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Auteur Anna SZEKELY |
Documents disponibles écrits par cet auteur (2)
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Annual Research Review: The promise of stem cell research for neuropsychiatric disorders / Flora M. VACCARINO in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)
[article]
Titre : Annual Research Review: The promise of stem cell research for neuropsychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : Flora M. VACCARINO, Auteur ; Alexander ECKEHART URBAN, Auteur ; Hanna E. STEVENS, Auteur ; Anna SZEKELY, Auteur ; Alexej ABYZOV, Auteur ; Elena L. GRIGORENKO, Auteur ; Mark GERSTEIN, Auteur ; Sherman WEISSMAN, Auteur Année de publication : 2011 Article en page(s) : p.504-516 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The study of the developing brain has begun to shed light on the underpinnings of both early and adult onset neuropsychiatric disorders. Neuroimaging of the human brain across developmental time points and the use of model animal systems have combined to reveal brain systems and gene products that may play a role in autism spectrum disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder and many other neurodevelopmental conditions. However, precisely how genes may function in human brain development and how they interact with each other leading to psychiatric disorders is unknown. Because of an increasing understanding of neural stem cells and how the nervous system subsequently develops from these cells, we have now the ability to study disorders of the nervous system in a new way – by rewinding and reviewing the development of human neural cells. Induced pluripotent stem cells (iPSCs), developed from mature somatic cells, have allowed the development of specific cells in patients to be observed in real time. Moreover, they have allowed some neuronal-specific abnormalities to be corrected with pharmacological intervention in tissue culture. These exciting advances based on the use of iPSCs hold great promise for understanding, diagnosing and, possibly, treating psychiatric disorders. Specifically, examination of iPSCs from typically developing individuals will reveal how basic cellular processes and genetic differences contribute to individually unique nervous systems. Moreover, by comparing iPSCs from typically developing individuals and patients, differences at stem cell stages, through neural differentiation, and into the development of functional neurons may be identified that will reveal opportunities for intervention. The application of such techniques to early onset neuropsychiatric disorders is still on the horizon but has become a reality of current research efforts as a consequence of the revelations of many years of basic developmental neurobiological science. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02348.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119
in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.504-516[article] Annual Research Review: The promise of stem cell research for neuropsychiatric disorders [Texte imprimé et/ou numérique] / Flora M. VACCARINO, Auteur ; Alexander ECKEHART URBAN, Auteur ; Hanna E. STEVENS, Auteur ; Anna SZEKELY, Auteur ; Alexej ABYZOV, Auteur ; Elena L. GRIGORENKO, Auteur ; Mark GERSTEIN, Auteur ; Sherman WEISSMAN, Auteur . - 2011 . - p.504-516.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.504-516
Index. décimale : PER Périodiques Résumé : The study of the developing brain has begun to shed light on the underpinnings of both early and adult onset neuropsychiatric disorders. Neuroimaging of the human brain across developmental time points and the use of model animal systems have combined to reveal brain systems and gene products that may play a role in autism spectrum disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder and many other neurodevelopmental conditions. However, precisely how genes may function in human brain development and how they interact with each other leading to psychiatric disorders is unknown. Because of an increasing understanding of neural stem cells and how the nervous system subsequently develops from these cells, we have now the ability to study disorders of the nervous system in a new way – by rewinding and reviewing the development of human neural cells. Induced pluripotent stem cells (iPSCs), developed from mature somatic cells, have allowed the development of specific cells in patients to be observed in real time. Moreover, they have allowed some neuronal-specific abnormalities to be corrected with pharmacological intervention in tissue culture. These exciting advances based on the use of iPSCs hold great promise for understanding, diagnosing and, possibly, treating psychiatric disorders. Specifically, examination of iPSCs from typically developing individuals will reveal how basic cellular processes and genetic differences contribute to individually unique nervous systems. Moreover, by comparing iPSCs from typically developing individuals and patients, differences at stem cell stages, through neural differentiation, and into the development of functional neurons may be identified that will reveal opportunities for intervention. The application of such techniques to early onset neuropsychiatric disorders is still on the horizon but has become a reality of current research efforts as a consequence of the revelations of many years of basic developmental neurobiological science. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02348.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 Fundamental movement skills in children with autism spectrum disorder: A systematic review / Aditi GANDOTRA in Research in Autism Spectrum Disorders, 78 (October 2020)
[article]
Titre : Fundamental movement skills in children with autism spectrum disorder: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Aditi GANDOTRA, Auteur ; Eszter KOTYUK, Auteur ; Anna SZEKELY, Auteur ; Krisztian KASOS, Auteur ; Luca CSIRMAZ, Auteur ; Renata CSERJESI, Auteur Article en page(s) : 101632 Langues : Anglais (eng) Mots-clés : Fundamental movement skills Autism spectrum disorder Movement assessment batteries Index. décimale : PER Périodiques Résumé : Background Fundamental movement skills (FMS) are basic movement skills (i.e. balance, object control, and locomotor skills) that form the foundation for more advanced movement patterns. These skills are a crucial but often an overlooked part of the development process, especially in populations with autism spectrum disorder (ASD). In view of this, the present review was undertaken with the purpose of determining the extent of FMS impairments in children with ASD compared to typically developing children and those with other developmental disorders. Method A total of 24 studies that measured FMS in children with ASD using product- and process-oriented standardized movement assessment batteries were included in the review. Results The results showed that impairments in FMS are highly prevalent across the ASD spectrum and that children with ASD exhibited greater impairments in FMS competencies especially object control and locomotor skills compared to typically developing children and those with other developmental disorders. Moreover, these impairments in FMS appear to emerge early in life and persist throughout late childhood years in the majority of children with ASD. Conclusion These findings provide preliminary evidence suggesting that FMS has the potential to be an early motor marker in children with ASD, and that practitioners should therefore be encouraged to consider movement skill evaluations as a routine investigation for children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2020.101632 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433
in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101632[article] Fundamental movement skills in children with autism spectrum disorder: A systematic review [Texte imprimé et/ou numérique] / Aditi GANDOTRA, Auteur ; Eszter KOTYUK, Auteur ; Anna SZEKELY, Auteur ; Krisztian KASOS, Auteur ; Luca CSIRMAZ, Auteur ; Renata CSERJESI, Auteur . - 101632.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101632
Mots-clés : Fundamental movement skills Autism spectrum disorder Movement assessment batteries Index. décimale : PER Périodiques Résumé : Background Fundamental movement skills (FMS) are basic movement skills (i.e. balance, object control, and locomotor skills) that form the foundation for more advanced movement patterns. These skills are a crucial but often an overlooked part of the development process, especially in populations with autism spectrum disorder (ASD). In view of this, the present review was undertaken with the purpose of determining the extent of FMS impairments in children with ASD compared to typically developing children and those with other developmental disorders. Method A total of 24 studies that measured FMS in children with ASD using product- and process-oriented standardized movement assessment batteries were included in the review. Results The results showed that impairments in FMS are highly prevalent across the ASD spectrum and that children with ASD exhibited greater impairments in FMS competencies especially object control and locomotor skills compared to typically developing children and those with other developmental disorders. Moreover, these impairments in FMS appear to emerge early in life and persist throughout late childhood years in the majority of children with ASD. Conclusion These findings provide preliminary evidence suggesting that FMS has the potential to be an early motor marker in children with ASD, and that practitioners should therefore be encouraged to consider movement skill evaluations as a routine investigation for children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2020.101632 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433