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Autism Research . 4-2Paru le : 01/04/2011 |
[n° ou bulletin]
[n° ou bulletin]
4-2 - April 2011 [Texte imprimé et/ou numérique] . - 2011.
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Dépouillements
Ajouter le résultat dans votre panierA genotype resource for postmortem brain samples from the Autism Tissue Program / Richard F. WINTLE in Autism Research, 4-2 (April 2011)
[article]
Titre : A genotype resource for postmortem brain samples from the Autism Tissue Program Type de document : Texte imprimé et/ou numérique Auteurs : Richard F. WINTLE, Auteur ; Anath C. LIONEL, Auteur ; Pingzhao HU, Auteur ; Stephen D. GINSBERG, Auteur ; Dalila PINTO, Auteur ; Bhooma THIRUVAHINDRAPDURAM, Auteur ; John WEI, Auteur ; Christian R. MARSHALL, Auteur ; Jane PICKETT, Auteur ; Edwin H. Jr COOK, Auteur ; Stephen SCHERER, Auteur Année de publication : 2011 Article en page(s) : p.89-97 Langues : Anglais (eng) Mots-clés : autism autism spectrum disorder brain brodmann area 19 copy number variation genome-wide microarray single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : The Autism Tissue Program (ATP), a science program of Autism Speaks, provides researchers with access to well-characterized postmortem brain tissues. Researchers access these tissues through a peer-reviewed, project-based approval process, and obtain related clinical information from a secure, online informatics portal. However, few of these samples have DNA banked from other sources (such as a blood sample from the same individual), hindering genotype–phenotype correlation and interpretation of gene expression data derived from the banked brain tissue. Here, we describe an initiative to extract DNA from Brodmann Area 19, and genotype these samples using both the Affymetrix Genome-Wide Human SNP Array 6.0 and the Illumina Human1M-Duo DNA Analysis BeadChip genome-wide microarray technologies. We additionally verify reported gender, and infer ethnic background from the single nucleotide polymorphism data. We have also used a rigorous, multiple algorithm approach to identify genomic copy number variation (CNV) from these array data. Following an initial proof of principle study using two samples, 52 experimental samples, consisting of 27 subjects with confirmed or suspected autism and related disorders, 5 subjects with cytogenetically visible duplications of 15q, 2 with epilepsy and 18 age-matched normal controls were processed, yielding high-quality genotype data in all cases. The genotype and CNV data are provided via the ATP informatics portal as a resource for the autism research community. En ligne : http://dx.doi.org/10.1002/aur.173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.89-97[article] A genotype resource for postmortem brain samples from the Autism Tissue Program [Texte imprimé et/ou numérique] / Richard F. WINTLE, Auteur ; Anath C. LIONEL, Auteur ; Pingzhao HU, Auteur ; Stephen D. GINSBERG, Auteur ; Dalila PINTO, Auteur ; Bhooma THIRUVAHINDRAPDURAM, Auteur ; John WEI, Auteur ; Christian R. MARSHALL, Auteur ; Jane PICKETT, Auteur ; Edwin H. Jr COOK, Auteur ; Stephen SCHERER, Auteur . - 2011 . - p.89-97.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.89-97
Mots-clés : autism autism spectrum disorder brain brodmann area 19 copy number variation genome-wide microarray single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : The Autism Tissue Program (ATP), a science program of Autism Speaks, provides researchers with access to well-characterized postmortem brain tissues. Researchers access these tissues through a peer-reviewed, project-based approval process, and obtain related clinical information from a secure, online informatics portal. However, few of these samples have DNA banked from other sources (such as a blood sample from the same individual), hindering genotype–phenotype correlation and interpretation of gene expression data derived from the banked brain tissue. Here, we describe an initiative to extract DNA from Brodmann Area 19, and genotype these samples using both the Affymetrix Genome-Wide Human SNP Array 6.0 and the Illumina Human1M-Duo DNA Analysis BeadChip genome-wide microarray technologies. We additionally verify reported gender, and infer ethnic background from the single nucleotide polymorphism data. We have also used a rigorous, multiple algorithm approach to identify genomic copy number variation (CNV) from these array data. Following an initial proof of principle study using two samples, 52 experimental samples, consisting of 27 subjects with confirmed or suspected autism and related disorders, 5 subjects with cytogenetically visible duplications of 15q, 2 with epilepsy and 18 age-matched normal controls were processed, yielding high-quality genotype data in all cases. The genotype and CNV data are provided via the ATP informatics portal as a resource for the autism research community. En ligne : http://dx.doi.org/10.1002/aur.173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication / Karen J. MATHEWSON in Autism Research, 4-2 (April 2011)
[article]
