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Auteur Patricia A. BRENNAN |
Documents disponibles écrits par cet auteur (11)
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Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)
[article]
Titre : Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur Année de publication : 2010 Article en page(s) : p.180-187 Langues : Anglais (eng) Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20.
Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S.
Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant.
Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187[article] Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur . - 2010 . - p.180-187.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187
Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20.
Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S.
Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant.
Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 49-4 (April 2008)
[article]
Titre : Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur Année de publication : 2008 Article en page(s) : p.433–440 Langues : Anglais (eng) Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed.
Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles.
Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20.
Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339
in Journal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440[article] Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur . - 2008 . - p.433–440.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440
Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed.
Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles.
Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20.
Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood / Brooke G. MCKENNA in Development and Psychopathology, 33-1 (February 2021)
[article]
Titre : HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.122-134 Langues : Anglais (eng) Mots-clés : HPA Axis depression fetal programming polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Development and Psychopathology > 33-1 (February 2021) . - p.122-134[article] HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood [Texte imprimé et/ou numérique] / Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur . - p.122-134.
Langues : Anglais (eng)
in Development and Psychopathology > 33-1 (February 2021) . - p.122-134
Mots-clés : HPA Axis depression fetal programming polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 Maternal depression and infant cortisol: influences of timing, comorbidity and treatment / Patricia A. BRENNAN in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)
[article]
Titre : Maternal depression and infant cortisol: influences of timing, comorbidity and treatment Type de document : Texte imprimé et/ou numérique Auteurs : Patricia A. BRENNAN, Auteur ; Rebecca PARGAS, Auteur ; Elaine F. WALKER, Auteur ; Paula GREEN, Auteur ; D. Jeffrey NEWPORT, Auteur ; Zachary STOWE, Auteur Année de publication : 2008 Article en page(s) : p.1099-1107 Langues : Anglais (eng) Mots-clés : Anxiety cortisol depression infant perinatal prenatal psychotropic stress Index. décimale : PER Périodiques Résumé : Background: The current study examines the relationship between maternal depression and infant cortisol concentrations. The potential roles of comorbid maternal anxiety disorders, timing of maternal depression, and maternal treatment with psychotropic medications during pregnancy are addressed.
Methods: Women with 6-month-old infants (105 boys and 84 girls) participated in a laboratory paradigm that included infant saliva collection at six points, noise burst and arm restraint stressor tasks, and a diagnostic interview of the mother.
Results: Lifetime history of maternal depression was associated with increased baseline and mean (average) infant cortisol levels. Comorbidity with anxiety disorder was related to infant cortisol reactivity. Peripartum (prepartum and/or postpartum) maternal depression, rather than a pre-pregnancy history of disorder, was associated with higher infant cortisol reactivity. Prenatal and postnatal exposure to maternal disorder had similar effects, but prenatal maternal psychotropic medication treatment appeared to attenuate infant cortisol increases associated with prenatal maternal disorder exposure.
Conclusions: These data suggest that exposure to maternal depression and anxiety during pregnancy and the postpartum period may increase infant salivary cortisol. This maternal depression–infant cortisol association is independent of the effects of delivery complications, and appears to be modulated by prenatal maternal psychotropic treatment.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01914.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=607
in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1099-1107[article] Maternal depression and infant cortisol: influences of timing, comorbidity and treatment [Texte imprimé et/ou numérique] / Patricia A. BRENNAN, Auteur ; Rebecca PARGAS, Auteur ; Elaine F. WALKER, Auteur ; Paula GREEN, Auteur ; D. Jeffrey NEWPORT, Auteur ; Zachary STOWE, Auteur . - 2008 . - p.1099-1107.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1099-1107
Mots-clés : Anxiety cortisol depression infant perinatal prenatal psychotropic stress Index. décimale : PER Périodiques Résumé : Background: The current study examines the relationship between maternal depression and infant cortisol concentrations. The potential roles of comorbid maternal anxiety disorders, timing of maternal depression, and maternal treatment with psychotropic medications during pregnancy are addressed.
Methods: Women with 6-month-old infants (105 boys and 84 girls) participated in a laboratory paradigm that included infant saliva collection at six points, noise burst and arm restraint stressor tasks, and a diagnostic interview of the mother.
