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Auteur Murray T. MAYBERY |
Documents disponibles écrits par cet auteur (24)
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Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach / Maryam BOUTRUS in Autism Research, 10-12 (December 2017)
[article]
Titre : Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach Type de document : Texte imprimé et/ou numérique Auteurs : Maryam BOUTRUS, Auteur ; Murray T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; Diana Weiting TAN, Auteur ; Kandice J. VARCIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1910-1918 Langues : Anglais (eng) Mots-clés : neurodevelopment facial phenotype morphology subgroups autism Index. décimale : PER Périodiques Résumé : Atypical facial characteristics have been observed in many disorders associated with developmental disability. While autism spectrum conditions (ASC) have not previously been thought to be associated with a distinct facial phenotype, an emerging research literature is casting doubt on this assumption. The identification of differences in the facial phenotype of individuals with ASC may contribute to efforts to promote early identification of the condition and help elucidate etiological pathways. With the aim of identifying facial phenotypes associated with ASC, this commentary evaluated facial features purported to distinguish ASC from typical development. Although there is little consensus across the reviewed studies for the majority of facial characteristics described, preliminary evidence suggests increased facial asymmetry may be more common in ASC. There is also evidence to suggest that there are morphologically distinct subgroups within ASC that correspond with different cognitive and behavioral symptomatology. However, in light of the various inconsistencies in the reported literature, and based on an accumulating understanding of etiological pathways proposed to be associated with ASC, we propose an alternative paradigm for investigating facial phenotypes in ASC. A series of studies are outlined to demonstrate the promise of a research program that has taken a hypothesis-driven approach to examine facial phenotypes associated with increased exposure to prenatal testosterone and to ASC. Autism Res 2017, 10: 1910–1918. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This commentary reviewed studies that found differences in the facial features of individuals with autism spectrum conditions (ASC) compared to typically developing individuals. While there is little agreement between studies, there is some support for asymmetrical facial features associated with ASC, and preliminary evidence that particular facial features relate to specific patterns of cognitive and behavioral symptoms. However, in light of inconsistencies between studies and based on accumulating understanding of etiological pathways, we propose an alternative approach to investigating facial differences in ASC. En ligne : http://dx.doi.org/10.1002/aur.1824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-12 (December 2017) . - p.1910-1918[article] Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach [Texte imprimé et/ou numérique] / Maryam BOUTRUS, Auteur ; Murray T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; Diana Weiting TAN, Auteur ; Kandice J. VARCIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1910-1918.
Langues : Anglais (eng)
in Autism Research > 10-12 (December 2017) . - p.1910-1918
Mots-clés : neurodevelopment facial phenotype morphology subgroups autism Index. décimale : PER Périodiques Résumé : Atypical facial characteristics have been observed in many disorders associated with developmental disability. While autism spectrum conditions (ASC) have not previously been thought to be associated with a distinct facial phenotype, an emerging research literature is casting doubt on this assumption. The identification of differences in the facial phenotype of individuals with ASC may contribute to efforts to promote early identification of the condition and help elucidate etiological pathways. With the aim of identifying facial phenotypes associated with ASC, this commentary evaluated facial features purported to distinguish ASC from typical development. Although there is little consensus across the reviewed studies for the majority of facial characteristics described, preliminary evidence suggests increased facial asymmetry may be more common in ASC. There is also evidence to suggest that there are morphologically distinct subgroups within ASC that correspond with different cognitive and behavioral symptomatology. However, in light of the various inconsistencies in the reported literature, and based on an accumulating understanding of etiological pathways proposed to be associated with ASC, we propose an alternative paradigm for investigating facial phenotypes in ASC. A series of studies are outlined to demonstrate the promise of a research program that has taken a hypothesis-driven approach to examine facial phenotypes associated with increased exposure to prenatal testosterone and to ASC. Autism Res 2017, 10: 1910–1918. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This commentary reviewed studies that found differences in the facial features of individuals with autism spectrum conditions (ASC) compared to typically developing individuals. While there is little agreement between studies, there is some support for asymmetrical facial features associated with ASC, and preliminary evidence that particular facial features relate to specific patterns of cognitive and behavioral symptoms. However, in light of inconsistencies between studies and based on accumulating understanding of etiological pathways, we propose an alternative approach to investigating facial differences in ASC. En ligne : http://dx.doi.org/10.1002/aur.1824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Modulating attentional biases of adults with autistic traits using transcranial direct current stimulation: A pilot study / Michael C. W. ENGLISH in Autism Research, 11-2 (February 2018)
[article]
