Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Scott A. HUETTEL |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards / Cara R. DAMIANO in Molecular Autism, (January 2014)
[article]
Titre : Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards Type de document : Texte imprimé et/ou numérique Auteurs : Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227
in Molecular Autism > (January 2014)[article] Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards [Texte imprimé et/ou numérique] / Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur.
Langues : Anglais (eng)
in Molecular Autism > (January 2014)
Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: Does gender matter? / Joseph C. CROZIER in Development and Psychopathology, 26-2 (May 2014)
[article]
Titre : Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: Does gender matter? Type de document : Texte imprimé et/ou numérique Auteurs : Joseph C. CROZIER, Auteur ; Lihong WANG, Auteur ; Scott A. HUETTEL, Auteur ; Michael D. DE BELLIS, Auteur Article en page(s) : p.491-513 Index. décimale : PER Périodiques Résumé : We investigated the relationship of gender to cognitive and affective processing in maltreated youth with posttraumatic stress disorder symptoms using functional magnetic resonance imaging. Maltreated (N = 29, 13 females, 16 males) and nonmaltreated participants (N = 45, 26 females, 19 males) performed an emotional oddball task that involved detection of targets with fear or scrambled face distractors. Results were moderated by gender. During the executive component of this task, left precuneus/posterior middle cingulate hypoactivation to fear versus calm or scrambled face targets were seen in maltreated versus control males and may represent dysfunction and less resilience in attentional networks. Maltreated males also showed decreased activation in the inferior frontal gyrus compared to control males. No differences were found in females. Posterior cingulate activations positively correlated with posttraumatic stress disorder symptoms. While viewing fear faces, maltreated females exhibited decreased activity in the dorsomedial prefrontal cortex and cerebellum I–VI, whereas maltreated males exhibited increased activity in the left hippocampus, fusiform cortex, right cerebellar crus I, and visual cortex compared to their same-gender controls. Gender by maltreatment effects were not attributable to demographic, clinical, or maltreatment parameters. Maltreated girls and boys exhibited distinct patterns of neural activations during executive and affective processing, a new finding in the maltreatment literature. En ligne : http://dx.doi.org/10.1017/S095457941400008X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230
in Development and Psychopathology > 26-2 (May 2014) . - p.491-513[article] Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: Does gender matter? [Texte imprimé et/ou numérique] / Joseph C. CROZIER, Auteur ; Lihong WANG, Auteur ; Scott A. HUETTEL, Auteur ; Michael D. DE BELLIS, Auteur . - p.491-513.
in Development and Psychopathology > 26-2 (May 2014) . - p.491-513
Index. décimale : PER Périodiques Résumé : We investigated the relationship of gender to cognitive and affective processing in maltreated youth with posttraumatic stress disorder symptoms using functional magnetic resonance imaging. Maltreated (N = 29, 13 females, 16 males) and nonmaltreated participants (N = 45, 26 females, 19 males) performed an emotional oddball task that involved detection of targets with fear or scrambled face distractors. Results were moderated by gender. During the executive component of this task, left precuneus/posterior middle cingulate hypoactivation to fear versus calm or scrambled face targets were seen in maltreated versus control males and may represent dysfunction and less resilience in attentional networks. Maltreated males also showed decreased activation in the inferior frontal gyrus compared to control males. No differences were found in females. Posterior cingulate activations positively correlated with posttraumatic stress disorder symptoms. While viewing fear faces, maltreated females exhibited decreased activity in the dorsomedial prefrontal cortex and cerebellum I–VI, whereas maltreated males exhibited increased activity in the left hippocampus, fusiform cortex, right cerebellar crus I, and visual cortex compared to their same-gender controls. Gender by maltreatment effects were not attributable to demographic, clinical, or maltreatment parameters. Maltreated girls and boys exhibited distinct patterns of neural activations during executive and affective processing, a new finding in the maltreatment literature. En ligne : http://dx.doi.org/10.1017/S095457941400008X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230