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Détail de l'auteur
Auteur Luke HEUER |
Documents disponibles écrits par cet auteur (3)
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Immune Abnormalities and Autism Spectrum Disorders / Majannie ELOI AKINTUDE
Titre : Immune Abnormalities and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Majannie ELOI AKINTUDE, Auteur ; Luke HEUER, Auteur ; Judy VAN DE WATER, Auteur Année de publication : 2013 Importance : p.233-248 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : This chapter explores the link between autism spectrum disorders and the immune system. It begins with a discussion of basic immunology for each topic, integrated with a comprehensive review of the most recent studies describing dysfunction of the immune system in the context of autism. Although many of these observations are still under investigation with respect to their mechanistic relevance to autism, they remain valuable as biologic markers in the quest for understanding the etiology and pathology of this complex disorder Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Immune Abnormalities and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Majannie ELOI AKINTUDE, Auteur ; Luke HEUER, Auteur ; Judy VAN DE WATER, Auteur . - 2013 . - p.233-248.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : This chapter explores the link between autism spectrum disorders and the immune system. It begins with a discussion of basic immunology for each topic, integrated with a comprehensive review of the most recent studies describing dysfunction of the immune system in the context of autism. Although many of these observations are still under investigation with respect to their mechanistic relevance to autism, they remain valuable as biologic markers in the quest for understanding the etiology and pathology of this complex disorder Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms / Luke HEUER in Autism Research, 1-5 (October 2008)
[article]
Titre : Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Luke HEUER, Auteur ; David J. HANSEN, Auteur ; Joseph SCHAUER, Auteur ; Paula GOINES, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; Paula KRAKOWIAK, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2008 Article en page(s) : p.275-283 Langues : Anglais (eng) Mots-clés : Autism immunoglobulin behavior IgG Index. décimale : PER Périodiques Résumé : Objectives: To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms.
Methods: Plasma was collected from children with autistic disorder (AU; n=116), DD but not autism (n=32), autism spectrum disorder but not full autism (n=27), and age-matched typically developing (TD) controls (n=96). Samples were assayed for systemic levels of immunoglobulin (IgG, IgM, IgA, and IgE) by enzyme-linked immunosorbent assay. Subjects with autism were evaluated using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview - Revised, and all subjects were scored on the Aberrant Behavior Checklist (ABC) by the parents. Numerical scores for each of the ABC subscales as well as the total scores were then correlated with Ig levels.
Results: Children with AU have a significantly reduced level of plasma IgG (5.39±0.29 mg/mL) compared to the TD (7.72±0.28 mg/mL; P<0.001) and DD children (8.23±0.49 mg/mL; P<0.001). Children with autism also had a reduced level of plasma IgM (0.670.06mg/mL) compared to TD (0.79±0.05 mg/mL; P<0.05). Ig levels were negatively correlated with ABC scores for all children (IgG: r=-0.334, P<0.0001; IgM: r=-0.167, P=0.0285).
Conclusion: Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM.En ligne : http://dx.doi.org/10.1002/aur.42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.275-283[article] Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms [Texte imprimé et/ou numérique] / Luke HEUER, Auteur ; David J. HANSEN, Auteur ; Joseph SCHAUER, Auteur ; Paula GOINES, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; Paula KRAKOWIAK, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lisa A. CROEN, Auteur . - 2008 . - p.275-283.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.275-283
Mots-clés : Autism immunoglobulin behavior IgG Index. décimale : PER Périodiques Résumé : Objectives: To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms.
Methods: Plasma was collected from children with autistic disorder (AU; n=116), DD but not autism (n=32), autism spectrum disorder but not full autism (n=27), and age-matched typically developing (TD) controls (n=96). Samples were assayed for systemic levels of immunoglobulin (IgG, IgM, IgA, and IgE) by enzyme-linked immunosorbent assay. Subjects with autism were evaluated using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview - Revised, and all subjects were scored on the Aberrant Behavior Checklist (ABC) by the parents. Numerical scores for each of the ABC subscales as well as the total scores were then correlated with Ig levels.
Results: Children with AU have a significantly reduced level of plasma IgG (5.39±0.29 mg/mL) compared to the TD (7.72±0.28 mg/mL; P<0.001) and DD children (8.23±0.49 mg/mL; P<0.001). Children with autism also had a reduced level of plasma IgM (0.670.06mg/mL) compared to TD (0.79±0.05 mg/mL; P<0.05). Ig levels were negatively correlated with ABC scores for all children (IgG: r=-0.334, P<0.0001; IgM: r=-0.167, P=0.0285).
Conclusion: Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM.En ligne : http://dx.doi.org/10.1002/aur.42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 The Immune System in Autism : Is There a Connection? / Luke HEUER
Titre : The Immune System in Autism : Is There a Connection? Type de document : Texte imprimé et/ou numérique Auteurs : Luke HEUER, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur Année de publication : 2008 Importance : p.271-288 Langues : Anglais (eng) Mots-clés : Immunologie Maternité Foetus Auto-anticorps Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=704 The Immune System in Autism : Is There a Connection? [Texte imprimé et/ou numérique] / Luke HEUER, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur . - 2008 . - p.271-288.
Langues : Anglais (eng)
Mots-clés : Immunologie Maternité Foetus Auto-anticorps Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=704 Exemplaires
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