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Détail de l'auteur
Auteur Paul D. CHAMBERLAIN |
Documents disponibles écrits par cet auteur (2)
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Delayed Reversal Learning and Association With Repetitive Behavior in Autism Spectrum Disorders / Mikle SOUTH in Autism Research, 5-6 (December 2012)
[article]
Titre : Delayed Reversal Learning and Association With Repetitive Behavior in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mikle SOUTH, Auteur ; Tiffani NEWTON, Auteur ; Paul D. CHAMBERLAIN, Auteur Article en page(s) : p.398-406 Mots-clés : behavioral analysis of animal models animal models cognitive neuroscience psychopathology Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Autism Research > 5-6 (December 2012) . - p.398-406[article] Delayed Reversal Learning and Association With Repetitive Behavior in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Mikle SOUTH, Auteur ; Tiffani NEWTON, Auteur ; Paul D. CHAMBERLAIN, Auteur . - p.398-406.
in Autism Research > 5-6 (December 2012) . - p.398-406
Mots-clés : behavioral analysis of animal models animal models cognitive neuroscience psychopathology Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 A potentiated startle study of uncertainty and contextual anxiety in adolescents diagnosed with autism spectrum disorder / Paul D. CHAMBERLAIN in Molecular Autism, (September 2013)
[article]
Titre : A potentiated startle study of uncertainty and contextual anxiety in adolescents diagnosed with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Paul D. CHAMBERLAIN, Auteur ; Jacqui RODGERS, Auteur ; Michael J. CROWLEY, Auteur ; Sarah WHITE, Auteur ; Mark FREESTON, Auteur ; Mikle SOUTH, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Beyond the core symptoms of autism spectrum disorder (ASD), associated symptoms of anxiety can cause substantial impairment for individuals affected by ASD and those who care for them. We utilized a potentiated startle paradigm with a puff of air to the neck as the unconditioned stimulus in order to investigate differences between response to cued fear and contextual anxiety among cognitively able adolescents diagnosed with ASD and an age- and IQ-matched typically developing group. In a threat-modulated startle paradigm, response patterns to neutral, predictable, and unpredictable conditions were comparable across typically developing and ASD youth in terms of startle response magnitude and latency. However, the ASD group showed significantly greater absolute startle responsivity at baseline and throughout the experiment, suggesting possibly enhanced general sensitivity to threatening contexts. The ASD group, but not the control group, demonstrated moderate to strong negative correlations between psychophysiological response to unpredictable threats (uncertainty) and questionnaire measures of generalized anxiety, intolerance of uncertainty, and repetitive behavior. Our data suggest enhanced general reactivity among the ASD group, possibly reflecting greater sensitivity to the threatening context of the startle paradigm. Associations with the response to uncertainty may help explain shared neurobehavioral mechanisms in ASD and anxiety. This task can provide useful targets for future neuroimaging and genetics studies as well as specific avenues for intervention. We emphasize the importance of further basic and clinical research into links among these important constructs. En ligne : http://dx.doi.org/10.1186/2040-2392-4-31 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227
in Molecular Autism > (September 2013)[article] A potentiated startle study of uncertainty and contextual anxiety in adolescents diagnosed with autism spectrum disorder [Texte imprimé et/ou numérique] / Paul D. CHAMBERLAIN, Auteur ; Jacqui RODGERS, Auteur ; Michael J. CROWLEY, Auteur ; Sarah WHITE, Auteur ; Mark FREESTON, Auteur ; Mikle SOUTH, Auteur.
Langues : Anglais (eng)
in Molecular Autism > (September 2013)
Index. décimale : PER Périodiques Résumé : Beyond the core symptoms of autism spectrum disorder (ASD), associated symptoms of anxiety can cause substantial impairment for individuals affected by ASD and those who care for them. We utilized a potentiated startle paradigm with a puff of air to the neck as the unconditioned stimulus in order to investigate differences between response to cued fear and contextual anxiety among cognitively able adolescents diagnosed with ASD and an age- and IQ-matched typically developing group. In a threat-modulated startle paradigm, response patterns to neutral, predictable, and unpredictable conditions were comparable across typically developing and ASD youth in terms of startle response magnitude and latency. However, the ASD group showed significantly greater absolute startle responsivity at baseline and throughout the experiment, suggesting possibly enhanced general sensitivity to threatening contexts. The ASD group, but not the control group, demonstrated moderate to strong negative correlations between psychophysiological response to unpredictable threats (uncertainty) and questionnaire measures of generalized anxiety, intolerance of uncertainty, and repetitive behavior. Our data suggest enhanced general reactivity among the ASD group, possibly reflecting greater sensitivity to the threatening context of the startle paradigm. Associations with the response to uncertainty may help explain shared neurobehavioral mechanisms in ASD and anxiety. This task can provide useful targets for future neuroimaging and genetics studies as well as specific avenues for intervention. We emphasize the importance of further basic and clinical research into links among these important constructs. En ligne : http://dx.doi.org/10.1186/2040-2392-4-31 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227