Results: Lifetime history of maternal depression was associated with increased baseline and mean (average) infant cortisol levels. Comorbidity with anxiety disorder was related to infant cortisol reactivity. Peripartum (prepartum and/or postpartum) maternal depression, rather than a pre-pregnancy history of disorder, was associated with higher infant cortisol reactivity. Prenatal and postnatal exposure to maternal disorder had similar effects, but prenatal maternal psychotropic medication treatment appeared to attenuate infant cortisol increases associated with prenatal maternal disorder exposure.
Conclusions: These data suggest that exposure to maternal depression and anxiety during pregnancy and the postpartum period may increase infant salivary cortisol. This maternal depression–infant cortisol association is independent of the effects of delivery complications, and appears to be modulated by prenatal maternal psychotropic treatment.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01914.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=607 Physiological attunement in mother–infant dyads at clinical high risk: The influence of maternal depression and positive parenting / Cassandra L. HENDRIX in Development and Psychopathology, 30-2 (May 2018)
[article]
Titre : Physiological attunement in mother–infant dyads at clinical high risk: The influence of maternal depression and positive parenting Type de document : Texte imprimé et/ou numérique Auteurs : Cassandra L. HENDRIX, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.623-634 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A growing number of research studies have examined the intradyadic coregulation (or attunement) of hypothalamus–pituitary–adrenal axis functioning in mothers and their children. However, it is unclear how early this coregulation may be present in dyads at clinical high risk and whether certain factors, such as maternal depression or positive parenting, are associated with the strength of this coregulation. The present study examined cortisol attunement within mother–infant dyads in a high-risk sample of 233 mothers who received treatment for psychiatric illness during pregnancy and whose infants were 6 months old at the study visit. Results showed that maternal and infant cortisol covaried across four time points that included a stressor paradigm and a mother–infant interaction task. Greater maternal positive affect, but not depression, predicted stronger cortisol attunement. In addition, infants’ cortisol level following separation from the mother predicted mothers’ cortisol level at the next time point. Mothers’ cortisol level following the separation and the laboratory stress paradigm predicted infants’ cortisol levels at each successive time point, over and above infants’ own cortisol at the previous time point. These findings suggest that maternal and infant cortisol levels influence one another in a bidirectional fashion that may be temporally and context dependent. En ligne : http://dx.doi.org/10.1017/S0954579417001158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359
in Development and Psychopathology > 30-2 (May 2018) . - p.623-634[article] Physiological attunement in mother–infant dyads at clinical high risk: The influence of maternal depression and positive parenting [Texte imprimé et/ou numérique] / Cassandra L. HENDRIX, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur . - p.623-634.
Langues : Anglais (eng)
in Development and Psychopathology > 30-2 (May 2018) . - p.623-634
Index. décimale : PER Périodiques Résumé : A growing number of research studies have examined the intradyadic coregulation (or attunement) of hypothalamus–pituitary–adrenal axis functioning in mothers and their children. However, it is unclear how early this coregulation may be present in dyads at clinical high risk and whether certain factors, such as maternal depression or positive parenting, are associated with the strength of this coregulation. The present study examined cortisol attunement within mother–infant dyads in a high-risk sample of 233 mothers who received treatment for psychiatric illness during pregnancy and whose infants were 6 months old at the study visit. Results showed that maternal and infant cortisol covaried across four time points that included a stressor paradigm and a mother–infant interaction task. Greater maternal positive affect, but not depression, predicted stronger cortisol attunement. In addition, infants’ cortisol level following separation from the mother predicted mothers’ cortisol level at the next time point. Mothers’ cortisol level following the separation and the laboratory stress paradigm predicted infants’ cortisol levels at each successive time point, over and above infants’ own cortisol at the previous time point. These findings suggest that maternal and infant cortisol levels influence one another in a bidirectional fashion that may be temporally and context dependent. En ligne : http://dx.doi.org/10.1017/S0954579417001158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 Physiological regulation in infants of women with a mood disorder: examining associations with maternal symptoms and stress / Katrina C. JOHNSON in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)
PermalinkPrenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program / Lyndsay A. AVALOS in Autism Research, 16-9 (September 2023)
PermalinkSchool-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure / Erica L. SMEARMAN in Development and Psychopathology, 32-1 (February 2020)
PermalinkSensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study / Lisa R. STARR in Development and Psychopathology, 26-4 (Part 2) (November 2014)
PermalinkSocial stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort / Erica L. SMEARMAN in Development and Psychopathology, 27-1 (February 2015)
PermalinkTransdiagnostic pathways from early social stress to psychopathology: a 20-year prospective study / C. C. CONWAY in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)
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