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Détail de l'auteur
Auteur Tamer H. HASSAN |
Documents disponibles écrits par cet auteur (1)
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Blood and brain glutamate levels in children with autistic disorder / Tamer H. HASSAN in Research in Autism Spectrum Disorders, 7-4 (April 2013)
[article]
Titre : Blood and brain glutamate levels in children with autistic disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tamer H. HASSAN, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Nelly R. ABDEL FATTAH, Auteur ; Nagda M. EL-MASRY, Auteur ; Haitham M. HASHIM, Auteur ; Khaled M. EL-GERBY, Auteur ; Nermin R. ABDEL FATTAH, Auteur Article en page(s) : p.541-548 Langues : Anglais (eng) Mots-clés : Blood glutamate Brain glutamate Autism Index. décimale : PER Périodiques Résumé : Despite of the great efforts that move forward to clarify the pathophysiologic mechanisms in autism, the cause of this disorder, however, remains largely unknown. There is an increasing body of literature concerning neurochemical contributions to the pathophysiology of autism. We aimed to determine blood and brain levels of glutamate in children with autistic disorder and to correlate between them. The study included 10 children with autism and 10 age- and sex-matched healthy controls. Blood glutamate levels were measured using high performance liquid chromatography technique. Brain glutamate levels were measured using proton magnetic resonance spectroscopy. The mean blood and brain glutamate levels were significantly higher in patients than controls (p lt; 0.001). There was highly significant positive correlation between blood glutamate level and brain glutamate levels in the four tested brain regions (p lt; 0.001). Glutamate plays an important role in the pathogenesis of autism. Further larger studies are required to support our findings. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192
in Research in Autism Spectrum Disorders > 7-4 (April 2013) . - p.541-548[article] Blood and brain glutamate levels in children with autistic disorder [Texte imprimé et/ou numérique] / Tamer H. HASSAN, Auteur ; Hadeel M. ABDELRAHMAN, Auteur ; Nelly R. ABDEL FATTAH, Auteur ; Nagda M. EL-MASRY, Auteur ; Haitham M. HASHIM, Auteur ; Khaled M. EL-GERBY, Auteur ; Nermin R. ABDEL FATTAH, Auteur . - p.541-548.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-4 (April 2013) . - p.541-548
Mots-clés : Blood glutamate Brain glutamate Autism Index. décimale : PER Périodiques Résumé : Despite of the great efforts that move forward to clarify the pathophysiologic mechanisms in autism, the cause of this disorder, however, remains largely unknown. There is an increasing body of literature concerning neurochemical contributions to the pathophysiology of autism. We aimed to determine blood and brain levels of glutamate in children with autistic disorder and to correlate between them. The study included 10 children with autism and 10 age- and sex-matched healthy controls. Blood glutamate levels were measured using high performance liquid chromatography technique. Brain glutamate levels were measured using proton magnetic resonance spectroscopy. The mean blood and brain glutamate levels were significantly higher in patients than controls (p lt; 0.001). There was highly significant positive correlation between blood glutamate level and brain glutamate levels in the four tested brain regions (p lt; 0.001). Glutamate plays an important role in the pathogenesis of autism. Further larger studies are required to support our findings. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192