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Détail de l'auteur
Auteur Erik A. EHLI |
Documents disponibles écrits par cet auteur (2)
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Candidate gene associations with withdrawn behavior / David H. RUBIN in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)
[article]
Titre : Candidate gene associations with withdrawn behavior Type de document : Texte imprimé et/ou numérique Auteurs : David H. RUBIN, Auteur ; Robert R. ALTHOFF, Auteur ; Erik A. EHLI, Auteur ; Gareth E. DAVIES, Auteur ; David C. RETTEW, Auteur ; Eileen T. CREHAN, Auteur ; John T. WALKUP, Auteur ; James J. HUDZIAK, Auteur Article en page(s) : p.1337-1345 Langues : Anglais (eng) Mots-clés : Withdrawn behavior Child Behavior Checklist Adult Self-Report behavioral inhibition social withdrawal Index. décimale : PER Périodiques Résumé : Background Social withdrawal is a core neuropsychiatric phenomenon in developmental psychopathology. Its presence predicts psychopathology across many domains, including depression, psychosis, autism, anxiety, and suicide. Withdrawn behavior is highly heritable, persistent, and characteristically worsens without intervention. To date, few studies have successfully identified genetic associations with withdrawn behavior, despite the abundance of evidence of its heritability. This may be due to reliance of categorical over dimensional measures of the behaviorally inhibited phenotype. The aim of this study is to identify associations between known psychiatric candidate genes and a dimensionally derived measure of withdrawn behavior. Methods Genetic information was collected on 20 single-nucleotide polymorphisms (SNPs) from a custom-designed SNP chip and TAQMAN arrays of 4 variable number of tandem repeat (VNTR) genes for 551 individuals from 187 families. Linear mixed modeling was employed to examine the relationship between genotypes of interest and Child Behavior Checklist (CBCL) Withdrawn Behavior Subscale Score (WBS) while controlling for gender and age through multiple linear regressions. Results Withdrawn behavior was highly associated with polymorphism rs6314 of the serotonin receptor 2A (HTR2A) [p = .009, estimate = 0.310 (bootstrap 95% CI 0.155–0.448), bootstrap p = .001] and rs1800544 of the alpha 2-adrenergic (ADRA2A) [p = .001, estimate = ?0.310 (bootstrap 95% CI ?0.479 to ?0.126), bootstrap p = .001] genes after correction for gender and age. The association between withdrawn behavior and ADRA2A was stronger for younger children. Conclusions HTR2A and ADRA2A genes are associated with withdrawn behavior. This reinforces the role of catecholaminergic genes in the heritability of withdrawn behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1337-1345[article] Candidate gene associations with withdrawn behavior [Texte imprimé et/ou numérique] / David H. RUBIN, Auteur ; Robert R. ALTHOFF, Auteur ; Erik A. EHLI, Auteur ; Gareth E. DAVIES, Auteur ; David C. RETTEW, Auteur ; Eileen T. CREHAN, Auteur ; John T. WALKUP, Auteur ; James J. HUDZIAK, Auteur . - p.1337-1345.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1337-1345
Mots-clés : Withdrawn behavior Child Behavior Checklist Adult Self-Report behavioral inhibition social withdrawal Index. décimale : PER Périodiques Résumé : Background Social withdrawal is a core neuropsychiatric phenomenon in developmental psychopathology. Its presence predicts psychopathology across many domains, including depression, psychosis, autism, anxiety, and suicide. Withdrawn behavior is highly heritable, persistent, and characteristically worsens without intervention. To date, few studies have successfully identified genetic associations with withdrawn behavior, despite the abundance of evidence of its heritability. This may be due to reliance of categorical over dimensional measures of the behaviorally inhibited phenotype. The aim of this study is to identify associations between known psychiatric candidate genes and a dimensionally derived measure of withdrawn behavior. Methods Genetic information was collected on 20 single-nucleotide polymorphisms (SNPs) from a custom-designed SNP chip and TAQMAN arrays of 4 variable number of tandem repeat (VNTR) genes for 551 individuals