Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Michael RUTTER |
Documents disponibles écrits par cet auteur (64)
Faire une suggestion Affiner la recherche
Understanding and testing risk mechanisms for mental disorders / Michael RUTTER in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)
[article]
Titre : Understanding and testing risk mechanisms for mental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Michael RUTTER, Auteur Année de publication : 2009 Article en page(s) : p.44-52 Langues : Anglais (eng) Mots-clés : Mediation moderation genetic-vs.-environmental-mediation natural-experiments causal-inferences Index. décimale : PER Périodiques Résumé : Over the past 50 years there has been a virtual revolution in thinking about risk mechanisms. The key areas of challenge and opportunity include: identification of environmental causes; use of natural experiments; gene–environment interaction; testing for mediation; developmental moderation; biological programming; and developmental perturbations. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01976.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=693
in Journal of Child Psychology and Psychiatry > 50-1-2 (January/February 2009) . - p.44-52[article] Understanding and testing risk mechanisms for mental disorders [Texte imprimé et/ou numérique] / Michael RUTTER, Auteur . - 2009 . - p.44-52.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-1-2 (January/February 2009) . - p.44-52
Mots-clés : Mediation moderation genetic-vs.-environmental-mediation natural-experiments causal-inferences Index. décimale : PER Périodiques Résumé : Over the past 50 years there has been a virtual revolution in thinking about risk mechanisms. The key areas of challenge and opportunity include: identification of environmental causes; use of natural experiments; gene–environment interaction; testing for mediation; developmental moderation; biological programming; and developmental perturbations. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01976.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=693 Vulnerability and resilience after early institutional care: The Greek Metera study / Panayiota VORRIA in Development and Psychopathology, 27-3 (August 2015)
[article]
Titre : Vulnerability and resilience after early institutional care: The Greek Metera study Type de document : Texte imprimé et/ou numérique Auteurs : Panayiota VORRIA, Auteur ; Maria NTOUMA, Auteur ; Michael RUTTER, Auteur Article en page(s) : p.859-866 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The aim of the study was to examine possible influences on individual differences in adolescence in response to early institutional care in infancy not involving either generalized privation or subnutrition. Fifty-two adopted adolescents aged 13 years who received institutional care in infancy at the Metera Babies Centre and 36 adolescents of the same age who were raised in their biological families participated in the study. Adolescents' attachment relationships, cognition, behavioral adjustment and use of psychological services were assessed. Marked heterogeneity in outcomes was found. No predictive effects were found for preinstitutional features or for adoptive circumstances. By contrast a large effect was found for institutional care extending beyond the age of 2 years and for quality of institutional care as experienced at an individual level. There was a close association between prolonged institutional care and disorganized attachment while in the institution, but the main institutional effect derived from the length of time in the institution. En ligne : http://dx.doi.org/10.1017/S0954579415000243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263
in Development and Psychopathology > 27-3 (August 2015) . - p.859-866[article] Vulnerability and resilience after early institutional care: The Greek Metera study [Texte imprimé et/ou numérique] / Panayiota VORRIA, Auteur ; Maria NTOUMA, Auteur ; Michael RUTTER, Auteur . - p.859-866.
Langues : Anglais (eng)
in Development and Psychopathology > 27-3 (August 2015) . - p.859-866
Index. décimale : PER Périodiques Résumé : The aim of the study was to examine possible influences on individual differences in adolescence in response to early institutional care in infancy not involving either generalized privation or subnutrition. Fifty-two adopted adolescents aged 13 years who received institutional care in infancy at the Metera Babies Centre and 36 adolescents of the same age who were raised in their biological families participated in the study. Adolescents' attachment relationships, cognition, behavioral adjustment and use of psychological services were assessed. Marked heterogeneity in outcomes was found. No predictive effects were found for preinstitutional features or for adoptive circumstances. By contrast a large effect was found for institutional care extending beyond the age of 2 years and for quality of institutional care as experienced at an individual level. There was a close association between prolonged institutional care and disorganized attachment while in the institution, but the main institutional effect derived from the length of time in the institution. En ligne : http://dx.doi.org/10.1017/S0954579415000243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model / Dennis GOLM in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)
[article]
Titre : Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model Type de document : Texte imprimé et/ou numérique Auteurs : Dennis GOLM, Auteur ; Barbara MAUGHAN, Auteur ; Edward D. BARKER, Auteur ; Jonathan HILL, Auteur ; Mark KENNEDY, Auteur ; Nicky KNIGHTS, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Wolff SCHLOTZ, Auteur ; Michael RUTTER, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur Article en page(s) : p.1043-1053 Langues : Anglais (eng) Mots-clés : Institutional deprivation anxiety depression developmental cascades emotional problems longitudinal natural experiment neurodevelopmental problems prospective Index. décimale : PER Périodiques Résumé : BACKGROUND: Using data from the English & Romanian Adoptees (ERA) study, we recently reported that early time-limited exposure to severe institutional deprivation is associated with early-onset and persistent neurodevelopmental problems and later-onset emotional problems. Here, we examine possible reasons for the late emergence of emotional problems in this cohort. Our main focus is on testing a developmental cascade mediated via the functional impact of early-appearing neurodevelopmental problems on late adolescent functioning. We also explore a second putative pathway via sensitization to stress. METHODS: The ERA study includes 165 Romanian individuals who spent their early lives in grossly depriving institutions and were subsequently adopted into UK families, along with 52 UK adoptees with no history of deprivation. Age six years symptoms of neurodevelopmental problems and age 15 anxiety/depression symptoms were assessed via parental reports. Young adult symptoms of depression and anxiety were assessed by both parent and self-reports; young adults also completed measures of stress reactivity, exposure to adverse life events, and functioning in work and