72 recherche sur le mot-clé 'Aging'

Aging on the Autism Spectrum: Self-care Practices and Reported Impact on Well-Being / Danielle A. WALDRON in Journal of Autism and Developmental Disorders, 52-8 (August 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3512-3522 Titre : Aging on the Autism Spectrum: Self-care Practices and Reported Impact on Well-Being Type de document : texte imprimé Auteurs : Danielle A. WALDRON, Auteur ; Caitlin E. COYLE, Auteur ; John KRAMER, Auteur Article en page(s) : p.3512-3522 Langues : Anglais (eng) Mots-clés : Aged  Aging  Autism Spectrum Disorder/psychology/therapy  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Middle Aged  Self Care  Aging on the autism spectrum  Nutrition and autism spectrum  Physical activity and autism spectrum  Self-care and autism spectrum  Spirituality and autism spectrum Index. décimale : PER Périodiques Résumé : The population aging on the Autism Spectrum (AS) faces disproportionate physical and mental health comorbidities. This research describes self-care practices, including physical activity (PA), nutrition, and spirituality, and the impact of these practices on the health and well-being of older adults on the AS. Researchers conducted semi-structured interviews (N=30) with older adults (age 50+years) on the AS on the following topics: health, employment, relationships, and services/supports. Data were analyzed using Dedoose software and a constant comparative method. Participants described self-reported health benefits of their PA. Participants who engaged with organizations reported receiving instrumental support and fulfillment. Several themes emerged regarding socialization and routines in self-care in older adults on the AS, which may inform interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05229-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Aging on the Autism Spectrum: Self-care Practices and Reported Impact on Well-Being [texte imprimé] / Danielle A. WALDRON, Auteur ; Caitlin E. COYLE, Auteur ; John KRAMER, Auteur . - p.3512-3522. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3512-3522 Mots-clés : Aged  Aging  Autism Spectrum Disorder/psychology/therapy  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Middle Aged  Self Care  Aging on the autism spectrum  Nutrition and autism spectrum  Physical activity and autism spectrum  Self-care and autism spectrum  Spirituality and autism spectrum Index. décimale : PER Périodiques Résumé : The population aging on the Autism Spectrum (AS) faces disproportionate physical and mental health comorbidities. This research describes self-care practices, including physical activity (PA), nutrition, and spirituality, and the impact of these practices on the health and well-being of older adults on the AS. Researchers conducted semi-structured interviews (N=30) with older adults (age 50+years) on the AS on the following topics: health, employment, relationships, and services/supports. Data were analyzed using Dedoose software and a constant comparative method. Participants described self-reported health benefits of their PA. Participants who engaged with organizations reported receiving instrumental support and fulfillment. Several themes emerged regarding socialization and routines in self-care in older adults on the AS, which may inform interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05229-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Aging Well on the Autism Spectrum: An Examination of the Dominant Model of Successful Aging / Ye In HWANG in Journal of Autism and Developmental Disorders, 50-7 (July 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2326-2335 Titre : Aging Well on the Autism Spectrum: An Examination of the Dominant Model of Successful Aging Type de document : texte imprimé Auteurs : Ye In HWANG, Auteur ; Kitty-Rose FOLEY, Auteur ; Julian N. TROLLOR, Auteur Article en page(s) : p.2326-2335 Langues : Anglais (eng) Mots-clés : Activities of daily living  Adulthood  Aging  Aging well  Cognitive functioning  Education  Employment  Medical comorbidities  Physical functioning  Social participation  Successful aging  Theory Index. décimale : PER Périodiques Résumé : There is a gap in our knowledge of aging with autism. The present study examined the applicability of the popular gerontology concept of "aging well" to autistic adults. Using survey data, a model of "aging well" was operationalised and applied to 92 autistic adults and 60 controls. A very small proportion (3.3%) of autistic