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The implications of genotype–environment correlation for establishing causal processes in psychopathology / Sara R. JAFFEE in Development and Psychopathology, 24-4 (November 2012)
[article]
Titre : The implications of genotype–environment correlation for establishing causal processes in psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Sara R. JAFFEE, Auteur Année de publication : 2012 Article en page(s) : p.1253-1264 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The significance of genotype–environment interplay is its focus on how causal factors, whether environmental or genetic, have their effects. It is difficult to establish causality in observational research because of the potential for reverse causation and confounding. Most environmental measures are heritable, which means that their effects on the risk for psychopathology are potentially confounded by genotype. In contrast, genetic influences on psychopathology may be mediated by their effect on environmental exposures. The existence of genetic influences on putative environmental risk factors offers both possibilities and pitfalls for research into environmental epidemiology. We use the example of parenting and its influence on childhood externalizing problems to review how genotype–environment correlations can be exploited to demonstrate causal processes in pyschopathology. En ligne : http://dx.doi.org/10.1017/S0954579412000685 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Development and Psychopathology > 24-4 (November 2012) . - p.1253-1264[article] The implications of genotype–environment correlation for establishing causal processes in psychopathology [Texte imprimé et/ou numérique] / Sara R. JAFFEE, Auteur . - 2012 . - p.1253-1264.
Langues : Anglais (eng)
in Development and Psychopathology > 24-4 (November 2012) . - p.1253-1264
Index. décimale : PER Périodiques Résumé : The significance of genotype–environment interplay is its focus on how causal factors, whether environmental or genetic, have their effects. It is difficult to establish causality in observational research because of the potential for reverse causation and confounding. Most environmental measures are heritable, which means that their effects on the risk for psychopathology are potentially confounded by genotype. In contrast, genetic influences on psychopathology may be mediated by their effect on environmental exposures. The existence of genetic influences on putative environmental risk factors offers both possibilities and pitfalls for research into environmental epidemiology. We use the example of parenting and its influence on childhood externalizing problems to review how genotype–environment correlations can be exploited to demonstrate causal processes in pyschopathology. En ligne : http://dx.doi.org/10.1017/S0954579412000685 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 The Imprinted Brain / Christopher BADCOCK
Titre : The Imprinted Brain : How Genes Set the Balance Between Autism and Psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Christopher BADCOCK, Auteur Année de publication : 2009 Importance : 240 p. Format : 23,4cm x 15,6cm 2cm ISBN/ISSN/EAN : 978-1-84905-023-4 Note générale : Bibliogr., Index Langues : Anglais (eng) Index. décimale : SCI-B SCI-B - Génétique Résumé : The Imprinted Brain sets out a radical new theory of the mind and mental illness based on the recent discovery of genomic imprinting. Imprinted genes are those from one parent that, in that parent's interest, are expressed in an offspring rather than the diametrically opposed genes from the other parent. For example, a higher birth weight may represent the dominance of the father's genes in leading to a healthy child, whereas a lower birth weight is beneficial to the mother's immediate wellbeing, and the imprint of the mother's genes will result in a smaller baby. According to this view, a win for the father's genes may result in autism, whereas one for the mother's may result in psychosis. A state of equilibrium - normality - is the most likely outcome, with a no-win situation of balanced expression. Imprinted genes typically produce symptoms that are opposites of each other, and the author uses psychiatric case material to show how many of the symptoms of psychosis can be shown to be the mental mirror-images of those of autism.
Combining psychiatry with insights from modern genetics and cognitive science, Christopher Badcock explains the fascinating imprinted brain theory to the reader in a thorough but accessible way. This new theory casts some intriguing new light on other topics as diverse as the nature of genius, the appeal of detective fiction, and the successes - and failures - of psychoanalysis.
This thought-provoking book is a must-read for anyone with an interest in autism, psychiatry, cognitive science or psychology in general.
"The Imprinted Brain is a true tour de force, surveying the cutting-edge research in genomics and neuroscience and providing a fresh view on what it means to be male or female, "things people" or "people people," autistic or schizophrenic. You will never look at your parents the same way again!"