Titre : Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication Type de document : Texte imprimé et/ou numérique Auteurs : Karen J. MATHEWSON, Auteur ; Irene E. DRMIC, Auteur ; Michelle K. JETHA, Auteur ; Susan E. BRYSON, Auteur ; Joel O. GOLDBERG, Auteur ; Geoffrey B. C. HALL, Auteur ; Diane L. SANTESSO, Auteur ; Sidney SEGALOWITZ, Auteur ; Louis A. SCHMIDT, Auteur Année de publication : 2011 Article en page(s) : p.98-108 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASD) heart period respiratory sinus arrhythmia (RSA) Stroop task Index. décimale : PER Périodiques Résumé : Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. En ligne : http://dx.doi.org/10.1002/aur.176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.98-108[article] Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication [Texte imprimé et/ou numérique] / Karen J. MATHEWSON, Auteur ; Irene E. DRMIC, Auteur ; Michelle K. JETHA, Auteur ; Susan E. BRYSON, Auteur ; Joel O. GOLDBERG, Auteur ; Geoffrey B. C. HALL, Auteur ; Diane L. SANTESSO, Auteur ; Sidney SEGALOWITZ, Auteur ; Louis A. SCHMIDT, Auteur . - 2011 . - p.98-108.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.98-108
Mots-clés : autism spectrum disorders (ASD) heart period respiratory sinus arrhythmia (RSA) Stroop task Index. décimale : PER Périodiques Résumé : Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. En ligne : http://dx.doi.org/10.1002/aur.176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Probabilistic reinforcement learning in adults with autism spectrum disorders / Marjorie SOLOMON in Autism Research, 4-2 (April 2011)
[article]
Titre : Probabilistic reinforcement learning in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Marjorie SOLOMON, Auteur ; Anne C. SMITH, Auteur ; Michael J. FRANK, Auteur ; Stanford LY, Auteur ; Cameron S. CARTER, Auteur Année de publication : 2011 Article en page(s) : p.109-120 Langues : Anglais (eng) Mots-clés : autism spectrum disorders probabilistic reinforcement learning basal ganglia orbito-frontal cortex computational model Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) can be conceptualized as disorders of learning, however there have been few experimental studies taking this perspective. Methods: We examined the probabilistic reinforcement learning performance of 28 adults with ASDs and 30 typically developing adults on a task requiring learning relationships between three stimulus pairs consisting of Japanese characters with feedback that was valid with different probabilities (80%, 70%, and 60%). Both univariate and Bayesian state–space data analytic methods were employed. Hypotheses were based on the extant literature as well as on neurobiological and computational models of reinforcement learning. Results: Both groups learned the task after training. However, there were group differences in early learning in the first task block where individuals with ASDs acquired the most frequently accurately reinforced stimulus pair (80%) comparably to typically developing individuals; exhibited poorer acquisition of the less frequently reinforced 70% pair as assessed by state–space learning curves; and outperformed typically developing individuals on the near chance (60%) pair. Individuals with ASDs also demonstrated deficits in using positive feedback to exploit rewarded choices. Conclusions: Results support the contention that individuals with ASDs are slower learners. Based on neurobiology and on the results of computational modeling, one interpretation of this pattern of findings is that impairments are related to deficits in flexible updating of reinforcement history as mediated by the orbito-frontal cortex, with spared functioning of the basal ganglia. This hypothesis about the pathophysiology of learning in ASDs can be tested using functional magnetic resonance imaging. En ligne : http://dx.doi.org/10.1002/aur.177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.109-120[article] Probabilistic reinforcement learning in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Marjorie SOLOMON, Auteur ; Anne C. SMITH, Auteur ; Michael J. FRANK, Auteur ; Stanford LY, Auteur ; Cameron S. CARTER, Auteur . - 2011 . - p.109-120.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.109-120
Mots-clés : autism spectrum disorders probabilistic reinforcement learning basal ganglia orbito-frontal cortex computational model Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) can be conceptualized as disorders of learning, however there have been few experimental studies taking this perspective. Methods: We examined the probabilistic reinforcement learning performance of 28 adults with ASDs and 30 typically developing adults on a task requiring learning relationships between three stimulus pairs consisting of Japanese characters with feedback that was valid with different probabilities (80%, 70%, and 60%). Both univariate and Bayesian state–space data analytic methods were employed. Hypotheses were based on the extant literature as well as on neurobiological and computational models of reinforcement learning. Results: Both groups learned the task after training. However, there were group differences in early learning in the first task block where individuals with ASDs acquired the most frequently accurately reinforced stimulus pair (80%) comparably to typically developing individuals; exhibited poorer acquisition