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Auteur Soeren DALSGAARD |
Documents disponibles écrits par cet auteur (2)
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Otitis media, antibiotics, and risk of autism spectrum disorder / T. WIMBERLEY in Autism Research, 11-10 (October 2018)
[article]
Titre : Otitis media, antibiotics, and risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. WIMBERLEY, Auteur ; E. AGERBO, Auteur ; C. B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; H. T. HORSDAL, Auteur ; P. B. MORTENSEN, Auteur ; W. K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; R. H. YOLKEN, Auteur Article en page(s) : p.1432-1440 Langues : Anglais (eng) Mots-clés : antibiotics autism spectrum disorder epidemiology otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-10 (October 2018) . - p.1432-1440[article] Otitis media, antibiotics, and risk of autism spectrum disorder [Texte imprimé et/ou numérique] / T. WIMBERLEY, Auteur ; E. AGERBO, Auteur ; C. B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; H. T. HORSDAL, Auteur ; P. B. MORTENSEN, Auteur ; W. K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; R. H. YOLKEN, Auteur . - p.1432-1440.
Langues : Anglais (eng)
in Autism Research > 11-10 (October 2018) . - p.1432-1440
Mots-clés : antibiotics autism spectrum disorder epidemiology otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Validating neuropsychological subtypes of ADHD: how do children with and without an executive function deficit differ? / Rikke LAMBEK in Journal of Child Psychology and Psychiatry, 51-8 (August 2010)
[article]
Titre : Validating neuropsychological subtypes of ADHD: how do children with and without an executive function deficit differ? Type de document : Texte imprimé et/ou numérique Auteurs : Rikke LAMBEK, Auteur ; Rosemary TANNOCK, Auteur ; Soeren DALSGAARD, Auteur ; Anegen TRILLINGSGAARD, Auteur ; Dorte DAMM, Auteur ; Per Hove THOMSEN, Auteur Année de publication : 2010 Article en page(s) : p.895-904 Langues : Anglais (eng) Mots-clés : ADHD executive-function-deficit delay-aversion affective-decision-making multiple-pathway-models Index. décimale : PER Périodiques Résumé : Objective: The study investigates behavioural, academic, cognitive, and motivational aspects of functioning in school-age children with attention-deficit/hyperactivity disorder (ADHD) with and without an executive function deficit (EFD).
Method: Children with ADHD – EFD (n = 22) and children with ADHD + EFD (n = 26) were compared on aspects of ADHD behaviour, school functioning, general cognitive ability, intra-individual response variability, affective decision-making, and delay aversion.
Results: Children with ADHD – EFD and children with ADHD + EFD were comparable in terms of ADHD symptomatology and school functioning. However, children with ADHD + EFD had significantly lower IQ and more intra-individual response variability than no EFD counterparts. Children with ADHD alone appeared more delay averse on the C-DT task than children with ADHD + EFD.
Conclusions: Some children with ADHD were primarily characterised by problems with executive functions and variability others by problems with delay aversion supporting multiple pathway models of ADHD. Given the exploratory nature of the study, results are in need of replication.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02248.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108
in Journal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.895-904[article] Validating neuropsychological subtypes of ADHD: how do children with and without an executive function deficit differ? [Texte imprimé et/ou numérique] / Rikke LAMBEK, Auteur ; Rosemary TANNOCK, Auteur ; Soeren DALSGAARD, Auteur ; Anegen TRILLINGSGAARD, Auteur ; Dorte DAMM, Auteur ; Per Hove THOMSEN, Auteur . - 2010 . - p.895-904.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.895-904
Mots-clés : ADHD executive-function-deficit delay-aversion affective-decision-making multiple-pathway-models Index. décimale : PER Périodiques Résumé : Objective: The study investigates behavioural, academic, cognitive, and motivational aspects of functioning in school-age children with attention-deficit/hyperactivity disorder (ADHD) with and without an executive function deficit (EFD).
Method: Children with ADHD – EFD (n = 22) and children with ADHD + EFD (n = 26) were compared on aspects of ADHD behaviour, school functioning, general cognitive ability, intra-individual response variability, affective decision-making, and delay aversion.
Results: Children with ADHD – EFD and children with ADHD + EFD were comparable in terms of ADHD symptomatology and school functioning. However, children with ADHD + EFD had significantly lower IQ and more intra-individual response variability than no EFD counterparts. Children with ADHD alone appeared more delay averse on the C-DT task than children with ADHD + EFD.
Conclusions: Some children with ADHD were primarily characterised by problems with executive functions and variability others by problems with delay aversion supporting multiple pathway models of ADHD. Given the exploratory nature of the study, results are in need of replication.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02248.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108