Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Bhismadev CHAKRABARTI |
Documents disponibles écrits par cet auteur (23)
Faire une suggestion Affiner la recherche
Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome / Agnese DI NAPOLI in Molecular Autism, (February 2015)
[article]
Titre : Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Agnese DI NAPOLI, Auteur ; Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur Article en page(s) : p.1-7 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Conditions (ASC) are neurodevelopmental conditions characterized by difficulties in communication and social interaction, alongside unusually repetitive behaviours and narrow interests. Asperger Syndrome (AS) is one subgroup of ASC and differs from classic autism in that in AS there is no language or general cognitive delay. Genetic, epigenetic and environmental factors are implicated in ASC and genes involved in neural connectivity and neurodevelopment are good candidates for studying the susceptibility to ASC. The aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2) gene encodes a transcription factor involved in neurodevelopmental processes, neuronal connectivity and cellular responses to hypoxia. A mutation in this gene has been identified in individuals with ASC and single nucleotide polymorphisms (SNPs) have been nominally associated with AS and autistic traits in previous studies. En ligne : http://dx.doi.org/10.1186/s13229-015-0009-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (February 2015) . - p.1-7[article] Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome [Texte imprimé et/ou numérique] / Agnese DI NAPOLI, Auteur ; Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur . - p.1-7.
Langues : Anglais (eng)
in Molecular Autism > (February 2015) . - p.1-7
Index. décimale : PER Périodiques Résumé : Autism Spectrum Conditions (ASC) are neurodevelopmental conditions characterized by difficulties in communication and social interaction, alongside unusually repetitive behaviours and narrow interests. Asperger Syndrome (AS) is one subgroup of ASC and differs from classic autism in that in AS there is no language or general cognitive delay. Genetic, epigenetic and environmental factors are implicated in ASC and genes involved in neural connectivity and neurodevelopment are good candidates for studying the susceptibility to ASC. The aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2) gene encodes a transcription factor involved in neurodevelopmental processes, neuronal connectivity and cellular responses to hypoxia. A mutation in this gene has been identified in individuals with ASC and single nucleotide polymorphisms (SNPs) have been nominally associated with AS and autistic traits in previous studies. En ligne : http://dx.doi.org/10.1186/s13229-015-0009-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism / Varun WARRIER in Molecular Autism, (December 2013)
[article]
Titre : Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism Type de document : Texte imprimé et/ou numérique Auteurs : Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum conditions (ASC) are associated with deficits in social interaction and communication, alongside repetitive, restricted, and stereotyped behavior. ASC is highly heritable. The gamma-aminobutyric acid (GABA)-ergic system has been associated consistently with atypicalities in autism, in both genetic association and expression studies. A key component of the GABA-ergic system is encoded by the GABRB3 gene, which has been previously implicated both in ASC and in individual differences in empathy. In this study, 45 genotyped single nucleotide polymorphisms (SNPs) within GABRB3 were tested for association with Asperger syndrome (AS), and related quantitative traits measured through the following tests: the Empathy Quotient (EQ), the Autism Spectrum Quotient (AQ), the Systemizing Quotient-Revised (SQ-R), the Embedded Figures Test (EFT), the Reading the Mind in the Eyes Test (RMET), and the Mental Rotation Test (MRT). Two-loci, three-loci, four-loci haplotype analyses, and one seven-loci haplotype analysis were also performed in the AS case-control sample. Three SNPs (rs7180158, rs7165604, rs12593579) were significantly associated with AS, and two SNPs (rs9806546, rs11636966) were significantly associated with EQ. Two SNP-SNP pairs, rs12438141-rs1035751 and rs12438141-rs7179514, showed significant association with variation in the EFT scores. One SNP-SNP pair, rs7174437-rs1863455, was significantly associated with variation in the MRT scores. Additionally, a few haplotypes, including a 19kb genomic region that formed a linkage disequilibrium (LD) block in our sample and contained several nominally significant SNPs, were found to be significantly associated with AS.CONCLUSION:The current study confirms the role of GABRB3 as an important candidate gene in both ASC and normative variation in related endophenotypes. En ligne : http://dx.doi.org/10.1186/2040-2392-4-48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227
in Molecular Autism > (December 2013)[article] Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism [Texte imprimé et/ou numérique] / Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur.