of the less frequently reinforced 70% pair as assessed by state–space learning curves; and outperformed typically developing individuals on the near chance (60%) pair. Individuals with ASDs also demonstrated deficits in using positive feedback to exploit rewarded choices. Conclusions: Results support the contention that individuals with ASDs are slower learners. Based on neurobiology and on the results of computational modeling, one interpretation of this pattern of findings is that impairments are related to deficits in flexible updating of reinforcement history as mediated by the orbito-frontal cortex, with spared functioning of the basal ganglia. This hypothesis about the pathophysiology of learning in ASDs can be tested using functional magnetic resonance imaging. En ligne : http://dx.doi.org/10.1002/aur.177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Toward specifying pervasive developmental disorder—not otherwise specified / William P.L. MANDY in Autism Research, 4-2 (April 2011)
[article]
Titre : Toward specifying pervasive developmental disorder—not otherwise specified Type de document : Texte imprimé et/ou numérique Auteurs : William P.L. MANDY, Auteur ; Tony CHARMAN, Auteur ; Jane GILMOUR, Auteur ; David H. SKUSE, Auteur Année de publication : 2011 Article en page(s) : p.121-131 Langues : Anglais (eng) Mots-clés : pervasive developmental disorder—not otherwise specified (PDD-NOS) Autistic disorder Asperger's disorder autism spectrum disorder diagnostic and statistical manual (DSM) Index. décimale : PER Périodiques Résumé : Pervasive developmental disorder—not otherwise specified (PDD-NOS) is the most common and least satisfactory of the PDD diagnoses. It is not formally operationalized, which limits its reliability and has hampered attempts to assess its validity. We aimed, first, to improve the reliability and replicability of PDD-NOS by operationalizing its DSM-IV-TR description and, second, to test its validity through comparison with autistic disorder (AD) and Asperger's disorder (AsD). In a sample of 256 young people (mean age = 9.1 years) we used Developmental, Diagnostic and Dimensional (3Di) algorithmic analysis to classify DSM-IV-TR AD (n = 97), AsD (n = 93) and PDD-NOS (n = 66). Groups were compared on independent measures of core PDD symptomatology, associated autistic features, and intelligence. Contrary to the assumption that PDD-NOS is heterogeneous, almost all (97%) of those with PDD-NOS had one distinct symptom pattern, namely impairments in social reciprocity and communication, without significant repetitive and stereotyped behaviors (RSB). Compared to AD and AsD, they had comparably severe but more circumscribed social communication difficulties, with fewer non-social features of autism, such as sensory, feeding and visuo-spatial problems. These individuals appear to have a distinct variant of autism that does not merely sit at the less severe end of the same continuum of symptoms. The current draft guidelines for DSM-V, which mandate the presence of RSBs for any PDD diagnosis, would exclude such people from the autistic spectrum. En ligne : http://dx.doi.org/10.1002/aur.178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.121-131[article] Toward specifying pervasive developmental disorder—not otherwise specified [Texte imprimé et/ou numérique] / William P.L. MANDY, Auteur ; Tony CHARMAN, Auteur ; Jane GILMOUR, Auteur ; David H. SKUSE, Auteur . - 2011 . - p.121-131.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.121-131
Mots-clés : pervasive developmental disorder—not otherwise specified (PDD-NOS) Autistic disorder Asperger's disorder autism spectrum disorder diagnostic and statistical manual (DSM) Index. décimale : PER Périodiques Résumé : Pervasive developmental disorder—not otherwise specified (PDD-NOS) is the most common and least satisfactory of the PDD diagnoses. It is not formally operationalized, which limits its reliability and has hampered attempts to assess its validity. We aimed, first, to improve the reliability and replicability of PDD-NOS by operationalizing its DSM-IV-TR description and, second, to test its validity through comparison with autistic disorder (AD) and Asperger's disorder (AsD). In a sample of 256 young people (mean age = 9.1 years) we used Developmental, Diagnostic and Dimensional (3Di) algorithmic analysis to classify DSM-IV-TR AD (n = 97), AsD (n = 93) and PDD-NOS (n = 66). Groups were compared on independent measures of core PDD symptomatology, associated autistic features, and intelligence. Contrary to the assumption that PDD-NOS is heterogeneous, almost all (97%) of those with PDD-NOS had one distinct symptom pattern, namely impairments in social reciprocity and communication, without significant repetitive and stereotyped behaviors (RSB). Compared to AD and AsD, they had comparably severe but more circumscribed social communication difficulties, with fewer non-social features of autism, such as sensory, feeding and visuo-spatial problems. These individuals appear to have a distinct variant of autism that does not merely sit at the less severe end of the same continuum of symptoms. The current draft guidelines for DSM-V, which mandate the presence of RSBs for any PDD diagnosis, would exclude such people from the autistic spectrum. En ligne : http://dx.doi.org/10.1002/aur.178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Deficits in adults with autism spectrum disorders when processing multiple objects in dynamic scenes / Kirsten O'HEARN in Autism Research, 4-2 (April 2011)
