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Auteur Christopher GILLBERG |
Documents disponibles écrits par cet auteur (94)
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The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins / Albert CASTELLHEIM in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)
[article]
Titre : The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins Type de document : Texte imprimé et/ou numérique Auteurs : Albert CASTELLHEIM, Auteur ; Sebastian LUNDSTROM, Auteur ; Mattias MOLIN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur Article en page(s) : p.966-972 Langues : Anglais (eng) Mots-clés : Neurodevelopmental disorders ADHD general anesthesia congenital abnormalities system diseases Index. décimale : PER Périodiques Résumé : Background The role of general anesthetics as a risk factor for possible neurodevelopmental disorders (NDDs) in humans is unresolved. The investigation of the role of anesthetics in the development of postgeneral anesthesia (anesthesia onward) NDDs has proven to be complicated, partly because of the inherent confounding in clinical cohort studies, and partly by the fact that anesthetics are only one part in the complex process of anesthesia-surgery. Methods Utilizing the Swedish databases Child and Adolescent Twins Study in Sweden (CATSS) and National Patient Register (NPR), we investigated twins discordant for anesthesia, born between 1997 and 2004 for traits of NDDs. We identified 68 twin pairs discordant for anesthesia and explored traits of Attention-Deficit/Hyperactivity Disorder (ADHD), Learning Disability (LD), and Autism Spectrum Disorder (ASD) in them while simultaneously taking congenital abnormalities and systemic disorders (CSDs) into account. We analyzed the possible effect of anesthesia on neurodevelopmental problems, and we analyzed the within-pair differences using conditional linear regression. Results Twins with a recorded episode of anesthesia had higher traits of NDDs than twins without; similarly twins with CSDs had higher mean scores on all traits than twins without CSDs. The within-pair analyses suggested that exposure to anesthesia was associated with higher scores of ADHD (regression coefficient 1.02 and 95% confidence intervals: 0.27?1.78) in monozygotic (MZ) twins discordant for anesthesia. This effect remained when adjusting for congenital abnormalities. Discussion Our finding that traits of ADHD were slightly associated with anesthesia in a genetically sensitive design is in need of replication and warrants further investigation. Future studies should aim to elucidate mechanisms behind this possible association (e.g. anesthetics doses, age at exposure, exposure duration). En ligne : https://doi.org/10.1111/jcpp.12885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.966-972[article] The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins [Texte imprimé et/ou numérique] / Albert CASTELLHEIM, Auteur ; Sebastian LUNDSTROM, Auteur ; Mattias MOLIN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur . - p.966-972.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.966-972
Mots-clés : Neurodevelopmental disorders ADHD general anesthesia congenital abnormalities system diseases Index. décimale : PER Périodiques Résumé : Background The role of general anesthetics as a risk factor for possible neurodevelopmental disorders (NDDs) in humans is unresolved. The investigation of the role of anesthetics in the development of postgeneral anesthesia (anesthesia onward) NDDs has proven to be complicated, partly because of the inherent confounding in clinical cohort studies, and partly by the fact that anesthetics are only one part in the complex process of anesthesia-surgery. Methods Utilizing the Swedish databases Child and Adolescent Twins Study in Sweden (CATSS) and National Patient Register (NPR), we investigated twins discordant for anesthesia, born between 1997 and 2004 for traits of NDDs. We identified 68 twin pairs discordant for anesthesia and explored traits of Attention-Deficit/Hyperactivity Disorder (ADHD), Learning Disability (LD), and Autism Spectrum Disorder (ASD) in them while simultaneously taking congenital abnormalities and systemic disorders (CSDs) into account. We analyzed the possible effect of anesthesia on neurodevelopmental problems, and we analyzed the within-pair differences using conditional linear regression. Results Twins with a recorded episode of anesthesia had higher traits of NDDs than twins without; similarly twins with CSDs had higher mean scores on all traits than twins without CSDs. The within-pair analyses suggested that exposure to anesthesia was associated with higher scores of ADHD (regression coefficient 1.02 and 95% confidence intervals: 0.27?1.78) in monozygotic (MZ) twins discordant for anesthesia. This effect remained when adjusting for congenital abnormalities. Discussion Our finding that traits of ADHD were slightly associated with anesthesia in a genetically sensitive design is in need of replication and warrants further investigation. Future studies should aim to elucidate mechanisms behind this possible association (e.g. anesthetics doses, age at exposure, exposure duration). En ligne : https://doi.org/10.1111/jcpp.12885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 The Swedish Version of the Diagnostic Interview for Social and Communication Disorders (DISCO-10). Psychometric Properties / Gudrun NYGREN in Journal of Autism and Developmental Disorders, 39-5 (May 2009)
