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Auteur Ana?Maria IOSIF |
Documents disponibles écrits par cet auteur (2)
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Onset patterns in autism: Variation across informants, methods, and timing / Sally OZONOFF in Autism Research, 11-5 (May 2018)
[article]
Titre : Onset patterns in autism: Variation across informants, methods, and timing Type de document : Texte imprimé et/ou numérique Auteurs : Sally OZONOFF, Auteur ; Devon GANGI, Auteur ; P. HANZEL ELISE, Auteur ; Alesha HILL, Auteur ; M. HILL MONIQUE, Auteur ; Meghan MILLER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Beth STEINFELD MARY, Auteur ; Chandni PARIKH, Auteur ; Ana?Maria IOSIF, Auteur Article en page(s) : p.788-797 Langues : Anglais (eng) Mots-clés : early signs infants regression Index. décimale : PER Périodiques Résumé : While previous studies suggested that regressive forms of onset were not common in autism spectrum disorder (ASD), more recent investigations suggest that the rates are quite high and may be under?reported using certain methods. The current study undertook a systematic investigation of how rates of regression differed by measurement method. Infants with (n=147) and without a family history of ASD (n=83) were seen prospectively for up to 7 visits in the first three years of life. Reports of symptom onset were collected using four measures that systematically varied the informant (examiner vs. parent), the decision type (categorical [regression absent or present] vs. dimensional [frequency of social behaviors]), and the timing of the assessment (retrospective vs. prospective). Latent class growth models were used to classify individual trajectories to see whether regressive onset patterns were infrequent or widespread within the ASD group. A majority of the sample was classified as having a regressive onset using either examiner (88%) or parent (69%) prospective dimensional ratings. Rates of regression were much lower using retrospective or categorical measures (from 29 to 47%). Agreement among different measurement methods was low. Declining trajectories of development, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The accuracy of widely used methods of measuring onset is questionable and the present findings argue against their widespread use. Autism Res 2018, 11: 788?797. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study examines different ways of measuring the onset of symptoms in autism spectrum disorder (ASD). The present findings suggest that declining developmental skills, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The results question the accuracy of widely used methods of measuring symptom onset and argue against their widespread use. En ligne : https://doi.org/10.1002/aur.1943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363
in Autism Research > 11-5 (May 2018) . - p.788-797[article] Onset patterns in autism: Variation across informants, methods, and timing [Texte imprimé et/ou numérique] / Sally OZONOFF, Auteur ; Devon GANGI, Auteur ; P. HANZEL ELISE, Auteur ; Alesha HILL, Auteur ; M. HILL MONIQUE, Auteur ; Meghan MILLER, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Beth STEINFELD MARY, Auteur ; Chandni PARIKH, Auteur ; Ana?Maria IOSIF, Auteur . - p.788-797.
Langues : Anglais (eng)
in Autism Research > 11-5 (May 2018) . - p.788-797
Mots-clés : early signs infants regression Index. décimale : PER Périodiques Résumé : While previous studies suggested that regressive forms of onset were not common in autism spectrum disorder (ASD), more recent investigations suggest that the rates are quite high and may be under?reported using certain methods. The current study undertook a systematic investigation of how rates of regression differed by measurement method. Infants with (n=147) and without a family history of ASD (n=83) were seen prospectively for up to 7 visits in the first three years of life. Reports of symptom onset were collected using four measures that systematically varied the informant (examiner vs. parent), the decision type (categorical [regression absent or present] vs. dimensional [frequency of social behaviors]), and the timing of the assessment (retrospective vs. prospective). Latent class growth models were used to classify individual trajectories to see whether regressive onset patterns were infrequent or widespread within the ASD group. A majority of the sample was classified as having a regressive onset using either examiner (88%) or parent (69%) prospective dimensional ratings. Rates of regression were much lower using retrospective or categorical measures (from 29 to 47%). Agreement among different measurement methods was low. Declining trajectories of development, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The accuracy of widely used methods of measuring onset is questionable and the present findings argue against their widespread use. Autism Res 2018, 11: 788?797. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary This study examines different ways of measuring the onset of symptoms in autism spectrum disorder (ASD). The present findings suggest that declining developmental skills, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The results question the accuracy of widely used methods of measuring symptom onset and argue against their widespread use. En ligne : https://doi.org/10.1002/aur.1943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 What will my child's future hold? phenotypes of intellectual development in 2–8?year?olds with autism spectrum disorder / Marjorie SOLOMON in Autism Research, 11-1 (January 2018)
[article]
