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Détail de l'auteur
Auteur Nell MALTMAN |
Documents disponibles écrits par cet auteur (2)
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Parental Broader Autism Subphenotypes in ASD Affected Families: Relationship to Gender, Child's Symptoms, SSRI Treatment, and Platelet Serotonin / Tal LEVIN-DECANINI in Autism Research, 6-6 (December 2013)
[article]
Titre : Parental Broader Autism Subphenotypes in ASD Affected Families: Relationship to Gender, Child's Symptoms, SSRI Treatment, and Platelet Serotonin Type de document : Texte imprimé et/ou numérique Auteurs : Tal LEVIN-DECANINI, Auteur ; Nell MALTMAN, Auteur ; Sunday M. FRANCIS, Auteur ; Steve GUTER, Auteur ; George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur ; Suma JACOB, Auteur Année de publication : 2013 Article en page(s) : p.621-630 Langues : Anglais (eng) Mots-clés : broader autism phenotype serotonin autism SSRI Index. décimale : PER Périodiques Résumé : Relationships between parental broader autism phenotype (BAP) scores, gender, selective serotonin reuptake inhibitor (SSRI) treatment, serotonin (5HT) levels, and the child's symptoms were investigated in a family study of autism spectrum disorder (ASD). The Broader Autism Phenotype Questionnaire (BAPQ) was used to measure the BAP of 275 parents. Fathers not taking SSRIs (F-SSRI; n?=?115) scored significantly higher on BAP Total and Aloof subscales compared to mothers not receiving treatment (M-SSRI; n?=?136.) However, mothers taking SSRIs (M?+?SSRI; n?=?19) scored higher than those not taking medication on BAP Total and Rigid subscales, and they were more likely to be BAPQ Total, Aloof, and Rigid positive. Significant correlations were noted between proband autism symptoms and parental BAPQ scores such that Total, Aloof, and Rigid subscale scores of F-SSRI correlated with proband restricted repetitive behavior (RRB) measures on the ADOS, CRI, and RBS-R. However, only the Aloof subscale score of M?+?SSRI correlated with proband RRB on the ADOS. The correlation between the BAPQ scores of mothers taking SSRIs and child scores, as well as the increase in BAPQ scores of this group of mothers, requires careful interpretation and further study because correlations would not withstand multiple corrections. As expected by previous research, significant parent–child correlations were observed for 5HT levels. However, 5HT levels were not correlated with behavioral measures. Study results suggest that the expression of the BAP varies not only across parental gender, but also across individuals using psychotropic medication and those who do not. En ligne : http://dx.doi.org/10.1002/aur.1322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221
in Autism Research > 6-6 (December 2013) . - p.621-630[article] Parental Broader Autism Subphenotypes in ASD Affected Families: Relationship to Gender, Child's Symptoms, SSRI Treatment, and Platelet Serotonin [Texte imprimé et/ou numérique] / Tal LEVIN-DECANINI, Auteur ; Nell MALTMAN, Auteur ; Sunday M. FRANCIS, Auteur ; Steve GUTER, Auteur ; George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur ; Suma JACOB, Auteur . - 2013 . - p.621-630.