Langues : Anglais (eng)
in Molecular Autism > (December 2013)
Index. décimale : PER Périodiques Résumé : Autism spectrum conditions (ASC) are associated with deficits in social interaction and communication, alongside repetitive, restricted, and stereotyped behavior. ASC is highly heritable. The gamma-aminobutyric acid (GABA)-ergic system has been associated consistently with atypicalities in autism, in both genetic association and expression studies. A key component of the GABA-ergic system is encoded by the GABRB3 gene, which has been previously implicated both in ASC and in individual differences in empathy. In this study, 45 genotyped single nucleotide polymorphisms (SNPs) within GABRB3 were tested for association with Asperger syndrome (AS), and related quantitative traits measured through the following tests: the Empathy Quotient (EQ), the Autism Spectrum Quotient (AQ), the Systemizing Quotient-Revised (SQ-R), the Embedded Figures Test (EFT), the Reading the Mind in the Eyes Test (RMET), and the Mental Rotation Test (MRT). Two-loci, three-loci, four-loci haplotype analyses, and one seven-loci haplotype analysis were also performed in the AS case-control sample. Three SNPs (rs7180158, rs7165604, rs12593579) were significantly associated with AS, and two SNPs (rs9806546, rs11636966) were significantly associated with EQ. Two SNP-SNP pairs, rs12438141-rs1035751 and rs12438141-rs7179514, showed significant association with variation in the EFT scores. One SNP-SNP pair, rs7174437-rs1863455, was significantly associated with variation in the MRT scores. Additionally, a few haplotypes, including a 19kb genomic region that formed a linkage disequilibrium (LD) block in our sample and contained several nominally significant SNPs, were found to be significantly associated with AS.CONCLUSION:The current study confirms the role of GABRB3 as an important candidate gene in both ASC and normative variation in related endophenotypes. En ligne : http://dx.doi.org/10.1186/2040-2392-4-48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome / Agnese DI NAPOLI in Molecular Autism, (September 2014)
[article]
Titre : Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Agnese DI NAPOLI, Auteur ; Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur Article en page(s) : p.1-7 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction, alongside unusually repetitive behaviors and narrow interests. ASC are highly heritable and have complex patterns of inheritance where multiple genes are involved, alongside environmental and epigenetic factors. Asperger Syndrome (AS) is a subgroup of these conditions, where there is no history of language or cognitive delay. Animal models suggest a role for oxytocin (OXT) and oxytocin receptor (OXTR) genes in social-emotional behaviors, and several studies indicate that the oxytocin/oxytocin receptor system is altered in individuals with ASC. Previous studies have reported associations between genetic variations in the OXTR gene and ASC. En ligne : http://dx.doi.org/10.1186/2040-2392-5-48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276
in Molecular Autism > (September 2014) . - p.1-7[article] Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome [Texte imprimé et/ou numérique] / Agnese DI NAPOLI, Auteur ; Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur . - p.1-7.
Langues : Anglais (eng)
in Molecular Autism > (September 2014) . - p.1-7
Index. décimale : PER Périodiques Résumé : Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction, alongside unusually repetitive behaviors and narrow interests. ASC are highly heritable and have complex patterns of inheritance where multiple genes are involved, alongside environmental and epigenetic factors. Asperger Syndrome (AS) is a subgroup of these conditions, where there is no history of language or cognitive delay. Animal models suggest a role for oxytocin (OXT) and oxytocin receptor (OXTR) genes in social-emotional behaviors, and several studies indicate that the oxytocin/oxytocin receptor system is altered in individuals with ASC. Previous studies have reported associations between genetic variations in the OXTR gene and ASC. En ligne : http://dx.doi.org/10.1186/2040-2392-5-48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 Greater interpersonal distance in adults with autism / Martina FUSARO in Autism Research, 16-10 (October 2023)
[article]
Titre : Greater interpersonal distance in adults with autism Type de document : Texte imprimé et/ou numérique Auteurs : Martina FUSARO, Auteur ; Valentina FANTI, Auteur ; Bhismadev CHAKRABARTI, Auteur Article en page(s) : p.2002-2007 Index. décimale : PER Périodiques Résumé : Abstract Social interactions are often shaped by the space we prefer to maintain between us and others, that is, interpersonal distance. Being too distant or too close to a stranger can often be perceived as odd, and lead to atypical social interactions. This calibration of appropriate interpersonal distance thus constitutes an important social skill. Individuals with autism spectrum disorder (ASD, hereafter autism) often experience difficulties with this skill, and anecdotal accounts suggest atypical interpersonal distances in their social interactions. In the current study, we systematically measured interpersonal distance in individuals with autism using immersive virtual reality (IVR) to recreate a naturalistic interaction with a full body avatar of a similar age. Participants observed their own virtual body in first-person perspective, and the other avatar in two tasks: in the first task, they approached the other avatar (active), in the second one they were approached by the other avatar (passive). Two groups of neurotypical and autistic adults, performed both tasks. Autistic adults showed greater interpersonal distance when compared to non-autistic adults. Additionally, the difference between the passive and active conditions was smaller for non-autistic compared to autistic adults. Across the full sample, greater interpersonal distance was associated with higher autism-related traits. This study provides systematic evidence for greater interpersonal distance in autistic adults using a paradigm with high ecological validity and can be useful in informing the design of appropriate environmental adjustments for shared spaces. En ligne : https://doi.org/10.1002/aur.3013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Autism Research > 16-10 (October 2023) . - p.2002-2007[article] Greater interpersonal distance in adults with autism [Texte imprimé et/ou numérique] / Martina FUSARO, Auteur ; Valentina FANTI, Auteur ; Bhismadev CHAKRABARTI, Auteur . - p.2002-2007.
