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Détail de l'auteur
Auteur Melissa D. BAUMAN |
Documents disponibles écrits par cet auteur (2)
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Nonhuman Primate Models for Autism Spectrum Disorders / Melissa D. BAUMAN
Titre : Nonhuman Primate Models for Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur Année de publication : 2013 Importance : p.379-390 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism is a complex neurodevelopmental disorder characterized by impairments in social interaction and verbal and nonverbal communication, and the occurrence of pathological repetitive behaviors or circumscribed interests. As discussed more completely in other chapters, the defining characteristics are manifest in a spectrum of severity, leading to the term autism spectrum disorders (ASD) to encompass this heterogeneity. ASD are challenging to study in human populations because of the heterogeneity of symptoms, lack of consistent biomarkers, and the complex interplay between genetic and environmental risk factors. In recent years, some progress has been made in developing animal models of autism. These animal models provide an experimental system to evaluate hypotheses that, for ethical and practical reasons, are impossible to test using human subjects. However, a major challenge for complex brain disorders such as autism is to model a human disorder that has impairments of complex cognitive functions in a nonhuman species. In this chapter, we summarize different approaches to modeling features of autism in nonhuman primates, focusing on the rhesus macaque (Macacca mulatta). We review expectations for a valid nonhuman primate model of autism, evaluate the strengths and weaknesses of current nonhuman primate models, and highlight promising future directions for integrating neuroscience research into these models. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Nonhuman Primate Models for Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur . - 2013 . - p.379-390.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism is a complex neurodevelopmental disorder characterized by impairments in social interaction and verbal and nonverbal communication, and the occurrence of pathological repetitive behaviors or circumscribed interests. As discussed more completely in other chapters, the defining characteristics are manifest in a spectrum of severity, leading to the term autism spectrum disorders (ASD) to encompass this heterogeneity. ASD are challenging to study in human populations because of the heterogeneity of symptoms, lack of consistent biomarkers, and the complex interplay between genetic and environmental risk factors. In recent years, some progress has been made in developing animal models of autism. These animal models provide an experimental system to evaluate hypotheses that, for ethical and practical reasons, are impossible to test using human subjects. However, a major challenge for complex brain disorders such as autism is to model a human disorder that has impairments of complex cognitive functions in a nonhuman species. In this chapter, we summarize different approaches to modeling features of autism in nonhuman primates, focusing on the rhesus macaque (Macacca mulatta). We review expectations for a valid nonhuman primate model of autism, evaluate the strengths and weaknesses of current nonhuman primate models, and highlight promising future directions for integrating neuroscience research into these models. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
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Titre : Nonhuman Primate Models of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur Année de publication : 2011 Importance : p.963-980 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Nonhuman Primate Models of Autism [Texte imprimé et/ou numérique] / Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur . - 2011 . - p.963-980.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire