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Détail de l'auteur
Auteur A. H. WHITAKER |
Documents disponibles écrits par cet auteur (2)
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Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder / K. G. MARGOLIS in Journal of Autism and Developmental Disorders, 49-1 (January 2019)
[article]
Titre : Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. G. MARGOLIS, Auteur ; Timothy M. BUIE, Auteur ; J. Blake TURNER, Auteur ; A. E. SILBERMAN, Auteur ; J. F. FELDMAN, Auteur ; K. F. MURRAY, Auteur ; M. MCSWIGGAN-HARDIN, Auteur ; J. LEVY, Auteur ; M. L. BAUMAN, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur ; A. H. WHITAKER, Auteur ; Harland S. WINTER, Auteur Article en page(s) : p.349-362 Langues : Anglais (eng) Mots-clés : Autism Behavior Comorbidities Gi Gastrointestinal Screen Index. décimale : PER Périodiques Résumé : Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in both clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-018-3767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377
in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.349-362[article] Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. G. MARGOLIS, Auteur ; Timothy M. BUIE, Auteur ; J. Blake TURNER, Auteur ; A. E. SILBERMAN, Auteur ; J. F. FELDMAN, Auteur ; K. F. MURRAY, Auteur ; M. MCSWIGGAN-HARDIN, Auteur ; J. LEVY, Auteur ; M. L. BAUMAN, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur ; A. H. WHITAKER, Auteur ; Harland S. WINTER, Auteur . - p.349-362.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.349-362
Mots-clés : Autism Behavior Comorbidities Gi Gastrointestinal Screen Index. décimale : PER Périodiques Résumé : Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in both clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-018-3767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 Prenatal maternal infection and risk for autism in offspring: A meta-analysis / N. TIOLECO in Autism Research, 14-6 (June 2021)
[article]
Titre : Prenatal maternal infection and risk for autism in offspring: A meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : N. TIOLECO, Auteur ; A. E. SILBERMAN, Auteur ; K. STRATIGOS, Auteur ; Sharmila BANERJEE-BASU, Auteur ; M. N. SPANN, Auteur ; A. H. WHITAKER, Auteur ; J. Blake TURNER, Auteur Article en page(s) : p.1296-1316 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder/epidemiology Causality Female Humans Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects/epidemiology Risk Factors autism infections pregnancy prenatal risk factors Index. décimale : PER Périodiques Résumé : While prenatal maternal infection has received attention as a preventable and treatable risk factor for autism, findings have been inconsistent. This paper presents the results of a meta-analysis to determine whether the weight of the evidence supports such an association. Studies with a categorical diagnosis of autism as the outcome and an assessment of its association with prenatal maternal infection or fever (or the data necessary to compute this association) were included. A total of 36 studies met these criteria. Two independent reviewers extracted data on study design, methods of assessment, type of infectious agent, site of infection, trimester of exposure, definition of autism, and effect size. Analyses demonstrated a statistically significant association of maternal infection/fever with autism in offspring (OR = 1.32; 95% CI = 1.20-1.46). Adjustment for evident publication bias slightly weakened this association. There was little variation in effect sizes across agent or site of infection. Small differences across trimester of exposure were not statistically significant. There was some evidence that recall bias associated with status on the outcome variable leads to differential misclassification of exposure status. Nonetheless, the overall association is only modestly reduced when studies potentially contaminated by such bias are removed. Although causality has not been firmly established, these findings suggest maternal infection during pregnancy confers an increase in risk for autism in offspring. Given the prevalence of this risk factor, it is possible that the incidence of autism would be reduced by 12%-17% if maternal infections could be prevented or safely treated in a timely manner. LAY SUMMARY: This study is a meta-analysis of the association of maternal infection during pregnancy and subsequent autism in offspring. In combining the results from 36 studies of this association we find that a significant relationship is present. The association does not vary much across the types of infections or when they occur during pregnancy. We conclude that the incidence of autism could be substantially reduced if maternal infections could be prevented or safely treated in a timely manner. En ligne : http://dx.doi.org/10.1002/aur.2499 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-6 (June 2021) . - p.1296-1316[article] Prenatal maternal infection and risk for autism in offspring: A meta-analysis [Texte imprimé et/ou numérique] / N. TIOLECO, Auteur ; A. E. SILBERMAN, Auteur ; K. STRATIGOS, Auteur ; Sharmila BANERJEE-BASU, Auteur ; M. N. SPANN, Auteur ; A. H. WHITAKER, Auteur ; J. Blake TURNER, Auteur . - p.1296-1316.
Langues : Anglais (eng)
in Autism Research > 14-6 (June 2021) . - p.1296-1316
Mots-clés : Autism Spectrum Disorder Autistic Disorder/epidemiology Causality Female Humans Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects/epidemiology Risk Factors autism infections pregnancy prenatal risk factors Index. décimale : PER Périodiques Résumé : While prenatal maternal infection has received attention as a preventable and treatable risk factor for autism, findings have been inconsistent. This paper presents the results of a meta-analysis to determine whether the weight of the evidence supports such an association. Studies with a categorical diagnosis of autism as the outcome and an assessment of its association with prenatal maternal infection or fever (or the data necessary to compute this association) were included. A total of 36 studies met these criteria. Two independent reviewers extracted data on study design, methods of assessment, type of infectious agent, site of infection, trimester of exposure, definition of autism, and effect size. Analyses demonstrated a statistically significant association of maternal infection/fever with autism in offspring (OR = 1.32; 95% CI = 1.20-1.46). Adjustment for evident publication bias slightly weakened this association. There was little variation in effect sizes across agent or site of infection. Small differences across trimester of exposure were not statistically significant. There was some evidence that recall bias associated with status on the outcome variable leads to differential misclassification of exposure status. Nonetheless, the overall association is only modestly reduced when studies potentially contaminated by such bias are removed. Although causality has not been firmly established, these findings suggest maternal infection during pregnancy confers an increase in risk for autism in offspring. Given the prevalence of this risk factor, it is possible that the incidence of autism would be reduced by 12%-17% if maternal infections could be prevented or safely treated in a timely manner. LAY SUMMARY: This study is a meta-analysis of the association of maternal infection during pregnancy and subsequent autism in offspring. In combining the results from 36 studies of this association we find that a significant relationship is present. The association does not vary much across the types of infections or when they occur during pregnancy. We conclude that the incidence of autism could be substantially reduced if maternal infections could be prevented or safely treated in a timely manner. En ligne : http://dx.doi.org/10.1002/aur.2499 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449