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Détail de l'auteur
Auteur Shay BEN-SHACHAR |
Documents disponibles écrits par cet auteur (2)
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Do risk factors for autism spectrum disorders affect gender representation? / Ditza A. ZACHOR in Research in Autism Spectrum Disorders, 7-11 (November 2013)
[article]
Titre : Do risk factors for autism spectrum disorders affect gender representation? Type de document : Texte imprimé et/ou numérique Auteurs : Ditza A. ZACHOR, Auteur ; Shay BEN-SHACHAR, Auteur ; Esther BEN-ITZCHAK, Auteur Article en page(s) : p.1397-1402 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Gender Male:female ratio Risk factors Low birth weight Multiplex families Index. décimale : PER Périodiques Résumé : Abstract To examine the M:F ratio in several known risk factors to demonstrate insights regarding autism spectrum disorders (ASD) etiology and sex. The study included 615 participants aged 18 months to 18 years age (mean = 49.8 months, SD = 28.4 months) diagnosed with ASD. Cognitive, adaptive and assessment of ASD were obtained using standardized tests. Detailed birth, familial, medical and developmental histories were obtained from the parents. Risk factors included ASD in the family (having a first-order family member with ASD); advanced maternal age (?35 years); advanced paternal age (?38 years); birth order (first-born versus third-born); low birth weight (LBW) (lt;2500 g); prematurity (gestational age lt;36 weeks). The M:F ratio (4.4:1) in the LBW group was lower than the M:F ratio (7.1:1) in the gt;2500 g group; however the difference showed only a statistical trend. No significant differences in M:F ratio were found between the ASD groups with and without the other examined risk factors. It is possible that the absence of a major association between most of the examined risk factors and sex representation points to the relatively minor role of these risk factors in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.08.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215
in Research in Autism Spectrum Disorders > 7-11 (November 2013) . - p.1397-1402[article] Do risk factors for autism spectrum disorders affect gender representation? [Texte imprimé et/ou numérique] / Ditza A. ZACHOR, Auteur ; Shay BEN-SHACHAR, Auteur ; Esther BEN-ITZCHAK, Auteur . - p.1397-1402.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-11 (November 2013) . - p.1397-1402
Mots-clés : Autism spectrum disorder Gender Male:female ratio Risk factors Low birth weight Multiplex families Index. décimale : PER Périodiques Résumé : Abstract To examine the M:F ratio in several known risk factors to demonstrate insights regarding autism spectrum disorders (ASD) etiology and sex. The study included 615 participants aged 18 months to 18 years age (mean = 49.8 months, SD = 28.4 months) diagnosed with ASD. Cognitive, adaptive and assessment of ASD were obtained using standardized tests. Detailed birth, familial, medical and developmental histories were obtained from the parents. Risk factors included ASD in the family (having a first-order family member with ASD); advanced maternal age (?35 years); advanced paternal age (?38 years); birth order (first-born versus third-born); low birth weight (LBW) (lt;2500 g); prematurity (gestational age lt;36 weeks). The M:F ratio (4.4:1) in the LBW group was lower than the M:F ratio (7.1:1) in the gt;2500 g group; however the difference showed only a statistical trend. No significant differences in M:F ratio were found between the ASD groups with and without the other examined risk factors. It is possible that the absence of a major association between most of the examined risk factors and sex representation points to the relatively minor role of these risk factors in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.08.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215 Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation / Esther BEN-ITZCHAK in Autism Research, 6-6 (December 2013)
[article]
Titre : Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation Type de document : Texte imprimé et/ou numérique Auteurs : Esther BEN-ITZCHAK, Auteur ; Shay BEN-SHACHAR, Auteur ; Ditza A. ZACHOR, Auteur Année de publication : 2013 Article en page(s) : p.596-604 Langues : Anglais (eng) Mots-clés : autism spectrum disorder male:female ratio microcephaly macrocephaly developmental regression, minor neurological and musculoskeletal deficits, seizures Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heritable disorder occurring predominantly in males. The aim of this study was to compare sex differences in the prevalence of specific neurological phenotypes commonly described in ASD. The study included 663 participants, aged 18 months to 15 years, diagnosed with ASD. Neurological and behavioral assessments were performed using standardized tests, and obtaining medical, developmental, and familial histories from the parents. Phenotypes under investigation were macro- and microcephaly, developmental regression, minor neurological and musculoskeletal deficits (MNMD), and seizures. Male?:?female ratio in the ASD group was 6.7:1. No sex differences in autism severity, cognitive ability, and adaptive functioning were noted. Mean head circumference percentile for males (50.1?±?25.6) was significantly larger than females (43.4?±?30.2). Micro- and macrocephaly were more frequent in ASD than expected (5.9%; 18.1%, respectively). Microcephaly in females (15.1%) was significantly more prevalent than in males (4.5%). The prevalence of macrocephaly in both sexes did not differ significantly. Regression was noted in 30.2% of the females with ASD, significantly higher than in males (18.9%). MNMD was documented in 73.8% of the females, significantly higher than in males (57.1%). M:F ratio decreased in a group with two or more phenotypes (3.6:1), while male predominance was more significant in the group without phenotypes (13.6:1). Neurological phenotypes associated with ASD are more prevalent in females than in males, resulting in more complex clinical and neurological manifestations in females. Therefore, involvement of different etiologies is suggested in ASD in females. En ligne : http://dx.doi.org/10.1002/aur.1319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221
in Autism Research > 6-6 (December 2013) . - p.596-604[article] Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation [Texte imprimé et/ou numérique] / Esther BEN-ITZCHAK, Auteur ; Shay BEN-SHACHAR, Auteur ; Ditza A. ZACHOR, Auteur . - 2013 . - p.596-604.
Langues : Anglais (eng)
in Autism Research > 6-6 (December 2013) . - p.596-604
Mots-clés : autism spectrum disorder male:female ratio microcephaly macrocephaly developmental regression, minor neurological and musculoskeletal deficits, seizures Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heritable disorder occurring predominantly in males. The aim of this study was to compare sex differences in the prevalence of specific neurological phenotypes commonly described in ASD. The study included 663 participants, aged 18 months to 15 years, diagnosed with ASD. Neurological and behavioral assessments were performed using standardized tests, and obtaining medical, developmental, and familial histories from the parents. Phenotypes under investigation were macro- and microcephaly, developmental regression, minor neurological and musculoskeletal deficits (MNMD), and seizures. Male?:?female ratio in the ASD group was 6.7:1. No sex differences in autism severity, cognitive ability, and adaptive functioning were noted. Mean head circumference percentile for males (50.1?±?25.6) was significantly larger than females (43.4?±?30.2). Micro- and macrocephaly were more frequent in ASD than expected (5.9%; 18.1%, respectively). Microcephaly in females (15.1%) was significantly more prevalent than in males (4.5%). The prevalence of macrocephaly in both sexes did not differ significantly. Regression was noted in 30.2% of the females with ASD, significantly higher than in males (18.9%). MNMD was documented in 73.8% of the females, significantly higher than in males (57.1%). M:F ratio decreased in a group with two or more phenotypes (3.6:1), while male predominance was more significant in the group without phenotypes (13.6:1). Neurological phenotypes associated with ASD are more prevalent in females than in males, resulting in more complex clinical and neurological manifestations in females. Therefore, involvement of different etiologies is suggested in ASD in females. En ligne : http://dx.doi.org/10.1002/aur.1319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221