interpersonal relationships. RESULTS: The path between early institutional deprivation and adult emotional problems was mediated via the impact of early neurodevelopmental problems on unemployment and poor friendship functioning during the transition to adulthood. The findings with regard to early deprivation, later life stress reactivity, and emotional problems were inconclusive. CONCLUSIONS: Our analysis suggests that the risk for adult depression and anxiety following extreme institutional deprivation is explained through the effects of early neurodevelopmental problems on later social and vocational functioning. Future research should more fully examine the role of stress susceptibility in this model. En ligne : http://dx.doi.org/10.1111/jcpp.13205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1043-1053[article] Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model [Texte imprimé et/ou numérique] / Dennis GOLM, Auteur ; Barbara MAUGHAN, Auteur ; Edward D. BARKER, Auteur ; Jonathan HILL, Auteur ; Mark KENNEDY, Auteur ; Nicky KNIGHTS, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Wolff SCHLOTZ, Auteur ; Michael RUTTER, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur . - p.1043-1053.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1043-1053
Mots-clés : Institutional deprivation anxiety depression developmental cascades emotional problems longitudinal natural experiment neurodevelopmental problems prospective Index. décimale : PER Périodiques Résumé : BACKGROUND: Using data from the English & Romanian Adoptees (ERA) study, we recently reported that early time-limited exposure to severe institutional deprivation is associated with early-onset and persistent neurodevelopmental problems and later-onset emotional problems. Here, we examine possible reasons for the late emergence of emotional problems in this cohort. Our main focus is on testing a developmental cascade mediated via the functional impact of early-appearing neurodevelopmental problems on late adolescent functioning. We also explore a second putative pathway via sensitization to stress. METHODS: The ERA study includes 165 Romanian individuals who spent their early lives in grossly depriving institutions and were subsequently adopted into UK families, along with 52 UK adoptees with no history of deprivation. Age six years symptoms of neurodevelopmental problems and age 15 anxiety/depression symptoms were assessed via parental reports. Young adult symptoms of depression and anxiety were assessed by both parent and self-reports; young adults also completed measures of stress reactivity, exposure to adverse life events, and functioning in work and interpersonal relationships. RESULTS: The path between early institutional deprivation and adult emotional problems was mediated via the impact of early neurodevelopmental problems on unemployment and poor friendship functioning during the transition to adulthood. The findings with regard to early deprivation, later life stress reactivity, and emotional problems were inconclusive. CONCLUSIONS: Our analysis suggests that the risk for adult depression and anxiety following extreme institutional deprivation is explained through the effects of early neurodevelopmental problems on later social and vocational functioning. Future research should more fully examine the role of stress susceptibility in this model. En ligne : http://dx.doi.org/10.1111/jcpp.13205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 Why is the topic of the biological embedding of experiences important for translation? / Michael RUTTER in Development and Psychopathology, 28-4 pt2 (November 2016)
[article]
Titre : Why is the topic of the biological embedding of experiences important for translation? Type de document : Texte imprimé et/ou numérique Auteurs : Michael RUTTER, Auteur Article en page(s) : p.1245-1258 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Translational research focuses on innovation in healthcare settings, but this is a two-way process that may have implications for either treatment or prevention. Smoking and lung cancer and the fetal alcohol syndrome are used as examples. Experimental medicine that budges basic and clinical science often constitutes a key way forward. Areas of scientific progress and challenge are discussed in relation to drug action, social cognition, cognitive neuroscience, molecular genetics, gene–environment interaction, and epigenetics. Key concepts and challenges in relation to stress include toxicity, allostatic load, the hypothalamus–pituitary–adrenal axis, and objectives versus subjective stress. The reasons for the need to test causal inferences are discussed. Various kinds of “natural experiments” are discussed in illustration using the assisted conception design, the discordant monozygotic twin design, and the study of universal exposure. Animal models are discussed in relation to enrichment and deprivation effects and the effects of infant separation experiences, epigenetic effects, and the biological embedding of experiences. Translational issues are discussed in relation to the hypothalamic–pituitary–adrenal axis, epigenetics, and inflammation. In conclusion, it is suggested that there are immediate possibilities for experimental medicine but caution is needed with respect to moving into translation too quickly. En ligne : http://dx.doi.org/10.1017/s0954579416000821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1245-1258[article] Why is the topic of the biological embedding of experiences important for translation? [Texte imprimé et/ou numérique] / Michael RUTTER, Auteur . - p.1245-1258.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1245-1258
Index. décimale : PER Périodiques Résumé : Translational research focuses on innovation in healthcare settings, but this is a two-way process that may have implications for either treatment or prevention. Smoking and lung cancer and the fetal alcohol syndrome are used as examples. Experimental medicine that budges basic and clinical science often constitutes a key way forward. Areas of scientific progress and challenge are discussed in relation to drug action, social cognition, cognitive neuroscience, molecular genetics, gene–environment interaction, and epigenetics. Key concepts and challenges in relation to stress include toxicity, allostatic load, the hypothalamus–pituitary–adrenal axis, and objectives versus subjective stress. The reasons for the need to test causal inferences are discussed. Various kinds of “natural experiments” are discussed in illustration using the assisted conception design, the discordant monozygotic twin design, and the study of universal exposure. Animal models are discussed in relation to enrichment and deprivation effects and the effects of infant separation experiences, epigenetic effects, and the biological embedding of experiences. Translational issues are discussed in relation to the hypothalamic–pituitary–adrenal axis, epigenetics, and inflammation. In conclusion, it is suggested that there are immediate possibilities for experimental medicine but caution is needed with respect to moving into translation too quickly. En ligne : http://dx.doi.org/10.1017/s0954579416000821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294