopathology. Second, the article places research on brain imaging in a broader context by discussing particular limitations and utilities of imaging. Specifically, while brain imaging is currently of limited clinical utility, work in this area is beginning to shape clinical thinking. Brain-imaging research offers a unique opportunity to constrain theories of pathophysiology based on understandings of brain function. This effect promises to open avenues for novel treatments. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01686.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787
in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.983–986[article] A primer on brain imaging in developmental psychopathology: What is it good for? [Texte imprimé et/ou numérique] / Daniel Samuel PINE, Auteur . - 2007 . - p.983–986.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.983–986
Index. décimale : PER Périodiques Résumé : This primer introduces a Special Section on brain imaging, which includes a commentary and 10 data papers presenting applications of brain imaging to questions on developmental psychopathology. This primer serves two purposes. First, the article summarizes the strength and weaknesses of various brain-imaging techniques typically employed in research on developmental psychopathology. Second, the article places research on brain imaging in a broader context by discussing particular limitations and utilities of imaging. Specifically, while brain imaging is currently of limited clinical utility, work in this area is beginning to shape clinical thinking. Brain-imaging research offers a unique opportunity to constrain theories of pathophysiology based on understandings of brain function. This effect promises to open avenues for novel treatments. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01686.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787 Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits / Stuart F. WHITE in Development and Psychopathology, 24-3 (August 2012)
PermalinkResearch Review: A neuroscience framework for pediatric anxiety disorders / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 48-7 (July 2007)
PermalinkSpecificity of facial expression labeling deficits in childhood psychopathology / Amanda E. GUYER in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)
PermalinkThe development of psychopathy / James R. BLAIR in Journal of Child Psychology and Psychiatry, 47-3/4 (March/April 2006)
PermalinkThe influence of emotional stimuli on attention orienting and inhibitory control in pediatric anxiety / Sven C. MUELLER in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)
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