from 187 families. Linear mixed modeling was employed to examine the relationship between genotypes of interest and Child Behavior Checklist (CBCL) Withdrawn Behavior Subscale Score (WBS) while controlling for gender and age through multiple linear regressions. Results Withdrawn behavior was highly associated with polymorphism rs6314 of the serotonin receptor 2A (HTR2A) [p = .009, estimate = 0.310 (bootstrap 95% CI 0.155–0.448), bootstrap p = .001] and rs1800544 of the alpha 2-adrenergic (ADRA2A) [p = .001, estimate = ?0.310 (bootstrap 95% CI ?0.479 to ?0.126), bootstrap p = .001] genes after correction for gender and age. The association between withdrawn behavior and ADRA2A was stronger for younger children. Conclusions HTR2A and ADRA2A genes are associated with withdrawn behavior. This reinforces the role of catecholaminergic genes in the heritability of withdrawn behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research / Yubin HU in Autism Research, 10-7 (July 2017)
[article]
Titre : MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research Type de document : Texte imprimé et/ou numérique Auteurs : Yubin HU, Auteur ; Erik A. EHLI, Auteur ; Dorret I. BOOMSMA, Auteur Article en page(s) : p.1184-1203 Langues : Anglais (eng) Mots-clés : microRNA miRNA psychiatric disorders autism spectrum disorder biomarkers genetic variation expression profiling animal studies Index. décimale : PER Périodiques Résumé : MicroRNAs (miRNAs) are a group of small noncoding RNA molecules, 18–25 nucleotides in length, which can negatively regulate gene expression at the post-transcriptional level by binding to messenger RNAs. About half of all identified miRNAs in humans are expressed in the brain and display regulatory functions important for many biological processes related to the development of the central nervous system (CNS). Disruptions in miRNA biogenesis and miRNA-target interaction have been related to CNS diseases, including psychiatric disorders. In this review, we focus on the role of miRNAs in autism spectrum disorder (ASD) and summarize recent findings about ASD-associated genetic variants in miRNA genes, in miRNA biogenesis genes, and miRNA targets. We discuss deregulation of miRNA expression in ASD and functional validation of ASD-related miRNAs in animal models. Including miRNAs in studies of ASD will contribute to our understanding of its etiology and pathogenesis and facilitate the discrimination between different disease subgroups. En ligne : http://dx.doi.org/10.1002/aur.1789 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309
in Autism Research > 10-7 (July 2017) . - p.1184-1203[article] MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research [Texte imprimé et/ou numérique] / Yubin HU, Auteur ; Erik A. EHLI, Auteur ; Dorret I. BOOMSMA, Auteur . - p.1184-1203.
Langues : Anglais (eng)
in Autism Research > 10-7 (July 2017) . - p.1184-1203
Mots-clés : microRNA miRNA psychiatric disorders autism spectrum disorder biomarkers genetic variation expression profiling animal studies Index. décimale : PER Périodiques Résumé : MicroRNAs (miRNAs) are a group of small noncoding RNA molecules, 18–25 nucleotides in length, which can negatively regulate gene expression at the post-transcriptional level by binding to messenger RNAs. About half of all identified miRNAs in humans are expressed in the brain and display regulatory functions important for many biological processes related to the development of the central nervous system (CNS). Disruptions in miRNA biogenesis and miRNA-target interaction have been related to CNS diseases, including psychiatric disorders. In this review, we focus on the role of miRNAs in autism spectrum disorder (ASD) and summarize recent findings about ASD-associated genetic variants in miRNA genes, in miRNA biogenesis genes, and miRNA targets. We discuss deregulation of miRNA expression in ASD and functional validation of ASD-related miRNAs in animal models. Including miRNAs in studies of ASD will contribute to our understanding of its etiology and pathogenesis and facilitate the discrimination between different disease subgroups. En ligne : http://dx.doi.org/10.1002/aur.1789 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309