[article]
Titre : The Swedish Version of the Diagnostic Interview for Social and Communication Disorders (DISCO-10). Psychometric Properties Type de document : Texte imprimé et/ou numérique Auteurs : Gudrun NYGREN, Auteur ; Eva BILLSTEDT, Auteur ; Christopher GILLBERG, Auteur ; Bibbi HAGBERG, Auteur ; Åsa SKOGLUND, Auteur ; Maria JOHANSSON, Auteur Année de publication : 2009 Article en page(s) : p.730-741 Langues : Anglais (eng) Mots-clés : Autism-Spectrum-Conditions DISCO-10 ADI-R Reliability Validity Index. décimale : PER Périodiques Résumé : Psychometric properties of the Diagnostic Interview for Social and Communication Disorders schedule (DISCO) have only been studied in the UK. The authorised Swedish translation of the tenth version of the DISCO (DISCO-10) was used in interviews with close relatives of 91 Swedish patients referred for neuropsychiatrical assessment. Validity analysis compared DISCO-10-algorithm diagnoses with clinical diagnoses and with Autism Diagnostic Interview Revised (ADI-R) algorithm diagnoses in 57 cases. Good-excellent inter-rater reliability was demonstrated in 40 cases of children and adults. The criterion validity was excellent when compared with clinical diagnoses and an investigator-based diagnostic interview. The DISCO-10 has good psychometric properties. Advantages over the ADI-R include valuable information of the broader autism phenotype and co-existing problems for clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-008-0678-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.730-741[article] The Swedish Version of the Diagnostic Interview for Social and Communication Disorders (DISCO-10). Psychometric Properties [Texte imprimé et/ou numérique] / Gudrun NYGREN, Auteur ; Eva BILLSTEDT, Auteur ; Christopher GILLBERG, Auteur ; Bibbi HAGBERG, Auteur ; Åsa SKOGLUND, Auteur ; Maria JOHANSSON, Auteur . - 2009 . - p.730-741.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.730-741
Mots-clés : Autism-Spectrum-Conditions DISCO-10 ADI-R Reliability Validity Index. décimale : PER Périodiques Résumé : Psychometric properties of the Diagnostic Interview for Social and Communication Disorders schedule (DISCO) have only been studied in the UK. The authorised Swedish translation of the tenth version of the DISCO (DISCO-10) was used in interviews with close relatives of 91 Swedish patients referred for neuropsychiatrical assessment. Validity analysis compared DISCO-10-algorithm diagnoses with clinical diagnoses and with Autism Diagnostic Interview Revised (ADI-R) algorithm diagnoses in 57 cases. Good-excellent inter-rater reliability was demonstrated in 40 cases of children and adults. The criterion validity was excellent when compared with clinical diagnoses and an investigator-based diagnostic interview. The DISCO-10 has good psychometric properties. Advantages over the ADI-R include valuable information of the broader autism phenotype and co-existing problems for clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-008-0678-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732 The Syndromes Described by Kanner and Rett-Hagberg: Overlap in an Extended Family / Christopher GILLBERG in Developmental Medicine & Child Neurology, 32-3 (March 1990)
[article]
Titre : The Syndromes Described by Kanner and Rett-Hagberg: Overlap in an Extended Family Type de document : Texte imprimé et/ou numérique Auteurs : Christopher GILLBERG, Auteur ; Stephan EHLERS, Auteur ; Jan WAHLSTROM, Auteur Année de publication : 1990 Article en page(s) : p.258-261 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Les syndromes décrits par Kanner et Rett-Hagberg: chevauchement dans une même famille étendue
L'article rapporte le cas d'une famile étendue dans laquelle un syndrome de Rett-Hagberg, un autisme avec ataxie modérée et un autisme avec arriération mentale sévère s'observaient séparément chez trois filles cousines au deuxième degré. Les auteurs suggèrent des explications alternatives pour l'association possible entre un autisme et un syndrome de Rett-Hagberg: qu'ils soient reliés étroitement à un défaut génétique ou qu'ils constituent des phénotypes relativement homogènes avec plusieurs étiologies possibles.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=133
