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Détail de l'auteur
Auteur James J. H. RUCKER |
Documents disponibles écrits par cet auteur (1)
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Genomic structural variation in psychiatric disorders / James J. H. RUCKER in Development and Psychopathology, 24-4 (November 2012)
[article]
Titre : Genomic structural variation in psychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : James J. H. RUCKER, Auteur ; Peter MCGUFFIN, Auteur Année de publication : 2012 Article en page(s) : p.1335-1344 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Copy number variants (CNVs) are submicroscopic deletions and duplications of genomic material that were previously thought to be rare phenomena. They have now been robustly associated with a variety of disorders such as autism, schizophrenia, and attention-deficit/hyperactivity disorder through an emerging research base in affective disorders. A complex picture is emerging of a polygenic, heterogeneous model of disease, with CNVs conferring broad susceptibility to a variety of neurodevelopmental disorders, rather than specific disorders per se. Although the insights gleaned thus far only represent a small piece of a much larger puzzle, progress has been rapid and new technologies promise even more insights into these hitherto opaque brain disorders. We will discuss CNVs, the current state of evidence for their role in the pathogenesis of classical psychiatric disorders, and the application of such knowledge in clinical settings. En ligne : http://dx.doi.org/10.1017/S0954579412000740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Development and Psychopathology > 24-4 (November 2012) . - p.1335-1344[article] Genomic structural variation in psychiatric disorders [Texte imprimé et/ou numérique] / James J. H. RUCKER, Auteur ; Peter MCGUFFIN, Auteur . - 2012 . - p.1335-1344.
Langues : Anglais (eng)
in Development and Psychopathology > 24-4 (November 2012) . - p.1335-1344
Index. décimale : PER Périodiques Résumé : Copy number variants (CNVs) are submicroscopic deletions and duplications of genomic material that were previously thought to be rare phenomena. They have now been robustly associated with a variety of disorders such as autism, schizophrenia, and attention-deficit/hyperactivity disorder through an emerging research base in affective disorders. A complex picture is emerging of a polygenic, heterogeneous model of disease, with CNVs conferring broad susceptibility to a variety of neurodevelopmental disorders, rather than specific disorders per se. Although the insights gleaned thus far only represent a small piece of a much larger puzzle, progress has been rapid and new technologies promise even more insights into these hitherto opaque brain disorders. We will discuss CNVs, the current state of evidence for their role in the pathogenesis of classical psychiatric disorders, and the application of such knowledge in clinical settings. En ligne : http://dx.doi.org/10.1017/S0954579412000740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182