Langues : Anglais (eng)
in Autism Research > 6-6 (December 2013) . - p.621-630
Mots-clés : broader autism phenotype serotonin autism SSRI Index. décimale : PER Périodiques Résumé : Relationships between parental broader autism phenotype (BAP) scores, gender, selective serotonin reuptake inhibitor (SSRI) treatment, serotonin (5HT) levels, and the child's symptoms were investigated in a family study of autism spectrum disorder (ASD). The Broader Autism Phenotype Questionnaire (BAPQ) was used to measure the BAP of 275 parents. Fathers not taking SSRIs (F-SSRI; n?=?115) scored significantly higher on BAP Total and Aloof subscales compared to mothers not receiving treatment (M-SSRI; n?=?136.) However, mothers taking SSRIs (M?+?SSRI; n?=?19) scored higher than those not taking medication on BAP Total and Rigid subscales, and they were more likely to be BAPQ Total, Aloof, and Rigid positive. Significant correlations were noted between proband autism symptoms and parental BAPQ scores such that Total, Aloof, and Rigid subscale scores of F-SSRI correlated with proband restricted repetitive behavior (RRB) measures on the ADOS, CRI, and RBS-R. However, only the Aloof subscale score of M?+?SSRI correlated with proband RRB on the ADOS. The correlation between the BAPQ scores of mothers taking SSRIs and child scores, as well as the increase in BAPQ scores of this group of mothers, requires careful interpretation and further study because correlations would not withstand multiple corrections. As expected by previous research, significant parent–child correlations were observed for 5HT levels. However, 5HT levels were not correlated with behavioral measures. Study results suggest that the expression of the BAP varies not only across parental gender, but also across individuals using psychotropic medication and those who do not. En ligne : http://dx.doi.org/10.1002/aur.1322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 Understanding Social Communication Differences in Autism Spectrum Disorder and First-Degree Relatives: A Study of Looking and Speaking / Michelle LEE in Journal of Autism and Developmental Disorders, 50-6 (June 2020)
[article]
Titre : Understanding Social Communication Differences in Autism Spectrum Disorder and First-Degree Relatives: A Study of Looking and Speaking Type de document : Texte imprimé et/ou numérique Auteurs : Michelle LEE, Auteur ; Kritika NAYAR, Auteur ; Nell MALTMAN, Auteur ; Daniel HAMBURGER, Auteur ; Gary E. MARTIN, Auteur ; Peter C. GORDON, Auteur ; Molly LOSH, Auteur Article en page(s) : p.2128-2141 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Communication Eye gaze Language Narrative Visual attention Index. décimale : PER Périodiques Résumé : This study examined narrative ability in ASD and parents across two contexts differing in structure and emotional content, and explored gaze patterns that may underlie narrative differences by presenting narrative tasks on an eye tracker. Participants included 37 individuals with ASD and 38 controls, 151 parents of individuals with ASD and 63 parent controls. The ASD and ASD parent groups demonstrated lower narrative quality than controls in the less structured narrative task only. Subtler, context-dependent differences emerged in gaze and showed some associations with narrative quality. Results indicate a narrative ability profile that may reflect genetic liability to ASD, and subtle links between visual attention and complex language skills that may be influenced by ASD genetic risk. En ligne : http://dx.doi.org/10.1007/s10803-019-03969-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425
in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2128-2141[article] Understanding Social Communication Differences in Autism Spectrum Disorder and First-Degree Relatives: A Study of Looking and Speaking [Texte imprimé et/ou numérique] / Michelle LEE, Auteur ; Kritika NAYAR, Auteur ; Nell MALTMAN, Auteur ; Daniel HAMBURGER, Auteur ; Gary E. MARTIN, Auteur ; Peter C. GORDON, Auteur ; Molly LOSH, Auteur . - p.2128-2141.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2128-2141
Mots-clés : Autism spectrum disorder Communication Eye gaze Language Narrative Visual attention Index. décimale : PER Périodiques Résumé : This study examined narrative ability in ASD and parents across two contexts differing in structure and emotional content, and explored gaze patterns that may underlie narrative differences by presenting narrative tasks on an eye tracker. Participants included 37 individuals with ASD and 38 controls, 151 parents of individuals with ASD and 63 parent controls. The ASD and ASD parent groups demonstrated lower narrative quality than controls in the less structured narrative task only. Subtler, context-dependent differences emerged in gaze and showed some associations with narrative quality. Results indicate a narrative ability profile that may reflect genetic liability to ASD, and subtle links between visual attention and complex language skills that may be influenced by ASD genetic risk. En ligne : http://dx.doi.org/10.1007/s10803-019-03969-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425