in Developmental Medicine & Child Neurology > 32-3 (March 1990) . - p.258-261[article] The Syndromes Described by Kanner and Rett-Hagberg: Overlap in an Extended Family [Texte imprimé et/ou numérique] / Christopher GILLBERG, Auteur ; Stephan EHLERS, Auteur ; Jan WAHLSTROM, Auteur . - 1990 . - p.258-261.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 32-3 (March 1990) . - p.258-261
Index. décimale : PER Périodiques Résumé : Les syndromes décrits par Kanner et Rett-Hagberg: chevauchement dans une même famille étendue
L'article rapporte le cas d'une famile étendue dans laquelle un syndrome de Rett-Hagberg, un autisme avec ataxie modérée et un autisme avec arriération mentale sévère s'observaient séparément chez trois filles cousines au deuxième degré. Les auteurs suggèrent des explications alternatives pour l'association possible entre un autisme et un syndrome de Rett-Hagberg: qu'ils soient reliés étroitement à un défaut génétique ou qu'ils constituent des phénotypes relativement homogènes avec plusieurs étiologies possibles.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=133 Three-year follow-up at age 10 of children with minor neurodevelopmental disorders. II: School achievement problems / I. Carina GILLBERG in Developmental Medicine & Child Neurology, 25-5 (October 1983)
[article]
Titre : Three-year follow-up at age 10 of children with minor neurodevelopmental disorders. II: School achievement problems Type de document : Texte imprimé et/ou numérique Auteurs : I. Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur ; Peder RASMUSSEN, Auteur Année de publication : 1983 Article en page(s) : p.566-573 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Part I of this paper considered the behavioural problems at age 10 of groups of children from a total population study of six-year-old children in Gothenburg and diagnosed according to strict criteria as suffering from minimal brain dysfunction (MBD), motor perception dysfunction (MPD) or attention deficit disorder (ADD), and a comparison group of normal children. Part II considers school achievement problems at age 10 among the same groups of children. 80 per cent of MBD children had obvious problems in school achievement, compared with 16 per cent in the comparison group. The MPD and ADD groups did not differ significantly from the comparison group in this respect. There was a considerable overlap between behaviour problems and school achievement problems, and the results indicate a gloomy prognosis for both types of problem among children with MBD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568
in Developmental Medicine & Child Neurology > 25-5 (October 1983) . - p.566-573[article] Three-year follow-up at age 10 of children with minor neurodevelopmental disorders. II: School achievement problems [Texte imprimé et/ou numérique] / I. Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur ; Peder RASMUSSEN, Auteur . - 1983 . - p.566-573.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 25-5 (October 1983) . - p.566-573
Index. décimale : PER Périodiques Résumé : Part I of this paper considered the behavioural problems at age 10 of groups of children from a total population study of six-year-old children in Gothenburg and diagnosed according to strict criteria as suffering from minimal brain dysfunction (MBD), motor perception dysfunction (MPD) or attention deficit disorder (ADD), and a comparison group of normal children. Part II considers school achievement problems at age 10 among the same groups of children. 80 per cent of MBD children had obvious problems in school achievement, compared with 16 per cent in the comparison group. The MPD and ADD groups did not differ significantly from the comparison group in this respect. There was a considerable overlap between behaviour problems and school achievement problems, and the results indicate a gloomy prognosis for both types of problem among children with MBD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)
[article]
Titre : Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies Type de document : Texte imprimé et/ou numérique Auteurs : Sebastian LUNDSTROM, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur ; Christina M. HULTMAN, Auteur ; Eva CARLSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonathan MILL, Auteur ; Angelica RONALD, Auteur ; Robert PLOMIN, Auteur ; Maria RASTAM, Auteur ; Paul LICHTENSTEIN, Auteur ; Claire Margaret Alison HAWORTH, Auteur Année de publication : 2010 Article en page(s) : p.850-856 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorders paternal-age autistic-traits behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Despite extensive efforts, the causes of autism remain unknown. Advancing paternal age has been associated with various neurodevelopmental disorders. We aim to investigate three unresolved questions: (a) What is the association between paternal age and autism spectrum disorders (ASD)?; (b) Does paternal age moderate the genetic and environmental etiological factors for ASD? (c) Does paternal age affect normal variation in autistic-like traits?
