372 recherche sur le mot-clé 'Imaging-skill'

The influence of long-term practice on mental rotation of 3-D objects / Gilles LEONE in Cognitive Brain Research, 1-4 (December 1993)

Public ISBD [article]  inCognitive Brain Research > 1-4 (December 1993) . - p.241-255 Titre : The influence of long-term practice on mental rotation of 3-D objects Type de document : texte imprimé Auteurs : Gilles LEONE, Auteur ; Marie Claire TAINE, Auteur ; Jacques DROULEZ, Auteur Année de publication : 1993 Article en page(s) : p.241-255 Langues : Anglais (eng) Mots-clés : Mental-rotation 3-D-object Practice Imaging-skill Complexity Index. décimale : PER Périodiques Résumé : We evaluated the influence of long-term practice on the performance of a mental rotation task in which subjects judged whether two 3-D objects presented in different orientations were identical. Stimuli and experimental conditions were analogous to those used by Shepard and Metzler. Sixteen subjects were selected, to test the influence of aptitude for mental imagery on this learning process. Subjects participated in 12 to 15 sessions over 6 weeks. Two catalogues of different stimuli were alternatively used during three (or six) consecutive sessions to determine the influence of complexity and familiarity of figures. For all subjects, the inverse of the velocity of mental rotation along the sessions was adequately fitted by a decreasing exponential curve. However, evidence for mental rotation did not disappear, even after 15 sessions. Asymptotic variations can be attributed to differences in stimuli as well as imaging skills of subjects. Our results lead to a new interpretation of the mental rotation process. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782 [article] The influence of long-term practice on mental rotation of 3-D objects [texte imprimé] / Gilles LEONE, Auteur ; Marie Claire TAINE, Auteur ; Jacques DROULEZ, Auteur . - 1993 . - p.241-255. Langues : Anglais (eng) in Cognitive Brain Research > 1-4 (December 1993) . - p.241-255 Mots-clés : Mental-rotation 3-D-object Practice Imaging-skill Complexity Index. décimale : PER Périodiques Résumé : We evaluated the influence of long-term practice on the performance of a mental rotation task in which subjects judged whether two 3-D objects presented in different orientations were identical. Stimuli and experimental conditions were analogous to those used by Shepard and Metzler. Sixteen subjects were selected, to test the influence of aptitude for mental imagery on this learning process. Subjects participated in 12 to 15 sessions over 6 weeks. Two catalogues of different stimuli were alternatively used during three (or six) consecutive sessions to determine the influence of complexity and familiarity of figures. For all subjects, the inverse of the velocity of mental rotation along the sessions was adequately fitted by a decreasing exponential curve. However, evidence for mental rotation did not disappear, even after 15 sessions. Asymptotic variations can be attributed to differences in stimuli as well as imaging skills of subjects. Our results lead to a new interpretation of the mental rotation process. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782

