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Détail de l'auteur
Auteur Susan L. CONNORS |
Documents disponibles écrits par cet auteur (2)
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Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress / Patrick M. HECHT in Autism Research, 9-11 (November 2016)
[article]
Titre : Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress Type de document : Texte imprimé et/ou numérique Auteurs : Patrick M. HECHT, Auteur ; Melissa HUDSON, Auteur ; Susan L. CONNORS, Auteur ; Michael R. TILLEY, Auteur ; Xudong LIU, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.1151-1160 Langues : Anglais (eng) Mots-clés : autism spectrum disorders serotonin stress prenatal stress development environmental influences Index. décimale : PER Périodiques Résumé : Stress exposure during gestation is implicated in several neuropsychiatric conditions, including autism spectrum disorder (ASD). Previous research showed that prenatal stress increases risk for ASD with peak exposure during the end of the second and the beginning of the third trimester. However, exposures to prenatal stress do not always result in ASD, suggesting that other factors may interact with environmental stressors to increase ASD risk. The present study examined a maternal genetic variation in the promoter region of the serotonin transporter gene (5-HTTLPR) affecting stress tolerance and its interaction with the effect of environmental stressors on risk for ASD. Two independent cohorts of mothers of ASD children recruited by the University of Missouri and Queen's University were surveyed regarding the prenatal environment and genotyping on 5-HTTLPR was performed to explore this relationship. In both samples, mothers of children with ASD carrying the stress susceptible short allele variant of 5-HTTLPR experienced a greater number of stressors and greater stress severity when compared to mothers carrying the long allele variant. The temporal peak of stressors during gestation in these mothers was consistent with previous findings. Additionally, increased exposure to prenatal stress was not reported in the pregnancies of typically developing siblings from the same mothers, regardless of maternal genotype, suggesting against the possibility that the short allele might increase the recall of stress during pregnancy. The present study provides further evidence of a specific maternal polymorphism that may affect the risk for ASD with exposure to prenatal stress. En ligne : http://dx.doi.org/10.1002/aur.1629 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Autism Research > 9-11 (November 2016) . - p.1151-1160[article] Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress [Texte imprimé et/ou numérique] / Patrick M. HECHT, Auteur ; Melissa HUDSON, Auteur ; Susan L. CONNORS, Auteur ; Michael R. TILLEY, Auteur ; Xudong LIU, Auteur ; David Q. BEVERSDORF, Auteur . - p.1151-1160.
Langues : Anglais (eng)
in Autism Research > 9-11 (November 2016) . - p.1151-1160
Mots-clés : autism spectrum disorders serotonin stress prenatal stress development environmental influences Index. décimale : PER Périodiques Résumé : Stress exposure during gestation is implicated in several neuropsychiatric conditions, including autism spectrum disorder (ASD). Previous research showed that prenatal stress increases risk for ASD with peak exposure during the end of the second and the beginning of the third trimester. However, exposures to prenatal stress do not always result in ASD, suggesting that other factors may interact with environmental stressors to increase ASD risk. The present study examined a maternal genetic variation in the promoter region of the serotonin transporter gene (5-HTTLPR) affecting stress tolerance and its interaction with the effect of environmental stressors on risk for ASD. Two independent cohorts of mothers of ASD children recruited by the University of Missouri and Queen's University were surveyed regarding the prenatal environment and genotyping on 5-HTTLPR was performed to explore this relationship. In both samples, mothers of children with ASD carrying the stress susceptible short allele variant of 5-HTTLPR experienced a greater number of stressors and greater stress severity when compared to mothers carrying the long allele variant. The temporal peak of stressors during gestation in these mothers was consistent with previous findings. Additionally, increased exposure to prenatal stress was not reported in the pregnancies of typically developing siblings from the same mothers, regardless of maternal genotype, suggesting against the possibility that the short allele might increase the recall of stress during pregnancy. The present study provides further evidence of a specific maternal polymorphism that may affect the risk for ASD with exposure to prenatal stress. En ligne : http://dx.doi.org/10.1002/aur.1629 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Prenatal β2-Adrenergic Receptor Signaling and Autism : Dysmaturation and Retained Fetal Function / Susan L. CONNORS
Titre : Prenatal β2-Adrenergic Receptor Signaling and Autism : Dysmaturation and Retained Fetal Function Type de document : Texte imprimé et/ou numérique Auteurs : Susan L. CONNORS, Auteur Année de publication : 2008 Importance : p.147-182 Langues : Anglais (eng) Mots-clés : Récepteur adrénergique prenatalité Foetal Polymorphie Adénylate cyclase cAMP Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=704 Prenatal β2-Adrenergic Receptor Signaling and Autism : Dysmaturation and Retained Fetal Function [Texte imprimé et/ou numérique] / Susan L. CONNORS, Auteur . - 2008 . - p.147-182.
Langues : Anglais (eng)
Mots-clés : Récepteur adrénergique prenatalité Foetal Polymorphie Adénylate cyclase cAMP Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=704 Exemplaires
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