in Autism Research > 16-10 (October 2023) . - p.2002-2007
Index. décimale : PER Périodiques Résumé : Abstract Social interactions are often shaped by the space we prefer to maintain between us and others, that is, interpersonal distance. Being too distant or too close to a stranger can often be perceived as odd, and lead to atypical social interactions. This calibration of appropriate interpersonal distance thus constitutes an important social skill. Individuals with autism spectrum disorder (ASD, hereafter autism) often experience difficulties with this skill, and anecdotal accounts suggest atypical interpersonal distances in their social interactions. In the current study, we systematically measured interpersonal distance in individuals with autism using immersive virtual reality (IVR) to recreate a naturalistic interaction with a full body avatar of a similar age. Participants observed their own virtual body in first-person perspective, and the other avatar in two tasks: in the first task, they approached the other avatar (active), in the second one they were approached by the other avatar (passive). Two groups of neurotypical and autistic adults, performed both tasks. Autistic adults showed greater interpersonal distance when compared to non-autistic adults. Additionally, the difference between the passive and active conditions was smaller for non-autistic compared to autistic adults. Across the full sample, greater interpersonal distance was associated with higher autism-related traits. This study provides systematic evidence for greater interpersonal distance in autistic adults using a paradigm with high ecological validity and can be useful in informing the design of appropriate environmental adjustments for shared spaces. En ligne : https://doi.org/10.1002/aur.3013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 Is it me? Self-recognition bias across sensory modalities and its relationship to autistic traits / Anya CHAKRABORTY in Molecular Autism, (March 2015)
[article]
Titre : Is it me? Self-recognition bias across sensory modalities and its relationship to autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Anya CHAKRABORTY, Auteur ; Bhismadev CHAKRABARTI, Auteur Article en page(s) : p.1-8 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Atypical self-processing is an emerging theme in autism research, suggested by lower self-reference effect in memory, and atypical neural responses to visual self-representations. Most research on physical self-processing in autism uses visual stimuli. However, the self is a multimodal construct, and therefore, it is essential to test self-recognition in other sensory modalities as well. Self-recognition in the auditory modality remains relatively unexplored and has not been tested in relation to autism and related traits. This study investigates self-recognition in auditory and visual domain in the general population and tests if it is associated with autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-015-0016-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (March 2015) . - p.1-8[article] Is it me? Self-recognition bias across sensory modalities and its relationship to autistic traits [Texte imprimé et/ou numérique] / Anya CHAKRABORTY, Auteur ; Bhismadev CHAKRABARTI, Auteur . - p.1-8.
Langues : Anglais (eng)
in Molecular Autism > (March 2015) . - p.1-8
Index. décimale : PER Périodiques Résumé : Atypical self-processing is an emerging theme in autism research, suggested by lower self-reference effect in memory, and atypical neural responses to visual self-representations. Most research on physical self-processing in autism uses visual stimuli. However, the self is a multimodal construct, and therefore, it is essential to test self-recognition in other sensory modalities as well. Self-recognition in the auditory modality remains relatively unexplored and has not been tested in relation to autism and related traits. This study investigates self-recognition in auditory and visual domain in the general population and tests if it is associated with autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-015-0016-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Lack of Privileged Access to Awareness for Rewarding Social Scenes in Autism Spectrum Disorder / K. L. H. GRAY in Journal of Autism and Developmental Disorders, 48-10 (October 2018)
PermalinkNeural self-representation in autistic women and association with 'compensatory camouflaging' / Meng-Chuan LAI in Autism, 23-5 (July 2019)
PermalinkPreference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers / L. MASON in Molecular Autism, 12 (2021)
PermalinkPrevalence of autism spectrum disorder and autistic symptoms in a school-based cohort of children in Kolkata, India / Alokananda RUDRA in Autism Research, 10-10 (October 2017)
PermalinkQuantifying and exploring camouflaging in men and women with autism / Meng-Chuan LAI in Autism, 21-6 (August 2017)
PermalinkResearch Review: The relationship between social anxiety and social cognition in children and adolescents: a systematic review and meta-analysis / S. PEARCEY in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)
PermalinkResponse to Smith’s Letter to the Editor ‘Emotional Empathy in Autism Spectrum Conditions: Weak, Intact, or Heightened?’ / Ilaria MINIO-PALUELLO in Journal of Autism and Developmental Disorders, 39-12 (December 2009)
PermalinkRigor in science and science reporting: updated guidelines for submissions to Molecular Autism / Joseph D. BUXBAUM in Molecular Autism, 10 (2019)
PermalinkSelf-referential and social cognition in a case of autism and agenesis of the corpus callosum / Michael V. LOMBARDO in Molecular Autism, (November 2012)
PermalinkSingle nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome / Jaroslava DURDIAKOVA in Molecular Autism, (March 2014)
Permalink