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Auteur Peter SZATMARI |
Documents disponibles écrits par cet auteur (66)
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Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders / Jeremy GOLDBERG in Journal of Autism and Developmental Disorders, 39-1 (January 2009)
[article]
Titre : Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur Année de publication : 2009 Article en page(s) : p.97-104 Langues : Anglais (eng) Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660
in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104[article] Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur . - 2009 . - p.97-104.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104
Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660 Dépistage, évaluation et diagnostic des troubles du spectre de l'autisme chez les enfants en bas âge / Jennifer NACHSHEN
Titre : Dépistage, évaluation et diagnostic des troubles du spectre de l'autisme chez les enfants en bas âge : Guide des pratiques exemplaires canadiennes Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer NACHSHEN, Auteur ; Shari JOSEPH, Auteur ; Ellen RISHIKOF, Auteur ; Ingrid E. SLADECZEK, Auteur ; Mandy STEIMAN, Auteur ; Lee TIDMARSH, Auteur ; Nancy TREPANIER, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Eric FOMBONNE, Auteur ; Peter SZATMARI, Auteur ; Alexa MARTIN-STOREY, Auteur ; Hélène OUELLETTE-KUNTZ, Auteur ; Angela CORNICK, Auteur ; Rosemary A. CONDILLAC, Auteur ; Nathalie GARCIN, Auteur ; Katherine MOXNESS, Auteur ; Yves TREMBLAY, Auteur ; Paula HUTCHINSON, Auteur ; Anne LACHANCE, Auteur ; Martine BEAURIVAGE, Auteur ; Marlene BREITENBACH, Auteur ; Susan E. BRYSON, Auteur ; Jake BURACK, Auteur ; Christine CARON, Auteur ; Paula RUTTLE, Auteur Editeur : Ville Mont Royal [Canada] : Fondation Miriam Année de publication : 2008 Importance : 95 p. Présentation : ill. Format : 21cm x 29,7cm x 0,6cm Note générale : Bibliogr. Langues : Français (fre) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://www.interteddi.ca/projet-pratiques-exemplaires/handbook_french.pdf Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 Dépistage, évaluation et diagnostic des troubles du spectre de l'autisme chez les enfants en bas âge : Guide des pratiques exemplaires canadiennes [Texte imprimé et/ou numérique] / Jennifer NACHSHEN, Auteur ; Shari JOSEPH, Auteur ; Ellen RISHIKOF, Auteur ; Ingrid E. SLADECZEK, Auteur ; Mandy STEIMAN, Auteur ; Lee TIDMARSH, Auteur ; Nancy TREPANIER, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Eric FOMBONNE, Auteur ; Peter SZATMARI, Auteur ; Alexa MARTIN-STOREY, Auteur ; Hélène OUELLETTE-KUNTZ, Auteur ; Angela CORNICK, Auteur ; Rosemary A. CONDILLAC, Auteur ; Nathalie GARCIN, Auteur ; Katherine MOXNESS, Auteur ; Yves TREMBLAY, Auteur ; Paula HUTCHINSON, Auteur ; Anne LACHANCE, Auteur ; Martine BEAURIVAGE, Auteur ; Marlene BREITENBACH, Auteur ; Susan E. BRYSON, Auteur ; Jake BURACK, Auteur ; Christine CARON, Auteur ; Paula RUTTLE, Auteur . - Ville Mont Royal [Canada] : Fondation Miriam, 2008 . - 95 p. : ill. ; 21cm x 29,7cm x 0,6cm.
Bibliogr.
Langues : Français (fre)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://www.interteddi.ca/projet-pratiques-exemplaires/handbook_french.pdf Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0001201 AUT-B MIR Livre Centre d'Information et de Documentation du CRA Rhône-Alpes AUT - L'Autisme Disponible Differentiating Autism and Asperger Syndrome on the Basis of Language Delay or Impairment / Terry BENNETT in Journal of Autism and Developmental Disorders, 38-4 (April 2008)
[article]
Titre : Differentiating Autism and Asperger Syndrome on the Basis of Language Delay or Impairment Type de document : Texte imprimé et/ou numérique Auteurs : Terry BENNETT, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; Michael H. BOYLE, Auteur ; Joanne VOLDEN, Auteur ; Liezanne VACCARELLA, Auteur ; Eric DUKU, Auteur Année de publication : 2008 Article en page(s) : p.616-625 Langues : Anglais (eng) Mots-clés : Autism Asperger-syndrome Language-impairment Outcomes Index. décimale : PER Périodiques Résumé : Asperger syndrome (AS) is differentiated from high-functioning autism (HFA) largely on a history of “language delay.” This study examined “specific language impairment” as a predictor of outcome. Language skills of 19 children with AS and 45 with HFA were assessed at 4–6 years of age (Time 1) and 2 years later (Time 2). Children’s symptoms and functional outcome scores were assessed every 2 years (Times 3, 4, and 5) until ages 15–17 years old. Regression analysis revealed that specific language impairment at time 2 more often accounted for the greatest variation in outcome scores in adolescence than the standard diagnosis of AS versus HFA based on history of language delay. Diagnostic implications are discussed.