adults were found to be aging well. Significantly less autistic adults were "maintaining physical and cognitive functioning" and "actively engaging with life" in comparison to controls. Whilst important differences in health and functioning status were found, the current dominant model of "aging well" is limited for examining autistic individuals. Suggested adjustments include development of a broader, more flexible and strengths -based model. En ligne : http://dx.doi.org/10.1007/s10803-018-3596-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Aging Well on the Autism Spectrum: An Examination of the Dominant Model of Successful Aging [texte imprimé] / Ye In HWANG, Auteur ; Kitty-Rose FOLEY, Auteur ; Julian N. TROLLOR, Auteur . - p.2326-2335. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2326-2335 Mots-clés : Activities of daily living  Adulthood  Aging  Aging well  Cognitive functioning  Education  Employment  Medical comorbidities  Physical functioning  Social participation  Successful aging  Theory Index. décimale : PER Périodiques Résumé : There is a gap in our knowledge of aging with autism. The present study examined the applicability of the popular gerontology concept of "aging well" to autistic adults. Using survey data, a model of "aging well" was operationalised and applied to 92 autistic adults and 60 controls. A very small proportion (3.3%) of autistic adults were found to be aging well. Significantly less autistic adults were "maintaining physical and cognitive functioning" and "actively engaging with life" in comparison to controls. Whilst important differences in health and functioning status were found, the current dominant model of "aging well" is limited for examining autistic individuals. Suggested adjustments include development of a broader, more flexible and strengths -based model. En ligne : http://dx.doi.org/10.1007/s10803-018-3596-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 / David MASON in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1684-1694 Titre : Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 Type de document : texte imprimé Auteurs : David MASON, Auteur ; Angelica RONALD, Auteur ; Antony AMBLER, Auteur ; Avshalom CASPI, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Jasmin WERTZ, Auteur ; Terrie E. MOFFITT, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1684-1694 Langues : Anglais (eng) Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45 years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (β = 0.09), facial age (β = 0.08), self- (β = -0.15), informant (β = -0.12), and interviewer-rated (β = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 [texte imprimé] / David MASON, Auteur ; Angelica RONALD, Auteur ; Antony AMBLER, Auteur ; Avshalom CASPI, Auteur ; Renate HOUTS, Auteur ; Richie POULTON, Auteur ; Sandhya RAMRAKHA, Auteur ; Jasmin WERTZ, Auteur ; Terrie E. MOFFITT, Auteur ; Francesca HAPPE, Auteur . - p.1684-1694. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1684-1694 Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45 years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (β = 0.09), facial age (β = 0.08), self- (β = -0.15), informant (β = -0.12), and interviewer-rated (β = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis / William E. COPELAND in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1308-1315 Titre : Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis Type de document : texte imprimé Auteurs : William E. COPELAND, Auteur ; Lilly SHANAHAN, Auteur ; Ellen W. MCGINNIS, Auteur ; Karolina A. ABERG, Auteur ; Edwin J.C.G. VAN DEN OORD, Auteur Article en page(s) : p.1308-1315 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Cross-Sectional Studies  Risk Factors  Anxiety Disorders  Aging/genetics  Epigenesis, Genetic  Childhood  DNA methylation  adversity  aging  epigenetic  longitudinal Index. décimale : PER Périodiques Résumé : BACKGROUND: Longitudinal studies are needed to clarify whether early adversities are associated with advanced methylation age or if they actually accelerate methylation aging. This study test whether different dimensions of childhood adversity accelerate biological aging from childhood to adulthood, and, if so, via which mechanisms. METHODS: 381 participants provided one blood sample in childhood (average age 15.0; SD=2.3) and another in young adulthood (average age 23.1; SD=2.8). Participants and their parents provided a median of 6 childhood assessments (total=1,950 childhood observations), reporting