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Auteur Frederick SHIC |
Documents disponibles écrits par cet auteur (16)
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Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis / Marta DEL VALLE RUBIDO in Journal of Autism and Developmental Disorders, 50-12 (December 2020)
[article]
Titre : Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur Article en page(s) : p.4412-4430 Langues : Anglais (eng) Mots-clés : Biomarker Eye movement Olfactory Social cognition Curemark, Coronado Biosciences, Forest, Simons Foundation, Foundation for Prader Willi Research, and the Orphan Products Division of the Food and Drug Administration, and has intellectual property relating to oxytocin and autism. FS has provided consultation to Roche and Janssen Pharmaceutical and has received research grants from Roche, NIH, and the Simons Foundation. JTM has served as a consultant for Roche and Dart Neuroscience, has received research grants from Roche, and has received study drug from Shire and AstraZeneca. FS has received research funding from Roche and Janssen Pharmaceuticals. MVR, DU, JN, LB, OK, SS and PF are full-time employees of F. Hoffmann-La Roche. Index. décimale : PER Périodiques Résumé : Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p?=?0.0001-0.037) and pupillometry (various tasks, p?=?0.017-0.05). Impaired olfaction was more common in the ASD sample versus HC (p?=?0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04493-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4412-4430[article] Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis [Texte imprimé et/ou numérique] / Marta DEL VALLE RUBIDO, Auteur ; Eric HOLLANDER, Auteur ; James T MCCRACKEN, Auteur ; Frederick SHIC, Auteur ; Jana NOELDEKE, Auteur ; Lauren BOAK, Auteur ; Omar KHWAJA, Auteur ; Shamil SADIKHOV, Auteur ; Paulo FONTOURA, Auteur ; Daniel UMBRICHT, Auteur . - p.4412-4430.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4412-4430
Mots-clés : Biomarker Eye movement Olfactory Social cognition Curemark, Coronado Biosciences, Forest, Simons Foundation, Foundation for Prader Willi Research, and the Orphan Products Division of the Food and Drug Administration, and has intellectual property relating to oxytocin and autism. FS has provided consultation to Roche and Janssen Pharmaceutical and has received research grants from Roche, NIH, and the Simons Foundation. JTM has served as a consultant for Roche and Dart Neuroscience, has received research grants from Roche, and has received study drug from Shire and AstraZeneca. FS has received research funding from Roche and Janssen Pharmaceuticals. MVR, DU, JN, LB, OK, SS and PF are full-time employees of F. Hoffmann-La Roche. Index. décimale : PER Périodiques Résumé : Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p?=?0.0001-0.037) and pupillometry (various tasks, p?=?0.017-0.05). Impaired olfaction was more common in the ASD sample versus HC (p?=?0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04493-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa) / Nina STENBERG in Journal of Autism and Developmental Disorders, 51-3 (March 2021)
[article]
Titre : Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa) Type de document : Texte imprimé et/ou numérique Auteurs : Nina STENBERG, Auteur ; Synnve SCHJØLBERG, Auteur ; Frederick SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anne-Siri ØYEN, Auteur ; Michaeline BRESNAHAN, Auteur ; Britt Kveim SVENDSEN, Auteur ; Stephen VON TETZCHNER, Auteur ; Nina Torheim THRONÆS, Auteur ; Suzanne MACARI, Auteur ; Domenic V. CICCHETTI, Auteur ; Katarzyna CHAWARSKA, Auteur ; Pål SUREN, Auteur ; Roald A. ØIEN, Auteur Article en page(s) : p.922-932 Langues : Anglais (eng) Mots-clés : Ados Autism spectrum disorders Cognition Early identification Father and child cohort study Language MoBa Norwegian mother Screening Vineland Index. décimale : PER Périodiques Résumé : Early identification of autism spectrum disorder (ASD) is regarded as crucial for swift access to early intervention and, subsequently, better outcomes later in life. However, current instruments miss large proportions of children who later go on to be diagnosed with ASD, raising a question of what these instruments measure. The present study utilized data from the Norwegian Mother, Father, and Child Cohort Study and the Autism Birth Cohort study to explore the subsequent developmental and diagnostic characteristics of children raising developmental concern on the six-critical discriminative item criterion of the M-CHAT (DFA6) at 18 months of age (N = 834). The DFA6 identified 28.8% of children diagnosed with ASD (N = 163), but 4.4% with language disorder (N = 188) and 81.3% with intellectual disability (N = 32) without ASD. Scoring in the «at-risk» range was associated with lower IQ, impaired functional language, and greater severity of autism symptoms whether children had ASD or not. En ligne : http://dx.doi.org/10.1007/s10803-020-04539-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443
in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.922-932[article] Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa) [Texte imprimé et/ou numérique] / Nina STENBERG, Auteur ; Synnve SCHJØLBERG, Auteur ; Frederick SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anne-Siri ØYEN, Auteur ; Michaeline BRESNAHAN, Auteur ; Britt Kveim SVENDSEN, Auteur ; Stephen VON TETZCHNER, Auteur ; Nina Torheim THRONÆS, Auteur ; Suzanne MACARI, Auteur ; Domenic V. CICCHETTI, Auteur ; Katarzyna CHAWARSKA, Auteur ; Pål SUREN, Auteur ; Roald A. ØIEN, Auteur . - p.922-932.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.922-932