En ligne : http://dx.doi.org/10.1007/s10803-007-0428-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340
in Journal of Autism and Developmental Disorders > 38-4 (April 2008) . - p.616-625[article] Differentiating Autism and Asperger Syndrome on the Basis of Language Delay or Impairment [Texte imprimé et/ou numérique] / Terry BENNETT, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; Michael H. BOYLE, Auteur ; Joanne VOLDEN, Auteur ; Liezanne VACCARELLA, Auteur ; Eric DUKU, Auteur . - 2008 . - p.616-625.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-4 (April 2008) . - p.616-625
Mots-clés : Autism Asperger-syndrome Language-impairment Outcomes Index. décimale : PER Périodiques Résumé : Asperger syndrome (AS) is differentiated from high-functioning autism (HFA) largely on a history of “language delay.” This study examined “specific language impairment” as a predictor of outcome. Language skills of 19 children with AS and 45 with HFA were assessed at 4–6 years of age (Time 1) and 2 years later (Time 2). Children’s symptoms and functional outcome scores were assessed every 2 years (Times 3, 4, and 5) until ages 15–17 years old. Regression analysis revealed that specific language impairment at time 2 more often accounted for the greatest variation in outcome scores in adolescence than the standard diagnosis of AS versus HFA based on history of language delay. Diagnostic implications are discussed.
En ligne : http://dx.doi.org/10.1007/s10803-007-0428-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340 Disentangling global and domain-level adaptive behavior trajectories among children with autism spectrum disorder / Cristan FARMER in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)
[article]
Titre : Disentangling global and domain-level adaptive behavior trajectories among children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Cristan FARMER, Auteur ; Audrey THURM, Auteur ; Emma CONDY, Auteur ; Eric DUKU, Auteur ; Peter SZATMARI, Auteur ; Teresa BENNETT, Auteur ; Mayada ELSABBAGH, Auteur ; Connor M. KERNS, Auteur ; Isabel M. SMITH, Auteur ; Tracy VAILLANCOURT, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stelios GEORGIADES, Auteur Article en page(s) : p.868-875 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Heterogeneity in adaptive behavior abilities among people with autism spectrum disorder (ASD) is expressed not only as uneven levels of impairment across domains, but also in the developmental trajectories of adaptive skills. We studied the question of whether, after accounting for global adaptive behavior development, we find evidence of heterogeneity in the trajectories of specific domains of adaptive behavior. Methods A sample of 504 children with ASD was obtained by combining data from two independent natural history studies conducted in North America. We used a factor of curves model to explain growth between 36 and 138?months in Vineland Adaptive Behavior Scales, Second Edition (VABS) age equivalents as a function of domain-specific and global growth processes. Results The domain-specific trajectories in all three domains (Communication, Daily Living Skills, and Socialization) reflected impairment relative to age expectations as well as slower-than-expected growth with age, and the parameters of these trajectories were moderately-to-strongly correlated across domains. The global adaptive behavior trajectory had an initial (36-41?months of age) developmental level of about 22 age-equivalent months, and eventually slowed after initially increasing by about 6 months each year. The global trajectory accounted for the majority of variance in the domain-level processes; however, additional variance remained (14%-38%) in the domain-level intercepts, slopes, and quadratic processes. Conclusions These results extend existing theoretical and empirical support for the hierarchical structure of adaptive behavior to include its development over time in clinical samples of children with ASD. A latent global trajectory may be sufficient to describe the growth of adaptive behavior in children with ASD; however, the remaining domain-specific variability after accounting for global adaptive behavior development allows for the possibility that differential effects of intervention on specific domains may be possible and detectable. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504
in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.868-875[article] Disentangling global and domain-level adaptive behavior trajectories among children with autism spectrum disorder [Texte imprimé et/ou numérique] / Cristan FARMER, Auteur ; Audrey THURM, Auteur ; Emma CONDY, Auteur ; Eric DUKU, Auteur ; Peter SZATMARI, Auteur ; Teresa BENNETT, Auteur ; Mayada ELSABBAGH, Auteur ; Connor M. KERNS, Auteur ; Isabel M. SMITH, Auteur ; Tracy VAILLANCOURT, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stelios GEORGIADES, Auteur . - p.868-875.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.868-875