exposures to different types of adversity dimensions (i.e. threat, material deprivation, loss, unpredictability). The blood samples were assayed to estimate DNA methylation age in both childhood and adulthood and also change in methylation age across this period. RESULTS: Cross-sectional associations between the childhood adversity dimensions and childhood measures of methylation age were non-significant. In contrast, multiple adversity dimensions were associated with accelerated within-person change in methylation age from adolescence to young adulthood. These associations attenuated in model testing all dimensions at the same time. Accelerated aging increased with increasing number of childhood adversities: Individuals with highest number of adversities experienced 2+ additional years of methylation aging compared to those with no exposure to childhood adversities. The association between total childhood adversity exposure and accelerated aging was partially explained by childhood depressive symptoms, but not anxiety or behavioral symptoms. CONCLUSIONS: Early adversities accelerate epigenetic aging long after they occur, in proportion to the total number of such experiences, and in a manner consistent with a shared effect that crosses multiple early dimensions of risk. En ligne : http://dx.doi.org/10.1111/jcpp.13575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis [texte imprimé] / William E. COPELAND, Auteur ; Lilly SHANAHAN, Auteur ; Ellen W. MCGINNIS, Auteur ; Karolina A. ABERG, Auteur ; Edwin J.C.G. VAN DEN OORD, Auteur . - p.1308-1315. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1308-1315 Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Cross-Sectional Studies  Risk Factors  Anxiety Disorders  Aging/genetics  Epigenesis, Genetic  Childhood  DNA methylation  adversity  aging  epigenetic  longitudinal Index. décimale : PER Périodiques Résumé : BACKGROUND: Longitudinal studies are needed to clarify whether early adversities are associated with advanced methylation age or if they actually accelerate methylation aging. This study test whether different dimensions of childhood adversity accelerate biological aging from childhood to adulthood, and, if so, via which mechanisms. METHODS: 381 participants provided one blood sample in childhood (average age 15.0; SD=2.3) and another in young adulthood (average age 23.1; SD=2.8). Participants and their parents provided a median of 6 childhood assessments (total=1,950 childhood observations), reporting exposures to different types of adversity dimensions (i.e. threat, material deprivation, loss, unpredictability). The blood samples were assayed to estimate DNA methylation age in both childhood and adulthood and also change in methylation age across this period. RESULTS: Cross-sectional associations between the childhood adversity dimensions and childhood measures of methylation age were non-significant. In contrast, multiple adversity dimensions were associated with accelerated within-person change in methylation age from adolescence to young adulthood. These associations attenuated in model testing all dimensions at the same time. Accelerated aging increased with increasing number of childhood adversities: Individuals with highest number of adversities experienced 2+ additional years of methylation aging compared to those with no exposure to childhood adversities. The association between total childhood adversity exposure and accelerated aging was partially explained by childhood depressive symptoms, but not anxiety or behavioral symptoms. CONCLUSIONS: Early adversities accelerate epigenetic aging long after they occur, in proportion to the total number of such experiences, and in a manner consistent with a shared effect that crosses multiple early dimensions of risk. En ligne : http://dx.doi.org/10.1111/jcpp.13575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Epigenetic aging in Williams syndrome / Satoshi OKAZAKI in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1553-1562 Titre : Epigenetic aging in Williams syndrome Type de document : texte imprimé Auteurs : Satoshi OKAZAKI, Auteur ; Ryo KIMURA, Auteur ; Ikuo OTSUKA, Auteur ; Kiyotaka TOMIWA, Auteur ; Yasuko FUNABIKI, Auteur ; Masatoshi HAGIWARA, Auteur ; Toshiya MURAI, Auteur ; Akitoyo HISHIMOTO, Auteur Article en page(s) : p.1553-1562 Langues : Anglais (eng) Mots-clés : Humans  Williams Syndrome/genetics  Aging/genetics  DNA Methylation/genetics  Biomarkers  Epigenesis, Genetic  Aging  Williams syndrome  epigenetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Williams syndrome (WS) is a rare genetic disorder caused by a microdeletion at the 7q11.23 region and is characterized by diverse symptoms encompassing physical and cognitive features. WS was reported to be associated to altered DNA methylation (DNAm) patterns. However, due to the limited information from long-term studies, it remains unclear whether WS accelerates aging. Genome-wide DNAm profiles can serve as "epigenetic clocks" to help estimate biological aging along with age-related markers, such as plasma proteins and telomere length. METHODS: We investigated GrimAge, DNAm-based telomere length (DNAmTL), and other epigenetic clocks in blood samples of 32 patients with WS and 32 healthy controls. RESULTS: We observed a significant acceleration in GrimAge, DNAmTL, and other epigenetic clocks in patients with WS as compared with those of controls. In addition, several GrimAge components, such as adrenomedullin, growth differentiation factor-15, leptin and plasminogen activator inhibitor-1, were altered in patients with WS. CONCLUSIONS: This study provides novel evidence supporting the hypothesis that WS may be associated to accelerated biological aging. A better understanding of the overall underlying biological effects of WS can provide new foundations for improved patient care; thus, long-term follow-up studies are still warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Epigenetic aging in Williams syndrome [texte imprimé] / Satoshi OKAZAKI, Auteur ; Ryo KIMURA, Auteur ; Ikuo OTSUKA, Auteur ; Kiyotaka TOMIWA, Auteur ; Yasuko FUNABIKI, Auteur ; Masatoshi HAGIWARA, Auteur ; Toshiya MURAI, Auteur ; Akitoyo HISHIMOTO, Auteur . - p.1553-1562. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1553-1562 Mots-clés : Humans  Williams Syndrome/genetics  Aging/genetics  DNA Methylation/genetics  Biomarkers  Epigenesis, Genetic  Aging  Williams syndrome  epigenetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Williams syndrome (WS) is a rare genetic disorder caused by a microdeletion at the 7q11.23 region and is characterized by diverse symptoms encompassing physical and cognitive features. WS was reported to be associated to altered DNA methylation (DNAm) patterns. However, due to the limited information from long-term studies, it remains unclear whether WS accelerates aging. Genome-wide DNAm profiles can serve as "epigenetic clocks" to help estimate biological aging along with age-related markers, such as plasma proteins and telomere length. METHODS: We investigated GrimAge, DNAm-based telomere length (DNAmTL), and other epigenetic clocks in blood samples of 32 patients with WS and 32 healthy controls. RESULTS: We observed a significant acceleration in GrimAge, DNAmTL, and other epigenetic clocks in patients with WS as compared with those of controls. In addition, several GrimAge components, such as adrenomedullin, growth differentiation factor-15, leptin and plasminogen activator inhibitor-1, were altered in patients with WS. CONCLUSIONS: This study provides novel evidence supporting the hypothesis that WS may be associated to accelerated biological aging. A better understanding of the overall underlying biological effects of WS can provide new foundations for improved patient care; thus, long-term follow-up studies are still warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging / Helen WONG in Journal of Neurodevelopmental Disorders, 14 (2022)  

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Age and Sensory Processing Abnormalities Predict Declines in Encoding and Recall of Temporally Manipulated Speech in High-Functioning Adults with ASD / Jennifer L. MAYER in Autism Research, 7-1 (February 2014)  

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Age group differences in executive network functional connectivity and relationships with social behavior in men with autism spectrum disorder / Melissa J.M. WALSH in Research in Autism Spectrum Disorders, 63 (July 2019)  

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Age-related changes in brain signal variability in autism spectrum disorder / Nicholas KATHREIN ; Elijah GRAGAS ; Lauren KUPIS ; Lucina Q. UDDIN ; Jason S. NOMI in Molecular Autism, 16 (2025)  

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Age-related differences in cognition across the adult lifespan in autism spectrum disorder / Anne G. LEVER in Autism Research, 9-6 (June 2016)  

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