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Détail de l'auteur
Auteur Willie KWOK |
Documents disponibles écrits par cet auteur (1)
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Meta-Analysis of Gene Expression in Autism Spectrum Disorder / Carolyn CH'NG in Autism Research, 8-5 (October 2015)
[article]
Titre : Meta-Analysis of Gene Expression in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Carolyn CH'NG, Auteur ; Willie KWOK, Auteur ; Sanja ROGIC, Auteur ; Paul PAVLIDIS, Auteur Article en page(s) : p.593-608 Langues : Anglais (eng) Mots-clés : gene expression meta-analysis molecular genetics microarray Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are clinically heterogeneous and biologically complex. In general it remains unclear, what biological factors lead to changes in the brains of autistic individuals. A considerable number of transcriptome analyses have been performed in attempts to address this question, but their findings lack a clear consensus. As a result, each of these individual studies has not led to any significant advance in understanding the autistic phenotype as a whole. Here, we report a meta-analysis of more than 1000 microarrays across twelve independent studies on expression changes in ASD compared to unaffected individuals, in both blood and brain tissues. We identified a number of known and novel genes that are consistently differentially expressed across three studies of the brain (71 samples in total). A subset of the highly ranked genes is suggestive of effects on mitochondrial function. In blood, consistent changes were more difficult to identify, despite individual studies tending to exhibit larger effects than the brain studies. Our results are the strongest evidence to date of a common transcriptome signature in the brains of individuals with ASD. Autism Res 2015, 8: 593–608. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270
in Autism Research > 8-5 (October 2015) . - p.593-608[article] Meta-Analysis of Gene Expression in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Carolyn CH'NG, Auteur ; Willie KWOK, Auteur ; Sanja ROGIC, Auteur ; Paul PAVLIDIS, Auteur . - p.593-608.
Langues : Anglais (eng)
in Autism Research > 8-5 (October 2015) . - p.593-608
Mots-clés : gene expression meta-analysis molecular genetics microarray Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are clinically heterogeneous and biologically complex. In general it remains unclear, what biological factors lead to changes in the brains of autistic individuals. A considerable number of transcriptome analyses have been performed in attempts to address this question, but their findings lack a clear consensus. As a result, each of these individual studies has not led to any significant advance in understanding the autistic phenotype as a whole. Here, we report a meta-analysis of more than 1000 microarrays across twelve independent studies on expression changes in ASD compared to unaffected individuals, in both blood and brain tissues. We identified a number of known and novel genes that are consistently differentially expressed across three studies of the brain (71 samples in total). A subset of the highly ranked genes is suggestive of effects on mitochondrial function. In blood, consistent changes were more difficult to identify, despite individual studies tending to exhibit larger effects than the brain studies. Our results are the strongest evidence to date of a common transcriptome signature in the brains of individuals with ASD. Autism Res 2015, 8: 593–608. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270