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Détail de l'auteur
Auteur Robert T. FITZGERALD |
Documents disponibles écrits par cet auteur (2)
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Brief Report: Under-Representation of African Americans in Autism Genetic Research: A Rationale for Inclusion of Subjects Representing Diverse Family Structures / Claudia HILTON in Journal of Autism and Developmental Disorders, 40-5 (May 2010)
[article]
Titre : Brief Report: Under-Representation of African Americans in Autism Genetic Research: A Rationale for Inclusion of Subjects Representing Diverse Family Structures Type de document : Texte imprimé et/ou numérique Auteurs : Claudia HILTON, Auteur ; John N. CONSTANTINO, Auteur ; Paul T. SHATTUCK, Auteur ; Rolanda A. MAXIM, Auteur ; Robert T. FITZGERALD, Auteur ; Kelley M. JACKSON, Auteur ; Christopher C. BOSWORTH, Auteur ; Daniel H. GESCHWIND, Auteur Année de publication : 2010 Article en page(s) : p.633-639 Langues : Anglais (eng) Mots-clés : Ethnicity African-American Minority-representation Index. décimale : PER Périodiques Résumé : African American children with autism are seriously under-represented in existing genetic registries and biomedical research studies of autism. We estimated the number of African American children with autism in the St. Louis region using CDC surveillance data and present the outcomes of a concerted effort to enroll approximately one-third of that population into either of two large national genetic autism registries. The results revealed that even after traditional barriers to research participation were addressed and all contacted families expressed a willingness to participate, 67% of the reachable families were disqualified from participation because of family structure alone. Comprehensive efforts—including expansion of eligibility to families of diverse structure—are warranted to facilitate the inclusion of African American children in biomedical research. En ligne : http://dx.doi.org/10.1007/s10803-009-0905-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101
in Journal of Autism and Developmental Disorders > 40-5 (May 2010) . - p.633-639[article] Brief Report: Under-Representation of African Americans in Autism Genetic Research: A Rationale for Inclusion of Subjects Representing Diverse Family Structures [Texte imprimé et/ou numérique] / Claudia HILTON, Auteur ; John N. CONSTANTINO, Auteur ; Paul T. SHATTUCK, Auteur ; Rolanda A. MAXIM, Auteur ; Robert T. FITZGERALD, Auteur ; Kelley M. JACKSON, Auteur ; Christopher C. BOSWORTH, Auteur ; Daniel H. GESCHWIND, Auteur . - 2010 . - p.633-639.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-5 (May 2010) . - p.633-639
Mots-clés : Ethnicity African-American Minority-representation Index. décimale : PER Périodiques Résumé : African American children with autism are seriously under-represented in existing genetic registries and biomedical research studies of autism. We estimated the number of African American children with autism in the St. Louis region using CDC surveillance data and present the outcomes of a concerted effort to enroll approximately one-third of that population into either of two large national genetic autism registries. The results revealed that even after traditional barriers to research participation were addressed and all contacted families expressed a willingness to participate, 67% of the reachable families were disqualified from participation because of family structure alone. Comprehensive efforts—including expansion of eligibility to families of diverse structure—are warranted to facilitate the inclusion of African American children in biomedical research. En ligne : http://dx.doi.org/10.1007/s10803-009-0905-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study / Natasha MARRUS in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)
[article]