[article]
Titre : Deficits in adults with autism spectrum disorders when processing multiple objects in dynamic scenes Type de document : Texte imprimé et/ou numérique Auteurs : Kirsten O'HEARN, Auteur ; Laura LAKUSTA, Auteur ; Elizabeth SCHROER, Auteur ; Nancy J. MINSHEW, Auteur ; Beatriz LUNA, Auteur Année de publication : 2011 Article en page(s) : p.132-142 Langues : Anglais (eng) Mots-clés : ASD change detection development developmental disorder people perception social cognition Index. décimale : PER Périodiques Résumé : People with autism spectrum disorders (ASD) process visual information in a manner that is distinct from typically developing individuals. They may be less sensitive to people's goals and, more generally, focus on visual details instead of the entire scene. To examine these differences, people with and without ASD were asked to detect changes in dynamic scenes with multiple elements. Participants viewed a brief video of a person or an inanimate object (the “figure”) moving from one object to another; after a delay, they reported whether a second video was the same or different. Possible changes included the figure, the object the figure was moving from, or the object the figure was moving toward (the “goal”). We hypothesized that individuals with ASD would be less sensitive to changes in scenes with people, particularly elements that might be the person's goal. Alternately, people with ASD might attend to fewer elements regardless of whether the scene included a person. Our results indicate that, like controls, people with ASD noticed a change in the “goal” object at the end of a person's movement more often than the object at the start. However, the group with ASD did not undergo the developmental improvement that was evident typically when detecting changes in both the start and end objects. This atypical development led to deficits in adults with ASD that were not specific to scenes with people or to “goals.” Improvements in visual processing that underlie mature representation of scenes may not occur in ASD, suggesting that late developing brain processes are affected. En ligne : http://dx.doi.org/10.1002/aur.179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.132-142[article] Deficits in adults with autism spectrum disorders when processing multiple objects in dynamic scenes [Texte imprimé et/ou numérique] / Kirsten O'HEARN, Auteur ; Laura LAKUSTA, Auteur ; Elizabeth SCHROER, Auteur ; Nancy J. MINSHEW, Auteur ; Beatriz LUNA, Auteur . - 2011 . - p.132-142.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.132-142
Mots-clés : ASD change detection development developmental disorder people perception social cognition Index. décimale : PER Périodiques Résumé : People with autism spectrum disorders (ASD) process visual information in a manner that is distinct from typically developing individuals. They may be less sensitive to people's goals and, more generally, focus on visual details instead of the entire scene. To examine these differences, people with and without ASD were asked to detect changes in dynamic scenes with multiple elements. Participants viewed a brief video of a person or an inanimate object (the “figure”) moving from one object to another; after a delay, they reported whether a second video was the same or different. Possible changes included the figure, the object the figure was moving from, or the object the figure was moving toward (the “goal”). We hypothesized that individuals with ASD would be less sensitive to changes in scenes with people, particularly elements that might be the person's goal. Alternately, people with ASD might attend to fewer elements regardless of whether the scene included a person. Our results indicate that, like controls, people with ASD noticed a change in the “goal” object at the end of a person's movement more often than the object at the start. However, the group with ASD did not undergo the developmental improvement that was evident typically when detecting changes in both the start and end objects. This atypical development led to deficits in adults with ASD that were not specific to scenes with people or to “goals.” Improvements in visual processing that underlie mature representation of scenes may not occur in ASD, suggesting that late developing brain processes are affected. En ligne : http://dx.doi.org/10.1002/aur.179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Increased rates of depressed mood in mothers of children with ASD associated with the presence of the broader autism phenotype / Brooke R. INGERSOLL in Autism Research, 4-2 (April 2011)
[article]