- Satoshi Kanazawa, The Scientific Fundamentalist and co-author of Why Beautiful People Have More Daughters
'Deeply scholarly yet absorbing narrative, The Imprinted Brain will change the way we view the human brain and its functions, evolution, and disordering in mental illness. Badcock has drawn evolutionary biology together with genetics, psychology, psychiatry, and neuroscience to demonstrate, for the first time, how genomic conflicts play a central role in how the human brain works, and how the brain becomes dysregulated in social-brain disorders including autism and schizophrenia.'
- Professor Bernard Crespi
Christopher Badcock was educated at Maidstone Grammar School and The London School of Economics, where he graduated with a First in Sociology and Social Anthropology. Seeking to find a sound evolutionary, genetic, and neuro-scientific basis for psychoanalysis, he realized that research into autism completely discredited Freud but suggested a completely new basis for understanding the mind and mental illness. With the help of the leading Canadian bio-scientist, Bernard Crespi, he was eventually able to consolidate these insights into the imprinted brain theory outlined here and published a number of co-authored papers on the subject. Christopher Badcock is the author of a dozen books, and today teaches courses on evolutionary psychology, genetics, and sociobiology at the London School of Economics. He lives in London.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=825 The Imprinted Brain : How Genes Set the Balance Between Autism and Psychosis [Texte imprimé et/ou numérique] / Christopher BADCOCK, Auteur . - 2009 . - 240 p. ; 23,4cm x 15,6cm 2cm.
ISBN : 978-1-84905-023-4
Bibliogr., Index
Langues : Anglais (eng)
Index. décimale : SCI-B SCI-B - Génétique Résumé : The Imprinted Brain sets out a radical new theory of the mind and mental illness based on the recent discovery of genomic imprinting. Imprinted genes are those from one parent that, in that parent's interest, are expressed in an offspring rather than the diametrically opposed genes from the other parent. For example, a higher birth weight may represent the dominance of the father's genes in leading to a healthy child, whereas a lower birth weight is beneficial to the mother's immediate wellbeing, and the imprint of the mother's genes will result in a smaller baby. According to this view, a win for the father's genes may result in autism, whereas one for the mother's may result in psychosis. A state of equilibrium - normality - is the most likely outcome, with a no-win situation of balanced expression. Imprinted genes typically produce symptoms that are opposites of each other, and the author uses psychiatric case material to show how many of the symptoms of psychosis can be shown to be the mental mirror-images of those of autism.
Combining psychiatry with insights from modern genetics and cognitive science, Christopher Badcock explains the fascinating imprinted brain theory to the reader in a thorough but accessible way. This new theory casts some intriguing new light on other topics as diverse as the nature of genius, the appeal of detective fiction, and the successes - and failures - of psychoanalysis.
This thought-provoking book is a must-read for anyone with an interest in autism, psychiatry, cognitive science or psychology in general.
"The Imprinted Brain is a true tour de force, surveying the cutting-edge research in genomics and neuroscience and providing a fresh view on what it means to be male or female, "things people" or "people people," autistic or schizophrenic. You will never look at your parents the same way again!"
- Satoshi Kanazawa, The Scientific Fundamentalist and co-author of Why Beautiful People Have More Daughters
'Deeply scholarly yet absorbing narrative, The Imprinted Brain will change the way we view the human brain and its functions, evolution, and disordering in mental illness. Badcock has drawn evolutionary biology together with genetics, psychology, psychiatry, and neuroscience to demonstrate, for the first time, how genomic conflicts play a central role in how the human brain works, and how the brain becomes dysregulated in social-brain disorders including autism and schizophrenia.'
