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Auteur Yan LI |
Documents disponibles écrits par cet auteur (4)
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Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder / Yan LI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)
[article]
Titre : Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.3800-3809 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Deleted in colorectal carcinoma gene Haplotype analysis Single nucleotide polymorphisms Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809[article] Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3800-3809.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809
Mots-clés : Autism spectrum disorder Deleted in colorectal carcinoma gene Haplotype analysis Single nucleotide polymorphisms Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China / Hua WEI in Research in Autism Spectrum Disorders, 54 (October 2018)
[article]
Titre : Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China Type de document : Texte imprimé et/ou numérique Auteurs : Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur Article en page(s) : p.83-89 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Head circumference Body height Body weight Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Research in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89[article] Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China [Texte imprimé et/ou numérique] / Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur . - p.83-89.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89
Mots-clés : Autism spectrum disorder Head circumference Body height Body weight Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 Reply to Comment on "Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder" / Yan LI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)
[article]
Titre : Reply to Comment on "Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder" Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.3811-3812 Langues : Anglais (eng) Mots-clés : Comment Reason Respond Index. décimale : PER Périodiques Résumé : The comments from Dr. Meisami about our article "Association between DCC polymorphisms and Susceptibility to Autism Spectrum Disorder", and we wish to respond to several points. First, 100% of detection rate for each SNP genotype cannot be obtained. Second, we listed the detection rates in Supplemental Table 1. Last, Dr. Meisami referred an article focused on two SNPs; however, our article focused on seven SNPs. If we marked the number of detected cases, we had to make a table for each result, occupying a large part of the layout. Moreover, if the number of detected cases was marked respectively, it was not in accordance with academic norms. For these reasons, we provided the actual number of cases in Table 3. En ligne : http://dx.doi.org/10.1007/s10803-020-04585-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3811-3812[article] Reply to Comment on "Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder" [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3811-3812.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3811-3812
Mots-clés : Comment Reason Respond Index. décimale : PER Périodiques Résumé : The comments from Dr. Meisami about our article "Association between DCC polymorphisms and Susceptibility to Autism Spectrum Disorder", and we wish to respond to several points. First, 100% of detection rate for each SNP genotype cannot be obtained. Second, we listed the detection rates in Supplemental Table 1. Last, Dr. Meisami referred an article focused on two SNPs; however, our article focused on seven SNPs. If we marked the number of detected cases, we had to make a table for each result, occupying a large part of the layout. Moreover, if the number of detected cases was marked respectively, it was not in accordance with academic norms. For these reasons, we provided the actual number of cases in Table 3. En ligne : http://dx.doi.org/10.1007/s10803-020-04585-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder / Yan LI in Research in Autism Spectrum Disorders, 70 (February 2020)
[article]
Titre : rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Jikang SHI, Auteur ; Heran CUI, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.101475 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Disco-interacting protein 2 homolog agene Single nucleotide polymorphisms Behavior phenotype Index. décimale : PER Périodiques Résumé : Background The disco-interacting protein 2 homolog A gene (DIP2A) has been reported as a novel candidate gene of Autism spectrum disorder (ASD). Associations between single nucleotide polymorphisms (SNPs) and ASD behavior phenotypes provide an opportunity to timely treat an infant with potential ASD by earlier intervention targeting a specific behavior phenotype. Methods The association of SNPs (rs8130538, rs1007893, rs34736293, rs7279002, rs2070435, rs2255397, rs1107065,rs2248636) of DIP2A with both ASD susceptibility and ASD behaviour phenotypes were investigated in Chinese Han population using a case- control study on the basis of 231 ASD cases and 242 controls. Results The allele frequencies and genotype distributions of the eight SNPs of DIP2A in the cases were not different from those in the controls; the eight DIP2A SNPs were not associated with ASD risk under the five geneticmodels; and haplotypes were not different between the cases and the controls Conclusions We identified that rs1007893 and rs2070435 in DIP2A are associated with "visual reaction" behavior phenotype in Chinese Han population. En ligne : https://doi.org/10.1016/j.rasd.2019.101475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414
in Research in Autism Spectrum Disorders > 70 (February 2020) . - p.101475[article] rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Jikang SHI, Auteur ; Heran CUI, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.101475.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 70 (February 2020) . - p.101475
Mots-clés : Autism spectrum disorder Disco-interacting protein 2 homolog agene Single nucleotide polymorphisms Behavior phenotype Index. décimale : PER Périodiques Résumé : Background The disco-interacting protein 2 homolog A gene (DIP2A) has been reported as a novel candidate gene of Autism spectrum disorder (ASD). Associations between single nucleotide polymorphisms (SNPs) and ASD behavior phenotypes provide an opportunity to timely treat an infant with potential ASD by earlier intervention targeting a specific behavior phenotype. Methods The association of SNPs (rs8130538, rs1007893, rs34736293, rs7279002, rs2070435, rs2255397, rs1107065,rs2248636) of DIP2A with both ASD susceptibility and ASD behaviour phenotypes were investigated in Chinese Han population using a case- control study on the basis of 231 ASD cases and 242 controls. Results The allele frequencies and genotype distributions of the eight SNPs of DIP2A in the cases were not different from those in the controls; the eight DIP2A SNPs were not associated with ASD risk under the five geneticmodels; and haplotypes were not different between the cases and the controls Conclusions We identified that rs1007893 and rs2070435 in DIP2A are associated with "visual reaction" behavior phenotype in Chinese Han population. En ligne : https://doi.org/10.1016/j.rasd.2019.101475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414