Titre : What will my child's future hold? phenotypes of intellectual development in 2–8?year?olds with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Marjorie SOLOMON, Auteur ; Ana?Maria IOSIF, Auteur ; P. REINHARDT VANESSA, Auteur ; E. LIBERO LAUREN, Auteur ; Christine W. NORDAHL, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.121-132 Langues : Anglais (eng) Mots-clés : intellectual development phenotypes longitudinal ASD IQ early childhood autism spectrum disorder Index. décimale : PER Périodiques Résumé : We examined phenotypes of autism spectrum disorder (ASD) based on trajectories of intellectual development from early (ages 2?3 ½) to middle (ages 5?8) childhood in a recent clinically ascertained cohort. Participants included 102 children (82 males) initially diagnosed with ASD from the Autism Phenome Project longitudinal sample. Latent class growth analysis was used to identify distinct IQ trajectories. Baseline and developmental course differences among groups were assessed using univariate techniques and repeated measures regression models, respectively. A four class model best represented the data. Using the highest posterior probability, participants were assigned to High Challenges (25.5%), Stable Low (17.6%), Changers (35.3%), and Lesser Challenges (21.6%) groups. The High Challenges and Stable Low groups exhibited persistently low IQ, although, the High Challenges group experienced declines while the Stable Low group's scores remained more constant. Changers showed IQ improvement of >?2 standard deviations. The Lesser Challenges group had IQs in the average range at both times that were about 1 standard deviation higher at T2. In summation, 75% of the participants experienced some relative improvements in intellectual and/or other areas of functioning between ages 2 and 8 years. The Changers group demonstrated the most significant IQ change that was accompanied by adaptive communication improvement and declining externalizing symptoms. Only the Lesser Challenges group showed a significant reduction in ASD symptom severity, such that by age 8, 14% of them no longer met ADOS?2 criteria for ASD. All groups showed reductions in internalizing symptoms. Intervention history was not associated with group status. Autism Res 2018, 11: 121?132. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined how the IQs of children with autism spectrum disorder change between ages 2 and 8, and identified four patterns. Two groups exhibited persistently lower IQs. One group showed IQ increases of greater than 30 points with improved communicate abilities and declining disruptive behaviors. The final group had IQs in the average or better range at both time points, and 14% of them lost their diagnoses. Over half of the children experienced improved intellectual functioning between ages 2 and 8, whereas about 25% showed declines. Findings were not associated with intervention history. En ligne : https://doi.org/10.1002/aur.1884 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334
in Autism Research > 11-1 (January 2018) . - p.121-132[article] What will my child's future hold? phenotypes of intellectual development in 2–8?year?olds with autism spectrum disorder [Texte imprimé et/ou numérique] / Marjorie SOLOMON, Auteur ; Ana?Maria IOSIF, Auteur ; P. REINHARDT VANESSA, Auteur ; E. LIBERO LAUREN, Auteur ; Christine W. NORDAHL, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur . - p.121-132.
Langues : Anglais (eng)
in Autism Research > 11-1 (January 2018) . - p.121-132
Mots-clés : intellectual development phenotypes longitudinal ASD IQ early childhood autism spectrum disorder Index. décimale : PER Périodiques Résumé : We examined phenotypes of autism spectrum disorder (ASD) based on trajectories of intellectual development from early (ages 2?3 ½) to middle (ages 5?8) childhood in a recent clinically ascertained cohort. Participants included 102 children (82 males) initially diagnosed with ASD from the Autism Phenome Project longitudinal sample. Latent class growth analysis was used to identify distinct IQ trajectories. Baseline and developmental course differences among groups were assessed using univariate techniques and repeated measures regression models, respectively. A four class model best represented the data. Using the highest posterior probability, participants were assigned to High Challenges (25.5%), Stable Low (17.6%), Changers (35.3%), and Lesser Challenges (21.6%) groups. The High Challenges and Stable Low groups exhibited persistently low IQ, although, the High Challenges group experienced declines while the Stable Low group's scores remained more constant. Changers showed IQ improvement of >?2 standard deviations. The Lesser Challenges group had IQs in the average range at both times that were about 1 standard deviation higher at T2. In summation, 75% of the participants experienced some relative improvements in intellectual and/or other areas of functioning between ages 2 and 8 years. The Changers group demonstrated the most significant IQ change that was accompanied by adaptive communication improvement and declining externalizing symptoms. Only the Lesser Challenges group showed a significant reduction in ASD symptom severity, such that by age 8, 14% of them no longer met ADOS?2 criteria for ASD. All groups showed reductions in internalizing symptoms. Intervention history was not associated with group status. Autism Res 2018, 11: 121?132. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined how the IQs of children with autism spectrum disorder change between ages 2 and 8, and identified four patterns. Two groups exhibited persistently lower IQs. One group showed IQ increases of greater than 30 points with improved communicate abilities and declining disruptive behaviors. The final group had IQs in the average or better range at both time points, and 14% of them lost their diagnoses. Over half of the children experienced improved intellectual functioning between ages 2 and 8, whereas about 25% showed declines. Findings were not associated with intervention history. En ligne : https://doi.org/10.1002/aur.1884 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334