Index. décimale : PER Périodiques Résumé : Background Heterogeneity in adaptive behavior abilities among people with autism spectrum disorder (ASD) is expressed not only as uneven levels of impairment across domains, but also in the developmental trajectories of adaptive skills. We studied the question of whether, after accounting for global adaptive behavior development, we find evidence of heterogeneity in the trajectories of specific domains of adaptive behavior. Methods A sample of 504 children with ASD was obtained by combining data from two independent natural history studies conducted in North America. We used a factor of curves model to explain growth between 36 and 138?months in Vineland Adaptive Behavior Scales, Second Edition (VABS) age equivalents as a function of domain-specific and global growth processes. Results The domain-specific trajectories in all three domains (Communication, Daily Living Skills, and Socialization) reflected impairment relative to age expectations as well as slower-than-expected growth with age, and the parameters of these trajectories were moderately-to-strongly correlated across domains. The global adaptive behavior trajectory had an initial (36-41?months of age) developmental level of about 22 age-equivalent months, and eventually slowed after initially increasing by about 6 months each year. The global trajectory accounted for the majority of variance in the domain-level processes; however, additional variance remained (14%-38%) in the domain-level intercepts, slopes, and quadratic processes. Conclusions These results extend existing theoretical and empirical support for the hierarchical structure of adaptive behavior to include its development over time in clinical samples of children with ASD. A latent global trajectory may be sufficient to describe the growth of adaptive behavior in children with ASD; however, the remaining domain-specific variability after accounting for global adaptive behavior development allows for the possibility that differential effects of intervention on specific domains may be possible and detectable. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 Do reciprocal associations exist between social and language pathways in preschoolers with autism spectrum disorders? / Teresa BENNETT in Journal of Child Psychology and Psychiatry, 56-8 (August 2015)
[article]
Titre : Do reciprocal associations exist between social and language pathways in preschoolers with autism spectrum disorders? Type de document : Texte imprimé et/ou numérique Auteurs : Teresa BENNETT, Auteur ; Peter SZATMARI, Auteur ; Katholiki GEORGIADES, Auteur ; Steven HANNA, Auteur ; Magdelena JANUS, Auteur ; Stelios GEORGIADES, Auteur ; Eric DUKU, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Isabel M. SMITH, Auteur ; Pat MIRENDA, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Mayada ELSABBAGH, Auteur ; Ann THOMPSON, Auteur ; THE PATHWAYS IN A. S. D. STUDY TEAM,, Auteur Article en page(s) : p.874-883 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder social development language epidemiology reciprocal effects model Index. décimale : PER Périodiques Résumé : Background Differences in how developmental pathways interact dynamically in children with autism spectrum disorder (ASD) likely contribute in important ways to phenotypic heterogeneity. This study aimed to model longitudinal reciprocal associations between social competence (SOC) and language (LANG) pathways in young children with ASD. Methods Data were obtained from 365 participants aged 2–4 years who had recently been diagnosed with an ASD and who were followed over three time points: baseline (time of diagnosis), 6- and 12 months later. Using structural equation modeling, a cross-lagged reciprocal effects model was developed that incorporated auto-regressive (stability) paths for SOC (using the Socialization subscale of the Vineland Adaptive Behavior Scales-2) and LANG (using the Preschool Language Scale-4 Auditory Comprehension subscale). Cross-domain associations included within-time correlations and lagged associations. Results SOC and LANG were highly stable over 12 months. Small reciprocal cross-lagged associations were found across most time points and within-time correlations decreased over time. There were no differences in strength of cross-lagged associations between SOC-LANG and LANG-SOC across time points. Few differences were found between subgroups of children with ASD with and without cognitive impairment. Conclusions Longitudinal reciprocal cross-domain associations between social competence and language were small in this sample of young children with ASD. Instead, a pattern emerged to suggest that the two domains were strongly associated around time of diagnosis in preschoolers with ASD, and then appeared to become more independent over the ensuing 12 months. En ligne : http://dx.doi.org/10.1111/jcpp.12356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263
