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Auteur D. N. TOP |
Documents disponibles écrits par cet auteur (2)
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Functional MRI connectivity of children with autism and low verbal and cognitive performance / T. P. GABRIELSEN in Molecular Autism, 9 (2018)
[article]
Titre : Functional MRI connectivity of children with autism and low verbal and cognitive performance Type de document : Texte imprimé et/ou numérique Auteurs : T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Adolescent Autistic Disorder/*diagnostic imaging/physiopathology Case-Control Studies Child *Cognition Female Humans Intelligence *Language Development Magnetic Resonance Imaging Male *Autism spectrum disorder *Functional connectivity *Imaging methodology *Intelligence *Language Institutional Review Board, protocol #F25403. Written informed consent was obtained from parents, with assent obtained from participants following video review of procedures.The boy who modeled the MRI procedures in the video modeling procedure was filmed, and the final video was shared, with written permission of both of his parents and with his own assent.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 9 (2018) . - 67 p.[article] Functional MRI connectivity of children with autism and low verbal and cognitive performance [Texte imprimé et/ou numérique] / T. P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; K. G. STEPHENSON, Auteur ; J. BECK, Auteur ; J. B. KING, Auteur ; R. KELLEMS, Auteur ; D. N. TOP, Auteur ; N. C. C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; R. A. LUNDWALL, Auteur ; B. HANSEN, Auteur ; M. SOUTH, Auteur . - 67 p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 67 p.
Mots-clés : Adolescent Autistic Disorder/*diagnostic imaging/physiopathology Case-Control Studies Child *Cognition Female Humans Intelligence *Language Development Magnetic Resonance Imaging Male *Autism spectrum disorder *Functional connectivity *Imaging methodology *Intelligence *Language Institutional Review Board, protocol #F25403. Written informed consent was obtained from parents, with assent obtained from participants following video review of procedures.The boy who modeled the MRI procedures in the video modeling procedure was filmed, and the final video was shared, with written permission of both of his parents and with his own assent.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Overactive Pattern Separation Memory Associated with Negative Emotionality in Adults Diagnosed with Autism Spectrum Disorder / M. SOUTH in Journal of Autism and Developmental Disorders, 45-11 (November 2015)
[article]
Titre : Overactive Pattern Separation Memory Associated with Negative Emotionality in Adults Diagnosed with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. SOUTH, Auteur ; K. G. STEPHENSON, Auteur ; C. A. NIELSON, Auteur ; M. MAISEL, Auteur ; D. N. TOP, Auteur ; C. B. KIRWAN, Auteur Article en page(s) : p.3458-3467 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Memory Pattern separation Hippocampus Emotion regulation Anxiety Index. décimale : PER Périodiques Résumé : Bowler et al. (Journal of Autism and Developmental Disorders 44(9):2355–2362. doi:10.1007/s10803-014-2105-y, 2014) have suggested that a specific memory impairment in autism spectrum disorders (ASD) arises from hippocampal failure to consolidate multiple related pieces of information. Twenty-four adults diagnosed with ASD and matched healthy controls completed a pattern separation memory task that is known to critically depend on hippocampal involvement. They additionally completed questionnaires regarding anxiety, depression, and behavioral motivation. Specific deficits in pattern separation were significantly correlated with negative emotionality; the best predictor of memory deficit was from a measure of achievement motivation that has also been associated with hyperactivity and impulsivity. In the context of impaired emotion regulation in ASD, there is a need for integrated cognitive, affective, and neural systems approaches to build targeted interventions. En ligne : http://dx.doi.org/10.1007/s10803-015-2547-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270
in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3458-3467[article] Overactive Pattern Separation Memory Associated with Negative Emotionality in Adults Diagnosed with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / M. SOUTH, Auteur ; K. G. STEPHENSON, Auteur ; C. A. NIELSON, Auteur ; M. MAISEL, Auteur ; D. N. TOP, Auteur ; C. B. KIRWAN, Auteur . - p.3458-3467.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3458-3467
Mots-clés : Autism spectrum disorder Memory Pattern separation Hippocampus Emotion regulation Anxiety Index. décimale : PER Périodiques Résumé : Bowler et al. (Journal of Autism and Developmental Disorders 44(9):2355–2362. doi:10.1007/s10803-014-2105-y, 2014) have suggested that a specific memory impairment in autism spectrum disorders (ASD) arises from hippocampal failure to consolidate multiple related pieces of information. Twenty-four adults diagnosed with ASD and matched healthy controls completed a pattern separation memory task that is known to critically depend on hippocampal involvement. They additionally completed questionnaires regarding anxiety, depression, and behavioral motivation. Specific deficits in pattern separation were significantly correlated with negative emotionality; the best predictor of memory deficit was from a measure of achievement motivation that has also been associated with hyperactivity and impulsivity. In the context of impaired emotion regulation in ASD, there is a need for integrated cognitive, affective, and neural systems approaches to build targeted interventions. En ligne : http://dx.doi.org/10.1007/s10803-015-2547-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270