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Détail de l'auteur
Auteur Gregory Y. LAUWERS |
Documents disponibles écrits par cet auteur (1)
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Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation / Rafail I. KUSHAK in Autism, 15-3 (May 2011)
[article]
Titre : Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation Type de document : Texte imprimé et/ou numérique Auteurs : Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur Année de publication : 2011 Article en page(s) : p.285-294 Langues : Anglais (eng) Mots-clés : autism disaccharidases inflammation intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130
in Autism > 15-3 (May 2011) . - p.285-294[article] Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation [Texte imprimé et/ou numérique] / Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur . - 2011 . - p.285-294.
Langues : Anglais (eng)
in Autism > 15-3 (May 2011) . - p.285-294
Mots-clés : autism disaccharidases inflammation intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130