Titre : Modulating attentional biases of adults with autistic traits using transcranial direct current stimulation: A pilot study Type de document : Texte imprimé et/ou numérique Auteurs : Michael C. W. ENGLISH, Auteur ; Emma S. KITCHING, Auteur ; Murray T. MAYBERY, Auteur ; Troy A. W. VISSER, Auteur Année de publication : 2018 Article en page(s) : p.385-390 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While neurotypical individuals over?attend to the left?side of centrally?presented visual stimuli, this bias is reduced in individuals with autism/high levels of autistic traits. Because this difference is hypothesized to reflect relative reductions in right?hemisphere activation, it follows that increasing right?hemisphere activation should increase leftward bias. We administered transcranial direct current stimulation (tDCS) over the right posterior parietal cortex to individuals with low levels (n?=?19) and high levels (n?=?19) of autistic traits whilst they completed a greyscales task. Anodal tDCS increased leftward bias for high?trait, but not low?trait, individuals, while cathodal tDCS had no effect. This outcome suggests that typical attentional patterns driven by hemispheric lateralization could potentially be restored following right?hemisphere stimulation in high?trait individuals. Autism Res 2018, 11: 385–390. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Attentional differences between individuals with and without autism may reflect differences in underlying activation of the left and right hemispheres. In this study, we combine an attentional task that reflects relative hemispheric activation with non?invasive cortical stimulation, and show that attentional differences between healthy individuals with low and high levels of autistic?like traits can be reduced. This outcome is encouraging, and suggests that other aspects of attention in autism (e.g., face processing) may stand to benefit from similar stimulation techniques. En ligne : https://doi.org/10.1002/aur.1895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334
in Autism Research > 11-2 (February 2018) . - p.385-390[article] Modulating attentional biases of adults with autistic traits using transcranial direct current stimulation: A pilot study [Texte imprimé et/ou numérique] / Michael C. W. ENGLISH, Auteur ; Emma S. KITCHING, Auteur ; Murray T. MAYBERY, Auteur ; Troy A. W. VISSER, Auteur . - 2018 . - p.385-390.
Langues : Anglais (eng)
in Autism Research > 11-2 (February 2018) . - p.385-390
Index. décimale : PER Périodiques Résumé : While neurotypical individuals over?attend to the left?side of centrally?presented visual stimuli, this bias is reduced in individuals with autism/high levels of autistic traits. Because this difference is hypothesized to reflect relative reductions in right?hemisphere activation, it follows that increasing right?hemisphere activation should increase leftward bias. We administered transcranial direct current stimulation (tDCS) over the right posterior parietal cortex to individuals with low levels (n?=?19) and high levels (n?=?19) of autistic traits whilst they completed a greyscales task. Anodal tDCS increased leftward bias for high?trait, but not low?trait, individuals, while cathodal tDCS had no effect. This outcome suggests that typical attentional patterns driven by hemispheric lateralization could potentially be restored following right?hemisphere stimulation in high?trait individuals. Autism Res 2018, 11: 385–390. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Attentional differences between individuals with and without autism may reflect differences in underlying activation of the left and right hemispheres. In this study, we combine an attentional task that reflects relative hemispheric activation with non?invasive cortical stimulation, and show that attentional differences between healthy individuals with low and high levels of autistic?like traits can be reduced. This outcome is encouraging, and suggests that other aspects of attention in autism (e.g., face processing) may stand to benefit from similar stimulation techniques. En ligne : https://doi.org/10.1002/aur.1895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 Modulation of Global and Local Processing Biases in Adults with Autistic-like Traits / Michael C. W. ENGLISH in Journal of Autism and Developmental Disorders, 47-9 (September 2017)
[article]
Titre : Modulation of Global and Local Processing Biases in Adults with Autistic-like Traits Type de document : Texte imprimé et/ou numérique Auteurs : Michael C. W. ENGLISH, Auteur ; Murray T. MAYBERY, Auteur ; Troy A. W. VISSER, Auteur Article en page(s) : p.2757-2769 Langues : Anglais (eng) Mots-clés : Attention Global processing Local processing Autistic traits Autism Hierarchical figures Continuous performance task Attentional training Index. décimale : PER Périodiques Résumé : Previous work shows that doing a continuous performance task (CPT) shifts attentional biases in neurotypical individuals towards global aspects of hierarchical Navon figures by selectively activating right hemisphere regions associated with global processing. The present study examines whether CPT can induce similar modulations of attention in individuals with high levels of autistic traits who typically show global processing impairments. Participants categorized global or local aspects of Navon figures in pre- and post-CPT blocks. Post-CPT, high trait individuals showed increased global interference during local categorization. This result suggests that CPT may be useful for temporarily enhancing global processing in individuals with high levels of autistic traits and possibly those diagnosed with autism. En ligne : https://doi.org/10.1007/s10803-017-3198-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315
in Journal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2757-2769[article] Modulation of Global and Local Processing Biases in Adults with Autistic-like Traits [Texte imprimé et/ou numérique] / Michael C. W. ENGLISH, Auteur ; Murray T. MAYBERY, Auteur ; Troy A. W. VISSER, Auteur . - p.2757-2769.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2757-2769