Titre : Increased rates of depressed mood in mothers of children with ASD associated with the presence of the broader autism phenotype Type de document : Texte imprimé et/ou numérique Auteurs : Brooke R. INGERSOLL, Auteur ; Katherine MEYER, Auteur ; Mark W. BECKER, Auteur Année de publication : 2011 Article en page(s) : p.143-148 Langues : Anglais (eng) Mots-clés : broader autism phenotype depressed mood parenting stress Index. décimale : PER Périodiques Résumé : This study examined the relationship between the broader autism phenotype (BAP) and depressed mood in mothers of children with and without autism spectrum disorders (ASD). One hundred and sixty-five mothers (71 with an ASD child and 94 with a non-ASD child) completed a survey of child autism severity (ASD mothers only), parenting stress, BAP, and depression. Mothers of children with ASD reported greater depressed mood, higher parenting stress, and more characteristics associated with the BAP than mothers of children without ASD. For mothers of children with ASD, the BAP uniquely predicted number of depressive symptoms after controlling for child autism severity and parenting stress. In the full sample, the relationship between group status and depressed mood was no longer significant after controlling for parenting stress and maternal BAP. These findings suggest that the higher rate of depression found in mothers of children with ASD may be attributed both to the increased stress of raising a child with ASD, as well as a greater number of autistic features in the mothers that may place them at higher risk for developing depression. En ligne : http://dx.doi.org/10.1002/aur.170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.143-148[article] Increased rates of depressed mood in mothers of children with ASD associated with the presence of the broader autism phenotype [Texte imprimé et/ou numérique] / Brooke R. INGERSOLL, Auteur ; Katherine MEYER, Auteur ; Mark W. BECKER, Auteur . - 2011 . - p.143-148.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.143-148
Mots-clés : broader autism phenotype depressed mood parenting stress Index. décimale : PER Périodiques Résumé : This study examined the relationship between the broader autism phenotype (BAP) and depressed mood in mothers of children with and without autism spectrum disorders (ASD). One hundred and sixty-five mothers (71 with an ASD child and 94 with a non-ASD child) completed a survey of child autism severity (ASD mothers only), parenting stress, BAP, and depression. Mothers of children with ASD reported greater depressed mood, higher parenting stress, and more characteristics associated with the BAP than mothers of children without ASD. For mothers of children with ASD, the BAP uniquely predicted number of depressive symptoms after controlling for child autism severity and parenting stress. In the full sample, the relationship between group status and depressed mood was no longer significant after controlling for parenting stress and maternal BAP. These findings suggest that the higher rate of depression found in mothers of children with ASD may be attributed both to the increased stress of raising a child with ASD, as well as a greater number of autistic features in the mothers that may place them at higher risk for developing depression. En ligne : http://dx.doi.org/10.1002/aur.170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Developing the Frith-Happé animations: A quick and objective test of Theory of Mind for adults with autism / Sarah J. WHITE in Autism Research, 4-2 (April 2011)
[article]
Titre : Developing the Frith-Happé animations: A quick and objective test of Theory of Mind for adults with autism Type de document : Texte imprimé et/ou numérique Auteurs : Sarah J. WHITE, Auteur ; Devorah CONISTON, Auteur ; Rosannagh ROGERS, Auteur ; Uta FRITH, Auteur Année de publication : 2011 Article en page(s) : p.149-154 Langues : Anglais (eng) Mots-clés : autism Theory of Mind mentalizing triangle animations classification test sensitivity Index. décimale : PER Périodiques Résumé : It is now widely accepted that individuals with autism have a Theory of Mind (ToM) or mentalizing deficit. This has traditionally been assessed with false-belief tasks and, more recently, with silent geometric animations, an on-line ToM task. In adults with milder forms of autism standard false-belief tests, originally devised for children, often prove insensitive, while the Frith-Happé animations have had rather better success at capturing the on-line ToM deficit in this population. However, analysis of participants' verbal descriptions of these animations, which span scenarios from “Random” to “Goal-Directed” and “ToM,” is time consuming and subjective. In this study, we developed and established the feasibility of an objective method of response through a series of multiple-choice questions. Sixteen adults with autism and 15 typically developing adults took part, matched for age and intelligence. The adults with autism were less accurate as a group at categorizing the Frith-Happé animations by the presence or absence of mental and physical interactions. Furthermore, they were less able to select the correct emotions that are typically attributed to the triangles in the mental state animations. This new objective method for assessing the understanding of the animations succeeded in being as sensitive as the original subjective method in detecting the mentalizing difficulties in autism, as well as being quicker and easier to administer and analyze. En ligne : http://dx.doi.org/10.1002/aur.174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.149-154[article] Developing the Frith-Happé animations: A quick and objective test of Theory of Mind for adults with autism [Texte imprimé et/ou numérique] / Sarah J. WHITE, Auteur ; Devorah CONISTON, Auteur ; Rosannagh ROGERS, Auteur ; Uta FRITH, Auteur . - 2011 . - p.149-154.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.149-154
