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Détail de l'auteur
Auteur Jane YIP |
Documents disponibles écrits par cet auteur (3)
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Connecting Electroencephalography Profiles with the Gamma-Amino-Butyric Acid (GABA) Neuropathology of Autism as a Prelude to Treatment / Jane YIP
Titre : Connecting Electroencephalography Profiles with the Gamma-Amino-Butyric Acid (GABA) Neuropathology of Autism as a Prelude to Treatment Type de document : Texte imprimé et/ou numérique Auteurs : Jane YIP, Auteur ; Sara DAVIS, Auteur ; Oliver WENDT, Auteur Année de publication : 2011 Importance : p.464-484 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/22405 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Connecting Electroencephalography Profiles with the Gamma-Amino-Butyric Acid (GABA) Neuropathology of Autism as a Prelude to Treatment [Texte imprimé et/ou numérique] / Jane YIP, Auteur ; Sara DAVIS, Auteur ; Oliver WENDT, Auteur . - 2011 . - p.464-484.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/22405 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study / Jane YIP in Autism Research, 2-1 (February 2009)
[article]
Titre : Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study Type de document : Texte imprimé et/ou numérique Auteurs : Jane YIP, Auteur ; Gene J. BLATT, Auteur ; Jean Jacques SOGHOMONIAN, Auteur Année de publication : 2009 Article en page(s) : p.50-59 Langues : Anglais (eng) Mots-clés : dentate-nucleus cerebellum autistic GABA dysregulation cerebellar-nuclei Index. décimale : PER Périodiques Résumé : The laterally positioned dentate nuclei lie in a key position in the cerebellum to receive input from Purkinje cells in the lateral cerebellar hemisphere participating in both motor and cognitive functions. Although neuropathology of the four cerebellar nuclei using Nissl staining has been qualitatively reported in children and adults with autism, surprisingly the dentate nuclei appeared less affected despite reported reductions in Purkinje cells in the posterolateral cerebellar hemisphere. To determine any underlying abnormalities in the critically important GABAergic system, the rate-limiting GABA synthesizing enzyme, glutamic acid decarboxylase (GAD) type 65 was measured via in situ hybridization histochemistry in dentate somata. GAD65 mRNA labeling revealed two distinct subpopulations of neurons in adult control and autism postmortem brains: small-sized cells (about 10-12 µm in diameter, presumed interneurons) and larger-sized neurons (about 18-20 µm in diameter, likely feedback to inferior olivary neurons). A mean 51% reduction in GAD65 mRNA levels was found in the larger labeled cells in the autistic group compared with the control group (P=0.009; independent t-test) but not in the smaller cell subpopulation. This suggests a disturbance in the intrinsic cerebellar circuitry in the autism group potentially interfering with the synchronous firing of inferior olivary neurons, and the timing of Purkinje cell firing and inputs to the dentate nuclei. Disturbances in critical neural substrates within these key circuits could disrupt afferents to motor and/or cognitive cerebral association areas in the autistic brain likely contributing to the marked behavioral consequences characteristic of autism. En ligne : http://dx.doi.org/10.1002/aur.62 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=935
in Autism Research > 2-1 (February 2009) . - p.50-59[article] Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study [Texte imprimé et/ou numérique] / Jane YIP, Auteur ; Gene J. BLATT, Auteur ; Jean Jacques SOGHOMONIAN, Auteur . - 2009 . - p.50-59.
Langues : Anglais (eng)
in Autism Research > 2-1 (February 2009) . - p.50-59
Mots-clés : dentate-nucleus cerebellum autistic GABA dysregulation cerebellar-nuclei Index. décimale : PER Périodiques Résumé : The laterally positioned dentate nuclei lie in a key position in the cerebellum to receive input from Purkinje cells in the lateral cerebellar hemisphere participating in both motor and cognitive functions. Although neuropathology of the four cerebellar nuclei using Nissl staining has been qualitatively reported in children and adults with autism, surprisingly the dentate nuclei appeared less affected despite reported reductions in Purkinje cells in the posterolateral cerebellar hemisphere. To determine any underlying abnormalities in the critically important GABAergic system, the rate-limiting GABA synthesizing enzyme, glutamic acid decarboxylase (GAD) type 65 was measured via in situ hybridization histochemistry in dentate somata. GAD65 mRNA labeling revealed two distinct subpopulations of neurons in adult control and autism postmortem brains: small-sized cells (about 10-12 µm in diameter, presumed interneurons) and larger-sized neurons (about 18-20 µm in diameter, likely feedback to inferior olivary neurons). A mean 51% reduction in GAD65 mRNA levels was found in the larger labeled cells in the autistic group compared with the control group (P=0.009; independent t-test) but not in the smaller cell subpopulation. This suggests a disturbance in the intrinsic cerebellar circuitry in the autism group potentially interfering with the synchronous firing of inferior olivary neurons, and the timing of Purkinje cell firing and inputs to the dentate nuclei. Disturbances in critical neural substrates within these key circuits could disrupt afferents to motor and/or cognitive cerebral association areas in the autistic brain likely contributing to the marked behavioral consequences characteristic of autism. En ligne : http://dx.doi.org/10.1002/aur.62 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=935 Glutamic Acid Decarboxylase (GAD) as a Biomarker of GABAergic Activity in Autism: Impact on Cerebellar Circuitry and Function / Gene J. BLATT
Titre : Glutamic Acid Decarboxylase (GAD) as a Biomarker of GABAergic Activity in Autism: Impact on Cerebellar Circuitry and Function Type de document : Texte imprimé et/ou numérique Auteurs : Gene J. BLATT, Auteur ; Jean Jacques SOGHOMONIAN, Auteur ; Jane YIP, Auteur Année de publication : 2010 Importance : p.95-111 Langues : Anglais (eng) Mots-clés : Glutamate Decarboxylase Acide ?-aminobutyrique Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109 Glutamic Acid Decarboxylase (GAD) as a Biomarker of GABAergic Activity in Autism: Impact on Cerebellar Circuitry and Function [Texte imprimé et/ou numérique] / Gene J. BLATT, Auteur ; Jean Jacques SOGHOMONIAN, Auteur ; Jane YIP, Auteur . - 2010 . - p.95-111.
Langues : Anglais (eng)
Mots-clés : Glutamate Decarboxylase Acide ?-aminobutyrique Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109 Exemplaires
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