Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Brien P. RILEY |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Genetic and environmental influences on symptom domains in twins and siblings with autism / Carla A. MAZEFSKY in Research in Autism Spectrum Disorders, 2-2 (April-June 2008)
[article]
Titre : Genetic and environmental influences on symptom domains in twins and siblings with autism Type de document : Texte imprimé et/ou numérique Auteurs : Carla A. MAZEFSKY, Auteur ; Robin P. GOIN-KOCHEL, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur ; Hermine H. MAES, Auteur ; Brien P. RILEY, Auteur Année de publication : 2008 Article en page(s) : p.320-331 Langues : Anglais (eng) Mots-clés : Autism Autism-diagnostic-interview Behavioral-genetics Twins Social-interaction Nonverbal-communication Index. décimale : PER Périodiques Résumé : Clarifying the sources of variation among autism symptom domains is important to the identification of homogenous subgroups for molecular genetic studies. This study explored the genetic and environmental bases of nonverbal communication and social interaction, two symptom domains that have also been related to treatment response, in 1294 child and adolescent twins and siblings with pervasive developmental disorders (PDDs) from the Autism Genetic Resource Exchange under the age of 18. Twin/sibling resemblance was assessed through correlations and behavior genetic modeling of autism diagnostic interview (ADI) nonverbal communication and social scores. Variation in these phenotypes was explained by additive genetic, dominant genetic, and unique environmental factors with no evidence for shared environmental factors. Broad heritability estimates were higher for nonverbal communication (45%) than social interaction (28%). Nonverbal communication and social scores were partially accounted for by the same underlying genetic and environmental factors. Gender differences were not supported. These results add to information on familial resemblance of these symptom domains based on correlational methods, and this study is one of the first to apply behavioral genetic modeling to a PDD population. The results have implications for molecular genetics as well as treatment. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.08.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425
in Research in Autism Spectrum Disorders > 2-2 (April-June 2008) . - p.320-331[article] Genetic and environmental influences on symptom domains in twins and siblings with autism [Texte imprimé et/ou numérique] / Carla A. MAZEFSKY, Auteur ; Robin P. GOIN-KOCHEL, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur ; Hermine H. MAES, Auteur ; Brien P. RILEY, Auteur . - 2008 . - p.320-331.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 2-2 (April-June 2008) . - p.320-331
Mots-clés : Autism Autism-diagnostic-interview Behavioral-genetics Twins Social-interaction Nonverbal-communication Index. décimale : PER Périodiques Résumé : Clarifying the sources of variation among autism symptom domains is important to the identification of homogenous subgroups for molecular genetic studies. This study explored the genetic and environmental bases of nonverbal communication and social interaction, two symptom domains that have also been related to treatment response, in 1294 child and adolescent twins and siblings with pervasive developmental disorders (PDDs) from the Autism Genetic Resource Exchange under the age of 18. Twin/sibling resemblance was assessed through correlations and behavior genetic modeling of autism diagnostic interview (ADI) nonverbal communication and social scores. Variation in these phenotypes was explained by additive genetic, dominant genetic, and unique environmental factors with no evidence for shared environmental factors. Broad heritability estimates were higher for nonverbal communication (45%) than social interaction (28%). Nonverbal communication and social scores were partially accounted for by the same underlying genetic and environmental factors. Gender differences were not supported. These results add to information on familial resemblance of these symptom domains based on correlational methods, and this study is one of the first to apply behavioral genetic modeling to a PDD population. The results have implications for molecular genetics as well as treatment. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.08.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 Level of Functioning in Autism Spectrum Disorders: Phenotypic Congruence Among Affected Siblings / Robin P. GOIN-KOCHEL in Journal of Autism and Developmental Disorders, 38-6 (July 2008)
[article]
Titre : Level of Functioning in Autism Spectrum Disorders: Phenotypic Congruence Among Affected Siblings Type de document : Texte imprimé et/ou numérique Auteurs : Robin P. GOIN-KOCHEL, Auteur ; Carla A. MAZEFSKY, Auteur ; Brien P. RILEY, Auteur Année de publication : 2008 Article en page(s) : p.1019-1027 Langues : Anglais (eng) Mots-clés : AGRE Broad-spectrum Twins IQ Adaptive-behavior Index. décimale : PER Périodiques Résumé : Little evidence supports that siblings with autism exhibit the same behaviors; however, some findings suggest that level of functioning shows familial aggregation. We tested this notion among multiplex families participating with the Autism Genetic Resource Exchange (AGRE) Consortium, using scores on the Peabody Picture Vocabulary Test—Third Edition (N = 204 families), the Ravens Colored Progressive Matrices (N = 226 families), and the Vineland Adaptive Behavior Scales (N = 348 families). Intraclass Correlation Coefficients revealed that siblings with autism/autism spectrum disorders (ASD) were more similar on measures of verbal and nonverbal IQ and adaptive functioning than were unrelated children with autism/ASD. Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others. En ligne : http://dx.doi.org/10.1007/s10803-007-0476-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1019-1027[article] Level of Functioning in Autism Spectrum Disorders: Phenotypic Congruence Among Affected Siblings [Texte imprimé et/ou numérique] / Robin P. GOIN-KOCHEL, Auteur ; Carla A. MAZEFSKY, Auteur ; Brien P. RILEY, Auteur . - 2008 . - p.1019-1027.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1019-1027
Mots-clés : AGRE Broad-spectrum Twins IQ Adaptive-behavior Index. décimale : PER Périodiques Résumé : Little evidence supports that siblings with autism exhibit the same behaviors; however, some findings suggest that level of functioning shows familial aggregation. We tested this notion among multiplex families participating with the Autism Genetic Resource Exchange (AGRE) Consortium, using scores on the Peabody Picture Vocabulary Test—Third Edition (N = 204 families), the Ravens Colored Progressive Matrices (N = 226 families), and the Vineland Adaptive Behavior Scales (N = 348 families). Intraclass Correlation Coefficients revealed that siblings with autism/autism spectrum disorders (ASD) were more similar on measures of verbal and nonverbal IQ and adaptive functioning than were unrelated children with autism/ASD. Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others. En ligne : http://dx.doi.org/10.1007/s10803-007-0476-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473