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Auteur Katherine R. SABOURIN |
Documents disponibles écrits par cet auteur (6)
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Gastrointestinal Symptoms in 2- to 5-Year-Old Children in the Study to Explore Early Development / A. M. REYNOLDS in Journal of Autism and Developmental Disorders, 51-11 (November 2021)
[article]
Titre : Gastrointestinal Symptoms in 2- to 5-Year-Old Children in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : A. M. REYNOLDS, Auteur ; G. N. SOKE, Auteur ; Katherine R. SABOURIN, Auteur ; Lisa A. CROEN, Auteur ; Julie L. DANIELS, Auteur ; M. D. FALLIN, Auteur ; T. V. E. KRAL, Auteur ; L. C. LEE, Auteur ; C. J. NEWSCHAFFER, Auteur ; J. A. PINTO-MARTIN, Auteur ; Laura A. SCHIEVE, Auteur ; A. SIMS, Auteur ; Lisa D. WIGGINS, Auteur ; S. E. LEVY, Auteur Article en page(s) : p.3806-3817 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology Autistic Disorder Child Child, Preschool Developmental Disabilities/diagnosis/epidemiology Gastrointestinal Diseases/diagnosis/epidemiology Humans Prevalence Autism spectrum disorder Developmental delay Gastrointestinal Preschool Index. décimale : PER Périodiques Résumé : Gastrointestinal symptoms (GIS) are commonly reported in children with autism spectrum disorder (ASD). This multi-site study evaluated the prevalence of GIS in preschool-aged children with ASD/(n?=?672), with other developmental delays (DD)/(n?=?938), and children in the general population (POP)/(n?=?851). After adjusting for covariates, children in the ASD group were over 3 times more likely to have parent-reported GIS than the POP group, and almost 2 times more likely than the DD group. Children with GIS from all groups had more behavioral and sleep problems. Within the ASD group, children with developmental regression had more GIS than those without; however, there were no differences in autism severity scores between children with and without GIS. These findings have implications for clinical management. En ligne : http://dx.doi.org/10.1007/s10803-020-04786-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3806-3817[article] Gastrointestinal Symptoms in 2- to 5-Year-Old Children in the Study to Explore Early Development [Texte imprimé et/ou numérique] / A. M. REYNOLDS, Auteur ; G. N. SOKE, Auteur ; Katherine R. SABOURIN, Auteur ; Lisa A. CROEN, Auteur ; Julie L. DANIELS, Auteur ; M. D. FALLIN, Auteur ; T. V. E. KRAL, Auteur ; L. C. LEE, Auteur ; C. J. NEWSCHAFFER, Auteur ; J. A. PINTO-MARTIN, Auteur ; Laura A. SCHIEVE, Auteur ; A. SIMS, Auteur ; Lisa D. WIGGINS, Auteur ; S. E. LEVY, Auteur . - p.3806-3817.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3806-3817
Mots-clés : Autism Spectrum Disorder/epidemiology Autistic Disorder Child Child, Preschool Developmental Disabilities/diagnosis/epidemiology Gastrointestinal Diseases/diagnosis/epidemiology Humans Prevalence Autism spectrum disorder Developmental delay Gastrointestinal Preschool Index. décimale : PER Périodiques Résumé : Gastrointestinal symptoms (GIS) are commonly reported in children with autism spectrum disorder (ASD). This multi-site study evaluated the prevalence of GIS in preschool-aged children with ASD/(n?=?672), with other developmental delays (DD)/(n?=?938), and children in the general population (POP)/(n?=?851). After adjusting for covariates, children in the ASD group were over 3 times more likely to have parent-reported GIS than the POP group, and almost 2 times more likely than the DD group. Children with GIS from all groups had more behavioral and sleep problems. Within the ASD group, children with developmental regression had more GIS than those without; however, there were no differences in autism severity scores between children with and without GIS. These findings have implications for clinical management. En ligne : http://dx.doi.org/10.1007/s10803-020-04786-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development / Lisa A. CROEN in Autism Research, 12-10 (October 2019)
[article]
Titre : Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; Y. QIAN, Auteur ; Paul ASHWOOD, Auteur ; O. ZERBO, Auteur ; Diana SCHENDEL, Auteur ; J. PINTO-MARTIN, Auteur ; M. DANIELE FALLIN, Auteur ; S. LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; M. YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur Article en page(s) : p.1551-1561 Langues : Anglais (eng) Mots-clés : autism developmental disorder immune function infection neurodevelopment prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408
in Autism Research > 12-10 (October 2019) . - p.1551-1561[article] Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; Y. QIAN, Auteur ; Paul ASHWOOD, Auteur ; O. ZERBO, Auteur ; Diana SCHENDEL, Auteur ; J. PINTO-MARTIN, Auteur ; M. DANIELE FALLIN, Auteur ; S. LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; M. YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur . - p.1551-1561.