Mots-clés : Attention Global processing Local processing Autistic traits Autism Hierarchical figures Continuous performance task Attentional training Index. décimale : PER Périodiques Résumé : Previous work shows that doing a continuous performance task (CPT) shifts attentional biases in neurotypical individuals towards global aspects of hierarchical Navon figures by selectively activating right hemisphere regions associated with global processing. The present study examines whether CPT can induce similar modulations of attention in individuals with high levels of autistic traits who typically show global processing impairments. Participants categorized global or local aspects of Navon figures in pre- and post-CPT blocks. Post-CPT, high trait individuals showed increased global interference during local categorization. This result suggests that CPT may be useful for temporarily enhancing global processing in individuals with high levels of autistic traits and possibly those diagnosed with autism. En ligne : https://doi.org/10.1007/s10803-017-3198-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315 Parental perspectives of the everyday experiences of uncertainty among young children on the autism spectrum / Claudia S. Y. ONG in Research in Autism Spectrum Disorders, 101 (March 2023)
[article]
Titre : Parental perspectives of the everyday experiences of uncertainty among young children on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Claudia S. Y. ONG, Auteur ; Iliana MAGIATI, Auteur ; Murray T. MAYBERY, Auteur ; Jacqui RODGERS, Auteur ; Mirko ULJAREVIC, Auteur ; Gail A. ALVARES, Auteur Article en page(s) : 102087 Langues : Anglais (eng) Mots-clés : Autism Anxiety Intolerance of uncertainty Qualitative study Index. décimale : PER Périodiques Résumé : Background Anxiety commonly co-occurs in autism. Exploring and understanding potential underpinning mechanisms contributing to and maintaining anxiety in the early years is important in managing anxiety. Intolerance of uncertainty (IU), a tendency to find uncertainty difficult, is a transdiagnostic mechanism contributing to anxiety, but little is known about how IU may be experienced in young children on the autism spectrum. This study investigated parental perspectives of children’s experiences of uncertainty. Method Parents of 13 children aged 4 “7 years participated in focus groups. Participants were recruited until data saturation was reached. Thematic analysis using a framework analysis approach was employed, with 18 themes identified. Results Parents perceived IU as an important construct that often manifested in their children’s heightened emotional and behavioural reactivity. Parents described responses to uncertainty as more intense for their children on the spectrum compared to non-autistic children, with some behaviours associated with or exacerbated by autism characteristics. Parents also described various strategies aimed to reduce uncertainty or increase children’s ability to cope with uncertainty. Most reported that difficulties with uncertainty had a significant negative impact on family well-being. Conclusions Given that IU can present early in life for children on the spectrum, with distressing experiences that can negatively impact everyday life and well-being, further research into early and targeted interventions is needed. The findings highlight the support needs for families of young children on the spectrum and will inform the evaluation of a targeted parent-mediated intervention to support children in managing difficulties with uncertainty. En ligne : https://doi.org/10.1016/j.rasd.2022.102087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102087[article] Parental perspectives of the everyday experiences of uncertainty among young children on the autism spectrum [Texte imprimé et/ou numérique] / Claudia S. Y. ONG, Auteur ; Iliana MAGIATI, Auteur ; Murray T. MAYBERY, Auteur ; Jacqui RODGERS, Auteur ; Mirko ULJAREVIC, Auteur ; Gail A. ALVARES, Auteur . - 102087.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102087
Mots-clés : Autism Anxiety Intolerance of uncertainty Qualitative study Index. décimale : PER Périodiques Résumé : Background Anxiety commonly co-occurs in autism. Exploring and understanding potential underpinning mechanisms contributing to and maintaining anxiety in the early years is important in managing anxiety. Intolerance of uncertainty (IU), a tendency to find uncertainty difficult, is a transdiagnostic mechanism contributing to anxiety, but little is known about how IU may be experienced in young children on the autism spectrum. This study investigated parental perspectives of children’s experiences of uncertainty. Method Parents of 13 children aged 4 “7 years participated in focus groups. Participants were recruited until data saturation was reached. Thematic analysis using a framework analysis approach was employed, with 18 themes identified. Results Parents perceived IU as an important construct that often manifested in their children’s heightened emotional and behavioural reactivity. Parents described responses to uncertainty as more intense for their children on the spectrum compared to non-autistic children, with some behaviours associated with or exacerbated by autism characteristics. Parents also described various strategies aimed to reduce uncertainty or increase children’s ability to cope with uncertainty. Most reported that difficulties with uncertainty had a significant negative impact on family well-being. Conclusions Given that IU can present early in life for children on the spectrum, with distressing experiences that can negatively impact everyday life and well-being, further research into early and targeted interventions is needed. The findings highlight the support needs for families of young children on the spectrum and will inform the evaluation of a targeted parent-mediated intervention to support children in managing difficulties with uncertainty. En ligne : https://doi.org/10.1016/j.rasd.2022.102087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 Perception of shapes targeting local and global processes in autism spectrum disorders / Emma J. GRINTER in Journal of Child Psychology and Psychiatry, 51-6 (June 2010)
[article]
Titre : Perception of shapes targeting local and global processes in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Emma J. GRINTER, Auteur ; Murray T. MAYBERY, Auteur ; David R. BADCOCK, Auteur ; Elizabeth PELLICANO, Auteur ; Johanna C. BADCOCK, Auteur Année de publication : 2010 Article en page(s) : p.717-724 Langues : Anglais (eng) Mots-clés : Autism local-processing global-processing ventral-visual-pathway radial-frequency-patterns Index. décimale : PER Périodiques Résumé : Background: Several researchers have found evidence for impaired global processing in the dorsal visual stream in individuals with autism spectrum disorders (ASDs). However, support for a similar pattern of visual processing in the ventral visual stream is less consistent. Critical to resolving the inconsistency is the assessment of local and global form processing ability.