- Professor Bernard Crespi
Christopher Badcock was educated at Maidstone Grammar School and The London School of Economics, where he graduated with a First in Sociology and Social Anthropology. Seeking to find a sound evolutionary, genetic, and neuro-scientific basis for psychoanalysis, he realized that research into autism completely discredited Freud but suggested a completely new basis for understanding the mind and mental illness. With the help of the leading Canadian bio-scientist, Bernard Crespi, he was eventually able to consolidate these insights into the imprinted brain theory outlined here and published a number of co-authored papers on the subject. Christopher Badcock is the author of a dozen books, and today teaches courses on evolutionary psychology, genetics, and sociobiology at the London School of Economics. He lives in London.Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=825 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0000916 SCI-B BAD Livre Centre d'Information et de Documentation du CRA Rhône-Alpes SCI - Disciplines Scientifiques Disponible The Link between Genetic Abnormalities in the Monogenic Disorders and the Behavioral Phenotype of Polygenic Disorders Has Yet To Be Addressed in Research / Nagwa A. MEGUID in Autism - Open Access, 2-1 (March 2012)
[article]
Titre : The Link between Genetic Abnormalities in the Monogenic Disorders and the Behavioral Phenotype of Polygenic Disorders Has Yet To Be Addressed in Research Type de document : Texte imprimé et/ou numérique Auteurs : Nagwa A. MEGUID, Auteur Année de publication : 2012 Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism - Open Access > 2-1 (March 2012) . - 2 p.[article] The Link between Genetic Abnormalities in the Monogenic Disorders and the Behavioral Phenotype of Polygenic Disorders Has Yet To Be Addressed in Research [Texte imprimé et/ou numérique] / Nagwa A. MEGUID, Auteur . - 2012 . - 2 p.
Langues : Anglais (eng)
in Autism - Open Access > 2-1 (March 2012) . - 2 p.
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 The Neurochemical Basis of Autism / Gene J. BLATT
Titre : The Neurochemical Basis of Autism : From Molecules to Minicolumns Type de document : Texte imprimé et/ou numérique Auteurs : Gene J. BLATT, Directeur de publication Editeur : Berlin [Allemagne] : Springer Année de publication : 2010 Importance : 295 p. Présentation : ill. Format : 16cm x 24cm x 2,5cm ISBN/ISSN/EAN : 978-1-4419-1271-8 Note générale : Bibliogr., Index Langues : Anglais (eng) Mots-clés : Oxytocine Acide ?-aminobutyrique Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The recent perceived rise in autism worldwide has spurned a dramatic increase in autism research, but few studies have focused on determining the neurochemical basis of the disorder. The Neurochemical Basis of Autism: From Molecules to Minicolumns is a uniquely vital and interdisciplinary text that presents the latest findings and newest ideas regarding the physiological, neuropathological, neurochemical and clinical elements of autism.
This book contains an array of unique perspectives on autism from top researchers in their respective fields. It begins with a clinical and medical perspective that discusses etiologies, early identification, advancements in medical care and associated disorders. It then proceeds to cover a variety of topics such as neuropathological changes in autism to the pre- and post-natal development timing of the disorder, changes in the cerebellum in autism, the role of oxytocin in autism, the relationship of oxidative stress and autism, a comprehensive review of pharmacotherapies, and much more. Lastly, the book recounts the novel hypotheses being used to explore the causes and cures of the disorder.
Chapter introductions and lay abstracts make this book as accessible to the parents, siblings and caretakers of autistic children as it is indispensable to the scientists, researchers and clinicians on the front line of this baffling affliction.
Dr. Gene J. Blatt is currently an Associate Professor in the Department of Anatomy and Neurobiology at Boston University School of Medicine. He received his Ph.D. specializing in Neuroanatomy at Thomas Jefferson University in Philadelphia. For the past 10 years, Dr. Blatt’s research interests have focused on the neuropathological and neurochemical basis of autism, utilizing cerebellar, limbic and cerebral cortical human postmortem tissue and he has published extensively in these areas. A specific focus has been on the GABA system in autism and Dr. Blatt was one of the first researchers to demonstrate GABAergic abnormalities in the autism brain.
[Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109 The Neurochemical Basis of Autism : From Molecules to Minicolumns [Texte imprimé et/ou numérique] / Gene J. BLATT, Directeur de publication . - Berlin [Allemagne] : Springer, 2010 . - 295 p. : ill. ; 16cm x 24cm x 2,5cm.
