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Auteur Maryam BOUTRUS |
Documents disponibles écrits par cet auteur (8)
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Brief Report: Facial Asymmetry and Autistic-Like Traits in the General Population / Maryam BOUTRUS in Journal of Autism and Developmental Disorders, 51-6 (June 2021)
[article]
Titre : Brief Report: Facial Asymmetry and Autistic-Like Traits in the General Population Type de document : Texte imprimé et/ou numérique Auteurs : Maryam BOUTRUS, Auteur ; Z. GILANI, Auteur ; M. T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; D. W. TAN, Auteur ; P. R. EASTWOOD, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.2115-2123 Langues : Anglais (eng) Mots-clés : Autistic Disorder/complications/pathology Cephalometry Face/diagnostic imaging/pathology Facial Asymmetry/diagnostic imaging/psychology Female Humans Imaging, Three-Dimensional Male Phenotype Photography Young Adult Autism Facial asymmetry Morphology Neurodevelopment Neurotypical Index. décimale : PER Périodiques Résumé : Atypical facial morphology, particularly increased facial asymmetry, has been identified in some individuals with Autism Spectrum Conditions (ASC). Many cognitive, behavioural and biological features associated with ASC also occur on a continuum in the general population. The aim of the present study was to examine subthreshold levels of autistic traits and facial morphology in non-autistic individuals. Facial asymmetry was measured using three-dimensional facial photogrammetry, and the Autism-spectrum Quotient was used to measure autistic-like traits in a community-ascertained sample of young adults (n?=?289). After accounting for covariates, there were no significant associations observed between autistic-like traits and facial asymmetry, suggesting that any potential facial morphology differences linked to ASC may be limited to the clinical condition. En ligne : http://dx.doi.org/10.1007/s10803-020-04661-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2115-2123[article] Brief Report: Facial Asymmetry and Autistic-Like Traits in the General Population [Texte imprimé et/ou numérique] / Maryam BOUTRUS, Auteur ; Z. GILANI, Auteur ; M. T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; D. W. TAN, Auteur ; P. R. EASTWOOD, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.2115-2123.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2115-2123
Mots-clés : Autistic Disorder/complications/pathology Cephalometry Face/diagnostic imaging/pathology Facial Asymmetry/diagnostic imaging/psychology Female Humans Imaging, Three-Dimensional Male Phenotype Photography Young Adult Autism Facial asymmetry Morphology Neurodevelopment Neurotypical Index. décimale : PER Périodiques Résumé : Atypical facial morphology, particularly increased facial asymmetry, has been identified in some individuals with Autism Spectrum Conditions (ASC). Many cognitive, behavioural and biological features associated with ASC also occur on a continuum in the general population. The aim of the present study was to examine subthreshold levels of autistic traits and facial morphology in non-autistic individuals. Facial asymmetry was measured using three-dimensional facial photogrammetry, and the Autism-spectrum Quotient was used to measure autistic-like traits in a community-ascertained sample of young adults (n?=?289). After accounting for covariates, there were no significant associations observed between autistic-like traits and facial asymmetry, suggesting that any potential facial morphology differences linked to ASC may be limited to the clinical condition. En ligne : http://dx.doi.org/10.1007/s10803-020-04661-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits / Lacey CHETCUTI in Autism Research, 16-3 (March 2023)
[article]
Titre : Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits Type de document : Texte imprimé et/ou numérique Auteurs : Lacey CHETCUTI, Auteur ; Mirko ULJAREVI?, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Stefanie DIMOV, Auteur ; Sarah PILLAR, Auteur ; Josephine BARBARO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur Article en page(s) : p.591-604 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. 103 infants (68% male) showing early signs of autism were referred to the study by community healthcare professionals and seen for assessments when aged around 12-months (Time 1), 18-months (Time 2), and 24-months (Time 3). Latent profile analysis revealed inhibited/low positive, active/negative reactive, and sociable/well-regulated subgroups at each timepoint, and a unique reactive/regulated subgroup at Time 3. Cross-tabulations indicated a significant likelihood of children having a recurrent subgroup classification from one timepoint to the next, and no apparent patterns to the movement of children who did change from one subgroup to another over time. Temperament subgroups were associated with concurrent child social-emotional functioning and autism traits, but unrelated to child age, sex, or developmental level. These findings suggest that temperament subgroup classifications might represent a reliable and very early indicator of autism characteristics and social-emotional functioning among infants/toddlers with autism traits. En ligne : https://doi.org/10.1002/aur.2874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.591-604[article] Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits [Texte imprimé et/ou numérique] / Lacey CHETCUTI, Auteur ; Mirko ULJAREVI?, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Stefanie DIMOV, Auteur ; Sarah PILLAR, Auteur ; Josephine BARBARO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur . - p.591-604.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.591-604
