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Détail de l'auteur
Auteur Amy LY |
Documents disponibles écrits par cet auteur (1)
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AMBRA1, Autophagy, and the Extreme Male Brain Theory of Autism / Bernard CRESPI in Autism Research and Treatment, 2019 (2019)
[article]
Titre : AMBRA1, Autophagy, and the Extreme Male Brain Theory of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Bernard CRESPI, Auteur ; Silven READ, Auteur ; Amy LY, Auteur ; Peter HURD, Auteur Année de publication : 2019 Article en page(s) : 6 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The extreme male brain theory of autism posits that its male bias is mediated by exaggeration of male-biased sex differences inthe expression of autism-associated traits found in typical populations. 'e theory is supported by extensive phenotypicevidence, but no genes have yet been described with properties that fit its predictions. 'e autophagy-associated geneAMBRA1 represents one of the top genome-wide “hits” in recent GWAS studies of schizophrenia, shows sex-differentialexpression, and has been linked with autism risk and traits in humans and mice, especially or exclusively among females. Wegenotyped the AMBRA1 autism-risk SNP in a population of typical humans who were scored for the dimensional expressionof autistic and schizotypal traits. Females, but not males, homozygous for the GG genotype showed a significant increase inscore for the single trait, the Autism Quotient-Imagination subscale, that exhibits a strong, significant male bias in typicalpopulations. As such, females with this genotype resembled males for this highly sexually dimorphic, autism-associatedphenotype. 'ese findings support the extreme male brain hypothesis and indicate that sex-specific genetic effects canmediate aspects of risk for autism. En ligne : https://doi.org/10.1155/2019/1968580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism Research and Treatment > 2019 (2019) . - 6 p.[article] AMBRA1, Autophagy, and the Extreme Male Brain Theory of Autism [Texte imprimé et/ou numérique] / Bernard CRESPI, Auteur ; Silven READ, Auteur ; Amy LY, Auteur ; Peter HURD, Auteur . - 2019 . - 6 p.
Langues : Anglais (eng)
in Autism Research and Treatment > 2019 (2019) . - 6 p.
Index. décimale : PER Périodiques Résumé : The extreme male brain theory of autism posits that its male bias is mediated by exaggeration of male-biased sex differences inthe expression of autism-associated traits found in typical populations. 'e theory is supported by extensive phenotypicevidence, but no genes have yet been described with properties that fit its predictions. 'e autophagy-associated geneAMBRA1 represents one of the top genome-wide “hits” in recent GWAS studies of schizophrenia, shows sex-differentialexpression, and has been linked with autism risk and traits in humans and mice, especially or exclusively among females. Wegenotyped the AMBRA1 autism-risk SNP in a population of typical humans who were scored for the dimensional expressionof autistic and schizotypal traits. Females, but not males, homozygous for the GG genotype showed a significant increase inscore for the single trait, the Autism Quotient-Imagination subscale, that exhibits a strong, significant male bias in typicalpopulations. As such, females with this genotype resembled males for this highly sexually dimorphic, autism-associatedphenotype. 'ese findings support the extreme male brain hypothesis and indicate that sex-specific genetic effects canmediate aspects of risk for autism. En ligne : https://doi.org/10.1155/2019/1968580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409