Langues : Anglais (eng)
in Autism Research > 12-10 (October 2019) . - p.1551-1561
Mots-clés : autism developmental disorder immune function infection neurodevelopment prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED) / Katherine R. SABOURIN in Autism Research, 12-1 (January 2019)
[article]
Titre : Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED) Type de document : Texte imprimé et/ou numérique Auteurs : Katherine R. SABOURIN, Auteur ; A. REYNOLDS, Auteur ; Diana SCHENDEL, Auteur ; S. ROSENBERG, Auteur ; Lisa A. CROEN, Auteur ; J. A. PINTO-MARTIN, Auteur ; Laura A. SCHIEVE, Auteur ; C. NEWSCHAFFER, Auteur ; L. C. LEE, Auteur ; Carolyn G. DIGUISEPPI, Auteur Article en page(s) : p.136-146 Langues : Anglais (eng) Mots-clés : autism regression autism spectrum disorder childhood infection developmental disabilities temperature dysregulation Index. décimale : PER Périodiques Résumé : Immune system abnormalities have been widely reported among children with autism spectrum disorder (ASD), which may increase the risk of childhood infections. The Study to Explore Early Development (SEED) is a multisite case-control study of children aged 30-69 months, born in 2003-2006. Cases are children previously diagnosed and newly identified with ASD enrolled from education and clinical settings. Children with a previously diagnosed non-ASD developmental condition were included in the developmental delay/disorder (DD) control group. The population (POP) control group included children randomly sampled from birth certificates. Clinical illness from infection during the first 28 days ("neonatal," from medical records) and first three years of life (caregiver report) in cases was compared to DD and POP controls; and between cases with and without regression. Children with ASD had greater odds of neonatal (OR = 1.8; 95%CI: 1.1, 2.9) and early childhood infection (OR = 1.7; 95%CI: 1.5, 1.9) compared to POP children, and greater odds of neonatal infection (OR = 1.5; 95%CI: 1.1, 2.0) compared to DD children. Cases with regression had 1.6 times the odds (95%CI: 1.1, 2.3) of caregiver-reported infection during the first year of life compared to cases without regression, but neonatal infection risk and overall early childhood infection risk did not differ. Our results support the hypothesis that children with ASD are more likely to have infection early in life compared to the general population and to children with other developmental conditions. Future studies should examine the contributions of different causes, timing, frequency, and severity of infection to ASD risk. Autism Research 2019, 12: 136-146. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We looked at infections during early childhood in relation to autism spectrum disorder (ASD). We found that children with ASD were more likely to have an infection in the first 28 days of life and before age three compared to children with typical development. Children with ASD were also more likely than children with other developmental delays or disorders to have an infection in the first 28 days of life. En ligne : http://dx.doi.org/10.1002/aur.2012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Autism Research > 12-1 (January 2019) . - p.136-146[article] Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED) [Texte imprimé et/ou numérique] / Katherine R. SABOURIN, Auteur ; A. REYNOLDS, Auteur ; Diana SCHENDEL, Auteur ; S. ROSENBERG, Auteur ; Lisa A. CROEN, Auteur ; J. A. PINTO-MARTIN, Auteur ; Laura A. SCHIEVE, Auteur ; C. NEWSCHAFFER, Auteur ; L. C. LEE, Auteur ; Carolyn G. DIGUISEPPI, Auteur . - p.136-146.