Index. décimale : PER Périodiques Résumé : Abstract Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. 103 infants (68% male) showing early signs of autism were referred to the study by community healthcare professionals and seen for assessments when aged around 12-months (Time 1), 18-months (Time 2), and 24-months (Time 3). Latent profile analysis revealed inhibited/low positive, active/negative reactive, and sociable/well-regulated subgroups at each timepoint, and a unique reactive/regulated subgroup at Time 3. Cross-tabulations indicated a significant likelihood of children having a recurrent subgroup classification from one timepoint to the next, and no apparent patterns to the movement of children who did change from one subgroup to another over time. Temperament subgroups were associated with concurrent child social-emotional functioning and autism traits, but unrelated to child age, sex, or developmental level. These findings suggest that temperament subgroup classifications might represent a reliable and very early indicator of autism characteristics and social-emotional functioning among infants/toddlers with autism traits. En ligne : https://doi.org/10.1002/aur.2874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Facial asymmetry in parents of children on the autism spectrum / D. W. TAN in Autism Research, 14-11 (November 2021)
[article]
Titre : Facial asymmetry in parents of children on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : D. W. TAN, Auteur ; S. Z. GILANI, Auteur ; Maryam BOUTRUS, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. MIAN, Auteur ; D. SUTER, Auteur ; M. T. MAYBERY, Auteur Article en page(s) : p.2260-2269 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging Autistic Disorder Child Face/diagnostic imaging Facial Asymmetry Female Humans Middle Aged Parents autism spectrum disorder broad autism phenotype facial asymmetry facial morphology heritability neurodevelopment Index. décimale : PER Périodiques Résumé : Greater facial asymmetry has been consistently found in children with autism spectrum disorder (ASD) relative to children without ASD. There is substantial evidence that both facial structure and the recurrence of ASD diagnosis are highly heritable within a nuclear family. Furthermore, sub-clinical levels of autistic-like behavioural characteristics have also been reported in first-degree relatives of individuals with ASD, commonly known as the 'broad autism phenotype'. Therefore, the aim of the current study was to examine whether a broad autism phenotype expresses as facial asymmetry among 192 biological parents of autistic individuals (134 mothers) compared to those of 163 age-matched adults without a family history of ASD (113 females). Using dense surface-modelling techniques on three dimensional facial images, we found evidence for greater facial asymmetry in parents of autistic individuals compared to age-matched adults in the comparison group (p =?0.046, d =?0.21 [0.002, 0.42]). Considering previous findings and the current results, we conclude that facial asymmetry expressed in the facial morphology of autistic children may be related to heritability factors. LAY ABSTRACT: In a previous study, we showed that autistic children presented with greater facial asymmetry than non-autistic children. In the current study, we examined the amount of facial asymmetry shown on three-dimensional facial images of 192 parents of autistic children compared to a control group consisting of 163 similarly aged adults with no known history of autism. Although parents did show greater levels of facial asymmetry than those in the control group, this effect is statistically small. We concluded that the facial asymmetry previously found in autistic children may be related to genetic factors. En ligne : http://dx.doi.org/10.1002/aur.2612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2260-2269[article] Facial asymmetry in parents of children on the autism spectrum [Texte imprimé et/ou numérique] / D. W. TAN, Auteur ; S. Z. GILANI, Auteur ; Maryam BOUTRUS, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. MIAN, Auteur ; D. SUTER, Auteur ; M. T. MAYBERY, Auteur . - p.2260-2269.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2260-2269