Mots-clés : autism Theory of Mind mentalizing triangle animations classification test sensitivity Index. décimale : PER Périodiques Résumé : It is now widely accepted that individuals with autism have a Theory of Mind (ToM) or mentalizing deficit. This has traditionally been assessed with false-belief tasks and, more recently, with silent geometric animations, an on-line ToM task. In adults with milder forms of autism standard false-belief tests, originally devised for children, often prove insensitive, while the Frith-Happé animations have had rather better success at capturing the on-line ToM deficit in this population. However, analysis of participants' verbal descriptions of these animations, which span scenarios from “Random” to “Goal-Directed” and “ToM,” is time consuming and subjective. In this study, we developed and established the feasibility of an objective method of response through a series of multiple-choice questions. Sixteen adults with autism and 15 typically developing adults took part, matched for age and intelligence. The adults with autism were less accurate as a group at categorizing the Frith-Happé animations by the presence or absence of mental and physical interactions. Furthermore, they were less able to select the correct emotions that are typically attributed to the triangles in the mental state animations. This new objective method for assessing the understanding of the animations succeeded in being as sensitive as the original subjective method in detecting the mentalizing difficulties in autism, as well as being quicker and easier to administer and analyze. En ligne : http://dx.doi.org/10.1002/aur.174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 De novo autosomal dominant mutation in SYNGAP1 / Edwin H. Jr COOK in Autism Research, 4-2 (April 2011)
[article]
Titre : De novo autosomal dominant mutation in SYNGAP1 Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2011 Article en page(s) : p.155-156 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.155-156[article] De novo autosomal dominant mutation in SYNGAP1 [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2011 . - p.155-156.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.155-156
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
[article]
Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2011 Article en page(s) : p.157-159 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.157-159[article] Lay abstracts [Texte imprimé et/ou numérique] . - 2011 . - p.157-159.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.157-159
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Erratum : White matter integrity in Asperger syndrome: A preliminary diffusion tensor magnetic resonance imaging study in adults / Oswald J.N. BLOEMEN in Autism Research, 4-2 (April 2011)
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Titre : Erratum : White matter integrity in Asperger syndrome: A preliminary diffusion tensor magnetic resonance imaging study in adults Type de document : Texte imprimé et/ou numérique Auteurs : Oswald J.N. BLOEMEN, Auteur ; Quinton DEELEY, Auteur ; Fred SUNDRAM, Auteur ; Eileen DALY, Auteur ; Gareth J. BARKER, Auteur ; Derek K. JONES, Auteur ; Therese A.M.J. VAN AMELSVOORT, Auteur ; Nicole SCHMITZ, Auteur ; Dene ROBERTSON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur Année de publication : 2011 Article en page(s) : p.160 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.160[article] Erratum : White matter integrity in Asperger syndrome: A preliminary diffusion tensor magnetic resonance imaging study in adults [Texte imprimé et/ou numérique] / Oswald J.N. BLOEMEN, Auteur ; Quinton DEELEY, Auteur ; Fred SUNDRAM, Auteur ; Eileen DALY, Auteur ; Gareth J. BARKER, Auteur ; Derek K. JONES, Auteur ; Therese A.M.J. VAN AMELSVOORT, Auteur ; Nicole SCHMITZ, Auteur ; Dene ROBERTSON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur . - 2011 . - p.160.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.160
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
[article]
Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2011 Article en page(s) : p.161 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.161[article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2011 . - p.161.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.161
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
[article]
Titre : The International Meeting for Autism Research Type de document : Texte imprimé et/ou numérique Année de publication : 2011 Article en page(s) : p.162 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.162[article] The International Meeting for Autism Research [Texte imprimé et/ou numérique] . - 2011 . - p.162.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.162
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121