Langues : Anglais (eng)
in Autism Research > 12-1 (January 2019) . - p.136-146
Mots-clés : autism regression autism spectrum disorder childhood infection developmental disabilities temperature dysregulation Index. décimale : PER Périodiques Résumé : Immune system abnormalities have been widely reported among children with autism spectrum disorder (ASD), which may increase the risk of childhood infections. The Study to Explore Early Development (SEED) is a multisite case-control study of children aged 30-69 months, born in 2003-2006. Cases are children previously diagnosed and newly identified with ASD enrolled from education and clinical settings. Children with a previously diagnosed non-ASD developmental condition were included in the developmental delay/disorder (DD) control group. The population (POP) control group included children randomly sampled from birth certificates. Clinical illness from infection during the first 28 days ("neonatal," from medical records) and first three years of life (caregiver report) in cases was compared to DD and POP controls; and between cases with and without regression. Children with ASD had greater odds of neonatal (OR = 1.8; 95%CI: 1.1, 2.9) and early childhood infection (OR = 1.7; 95%CI: 1.5, 1.9) compared to POP children, and greater odds of neonatal infection (OR = 1.5; 95%CI: 1.1, 2.0) compared to DD children. Cases with regression had 1.6 times the odds (95%CI: 1.1, 2.3) of caregiver-reported infection during the first year of life compared to cases without regression, but neonatal infection risk and overall early childhood infection risk did not differ. Our results support the hypothesis that children with ASD are more likely to have infection early in life compared to the general population and to children with other developmental conditions. Future studies should examine the contributions of different causes, timing, frequency, and severity of infection to ASD risk. Autism Research 2019, 12: 136-146. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We looked at infections during early childhood in relation to autism spectrum disorder (ASD). We found that children with ASD were more likely to have an infection in the first 28 days of life and before age three compared to children with typical development. Children with ASD were also more likely than children with other developmental delays or disorders to have an infection in the first 28 days of life. En ligne : http://dx.doi.org/10.1002/aur.2012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 Injuries in Children with Autism Spectrum Disorder: Study to Explore Early Development (SEED) / Carolyn G. DIGUISEPPI in Journal of Autism and Developmental Disorders, 48-2 (February 2018)
[article]
Titre : Injuries in Children with Autism Spectrum Disorder: Study to Explore Early Development (SEED) Type de document : Texte imprimé et/ou numérique Auteurs : Carolyn G. DIGUISEPPI, Auteur ; S. E. LEVY, Auteur ; Katherine R. SABOURIN, Auteur ; G. N. SOKE, Auteur ; S. ROSENBERG, Auteur ; L. C. LEE, Auteur ; E. MOODY, Auteur ; Laura A. SCHIEVE, Auteur Article en page(s) : p.461-472 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Developmental delays and disorders Epidemiology Injuries Prevalence Index. décimale : PER Périodiques Résumé : This study examined caregiver-reported medically-attended injuries among 30-68 month old children with autism spectrum disorder (ASD) compared to general population (POP) and non-ASD developmental disorders (DD) controls in the Study to Explore Early Development. Injuries were common in ASD cases (32.3%) as well as POP (30.2%) and DD (27.8%) controls; most resulted in an emergency visit or hospitalization. After accounting for sociodemographic, health, IQ and behavior differences, odds of injury in ASD cases were significantly higher than DD controls but similar to POP controls. Attention problems mediated the relationships. Clinicians caring for children with both ASD and attention problems should consider providing targeted safety advice. Differences in injury risk between children with ASD vs. other developmental disorders need further study. En ligne : https://doi.org/10.1007/s10803-017-3337-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.461-472[article] Injuries in Children with Autism Spectrum Disorder: Study to Explore Early Development (SEED) [Texte imprimé et/ou numérique] / Carolyn G. DIGUISEPPI, Auteur ; S. E. LEVY, Auteur ; Katherine R. SABOURIN, Auteur ; G. N. SOKE, Auteur ; S. ROSENBERG, Auteur ; L. C. LEE, Auteur ; E. MOODY, Auteur ; Laura A. SCHIEVE, Auteur . - p.461-472.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.461-472
Mots-clés : Autism spectrum disorder Developmental delays and disorders Epidemiology Injuries Prevalence Index. décimale : PER Périodiques Résumé : This study examined caregiver-reported medically-attended injuries among 30-68 month old children with autism spectrum disorder (ASD) compared to general population (POP) and non-ASD developmental disorders (DD) controls in the Study to Explore Early Development. Injuries were common in ASD cases (32.3%) as well as POP (30.2%) and DD (27.8%) controls; most resulted in an emergency visit or hospitalization. After accounting for sociodemographic, health, IQ and behavior differences, odds of injury in ASD cases were significantly higher than DD controls but similar to POP controls. Attention problems mediated the relationships. Clinicians caring for children with both ASD and attention problems should consider providing targeted safety advice. Differences in injury risk between children with ASD vs. other developmental disorders need further study. En ligne : https://doi.org/10.1007/s10803-017-3337-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337 Injury-related treatments and outcomes in preschool children with autism spectrum disorder: Study to Explore Early Development (SEED) / Carolyn G. DIGUISEPPI in Research in Autism Spectrum Disorders, 66 (October 2019)