Titre : Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study Type de document : Texte imprimé et/ou numérique Auteurs : Natasha MARRUS, Auteur ; Anne L. GLOWINSKI, Auteur ; Theodore JACOB, Auteur ; Ami KLIN, Auteur ; Warren JONES, Auteur ; Caroline E. DRAIN, Auteur ; Kieran E. HOLZHAUER, Auteur ; Vaishnavi HARIPRASAD, Auteur ; Robert T. FITZGERALD, Auteur ; Erika L. MORTENSON, Auteur ; Sayli M. SANT, Auteur ; Lyndsey COLE, Auteur ; Satchel A. SIEGEL, Auteur ; Yi ZHANG, Auteur ; Arpana AGRAWAL, Auteur ; Andrew C. HEATH, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.1338-1346 Langues : Anglais (eng) Mots-clés : Autism reciprocal social behavior video twins toddlers Index. décimale : PER Périodiques Résumé : Background Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories and incremental responses to intervention. Methods We developed and validated a 20-min video-referenced rating scale, the video-referenced rating of reciprocal social behavior (vrRSB), for untrained caregivers to provide standardized ratings of quantitative variation in RSB. Parents of 252 toddler twins [Monozygotic (MZ) = 31 pairs, Dizygotic (DZ) = 95 pairs] ascertained through birth records, rated their twins’ RSB at two time points, on average 6 months apart, and completed two developmental measures, the Modified Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s). Results Scores on the vrRSB were fully continuously distributed, with excellent 6-month test–retest reliability ([intraclass correlation coefficient] ICC = 0.704, p < .000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC = 0.863, p < .000, DZ ICC = 0.231, p < .012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t = ?8.588, df = 31, p < .000), incrementally improved from 18–24 months, and were inversely correlated with receptive and expressive vocabulary on the MCDI-s. Conclusions Like quantitative autistic trait ratings in school-aged children and adults, toddler scores on the vrRSB are continuously distributed and appear highly heritable. These ratings exhibited minimal measurement error, high inter-individual stability, and developmental progression in RSB as children matured from 18–24 months, supporting their potential utility for serially quantifying the severity of early autistic syndromes over time and in response to intervention. In addition, these findings inform the genetic-environmental structure of RSB in early typical development. En ligne : http://dx.doi.org/10.1111/jcpp.12391 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273
in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1338-1346[article] Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study [Texte imprimé et/ou numérique] / Natasha MARRUS, Auteur ; Anne L. GLOWINSKI, Auteur ; Theodore JACOB, Auteur ; Ami KLIN, Auteur ; Warren JONES, Auteur ; Caroline E. DRAIN, Auteur ; Kieran E. HOLZHAUER, Auteur ; Vaishnavi HARIPRASAD, Auteur ; Robert T. FITZGERALD, Auteur ; Erika L. MORTENSON, Auteur ; Sayli M. SANT, Auteur ; Lyndsey COLE, Auteur ; Satchel A. SIEGEL, Auteur ; Yi ZHANG, Auteur ; Arpana AGRAWAL, Auteur ; Andrew C. HEATH, Auteur ; John N. CONSTANTINO, Auteur . - p.1338-1346.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1338-1346
Mots-clés : Autism reciprocal social behavior video twins toddlers Index. décimale : PER Périodiques Résumé : Background Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories and incremental responses to intervention. Methods We developed and validated a 20-min video-referenced rating scale, the video-referenced rating of reciprocal social behavior (vrRSB), for untrained caregivers to provide standardized ratings of quantitative variation in RSB. Parents of 252 toddler twins [Monozygotic (MZ) = 31 pairs, Dizygotic (DZ) = 95 pairs] ascertained through birth records, rated their twins’ RSB at two time points, on average 6 months apart, and completed two developmental measures, the Modified Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s). Results Scores on the vrRSB were fully continuously distributed, with excellent 6-month test–retest reliability ([intraclass correlation coefficient] ICC = 0.704, p < .000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC = 0.863, p < .000, DZ ICC = 0.231, p < .012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t = ?8.588, df = 31, p < .000), incrementally improved from 18–24 months, and were inversely correlated with receptive and expressive vocabulary on the MCDI-s. Conclusions Like quantitative autistic trait ratings in school-aged children and adults, toddler scores on the vrRSB are continuously distributed and appear highly heritable. These ratings exhibited minimal measurement error, high inter-individual stability, and developmental progression in RSB as children matured from 18–24 months, supporting their potential utility for serially quantifying the severity of early autistic syndromes over time and in response to intervention. In addition, these findings inform the genetic-environmental structure of RSB in early typical development. En ligne : http://dx.doi.org/10.1111/jcpp.12391 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273