Mots-clés : Ados Autism spectrum disorders Cognition Early identification Father and child cohort study Language MoBa Norwegian mother Screening Vineland Index. décimale : PER Périodiques Résumé : Early identification of autism spectrum disorder (ASD) is regarded as crucial for swift access to early intervention and, subsequently, better outcomes later in life. However, current instruments miss large proportions of children who later go on to be diagnosed with ASD, raising a question of what these instruments measure. The present study utilized data from the Norwegian Mother, Father, and Child Cohort Study and the Autism Birth Cohort study to explore the subsequent developmental and diagnostic characteristics of children raising developmental concern on the six-critical discriminative item criterion of the M-CHAT (DFA6) at 18 months of age (N = 834). The DFA6 identified 28.8% of children diagnosed with ASD (N = 163), but 4.4% with language disorder (N = 188) and 81.3% with intellectual disability (N = 32) without ASD. Scoring in the «at-risk» range was associated with lower IQ, impaired functional language, and greater severity of autism symptoms whether children had ASD or not. En ligne : http://dx.doi.org/10.1007/s10803-020-04539-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 Gaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis / Daniel J. CAMPBELL in Journal of Autism and Developmental Disorders, 44-2 (February 2014)
[article]
Titre : Gaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Daniel J. CAMPBELL, Auteur ; Frederick SHIC, Auteur ; Suzanne L. MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.431-442 Langues : Anglais (eng) Mots-clés : Autism Eye-tracking Visual attention Heterogeneity Eye contact Child-directed speech Index. décimale : PER Périodiques Résumé : Variability in attention towards direct gaze and child-directed speech may contribute to heterogeneity of clinical presentation in toddlers with autism spectrum disorders (ASD). To evaluate this hypothesis, we clustered sixty-five 20-month-old toddlers with ASD based on their visual responses to dyadic cues for engagement, identifying three subgroups. Subsequently, we compared social, language, and adaptive functioning of these subgroups at 3 years of age. The cluster displaying limited attention to social scenes in general exhibited poor outcome at 3 years; the cluster displaying good attention to the scene and to the speaker’s mouth was verbal and high functioning at 3 years. Analysis of visual responses to dyadic cues may provide a clinically meaningful approach to identifying early predictors of outcome. En ligne : http://dx.doi.org/10.1007/s10803-013-1885-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223
in Journal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.431-442[article] Gaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis [Texte imprimé et/ou numérique] / Daniel J. CAMPBELL, Auteur ; Frederick SHIC, Auteur ; Suzanne L. MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.431-442.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.431-442
Mots-clés : Autism Eye-tracking Visual attention Heterogeneity Eye contact Child-directed speech Index. décimale : PER Périodiques Résumé : Variability in attention towards direct gaze and child-directed speech may contribute to heterogeneity of clinical presentation in toddlers with autism spectrum disorders (ASD). To evaluate this hypothesis, we clustered sixty-five 20-month-old toddlers with ASD based on their visual responses to dyadic cues for engagement, identifying three subgroups. Subsequently, we compared social, language, and adaptive functioning of these subgroups at 3 years of age. The cluster displaying limited attention to social scenes in general exhibited poor outcome at 3 years; the cluster displaying good attention to the scene and to the speaker’s mouth was verbal and high functioning at 3 years. Analysis of visual responses to dyadic cues may provide a clinically meaningful approach to identifying early predictors of outcome. En ligne : http://dx.doi.org/10.1007/s10803-013-1885-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223 Introduction to Technologies in the Daily Lives of Individuals with Autism / Frederick SHIC in Journal of Autism and Developmental Disorders, 45-12 (December 2015)
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Titre : Introduction to Technologies in the Daily Lives of Individuals with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Frederick SHIC, Auteur ; Matthew GOODWIN, Auteur Année de publication : 2015 Article en page(s) : p.3773-3776 Langues : Anglais (eng) Mots-clés : Technologie Applications Technology Robots Games Apps Mobile Computers Ubiquitous computing Index. décimale : PER Périodiques Résumé : In this introduction to the Special Issue on Technology we explore the continued evolution of technologies designed to help individuals with autism. Through review articles, empirical reports, and perspectives, we examine how far the field has come and how much further we still can go. Notably, even as we highlight the continuing need for larger empirical studies of autism-focused technology, we note how improvements in the portability, sophistication, ubiquity, and reach of daily technologies are providing new opportunities for research, education, enhancement, knowledge, and inspiration. We conclude by discussing how the next generation of technologies may leverage the increasing promise of big-data approaches to move us towards a future where technology is more personal, more relevant, and pervasively transformative. En ligne : http://dx.doi.org/10.1007/s10803-015-2640-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.3773-3776[article] Introduction to Technologies in the Daily Lives of Individuals with Autism [Texte imprimé et/ou numérique] / Frederick SHIC, Auteur ; Matthew GOODWIN, Auteur . - 2015 . - p.3773-3776.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.3773-3776