Methods: Within the visual domain, radial frequency (RF) patterns – shapes formed by sinusoidally varying the radius of a circle to add 'bumps' of a certain number to a circle – can be used to examine local and global form perception. Typically developing children and children with an ASD discriminated between circles and RF patterns that are processed either locally (RF24) or globally (RF3).
Results: Children with an ASD required greater shape deformation to identify RF3 shapes compared to typically developing children, consistent with difficulty in global processing in the ventral stream. No group difference was observed for RF24 shapes, suggesting intact local ventral-stream processing.
Conclusions: These outcomes support the position that a deficit in global visual processing is present in ASDs, consistent with the notion of Weak Central Coherence.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02203.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101
in Journal of Child Psychology and Psychiatry > 51-6 (June 2010) . - p.717-724[article] Perception of shapes targeting local and global processes in autism spectrum disorders [Texte imprimé et/ou numérique] / Emma J. GRINTER, Auteur ; Murray T. MAYBERY, Auteur ; David R. BADCOCK, Auteur ; Elizabeth PELLICANO, Auteur ; Johanna C. BADCOCK, Auteur . - 2010 . - p.717-724.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-6 (June 2010) . - p.717-724
Mots-clés : Autism local-processing global-processing ventral-visual-pathway radial-frequency-patterns Index. décimale : PER Périodiques Résumé : Background: Several researchers have found evidence for impaired global processing in the dorsal visual stream in individuals with autism spectrum disorders (ASDs). However, support for a similar pattern of visual processing in the ventral visual stream is less consistent. Critical to resolving the inconsistency is the assessment of local and global form processing ability.
Methods: Within the visual domain, radial frequency (RF) patterns – shapes formed by sinusoidally varying the radius of a circle to add 'bumps' of a certain number to a circle – can be used to examine local and global form perception. Typically developing children and children with an ASD discriminated between circles and RF patterns that are processed either locally (RF24) or globally (RF3).
Results: Children with an ASD required greater shape deformation to identify RF3 shapes compared to typically developing children, consistent with difficulty in global processing in the ventral stream. No group difference was observed for RF24 shapes, suggesting intact local ventral-stream processing.
Conclusions: These outcomes support the position that a deficit in global visual processing is present in ASDs, consistent with the notion of Weak Central Coherence.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02203.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism / Lisa M. UNWIN in Autism Research, 9-2 (February 2016)
PermalinkReduced Pseudoneglect for Physical Space, but not Mental Representations of Space, for Adults with Autistic Traits / Michael C. W. ENGLISH in Journal of Autism and Developmental Disorders, 47-7 (July 2017)
PermalinkA review of behavioral evidence for hemispheric asymmetry of visuospatial attention in autism / Michael C. W. ENGLISH in Autism Research, 16-6 (June 2023)
PermalinkSupport for a Link Between the Local Processing Bias and Social Deficits in Autism: An Investigation of Embedded Figures Test Performance in Non-Clinical Individuals / Suzanna N. RUSSELL-SMITH in Journal of Autism and Developmental Disorders, 42-11 (November 2012)
PermalinkThreatening faces fail to guide attention for adults with autistic-like traits / Michael C. W. ENGLISH in Autism Research, 10-2 (February 2017)
PermalinkUnderstanding Oneself to Understand Others: The Role of Alexithymia and Anxiety in the Relationships Between Autistic Trait Dimensions and Empathy / Jack D. BRETT in Journal of Autism and Developmental Disorders, 52-5 (May 2022)
PermalinkVisual Search Targeting Either Local or Global Perceptual Processes Differs as a Function of Autistic-Like Traits in the Typically Developing Population / Renita A. ALMEIDA in Journal of Autism and Developmental Disorders, 43-6 (June 2013)
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