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Auteur Alexander HEISE |
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Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1 / Björn ALBRECHT in Journal of Child Psychology and Psychiatry, 55-8 (August 2014)
[article]
Titre : Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1 Type de document : Texte imprimé et/ou numérique Auteurs : Björn ALBRECHT, Auteur ; Daniel BRANDEIS, Auteur ; Henrik Uebel VON SANDERSLEBEN, Auteur ; Lilian VALKO, Auteur ; Hartmut HEINRICH, Auteur ; Xiaohui XU, Auteur ; Renate DRECHSLER, Auteur ; Alexander HEISE, Auteur ; Jonna KUNTSI, Auteur ; Ueli C. MÜLLER, Auteur ; Philip ASHERSON, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur Article en page(s) : p.914-923 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder ERP endophenotypes CPT CNV Nogo P3 Index. décimale : PER Périodiques Résumé : Background Difficulties with performance and brain activity related to attentional orienting (Cue-P3), cognitive or response preparation (Cue-CNV) and inhibitory response control (Nogo-P3) during tasks tapping executive functions are familial in ADHD and may represent endophenotypes. The aim of this study was to clarify the impact of dopamine receptor D4 (DRD4) and dopamine transporter (DAT1) gene polymorphisms on these processes in ADHD and control children. Methods Behavioural and electrophysiological parameters from cued continuous performance tests with low and high attentional load were assessed in boys with ADHD combined type (N = 94) and controls without family history of ADHD (N = 31). Both groups were split for the presence of at least one DRD4 7-repeat allele and the DAT1 10-6 haplotype. Results Children with ADHD showed diminished performance and lower Cue-P3, CNV and Nogo-P3 amplitudes. Children with DRD4 7R showed similar performance problems and lower Cue-P3 and CNV, but Nogo-P3 was not reduced. Children with the DAT1 10-6 haplotype had no difficulties with performance or Cue-P3 and CNV, but contrary to expectations increased Nogo-P3. There were no Genotype by ADHD interactions. Conclusions This study detected specific effects of DRD4 7R on performance and brain activity related to attentional orienting and response preparation, while DAT1 10-6 was associated with elevated brain activity related to inhibitory response control, which potentially compensates increased impulsivity. As these genotype effects were additive to the impact of ADHD, the current results indicate that DRD4 and DAT1 polymorphisms are functionally relevant risk factors for ADHD and presumably other disorders sharing these endophenotypes. En ligne : http://dx.doi.org/10.1111/jcpp.12212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237
in Journal of Child Psychology and Psychiatry > 55-8 (August 2014) . - p.914-923[article] Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1 [Texte imprimé et/ou numérique] / Björn ALBRECHT, Auteur ; Daniel BRANDEIS, Auteur ; Henrik Uebel VON SANDERSLEBEN, Auteur ; Lilian VALKO, Auteur ; Hartmut HEINRICH, Auteur ; Xiaohui XU, Auteur ; Renate DRECHSLER, Auteur ; Alexander HEISE, Auteur ; Jonna KUNTSI, Auteur ; Ueli C. MÜLLER, Auteur ; Philip ASHERSON, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur . - p.914-923.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-8 (August 2014) . - p.914-923
Mots-clés : Attention deficit hyperactivity disorder ERP endophenotypes CPT CNV Nogo P3 Index. décimale : PER Périodiques Résumé : Background Difficulties with performance and brain activity related to attentional orienting (Cue-P3), cognitive or response preparation (Cue-CNV) and inhibitory response control (Nogo-P3) during tasks tapping executive functions are familial in ADHD and may represent endophenotypes. The aim of this study was to clarify the impact of dopamine receptor D4 (DRD4) and dopamine transporter (DAT1) gene polymorphisms on these processes in ADHD and control children. Methods Behavioural and electrophysiological parameters from cued continuous performance tests with low and high attentional load were assessed in boys with ADHD combined type (N = 94) and controls without family history of ADHD (N = 31). Both groups were split for the presence of at least one DRD4 7-repeat allele and the DAT1 10-6 haplotype. Results Children with ADHD showed diminished performance and lower Cue-P3, CNV and Nogo-P3 amplitudes. Children with DRD4 7R showed similar performance problems and lower Cue-P3 and CNV, but Nogo-P3 was not reduced. Children with the DAT1 10-6 haplotype had no difficulties with performance or Cue-P3 and CNV, but contrary to expectations increased Nogo-P3. There were no Genotype by ADHD interactions. Conclusions This study detected specific effects of DRD4 7R on performance and brain activity related to attentional orienting and response preparation, while DAT1 10-6 was associated with elevated brain activity related to inhibitory response control, which potentially compensates increased impulsivity. As these genotype effects were additive to the impact of ADHD, the current results indicate that DRD4 and DAT1 polymorphisms are functionally relevant risk factors for ADHD and presumably other disorders sharing these endophenotypes. En ligne : http://dx.doi.org/10.1111/jcpp.12212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237 Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD / Henrik UEBEL in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)
[article]
Titre : Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Henrik UEBEL, Auteur ; Aribert ROTHENBERGER, Auteur ; Hanna CHRISTIANSEN, Auteur ; Rafaela MARCO, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Norbert A. BORGER, Auteur ; Alexander HEISE, Auteur ; Ulrike SCHAFER, Auteur ; Robert D. OADES, Auteur ; Louise BUTLER, Auteur ; Aisling MULLIGAN, Auteur ; Wai CHEN, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Björn ALBRECHT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jaap VAN DER MEERE, Auteur ; Penelope ANDREOU, Auteur Année de publication : 2010 Article en page(s) : p.210-218 Langues : Anglais (eng) Mots-clés : Attention-deficit-hyperactivity-disorder ADHD endophenotype executive-function reaction-time-variability false-alarms state-regulation incentives Index. décimale : PER Périodiques Résumé : Background: Attention-deficit hyperactivity disorder (ADHD) is one of the most common and highly heritable child psychiatric disorders. There is strong evidence that children with ADHD show slower and more variable responses in tasks such as Go/Nogo tapping aspects of executive functions like sustained attention and response control which may be modulated by motivational factors and/or state-regulation processes. The aim of this study was (1) to determine if these executive functions may constitute an endophenotype for ADHD; (2) to investigate for the first time whether known modulators of these executive functions may also be familial; and (3) to explore whether gender has an impact on these measures.