Methods: Two nationally representative twin studies from Sweden (n = 11, 122, assessed at age 9 or 12) and the UK (n = 13, 524, assessed at age 9) were used. Categorical and continuous measures of ASD, autistic-like traits and autistic similarity were calculated and compared over paternal age categories.
Results: Both cohorts showed a strong association between paternal age and the risk for ASD. A U-shaped risk association could be discerned since the offspring of both the youngest and oldest fathers showed an elevation in the risk for ASD. Autistic similarity increased with advancing paternal age in both monozygotic and dizygotic twins. Both cohorts showed significantly higher autistic-like traits in the offspring of the youngest and oldest fathers.
Conclusions: Phenomena associated with paternal age are clearly involved in the trajectories leading to autistic-like traits and ASD. Mechanisms influencing the trajectories might differ between older and younger fathers. Molecular genetic studies are now needed in order to further understand the association between paternal age and ASD, as well as normal variation in social, language, and repetitive behaviors in the general population.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02223.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102
in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.850-856[article] Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies [Texte imprimé et/ou numérique] / Sebastian LUNDSTROM, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur ; Christina M. HULTMAN, Auteur ; Eva CARLSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonathan MILL, Auteur ; Angelica RONALD, Auteur ; Robert PLOMIN, Auteur ; Maria RASTAM, Auteur ; Paul LICHTENSTEIN, Auteur ; Claire Margaret Alison HAWORTH, Auteur . - 2010 . - p.850-856.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.850-856
Mots-clés : Autism-spectrum-disorders paternal-age autistic-traits behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Despite extensive efforts, the causes of autism remain unknown. Advancing paternal age has been associated with various neurodevelopmental disorders. We aim to investigate three unresolved questions: (a) What is the association between paternal age and autism spectrum disorders (ASD)?; (b) Does paternal age moderate the genetic and environmental etiological factors for ASD? (c) Does paternal age affect normal variation in autistic-like traits?
Methods: Two nationally representative twin studies from Sweden (n = 11, 122, assessed at age 9 or 12) and the UK (n = 13, 524, assessed at age 9) were used. Categorical and continuous measures of ASD, autistic-like traits and autistic similarity were calculated and compared over paternal age categories.
Results: Both cohorts showed a strong association between paternal age and the risk for ASD. A U-shaped risk association could be discerned since the offspring of both the youngest and oldest fathers showed an elevation in the risk for ASD. Autistic similarity increased with advancing paternal age in both monozygotic and dizygotic twins. Both cohorts showed significantly higher autistic-like traits in the offspring of the youngest and oldest fathers.
Conclusions: Phenomena associated with paternal age are clearly involved in the trajectories leading to autistic-like traits and ASD. Mechanisms influencing the trajectories might differ between older and younger fathers. Molecular genetic studies are now needed in order to further understand the association between paternal age and ASD, as well as normal variation in social, language, and repetitive behaviors in the general population.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02223.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 Validation of the Autism Spectrum Screening Questionnaire in a Total Population Sample / Maj-Britt POSSERUD in Journal of Autism and Developmental Disorders, 39-1 (January 2009)
PermalinkVisualization and Analysis of Eye Movement Data from Children with Typical and Atypical Development / Terje FALCK-YTTER in Journal of Autism and Developmental Disorders, 43-10 (October 2013)
PermalinkVitamin D in the General Population of Young Adults with Autism in the Faroe Islands / Eva KOCOVSKA in Journal of Autism and Developmental Disorders, 44-12 (December 2014)
PermalinkWhy Autism Must be Taken Apart / Lynn WATERHOUSE in Journal of Autism and Developmental Disorders, 44-7 (July 2014)
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