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Détail de l'auteur
Auteur Francesco BARALE |
Documents disponibles écrits par cet auteur (1)
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Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies / Natascia BRONDINO in Journal of Autism and Developmental Disorders, 46-3 (March 2016)
[article]
Titre : Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies Type de document : Texte imprimé et/ou numérique Auteurs : Natascia BRONDINO, Auteur ; Laura FUSAR-POLI, Auteur ; Cristina PANISI, Auteur ; Stefano DAMIANI, Auteur ; Francesco BARALE, Auteur ; Pierluigi POLITI, Auteur Article en page(s) : p.825-839 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder GABA Clinical trials Systematic review Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in autism. To date there is insufficient evidence to suggest the use of these drugs in autistic subjects, even if data are promising. Of note, short-term use of all the reviewed medications appears to be safe. Future well designed trials are needed to elucidate these preliminary findings. En ligne : http://dx.doi.org/10.1007/s10803-015-2619-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.825-839[article] Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies [Texte imprimé et/ou numérique] / Natascia BRONDINO, Auteur ; Laura FUSAR-POLI, Auteur ; Cristina PANISI, Auteur ; Stefano DAMIANI, Auteur ; Francesco BARALE, Auteur ; Pierluigi POLITI, Auteur . - p.825-839.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.825-839
Mots-clés : Autism spectrum disorder GABA Clinical trials Systematic review Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in autism. To date there is insufficient evidence to suggest the use of these drugs in autistic subjects, even if data are promising. Of note, short-term use of all the reviewed medications appears to be safe. Future well designed trials are needed to elucidate these preliminary findings. En ligne : http://dx.doi.org/10.1007/s10803-015-2619-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281