Mots-clés : Autism Spectrum Disorder/diagnostic imaging Autistic Disorder Child Face/diagnostic imaging Facial Asymmetry Female Humans Middle Aged Parents autism spectrum disorder broad autism phenotype facial asymmetry facial morphology heritability neurodevelopment Index. décimale : PER Périodiques Résumé : Greater facial asymmetry has been consistently found in children with autism spectrum disorder (ASD) relative to children without ASD. There is substantial evidence that both facial structure and the recurrence of ASD diagnosis are highly heritable within a nuclear family. Furthermore, sub-clinical levels of autistic-like behavioural characteristics have also been reported in first-degree relatives of individuals with ASD, commonly known as the 'broad autism phenotype'. Therefore, the aim of the current study was to examine whether a broad autism phenotype expresses as facial asymmetry among 192 biological parents of autistic individuals (134 mothers) compared to those of 163 age-matched adults without a family history of ASD (113 females). Using dense surface-modelling techniques on three dimensional facial images, we found evidence for greater facial asymmetry in parents of autistic individuals compared to age-matched adults in the comparison group (p =?0.046, d =?0.21 [0.002, 0.42]). Considering previous findings and the current results, we conclude that facial asymmetry expressed in the facial morphology of autistic children may be related to heritability factors. LAY ABSTRACT: In a previous study, we showed that autistic children presented with greater facial asymmetry than non-autistic children. In the current study, we examined the amount of facial asymmetry shown on three-dimensional facial images of 192 parents of autistic children compared to a control group consisting of 163 similarly aged adults with no known history of autism. Although parents did show greater levels of facial asymmetry than those in the control group, this effect is statistically small. We concluded that the facial asymmetry previously found in autistic children may be related to genetic factors. En ligne : http://dx.doi.org/10.1002/aur.2612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Increased facial asymmetry in autism spectrum conditions is associated with symptom presentation / Maryam BOUTRUS in Autism Research, 12-12 (December)
[article]
Titre : Increased facial asymmetry in autism spectrum conditions is associated with symptom presentation Type de document : Texte imprimé et/ou numérique Auteurs : Maryam BOUTRUS, Auteur ; S. Z. GILANI, Auteur ; Gail A. ALVARES, Auteur ; M. T. MAYBERY, Auteur ; D. W. TAN, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Année de publication : 2019 Article en page(s) : p.1774-1783 Langues : Anglais (eng) Mots-clés : autism facial asymmetry morphology neurodevelopment subgroups Index. décimale : PER Périodiques Résumé : A key research priority in the study of autism spectrum conditions (ASC) is the discovery of biological markers that may help to identify and elucidate etiologically distinct subgroups. One physical marker that has received increasing research attention is facial structure. Although there remains little consensus in the field, findings relating to greater facial asymmetry (FA) in ASC exhibit some consistency. As there is growing recognition of the importance of replicatory studies in ASC research, the aim of this study was to investigate the replicability of increased FA in autistic children compared to nonautistic peers. Using three-dimensional photogrammetry, this study examined FA in 84 autistic children, 110 typically developing children with no family history of the condition, and 49 full siblings of autistic children. In support of previous literature, significantly greater depth-wise FA was identified in autistic children relative to the two comparison groups. As a further investigation, increased lateral FA in autistic children was found to be associated with greater severity of ASC symptoms on the Autism Diagnostic Observation Schedule, second edition, specifically related to repetitive and restrictive behaviors. These outcomes provide an important and independent replication of increased FA in ASC, as well as a novel contribution to the field. Having confirmed the direction and areas of increased FA in ASC, these findings could motivate a search for potential underlying brain dysmorphogenesis. Autism Res 2019, 12: 1774-1783. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study looked at the amount of facial asymmetry (FA) in autistic children compared to typically developing children and children who have siblings with autism. The study found that autistic children, compared to the other two groups, had greater FA, and that increased FA was related to greater severity of autistic symptoms. The face and brain grow together during the earliest stages of development, and so findings of facial differences in autism might inform future studies of early brain differences associated with the condition. En ligne : http://dx.doi.org/10.1002/aur.2161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413
in Autism Research > 12-12 (December) . - p.1774-1783[article] Increased facial asymmetry in autism spectrum conditions is associated with symptom presentation [Texte imprimé et/ou numérique] / Maryam BOUTRUS, Auteur ; S. Z. GILANI, Auteur ; Gail A. ALVARES, Auteur ; M. T. MAYBERY, Auteur ; D. W. TAN, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - 2019 . - p.1774-1783.