ISBN : 978-1-4419-1271-8
Bibliogr., Index
Langues : Anglais (eng)
Mots-clés : Oxytocine Acide ?-aminobutyrique Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The recent perceived rise in autism worldwide has spurned a dramatic increase in autism research, but few studies have focused on determining the neurochemical basis of the disorder. The Neurochemical Basis of Autism: From Molecules to Minicolumns is a uniquely vital and interdisciplinary text that presents the latest findings and newest ideas regarding the physiological, neuropathological, neurochemical and clinical elements of autism.
This book contains an array of unique perspectives on autism from top researchers in their respective fields. It begins with a clinical and medical perspective that discusses etiologies, early identification, advancements in medical care and associated disorders. It then proceeds to cover a variety of topics such as neuropathological changes in autism to the pre- and post-natal development timing of the disorder, changes in the cerebellum in autism, the role of oxytocin in autism, the relationship of oxidative stress and autism, a comprehensive review of pharmacotherapies, and much more. Lastly, the book recounts the novel hypotheses being used to explore the causes and cures of the disorder.
Chapter introductions and lay abstracts make this book as accessible to the parents, siblings and caretakers of autistic children as it is indispensable to the scientists, researchers and clinicians on the front line of this baffling affliction.
Dr. Gene J. Blatt is currently an Associate Professor in the Department of Anatomy and Neurobiology at Boston University School of Medicine. He received his Ph.D. specializing in Neuroanatomy at Thomas Jefferson University in Philadelphia. For the past 10 years, Dr. Blatt’s research interests have focused on the neuropathological and neurochemical basis of autism, utilizing cerebellar, limbic and cerebral cortical human postmortem tissue and he has published extensively in these areas. A specific focus has been on the GABA system in autism and Dr. Blatt was one of the first researchers to demonstrate GABAergic abnormalities in the autism brain.
[Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109 Contient
- Pharmacological Treatment of Autism / Terrell T. GIBBS
- Autism Spectrum Disorders: Clinical and Medical Perspectives / Margaret L. BAUMAN
- The Male Prevalence in Autism Spectrum Disorders : Hypotheses on its Neurobiological Basis / Flavio KELLER
- Neuroanatomical-Behavioral Correlates in Autism: A Working Hypothesis / Ricardo M. VELA
- The Morphology of Minicolumns / Alan PETERS
- The Developmental Neuropathology of Autism / Thomas L. KEMPER
- Understanding Alterations During Human Brain Development with Molecular Imaging: Role in Determining Serotonin and GABA Mechanisms in Autism / Diane C. CHUGANI
- Glutamic Acid Decarboxylase (GAD) as a Biomarker of GABAergic Activity in Autism: Impact on Cerebellar Circuitry and Function / Gene J. BLATT
- Epigenetic Dysregulation of 15q11-13 GABAA Receptor Genes in Autism / Amber HOGART
- Cholinergic Component of Autism Spectrum Disorder / Elizabeta B. MUKAETOVA-LADINSKA
- Oxytocin and Autism / Peter KIRSCH
- The Role of the Noradrenergic System in Autism Spectrum Disorders / David Q. BEVERSDORF
- Oxidative Stress in Autism and Its Implications for Dopamine-Stimulated Phospholipid Methylation / Richard DETH
- Neuroligins and Neurexins: Synaptic Bridges Implicated in Autism / Craig M. POWELL
- The Neurophysical Chemistry of Autism: Postulates from Intelligence Modeling / Peter R. BERGETHON
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0001292 SCI-D BLA Livre Centre d'Information et de Documentation du CRA Rhône-Alpes SCI - Disciplines Scientifiques Disponible The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM
Titre : The Neuroscience of Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Joseph D. BUXBAUM, Directeur de publication ; Patrick R. HOF, Directeur de publication Editeur : Issy les Moulineaux [France] : Academic Press Année de publication : 2013 Importance : 480 p. Présentation : ill. Format : 22cm x 28,5cm x 2,5cm ISBN/ISSN/EAN : 978-0-12-391924-3 Note générale : Bibliogr., Index Langues : Anglais (eng) Mots-clés : Facteurs de risque Immunologie, Hormones Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention.
Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. [Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 The Neuroscience of Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Joseph D. BUXBAUM, Directeur de publication ; Patrick R. HOF, Directeur de publication . - Issy les Moulineaux [France] : Academic Press, 2013 . - 480 p. : ill. ; 22cm x 28,5cm x 2,5cm.
ISBN : 978-0-12-391924-3
Bibliogr., Index
Langues : Anglais (eng)
Mots-clés : Facteurs de risque Immunologie, Hormones Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention.
Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. [Résumé d'Auteur/Editeur]Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Contenu
- Epidemiology of Autism Spectrum Disorders / Lisa R. FRENCH
- The Behavioral Manifestations of Autism Spectrum Disorders / So Hyun KIM
- Early Manifestations of Autism Spectrum Disorders / Marianne L. BARTON
- Asperger Syndrome and its Relationships to Autism / James C. MCPARTLAND
- Behavioral and Psychosocial Interventions for Individuals with ASD / Latha V. SOORYA
- Current Trends in the Pharmacological Treatment of Autism Spectrum Disorders / Alexander KOLEVZON
- Novel Therapeutics in Autism Spectrum Disorders / Evdokia ANAGNOSTOU
- Etiological Heterogeneity in Autism Spectrum Disorders: Role of Rare Variants / Catalina BETANCUR
- Copy Number Variation in Autism Spectrum Disorders / Christian R. MARSHALL
- Common Genetic Variants in Autism Spectrum Disorders / Richard ANNEY
- Next-Generation Sequencing For Gene and Pathway Discovery and Analysis in Autism Spectrum Disorders / Guiqing CAI
- Mitochondria and Autism Spectrum Disorders / Robert K. NAVIAUX
- Parental and Perinatal Risk Factors for Autism: Epidemiological Findings and Potential Mechanisms / Sven SANDIN
- The Environment in Autism Spectrum Disorders / Kristen LYALL
- Hormonal Influences in Typical Development: Implications for Autism / Bonnie AUYEUNG
- Immune Abnormalities and Autism Spectrum Disorders / Majannie ELOI AKINTUDE
- Structural and Functional MRI Studies of Autism Spectrum Disorders / Kimberly A. STIGLER
- DTI and Tractography in the Autistic Brain / Timothy P.L. ROBERTS
- Attentional Network Deficits in Autism Spectrum Disorders / Jin FAN
- The Cerebellum in Autism Spectrum Disorders / Margaret L. BAUMAN
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Code-barres Cote Support Localisation Section Disponibilité DOC0002321 SCI-D BUX Livre Centre d'Information et de Documentation du CRA Rhône-Alpes SCI - Disciplines Scientifiques Disponible The phenotypes of specifie language impairment in child development / Anna M. CHILOSI
PermalinkThe Research Basis for Autism Intervention / Eric SCHOPLER
PermalinkThe role of limbic system irritability in linking history of childhood maltreatment and psychiatric outcomes in low-income, high-risk women: Moderation by FK506 binding protein 5 haplotype / Melissa N. DACKIS in Development and Psychopathology, 24-4 (November 2012)
PermalinkThe roles of dopamine and norepinephrine in autism : from behavior and pharmacotherapy to genetics / Jeanette J. A. HOLDEN
PermalinkThe serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction / Stephen G. LINDELL in Development and Psychopathology, 24-4 (November 2012)
PermalinkThe Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network / Diana SCHENDEL in Journal of Autism and Developmental Disorders, 42-10 (October 2012)
PermalinkToi, moi et le trouble du déficit de l'attention avec hyperactivité / Hervé CACI
PermalinkTraité de Neuropsychologie de l'Enfant / Martine PONCELET
PermalinkTraiter l'autisme ? / Yehezkel BEN-ARI
PermalinkTroubles des conduites alimentaires de l'enfant et de l'adolescent / Noël PERETTI
Permalink