Methods: Two hundred and five children with ADHD combined type, 173 nonaffected biological siblings and 53 controls with no known family history of ADHD were examined using a Go/Nogo task in the framework of a multi-centre study. Performance-measures and modulating effects of event-rate and incentives were examined. Shared familial effects on these measures were assessed, and the influence of gender was tested.
Results: Children with ADHD responded more slowly and variably than nonaffected siblings or controls. Nonaffected siblings showed intermediate scores for reaction-time variability, false alarms and omission errors under fast and slow event-rates. A slower event-rate did not lead to reduced performance specific to ADHD. In the incentive condition, mean reaction-times speeded up and became less variable only in children with ADHD and their nonaffected siblings, while accuracy was improved in all groups. Males responded faster, but also committed more false alarms. There were no interactions of group by gender.
Conclusions: Reaction-time variability and accuracy parameters could be useful neuropsychological endophenotypes for ADHD. Performance-modulating effects of incentives suggested a familially driven motivational dysfunction which may play an important role on etiologic pathways and treatment approaches for ADHD. The effects of gender were independent of familial effects or ADHD-status, which in turn suggests that the proposed endophenotypes are independent of gender.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02139.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.210-218[article] Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD [Texte imprimé et/ou numérique] / Henrik UEBEL, Auteur ; Aribert ROTHENBERGER, Auteur ; Hanna CHRISTIANSEN, Auteur ; Rafaela MARCO, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Norbert A. BORGER, Auteur ; Alexander HEISE, Auteur ; Ulrike SCHAFER, Auteur ; Robert D. OADES, Auteur ; Louise BUTLER, Auteur ; Aisling MULLIGAN, Auteur ; Wai CHEN, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Björn ALBRECHT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jaap VAN DER MEERE, Auteur ; Penelope ANDREOU, Auteur . - 2010 . - p.210-218.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.210-218
Mots-clés : Attention-deficit-hyperactivity-disorder ADHD endophenotype executive-function reaction-time-variability false-alarms state-regulation incentives Index. décimale : PER Périodiques Résumé : Background: Attention-deficit hyperactivity disorder (ADHD) is one of the most common and highly heritable child psychiatric disorders. There is strong evidence that children with ADHD show slower and more variable responses in tasks such as Go/Nogo tapping aspects of executive functions like sustained attention and response control which may be modulated by motivational factors and/or state-regulation processes. The aim of this study was (1) to determine if these executive functions may constitute an endophenotype for ADHD; (2) to investigate for the first time whether known modulators of these executive functions may also be familial; and (3) to explore whether gender has an impact on these measures.
Methods: Two hundred and five children with ADHD combined type, 173 nonaffected biological siblings and 53 controls with no known family history of ADHD were examined using a Go/Nogo task in the framework of a multi-centre study. Performance-measures and modulating effects of event-rate and incentives were examined. Shared familial effects on these measures were assessed, and the influence of gender was tested.
Results: Children with ADHD responded more slowly and variably than nonaffected siblings or controls. Nonaffected siblings showed intermediate scores for reaction-time variability, false alarms and omission errors under fast and slow event-rates. A slower event-rate did not lead to reduced performance specific to ADHD. In the incentive condition, mean reaction-times speeded up and became less variable only in children with ADHD and their nonaffected siblings, while accuracy was improved in all groups. Males responded faster, but also committed more false alarms. There were no interactions of group by gender.
Conclusions: Reaction-time variability and accuracy parameters could be useful neuropsychological endophenotypes for ADHD. Performance-modulating effects of incentives suggested a familially driven motivational dysfunction which may play an important role on etiologic pathways and treatment approaches for ADHD. The effects of gender were independent of familial effects or ADHD-status, which in turn suggests that the proposed endophenotypes are independent of gender.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02139.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941