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Détail de l'auteur
Auteur Maya MOSNER |
Documents disponibles écrits par cet auteur (2)
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Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards / Cara R. DAMIANO in Molecular Autism, (January 2014)
[article]
Titre : Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards Type de document : Texte imprimé et/ou numérique Auteurs : Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227
in Molecular Autism > (January 2014)[article] Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards [Texte imprimé et/ou numérique] / Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur.
Langues : Anglais (eng)
in Molecular Autism > (January 2014)
Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings / Megan KOVAC in Research in Autism Spectrum Disorders, 29-30 (September–October 2016)
[article]
Titre : Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings Type de document : Texte imprimé et/ou numérique Auteurs : Megan KOVAC, Auteur ; Maya MOSNER, Auteur ; Stephanie MILLER, Auteur ; Eleanor K. HANNA, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.57-65 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Experience sampling Positive affect Restricted interests Index. décimale : PER Périodiques Résumé : AbstractBackground Experience sampling is a powerful method for obtaining ecologically valid data from research participants in real-world contexts. Given the urgent need for innovative and sensitive outcome measures in autism spectrum disorder (ASD) research, the present study sought to examine the feasibility of using experience sampling of positive affect and behavior in adolescents with ASD. Method Nineteen high functioning adolescents with ASD and 20 sex and age matched controls completed smartphone- and Qualtrics® ?based experience sampling of positive affect and behavior six times over four days. Results Adherence was excellent: adolescents with ASD completed 85% of the assessments, compared to 93% in controls, and response rates were not impacted by age or IQ. Groups did not differ in positive affect overall or as a function of activities, nor did groups differ in the proportion of assessments completed during social or nonsocial activities. However, groups did differ in the proportion of assessments completed during preferred activities. Conclusions Results suggest that smartphone- and Qualtrics® ?based experience sampling with high functioning adolescents with ASD is feasible and captures real-world behaviors that would not be possible using laboratory-based measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.06.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Research in Autism Spectrum Disorders > 29-30 (September–October 2016) . - p.57-65[article] Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings [Texte imprimé et/ou numérique] / Megan KOVAC, Auteur ; Maya MOSNER, Auteur ; Stephanie MILLER, Auteur ; Eleanor K. HANNA, Auteur ; Gabriel S. DICHTER, Auteur . - p.57-65.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 29-30 (September–October 2016) . - p.57-65
Mots-clés : Autism spectrum disorder Experience sampling Positive affect Restricted interests Index. décimale : PER Périodiques Résumé : AbstractBackground Experience sampling is a powerful method for obtaining ecologically valid data from research participants in real-world contexts. Given the urgent need for innovative and sensitive outcome measures in autism spectrum disorder (ASD) research, the present study sought to examine the feasibility of using experience sampling of positive affect and behavior in adolescents with ASD. Method Nineteen high functioning adolescents with ASD and 20 sex and age matched controls completed smartphone- and Qualtrics® ?based experience sampling of positive affect and behavior six times over four days. Results Adherence was excellent: adolescents with ASD completed 85% of the assessments, compared to 93% in controls, and response rates were not impacted by age or IQ. Groups did not differ in positive affect overall or as a function of activities, nor did groups differ in the proportion of assessments completed during social or nonsocial activities. However, groups did differ in the proportion of assessments completed during preferred activities. Conclusions Results suggest that smartphone- and Qualtrics® ?based experience sampling with high functioning adolescents with ASD is feasible and captures real-world behaviors that would not be possible using laboratory-based measures. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.06.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292