Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Anna MILLER |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood / Elizabeth P. HAYDEN in Development and Psychopathology, 25-3 (August 2013)
[article]
Titre : The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth P. HAYDEN, Auteur ; Thomas M. OLINO, Auteur ; Sara J. BUFFERD, Auteur ; Anna MILLER, Auteur ; Lea R. DOUGHERTY, Auteur ; Haroon I. SHEIKH, Auteur ; Shiva M. SINGH, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.587-598 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Preliminary work indicates that cognitive vulnerability to depression may be associated with variants of the serotonin transporter promoter polymorphism (5-HTTLPR) and the valine to methionine at position 66 (val66met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene; however, existing reports come from small samples. The present study sought to replicate and extend this research in a sample of 375 community-dwelling children and their parents. Following a negative mood induction, children completed a self-referent encoding task tapping memory for positive and negative self-descriptive traits. Consistent with previous work, we found that children with at least one short variant of the 5-HTTLPR had enhanced memory for negative self-descriptive traits. The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. The findings provide further support for the notion that the 5-HTTLPR is associated with cognitive markers of depression vulnerability and that the BDNF methionine allele moderates children's sensitivity to contextual factors. En ligne : http://dx.doi.org/10.1017/S0954579413000035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210
in Development and Psychopathology > 25-3 (August 2013) . - p.587-598[article] The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood [Texte imprimé et/ou numérique] / Elizabeth P. HAYDEN, Auteur ; Thomas M. OLINO, Auteur ; Sara J. BUFFERD, Auteur ; Anna MILLER, Auteur ; Lea R. DOUGHERTY, Auteur ; Haroon I. SHEIKH, Auteur ; Shiva M. SINGH, Auteur ; Daniel N. KLEIN, Auteur . - p.587-598.
Langues : Anglais (eng)
in Development and Psychopathology > 25-3 (August 2013) . - p.587-598
Index. décimale : PER Périodiques Résumé : Preliminary work indicates that cognitive vulnerability to depression may be associated with variants of the serotonin transporter promoter polymorphism (5-HTTLPR) and the valine to methionine at position 66 (val66met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene; however, existing reports come from small samples. The present study sought to replicate and extend this research in a sample of 375 community-dwelling children and their parents. Following a negative mood induction, children completed a self-referent encoding task tapping memory for positive and negative self-descriptive traits. Consistent with previous work, we found that children with at least one short variant of the 5-HTTLPR had enhanced memory for negative self-descriptive traits. The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. The findings provide further support for the notion that the 5-HTTLPR is associated with cognitive markers of depression vulnerability and that the BDNF methionine allele moderates children's sensitivity to contextual factors. En ligne : http://dx.doi.org/10.1017/S0954579413000035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210