[article]
Titre : Injury-related treatments and outcomes in preschool children with autism spectrum disorder: Study to Explore Early Development (SEED) Type de document : Texte imprimé et/ou numérique Auteurs : Carolyn G. DIGUISEPPI, Auteur ; Katherine R. SABOURIN, Auteur ; Susan E. LEVY, Auteur ; Gnakub N. SOKE, Auteur ; Li-Ching LEE, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur Article en page(s) : p.101413 Langues : Anglais (eng) Mots-clés : ASD Injuries Surgery Emergency care Injury outcomes Treatment Index. décimale : PER Périodiques Résumé : Background Evidence about injury management and outcomes in children with autism spectrum disorder (ASD) is limited. Method Cross-sectional analyses included children aged 30–68 months with at least one medically attended injury. Standardized diagnostic instruments determined ASD cases. Parent-reported injury treatments and outcomes were examined in ASD cases (n?=?224) versus developmental delays/disorders (DD) (n?=?188) and population (POP) (n?=?267) controls, adjusting for child and family characteristics using logistic regression. Results Injury characteristics were similar between groups. Most children (82.5%) had emergency care (EC) or hospitalization after injury. Nearly half (46.4%) ever received a medication or injection, mostly analgesics (53.4%) and local anesthetics (23.8%), while 9.4% ever received surgery, most often for open wound (47.0%) or fracture (16.7%). ASD group children were less likely than DD group children to receive medication/injection (41.1% vs. 53.2%, adjusted odds ratio [aOR]?=?0.60 [0.40, 0.90]); receipt of EC/hospitalization and surgery were comparable. Children with ASD more often had surgery than POP children (14.3% vs. 4.9%, aOR?=?2.62 [1.31, 5.25]); receipt of EC/hospitalization and medication/injection were similar. Loss of consciousness was uncommon (ASD?=?6.3%, DD?=?5.3%, POP?=?3.4%), as was long-term or significant behavior change (ASD?=?5.4%, DD?=?3.2%, POP?=?3.2%); differences were not significant. Conclusions Injured children with ASD received fewer medications/injections than children with non-ASD developmental delays/disorders and more surgical treatments than general population children. Injury management was otherwise similar between groups. Understanding whether these results reflect child or injury characteristics or provider perceptions about behaviors and pain thresholds of children with ASD, and how these may influence care, requires further study. En ligne : https://doi.org/10.1016/j.rasd.2019.101413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404
in Research in Autism Spectrum Disorders > 66 (October 2019) . - p.101413[article] Injury-related treatments and outcomes in preschool children with autism spectrum disorder: Study to Explore Early Development (SEED) [Texte imprimé et/ou numérique] / Carolyn G. DIGUISEPPI, Auteur ; Katherine R. SABOURIN, Auteur ; Susan E. LEVY, Auteur ; Gnakub N. SOKE, Auteur ; Li-Ching LEE, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur . - p.101413.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 66 (October 2019) . - p.101413
Mots-clés : ASD Injuries Surgery Emergency care Injury outcomes Treatment Index. décimale : PER Périodiques Résumé : Background Evidence about injury management and outcomes in children with autism spectrum disorder (ASD) is limited. Method Cross-sectional analyses included children aged 30–68 months with at least one medically attended injury. Standardized diagnostic instruments determined ASD cases. Parent-reported injury treatments and outcomes were examined in ASD cases (n?=?224) versus developmental delays/disorders (DD) (n?=?188) and population (POP) (n?=?267) controls, adjusting for child and family characteristics using logistic regression. Results Injury characteristics were similar between groups. Most children (82.5%) had emergency care (EC) or hospitalization after injury. Nearly half (46.4%) ever received a medication or injection, mostly analgesics (53.4%) and local anesthetics (23.8%), while 9.4% ever received surgery, most often for open wound (47.0%) or fracture (16.7%). ASD group children were less likely than DD group children to receive medication/injection (41.1% vs. 53.2%, adjusted odds ratio [aOR]?=?0.60 [0.40, 0.90]); receipt of EC/hospitalization and surgery were comparable. Children with ASD more often had surgery than POP children (14.3% vs. 4.9%, aOR?=?2.62 [1.31, 5.25]); receipt of EC/hospitalization and medication/injection were similar. Loss of consciousness was uncommon (ASD?=?6.3%, DD?=?5.3%, POP?=?3.4%), as was long-term or significant behavior change (ASD?=?5.4%, DD?=?3.2%, POP?=?3.2%); differences were not significant. Conclusions Injured children with ASD received fewer medications/injections than children with non-ASD developmental delays/disorders and more surgical treatments than general population children. Injury management was otherwise similar between groups. Understanding whether these results reflect child or injury characteristics or provider perceptions about behaviors and pain thresholds of children with ASD, and how these may influence care, requires further study. En ligne : https://doi.org/10.1016/j.rasd.2019.101413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 Peri-Pregnancy Cannabis Use and Autism Spectrum Disorder in the Offspring: Findings from the Study to Explore Early Development / Carolyn G. DIGUISEPPI in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
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