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Détail de l'auteur
Auteur Nathaniel HEINTZ |
Documents disponibles écrits par cet auteur (2)
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Mechanisms of Neural Patterning and Specification in the Development Cerebellum / Mary E. HATTEN in Annual Review of Neuroscience, 18 (1995)
[article]
Titre : Mechanisms of Neural Patterning and Specification in the Development Cerebellum Type de document : Texte imprimé et/ou numérique Auteurs : Mary E. HATTEN, Auteur ; Nathaniel HEINTZ, Auteur Année de publication : 1995 Article en page(s) : p.385-408 Langues : Anglais (eng) Mots-clés : Development Granule-cell Purkinje-cell Gene-regulation Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377
in Annual Review of Neuroscience > 18 (1995) . - p.385-408[article] Mechanisms of Neural Patterning and Specification in the Development Cerebellum [Texte imprimé et/ou numérique] / Mary E. HATTEN, Auteur ; Nathaniel HEINTZ, Auteur . - 1995 . - p.385-408.
Langues : Anglais (eng)
in Annual Review of Neuroscience > 18 (1995) . - p.385-408
Mots-clés : Development Granule-cell Purkinje-cell Gene-regulation Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice / Kathryn K. CHADMAN in Autism Research, 1-3 (June 2008)
[article]
Titre : Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn K. CHADMAN, Auteur ; Nathaniel HEINTZ, Auteur ; Shiaoching GONG, Auteur ; Maria Luisa SCATTONI, Auteur ; Sarah E. BOLTUCK, Auteur ; Shruti U. GANDHY, Auteur ; Jacqueline N. CRAWLEY, Auteur Année de publication : 2008 Article en page(s) : p.147-158 Langues : Anglais (eng) Mots-clés : autism mouse-model neuroligin behavior-phenotyping social-behavior Index. décimale : PER Périodiques Résumé : Neuroligin-3 is a member of the class of cell adhesion proteins that mediate synapse development and have been implicated in autism. Mice with the human R451C mutation (NL3), identical to the point mutation found in two brothers with autism spectrum disorders, were generated and phenotyped in multiple behavioral assays with face validity to the diagnostic symptoms of autism. No differences between NL3 and their wildtype (WT) littermate controls were detected on measures of juvenile reciprocal social interaction, adult social approach, cognitive abilities, and resistance to change in a spatial habit, findings which were replicated in several cohorts of males and females. Physical and procedural abilities were similar across genotypes on measures of general health, sensory abilities, sensorimotor gating, motor functions, and anxiety-related traits. Minor developmental differences were detected between NL3 and WT, including slightly different rates of somatic growth, slower righting reflexes at postnatal days 2-6, faster homing reflexes in females, and less vocalizations on postnatal day 8 in males. Significant differences in NL3 adults included somewhat longer latencies to fall from the rotarod, less vertical activity in the open field, and less acoustic startle to high decibel tones. The humanized R451C mutation in mice did not result in apparent autism-like phenotypes, but produced detectable functional consequences that may be interpreted in terms of physical development and/or reduced sensitivity to stimuli. En ligne : http://dx.doi.org/10.1002/aur.22 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=931
in Autism Research > 1-3 (June 2008) . - p.147-158[article] Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice [Texte imprimé et/ou numérique] / Kathryn K. CHADMAN, Auteur ; Nathaniel HEINTZ, Auteur ; Shiaoching GONG, Auteur ; Maria Luisa SCATTONI, Auteur ; Sarah E. BOLTUCK, Auteur ; Shruti U. GANDHY, Auteur ; Jacqueline N. CRAWLEY, Auteur . - 2008 . - p.147-158.
Langues : Anglais (eng)
in Autism Research > 1-3 (June 2008) . - p.147-158
Mots-clés : autism mouse-model neuroligin behavior-phenotyping social-behavior Index. décimale : PER Périodiques Résumé : Neuroligin-3 is a member of the class of cell adhesion proteins that mediate synapse development and have been implicated in autism. Mice with the human R451C mutation (NL3), identical to the point mutation found in two brothers with autism spectrum disorders, were generated and phenotyped in multiple behavioral assays with face validity to the diagnostic symptoms of autism. No differences between NL3 and their wildtype (WT) littermate controls were detected on measures of juvenile reciprocal social interaction, adult social approach, cognitive abilities, and resistance to change in a spatial habit, findings which were replicated in several cohorts of males and females. Physical and procedural abilities were similar across genotypes on measures of general health, sensory abilities, sensorimotor gating, motor functions, and anxiety-related traits. Minor developmental differences were detected between NL3 and WT, including slightly different rates of somatic growth, slower righting reflexes at postnatal days 2-6, faster homing reflexes in females, and less vocalizations on postnatal day 8 in males. Significant differences in NL3 adults included somewhat longer latencies to fall from the rotarod, less vertical activity in the open field, and less acoustic startle to high decibel tones. The humanized R451C mutation in mice did not result in apparent autism-like phenotypes, but produced detectable functional consequences that may be interpreted in terms of physical development and/or reduced sensitivity to stimuli. En ligne : http://dx.doi.org/10.1002/aur.22 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=931