in Journal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.874-883[article] Do reciprocal associations exist between social and language pathways in preschoolers with autism spectrum disorders? [Texte imprimé et/ou numérique] / Teresa BENNETT, Auteur ; Peter SZATMARI, Auteur ; Katholiki GEORGIADES, Auteur ; Steven HANNA, Auteur ; Magdelena JANUS, Auteur ; Stelios GEORGIADES, Auteur ; Eric DUKU, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Isabel M. SMITH, Auteur ; Pat MIRENDA, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Mayada ELSABBAGH, Auteur ; Ann THOMPSON, Auteur ; THE PATHWAYS IN A. S. D. STUDY TEAM,, Auteur . - p.874-883.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.874-883
Mots-clés : Autism spectrum disorder social development language epidemiology reciprocal effects model Index. décimale : PER Périodiques Résumé : Background Differences in how developmental pathways interact dynamically in children with autism spectrum disorder (ASD) likely contribute in important ways to phenotypic heterogeneity. This study aimed to model longitudinal reciprocal associations between social competence (SOC) and language (LANG) pathways in young children with ASD. Methods Data were obtained from 365 participants aged 2–4 years who had recently been diagnosed with an ASD and who were followed over three time points: baseline (time of diagnosis), 6- and 12 months later. Using structural equation modeling, a cross-lagged reciprocal effects model was developed that incorporated auto-regressive (stability) paths for SOC (using the Socialization subscale of the Vineland Adaptive Behavior Scales-2) and LANG (using the Preschool Language Scale-4 Auditory Comprehension subscale). Cross-domain associations included within-time correlations and lagged associations. Results SOC and LANG were highly stable over 12 months. Small reciprocal cross-lagged associations were found across most time points and within-time correlations decreased over time. There were no differences in strength of cross-lagged associations between SOC-LANG and LANG-SOC across time points. Few differences were found between subgroups of children with ASD with and without cognitive impairment. Conclusions Longitudinal reciprocal cross-domain associations between social competence and language were small in this sample of young children with ASD. Instead, a pattern emerged to suggest that the two domains were strongly associated around time of diagnosis in preschoolers with ASD, and then appeared to become more independent over the ensuing 12 months. En ligne : http://dx.doi.org/10.1111/jcpp.12356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder / Julie LONGARD in Autism & Developmental Language Impairments, 2 (January-December 2017)
PermalinkEducators Describe the "Best Things" About Students with Autism at School / Anat ZAIDMAN-ZAIT ; Katherine Tombeau COST ; Isabel M. SMITH ; Lonnie ZWAIGENBAUM ; Eric DUKU ; Connor KERNS ; Stelios GEORGIADES ; Tracy VAILLANCOURT ; Mayada ELSABBAGH ; Teresa BENNETT ; Peter SZATMARI in Journal of Autism and Developmental Disorders, 54-1 (January 2024)
PermalinkExamination of Bidirectional Relationships Between Parent Stress and Two Types of Problem Behavior in Children with Autism Spectrum Disorder / Anat ZAIDMAN-ZAIT in Journal of Autism and Developmental Disorders, 44-8 (August 2014)
PermalinkExamining clinical characteristics of autism and links with parent perceptions of sibling relationship quality / Alana J. MCVEY in Autism, 27-2 (February 2023)
PermalinkFactor analysis of the Parenting Stress Index-Short Form with parents of young children with autism spectrum disorders / Anat ZAIDMAN-ZAIT in Autism Research, 4-5 (October 2011)
PermalinkGenetic epidemiology of autism spectrum disorders / Peter SZATMARI
PermalinkHow do Individuals with Autism Plan Their Movements? / Cheryl M. GLAZEBROOK in Journal of Autism and Developmental Disorders, 38-1 (January 2008)
PermalinkImmunization uptake in younger siblings of children with autism spectrum disorder / Ghassan Abu KUWAIK in Autism, 18-2 (February 2014)
PermalinkImpact of personal and social resources on parenting stress in mothers of children with autism spectrum disorder / Anat ZAIDMAN-ZAIT in Autism, 21-2 (February 2017)
PermalinkInattention and hyperactive/impulsive component scores do not differentiate between autism spectrum disorder and attention-deficit/hyperactivity disorder in a clinical sample / Aneta D. KRAKOWSKI in Molecular Autism, 11 (2020)
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