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Détail de l'auteur
Auteur Linnea WIDMAN |
Documents disponibles écrits par cet auteur (2)
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Maternal hirsutism and autism spectrum disorders in offspring / Brian K. LEE in Autism Research, 10-9 (September 2017)
[article]
Titre : Maternal hirsutism and autism spectrum disorders in offspring Type de document : Texte imprimé et/ou numérique Auteurs : Brian K. LEE, Auteur ; Stefan ARVER, Auteur ; Linnea WIDMAN, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Christina DALMAN, Auteur ; Kyriaki KOSIDOU, Auteur Article en page(s) : p.1544-1546 Langues : Anglais (eng) Mots-clés : epidemiology - analytic (risk factors) pre- and perinatal risk factors environmental risk factors Index. décimale : PER Périodiques Résumé : Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD. In the same sample, we have now examined whether maternal diagnoses of hirsutism were associated with ASD. In both unadjusted logistic regression models and models adjusted for a variety of covariates, hirsutism was associated with higher odds of ASD. The most adjusted odds ratios for associations with ASD for hirsutism diagnosis before birth and lifetime diagnosis of hirsutism were 1.64 (95% CI: 0.94, 2.83) and 1.26 (95% CI: 1.01, 1.57), respectively. The presence of an association of maternal hirsutism with child ASD is consistent with the hypothesis that androgens may be involved in the etiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1797 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320
in Autism Research > 10-9 (September 2017) . - p.1544-1546[article] Maternal hirsutism and autism spectrum disorders in offspring [Texte imprimé et/ou numérique] / Brian K. LEE, Auteur ; Stefan ARVER, Auteur ; Linnea WIDMAN, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Christina DALMAN, Auteur ; Kyriaki KOSIDOU, Auteur . - p.1544-1546.
Langues : Anglais (eng)
in Autism Research > 10-9 (September 2017) . - p.1544-1546
Mots-clés : epidemiology - analytic (risk factors) pre- and perinatal risk factors environmental risk factors Index. décimale : PER Périodiques Résumé : Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD. In the same sample, we have now examined whether maternal diagnoses of hirsutism were associated with ASD. In both unadjusted logistic regression models and models adjusted for a variety of covariates, hirsutism was associated with higher odds of ASD. The most adjusted odds ratios for associations with ASD for hirsutism diagnosis before birth and lifetime diagnosis of hirsutism were 1.64 (95% CI: 0.94, 2.83) and 1.26 (95% CI: 1.01, 1.57), respectively. The presence of an association of maternal hirsutism with child ASD is consistent with the hypothesis that androgens may be involved in the etiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1797 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320 The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability / Sherlly XIE in Autism Research, 13-12 (December 2020)
[article]
Titre : The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Sherlly XIE, Auteur ; Håkan KARLSSON, Auteur ; Christina DALMAN, Auteur ; Linnea WIDMAN, Auteur ; Dheeraj RAI, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Sven SANDIN, Auteur ; Loni P. TABB, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.2242-2250 Langues : Anglais (eng) Mots-clés : autism spectrum disorders familial risk family study heritability intellectual disability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well understood. In this population-based cohort study, we examined the familial risk and heritability of ASD with and without co-occurring intellectual disability (ID). We estimated odds ratios and heritability of ASD with ID (ASD+ID) and ASD without ID (ASD-ID) using register-based diagnosis data of 567,436 index persons born in 1984-2009 in Stockholm County, Sweden, and their parents, siblings, cousins, aunts, and uncles. The familial risk profile exhibited differences between ASD-ID and ASD+ID, most notably for index persons with affected parents. For example, for an index person who had at least one parent with ASD, the child's odds of ASD-ID and ASD+ID (95% confidence interval (CI)) increased by 16.2 (14.2-18.6) and 7.4 (5.5-10.0) folds, respectively. The more closely related a family member with ASD was, the greater the observed risk was of ASD in the index person, especially for ASD-ID. The broad-sense heritability (95% CI) for ASD?-?ID and ASD+ID were 64.6% (46.0-100.0%) and 33.4% (14.4-58.4%), respectively. Familial risk and heritability of ASD may vary by intellectual ability, which implies that risk factors between these ASD phenotypes may differ. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. LAY SUMMARY: Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well-understood. In a population-based cohort study on families of 567,436 index persons using Swedish registers data, we found that the familial risk profile differed between ASD with and without intellectual disability. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. En ligne : http://dx.doi.org/10.1002/aur.2417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Autism Research > 13-12 (December 2020) . - p.2242-2250[article] The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability [Texte imprimé et/ou numérique] / Sherlly XIE, Auteur ; Håkan KARLSSON, Auteur ; Christina DALMAN, Auteur ; Linnea WIDMAN, Auteur ; Dheeraj RAI, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Sven SANDIN, Auteur ; Loni P. TABB, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Brian K. LEE, Auteur . - p.2242-2250.
Langues : Anglais (eng)
in Autism Research > 13-12 (December 2020) . - p.2242-2250
Mots-clés : autism spectrum disorders familial risk family study heritability intellectual disability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well understood. In this population-based cohort study, we examined the familial risk and heritability of ASD with and without co-occurring intellectual disability (ID). We estimated odds ratios and heritability of ASD with ID (ASD+ID) and ASD without ID (ASD-ID) using register-based diagnosis data of 567,436 index persons born in 1984-2009 in Stockholm County, Sweden, and their parents, siblings, cousins, aunts, and uncles. The familial risk profile exhibited differences between ASD-ID and ASD+ID, most notably for index persons with affected parents. For example, for an index person who had at least one parent with ASD, the child's odds of ASD-ID and ASD+ID (95% confidence interval (CI)) increased by 16.2 (14.2-18.6) and 7.4 (5.5-10.0) folds, respectively. The more closely related a family member with ASD was, the greater the observed risk was of ASD in the index person, especially for ASD-ID. The broad-sense heritability (95% CI) for ASD?-?ID and ASD+ID were 64.6% (46.0-100.0%) and 33.4% (14.4-58.4%), respectively. Familial risk and heritability of ASD may vary by intellectual ability, which implies that risk factors between these ASD phenotypes may differ. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. LAY SUMMARY: Autism spectrum disorder (ASD) is highly heritable, yet how its familial risk and heritability may vary by cognitive ability is not well-understood. In a population-based cohort study on families of 567,436 index persons using Swedish registers data, we found that the familial risk profile differed between ASD with and without intellectual disability. Our findings from the heritability analysis and familial risk analysis suggest that ASD-ID may have a greater genetic basis than ASD+ID, although this should be verified in future studies. En ligne : http://dx.doi.org/10.1002/aur.2417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434