Langues : Anglais (eng)
in Autism Research > 12-12 (December) . - p.1774-1783
Mots-clés : autism facial asymmetry morphology neurodevelopment subgroups Index. décimale : PER Périodiques Résumé : A key research priority in the study of autism spectrum conditions (ASC) is the discovery of biological markers that may help to identify and elucidate etiologically distinct subgroups. One physical marker that has received increasing research attention is facial structure. Although there remains little consensus in the field, findings relating to greater facial asymmetry (FA) in ASC exhibit some consistency. As there is growing recognition of the importance of replicatory studies in ASC research, the aim of this study was to investigate the replicability of increased FA in autistic children compared to nonautistic peers. Using three-dimensional photogrammetry, this study examined FA in 84 autistic children, 110 typically developing children with no family history of the condition, and 49 full siblings of autistic children. In support of previous literature, significantly greater depth-wise FA was identified in autistic children relative to the two comparison groups. As a further investigation, increased lateral FA in autistic children was found to be associated with greater severity of ASC symptoms on the Autism Diagnostic Observation Schedule, second edition, specifically related to repetitive and restrictive behaviors. These outcomes provide an important and independent replication of increased FA in ASC, as well as a novel contribution to the field. Having confirmed the direction and areas of increased FA in ASC, these findings could motivate a search for potential underlying brain dysmorphogenesis. Autism Res 2019, 12: 1774-1783. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study looked at the amount of facial asymmetry (FA) in autistic children compared to typically developing children and children who have siblings with autism. The study found that autistic children, compared to the other two groups, had greater FA, and that increased FA was related to greater severity of autistic symptoms. The face and brain grow together during the earliest stages of development, and so findings of facial differences in autism might inform future studies of early brain differences associated with the condition. En ligne : http://dx.doi.org/10.1002/aur.2161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach / Maryam BOUTRUS in Autism Research, 10-12 (December 2017)
[article]
Titre : Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach Type de document : Texte imprimé et/ou numérique Auteurs : Maryam BOUTRUS, Auteur ; Murray T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; Diana Weiting TAN, Auteur ; Kandice J. VARCIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1910-1918 Langues : Anglais (eng) Mots-clés : neurodevelopment facial phenotype morphology subgroups autism Index. décimale : PER Périodiques Résumé : Atypical facial characteristics have been observed in many disorders associated with developmental disability. While autism spectrum conditions (ASC) have not previously been thought to be associated with a distinct facial phenotype, an emerging research literature is casting doubt on this assumption. The identification of differences in the facial phenotype of individuals with ASC may contribute to efforts to promote early identification of the condition and help elucidate etiological pathways. With the aim of identifying facial phenotypes associated with ASC, this commentary evaluated facial features purported to distinguish ASC from typical development. Although there is little consensus across the reviewed studies for the majority of facial characteristics described, preliminary evidence suggests increased facial asymmetry may be more common in ASC. There is also evidence to suggest that there are morphologically distinct subgroups within ASC that correspond with different cognitive and behavioral symptomatology. However, in light of the various inconsistencies in the reported literature, and based on an accumulating understanding of etiological pathways proposed to be associated with ASC, we propose an alternative paradigm for investigating facial phenotypes in ASC. A series of studies are outlined to demonstrate the promise of a research program that has taken a hypothesis-driven approach to examine facial phenotypes associated with increased exposure to prenatal testosterone and to ASC. Autism Res 2017, 10: 1910–1918. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This commentary reviewed studies that found differences in the facial features of individuals with autism spectrum conditions (ASC) compared to typically developing individuals. While there is little agreement between studies, there is some support for asymmetrical facial features associated with ASC, and preliminary evidence that particular facial features relate to specific patterns of cognitive and behavioral symptoms. However, in light of inconsistencies between studies and based on accumulating understanding of etiological pathways, we propose an alternative approach to investigating facial differences in ASC. En ligne : http://dx.doi.org/10.1002/aur.1824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-12 (December 2017) . - p.1910-1918[article] Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach [Texte imprimé et/ou numérique] / Maryam BOUTRUS, Auteur ; Murray T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; Diana Weiting TAN, Auteur ; Kandice J. VARCIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1910-1918.
Langues : Anglais (eng)
in Autism Research > 10-12 (December 2017) . - p.1910-1918
Mots-clés : neurodevelopment facial phenotype morphology subgroups autism Index. décimale : PER Périodiques Résumé : Atypical facial characteristics have been observed in many disorders associated with developmental disability. While autism spectrum conditions (ASC) have not previously been thought to be associated with a distinct facial phenotype, an emerging research literature is casting doubt on this assumption. The identification of differences in the facial phenotype of individuals with ASC may contribute to efforts to promote early identification of the condition and help elucidate etiological pathways. With the aim of identifying facial phenotypes associated with ASC, this commentary evaluated facial features purported to distinguish ASC from typical development. Although there is little consensus across the reviewed studies for the majority of facial characteristics described, preliminary evidence suggests increased facial asymmetry may be more common in ASC. There is also evidence to suggest that there are morphologically distinct subgroups within ASC that correspond with different cognitive and behavioral symptomatology. However, in light of the various inconsistencies in the reported literature, and based on an accumulating understanding of etiological pathways proposed to be associated with ASC, we propose an alternative paradigm for investigating facial phenotypes in ASC. A series of studies are outlined to demonstrate the promise of a research program that has taken a hypothesis-driven approach to examine facial phenotypes associated with increased exposure to prenatal testosterone and to ASC. Autism Res 2017, 10: 1910–1918. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This commentary reviewed studies that found differences in the facial features of individuals with autism spectrum conditions (ASC) compared to typically developing individuals. While there is little agreement between studies, there is some support for asymmetrical facial features associated with ASC, and preliminary evidence that particular facial features relate to specific patterns of cognitive and behavioral symptoms. However, in light of inconsistencies between studies and based on accumulating understanding of etiological pathways, we propose an alternative approach to investigating facial differences in ASC. En ligne : http://dx.doi.org/10.1002/aur.1824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Performance of the Autism Observation Scale for Infants with community-ascertained infants showing early signs of autism / Kristelle HUDRY in Autism, 25-2 (February 2021)
PermalinkSubgroups of Temperament Associated with Social-Emotional Difficulties in Infants with Early Signs of Autism / Lacey CHETCUTI in Autism Research, 13-12 (December 2020)
PermalinkThe Role of Negative Affectivity in Concurrent Relations Between Caregiver Psychological Distress and Social-Emotional Difficulties in Infants With Early Signs of Autism / Lacey CHETCUTI in Autism Research, 13-8 (August 2020)
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