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Détail de l'auteur
Auteur Marian L. HAMSHERE |
Documents disponibles écrits par cet auteur (2)
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Factor Structure of Autistic Traits in Children with ADHD / Joanna MARTIN in Journal of Autism and Developmental Disorders, 44-1 (January 2014)
[article]
Titre : Factor Structure of Autistic Traits in Children with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Joanna MARTIN, Auteur ; Marian L. HAMSHERE, Auteur ; Michael C. O'DONOVAN, Auteur ; Michael RUTTER, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.204-215 Langues : Anglais (eng) Mots-clés : ADHD ASD Factor analysis Neurodevelopment Index. décimale : PER Périodiques Résumé : Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur. Factor analyses of ASD traits in children with and without ASD indicate the presence of social and restrictive–repetitive behaviour (RRB) factors. This study used exploratory factor analyses to determine the structure of ASD traits (assessed using the Social Communication Questionnaire) in children with ADHD. Distinct factors were observed for ‘social’ and ‘rigidity’ traits, corresponding to previous factor analyses in clinical ASD and population samples. This indicates that the split between social-communicative and RRB dimensions is unaffected by ADHD in children. Moreover, the study also finds that there is some overlap across hyperactive-impulsive symptoms and RRB traits in children with ADHD, which merits further investigation. En ligne : http://dx.doi.org/10.1007/s10803-013-1865-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220
in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.204-215[article] Factor Structure of Autistic Traits in Children with ADHD [Texte imprimé et/ou numérique] / Joanna MARTIN, Auteur ; Marian L. HAMSHERE, Auteur ; Michael C. O'DONOVAN, Auteur ; Michael RUTTER, Auteur ; Anita THAPAR, Auteur . - p.204-215.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.204-215
Mots-clés : ADHD ASD Factor analysis Neurodevelopment Index. décimale : PER Périodiques Résumé : Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur. Factor analyses of ASD traits in children with and without ASD indicate the presence of social and restrictive–repetitive behaviour (RRB) factors. This study used exploratory factor analyses to determine the structure of ASD traits (assessed using the Social Communication Questionnaire) in children with ADHD. Distinct factors were observed for ‘social’ and ‘rigidity’ traits, corresponding to previous factor analyses in clinical ASD and population samples. This indicates that the split between social-communicative and RRB dimensions is unaffected by ADHD in children. Moreover, the study also finds that there is some overlap across hyperactive-impulsive symptoms and RRB traits in children with ADHD, which merits further investigation. En ligne : http://dx.doi.org/10.1007/s10803-013-1865-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder / Joanna MARTIN in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)
[article]
Titre : Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Joanna MARTIN, Auteur ; Marian L. HAMSHERE, Auteur ; Evangelia STERGIAKOULI, Auteur ; Michael C. O'DONOVAN, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.648-656 Langues : Anglais (eng) Mots-clés : ALSPAC ADHD genetics cognition Index. décimale : PER Périodiques Résumé : Background The genetic architecture of ADHD is complex, with rare and common variants involved. Common genetic variants (as indexed by a composite risk score) associated with clinical ADHD significantly predict ADHD and autistic-like behavioural traits in children from the general population, suggesting that ADHD lies at the extreme of normal trait variation. ADHD and other neurodevelopmental disorders share neurocognitive difficulties in several domains (e.g. impaired cognitive ability and executive functions). We hypothesised that ADHD composite genetic risk scores derived from clinical ADHD cases would also contribute to variation in neurocognitive abilities in the general population. Methods Children (N = 6,832) from a UK population cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC), underwent neurocognitive testing. Parent-reported measures of their children's ADHD and autistic-like traits were used to construct a behavioural latent variable of ‘neurodevelopmental traits’. Composite genetic risk scores for ADHD were calculated for ALSPAC children based on findings from an independent ADHD case–control genome-wide association study. Structural equation modelling was used to assess associations between ADHD composite genetic risk scores and IQ, working memory, inhibitory control and facial emotion recognition, as well as the latent ‘neurodevelopmental trait’ measure. Results The results confirmed that neurocognitive and neurodevelopmental traits are correlated in children in the general population. Composite genetic risk scores for ADHD were independently associated with lower IQ (? = ?.05, p < .001) and working memory performance (? = ?.034, p = .013), even after accounting for the relationship with latent neurodevelopmental behavioural trait scores. No associations were found between composite genetic risk scores and inhibitory control or emotion recognition (p > .05). Conclusions These findings suggest that common genetic variants relevant to clinically diagnosed ADHD have pleiotropic effects on neurocognitive traits as well as behavioural dimensions in the general population. This further suggests that the well-recognised association between cognition and neurodevelopmental behavioural traits is underpinned at a biological level. En ligne : http://dx.doi.org/10.1111/jcpp.12336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.648-656[article] Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder [Texte imprimé et/ou numérique] / Joanna MARTIN, Auteur ; Marian L. HAMSHERE, Auteur ; Evangelia STERGIAKOULI, Auteur ; Michael C. O'DONOVAN, Auteur ; Anita THAPAR, Auteur . - p.648-656.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.648-656
Mots-clés : ALSPAC ADHD genetics cognition Index. décimale : PER Périodiques Résumé : Background The genetic architecture of ADHD is complex, with rare and common variants involved. Common genetic variants (as indexed by a composite risk score) associated with clinical ADHD significantly predict ADHD and autistic-like behavioural traits in children from the general population, suggesting that ADHD lies at the extreme of normal trait variation. ADHD and other neurodevelopmental disorders share neurocognitive difficulties in several domains (e.g. impaired cognitive ability and executive functions). We hypothesised that ADHD composite genetic risk scores derived from clinical ADHD cases would also contribute to variation in neurocognitive abilities in the general population. Methods Children (N = 6,832) from a UK population cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC), underwent neurocognitive testing. Parent-reported measures of their children's ADHD and autistic-like traits were used to construct a behavioural latent variable of ‘neurodevelopmental traits’. Composite genetic risk scores for ADHD were calculated for ALSPAC children based on findings from an independent ADHD case–control genome-wide association study. Structural equation modelling was used to assess associations between ADHD composite genetic risk scores and IQ, working memory, inhibitory control and facial emotion recognition, as well as the latent ‘neurodevelopmental trait’ measure. Results The results confirmed that neurocognitive and neurodevelopmental traits are correlated in children in the general population. Composite genetic risk scores for ADHD were independently associated with lower IQ (? = ?.05, p < .001) and working memory performance (? = ?.034, p = .013), even after accounting for the relationship with latent neurodevelopmental behavioural trait scores. No associations were found between composite genetic risk scores and inhibitory control or emotion recognition (p > .05). Conclusions These findings suggest that common genetic variants relevant to clinically diagnosed ADHD have pleiotropic effects on neurocognitive traits as well as behavioural dimensions in the general population. This further suggests that the well-recognised association between cognition and neurodevelopmental behavioural traits is underpinned at a biological level. En ligne : http://dx.doi.org/10.1111/jcpp.12336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260