Mots-clés : Technologie Applications Technology Robots Games Apps Mobile Computers Ubiquitous computing Index. décimale : PER Périodiques Résumé : In this introduction to the Special Issue on Technology we explore the continued evolution of technologies designed to help individuals with autism. Through review articles, empirical reports, and perspectives, we examine how far the field has come and how much further we still can go. Notably, even as we highlight the continuing need for larger empirical studies of autism-focused technology, we note how improvements in the portability, sophistication, ubiquity, and reach of daily technologies are providing new opportunities for research, education, enhancement, knowledge, and inspiration. We conclude by discussing how the next generation of technologies may leverage the increasing promise of big-data approaches to move us towards a future where technology is more personal, more relevant, and pervasively transformative. En ligne : http://dx.doi.org/10.1007/s10803-015-2640-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 Looking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder / Katarzyna CHAWARSKA in Journal of Autism and Developmental Disorders, 39-12 (December 2009)
[article]
Titre : Looking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Katarzyna CHAWARSKA, Auteur ; Frederick SHIC, Auteur Année de publication : 2009 Article en page(s) : p.1663-1672 Langues : Anglais (eng) Mots-clés : Autism ASD Face-scanning Face-recognition Toddlers Index. décimale : PER Périodiques Résumé : This study used eye-tracking to examine visual scanning and recognition of faces by 2- and 4-year-old children with autism spectrum disorder (ASD) (N = 44) and typically developing (TD) controls (N = 30). TD toddlers at both age levels scanned and recognized faces similarly. Toddlers with ASD looked increasingly away from faces with age, atypically attended to key features of faces, and were impaired in face recognition. Deficits in recognition were associated with imbalanced attention between key facial features. This study illustrates that face processing in ASD may be affected early and become further compromised with age. We propose that deficits in face processing likely impact the effectiveness of toddlers with ASD as social partners and thus should be targeted for intervention. En ligne : http://dx.doi.org/10.1007/s10803-009-0803-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=884
in Journal of Autism and Developmental Disorders > 39-12 (December 2009) . - p.1663-1672[article] Looking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Katarzyna CHAWARSKA, Auteur ; Frederick SHIC, Auteur . - 2009 . - p.1663-1672.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-12 (December 2009) . - p.1663-1672
Mots-clés : Autism ASD Face-scanning Face-recognition Toddlers Index. décimale : PER Périodiques Résumé : This study used eye-tracking to examine visual scanning and recognition of faces by 2- and 4-year-old children with autism spectrum disorder (ASD) (N = 44) and typically developing (TD) controls (N = 30). TD toddlers at both age levels scanned and recognized faces similarly. Toddlers with ASD looked increasingly away from faces with age, atypically attended to key features of faces, and were impaired in face recognition. Deficits in recognition were associated with imbalanced attention between key facial features. This study illustrates that face processing in ASD may be affected early and become further compromised with age. We propose that deficits in face processing likely impact the effectiveness of toddlers with ASD as social partners and thus should be targeted for intervention. En ligne : http://dx.doi.org/10.1007/s10803-009-0803-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=884 Parent-Endorsed Sex Differences in Toddlers with and Without ASD: Utilizing the M-CHAT / Roald A. ØIEN in Journal of Autism and Developmental Disorders, 47-1 (January 2017)
PermalinkPatterns of intervention utilization among school-aged children on the autism spectrum: Findings from a multi-site research consortium / Aksheya SRIDHAR in Research in Autism Spectrum Disorders, 94 (June 2022)
PermalinkPromoting social attention in 3-year-olds with ASD through gaze-contingent eye tracking / Quan WANG in Autism Research, 13-1 (January 2020)
PermalinkSex Differences on the ADOS-2 / Hannah M. REA in Journal of Autism and Developmental Disorders, 53-7 (July 2023)
PermalinkSocial attention to activities in children and adults with autism spectrum disorder: effects of context and age / Dzmitry A. KALIUKHOVICH in Molecular Autism, 11 (2020)
PermalinkSocial Robots as Embedded Reinforcers of Social Behavior in Children with Autism / Elizabeth S. KIM in Journal of Autism and Developmental Disorders, 43-5 (May 2013)
PermalinkThe autism biomarkers consortium for clinical trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials / Frederick SHIC in Molecular Autism, 13 (2022)
PermalinkThe relationship between autism symptoms and arousal level in toddlers with autism spectrum disorder, as measured by electrodermal activity / Emily Barbara PRINCE in Autism, 21-4 (May 2017)
PermalinkThe role of limited salience of speech in selective attention to faces in toddlers with autism spectrum disorders / Frederick SHIC in Journal of Child Psychology and Psychiatry, 61-4 (April 2020)
PermalinkVirtual and Augmented Reality in Social Skills Interventions for Individuals with Autism Spectrum Disorder: A Scoping Review / Anders DECHSLING in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
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