(1)H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome / Pooja Kri GUPTA in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 31p. Titre : (1)H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome Type de document : texte imprimé Auteurs : Pooja Kri GUPTA, Auteur ; Sharon BARAK, Auteur ; Yonatan FEUERMANN, Auteur ; Gil GOOBES, Auteur ; Hanoch KAPHZAN, Auteur Article en page(s) : 31p. Langues : Anglais (eng) Mots-clés : Animals  Angelman Syndrome/metabolism/genetics  Metabolomics  Disease Models, Animal  Brain/metabolism/diagnostic imaging  Mice  Proton Magnetic Resonance Spectroscopy  Metabolome  Ubiquitin-Protein Ligases/metabolism/genetics  Female  Acetate  Angelman syndrome  Developmental disorders  Glycolysis  Lactate  Metabolite  Mitochondria  Pyruvate metabolism  Reactive oxygen species  Succinate Index. décimale : PER Périodiques Résumé : BACKGROUND: Angelman syndrome (AS) is a rare neurodevelopmental genetic disorder caused by the loss of function of the ubiquitin ligase E3A (UBE3A) gene, affecting approximately 1:15,000 live births. We have recently shown that mitochondrial function in AS is altered during mid to late embryonic brain development leading to increased oxidative stress and enhanced apoptosis of neural precursor cells. However, the overall alterations of metabolic processes are still unknown. Hence, as a follow-up, we aim to investigate the metabolic profiles of wild-type (WT) and AS littermates and to identify which metabolic processes are aberrant in the brain of AS model mice during embryonic development. METHODS: We collected brain tissue samples from mice embryos at E16.5 and performed metabolomic analyses using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy. Multivariate and Univariate analyses were performed to determine the significantly altered metabolites in AS mice. Pathways associated with the altered metabolites were identified using metabolite set enrichment analysis. RESULTS: Our analysis showed that overall, the metabolomic fingerprint of AS embryonic brains differed from those of their WT littermates. Moreover, we revealed a significant elevation of distinct metabolites, such as acetate, lactate, and succinate in the AS samples compared to the WT samples. The elevated metabolites were significantly associated with the pyruvate metabolism and glycolytic pathways. LIMITATIONS: Only 14 metabolites were successfully identified and investigated in the present study. The effect of unidentified metabolites and their unresolved peaks was not determined. Additionally, we conducted the metabolomic study on whole brain tissue samples. Employing high-resolution NMR studies on different brain regions could further expand our knowledge regarding metabolic alterations in the AS brain. Furthermore, increasing the sample size could reveal the involvement of more significantly altered metabolites in the pathophysiology of the AS brain. CONCLUSIONS: Ube3a loss of function alters bioenergy-related metabolism in the AS brain during embryonic development. Furthermore, these neurochemical changes could be linked to the mitochondrial reactive oxygen species and oxidative stress that occurs during the AS embryonic development. En ligne : https://dx.doi.org/10.1186/s13229-024-00608-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] (1)H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome [texte imprimé] / Pooja Kri GUPTA, Auteur ; Sharon BARAK, Auteur ; Yonatan FEUERMANN, Auteur ; Gil GOOBES, Auteur ; Hanoch KAPHZAN, Auteur . - 31p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 31p. Mots-clés : Animals  Angelman Syndrome/metabolism/genetics  Metabolomics  Disease Models, Animal  Brain/metabolism/diagnostic imaging  Mice  Proton Magnetic Resonance Spectroscopy  Metabolome  Ubiquitin-Protein Ligases/metabolism/genetics  Female  Acetate  Angelman syndrome  Developmental disorders  Glycolysis  Lactate  Metabolite  Mitochondria  Pyruvate metabolism  Reactive oxygen species  Succinate Index. décimale : PER Périodiques Résumé : BACKGROUND: Angelman syndrome (AS) is a rare neurodevelopmental genetic disorder caused by the loss of function of the ubiquitin ligase E3A (UBE3A) gene, affecting approximately 1:15,000 live births. We have recently shown that mitochondrial function in AS is altered during mid to late embryonic brain development leading to increased oxidative stress and enhanced apoptosis of neural precursor cells. However, the overall alterations of metabolic processes are still unknown. Hence, as a follow-up, we aim to investigate the metabolic profiles of wild-type (WT) and AS littermates and to identify which metabolic processes are aberrant in the brain of AS model mice during embryonic development. METHODS: We collected brain tissue samples from mice embryos at E16.5 and performed metabolomic analyses using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy. Multivariate and Univariate analyses were performed to determine the significantly altered metabolites in AS mice. Pathways associated with the altered metabolites were identified using metabolite set enrichment analysis. RESULTS: Our analysis showed that overall, the metabolomic fingerprint of AS embryonic brains differed from those of their WT littermates. Moreover, we revealed a significant elevation of distinct metabolites, such as acetate, lactate, and succinate in the AS samples compared to the WT samples. The elevated metabolites were significantly associated with the pyruvate metabolism and glycolytic pathways. LIMITATIONS: Only 14 metabolites were successfully identified and investigated in the present study. The effect of unidentified metabolites and their unresolved peaks was not determined. Additionally, we conducted the metabolomic study on whole brain tissue samples. Employing high-resolution NMR studies on different brain regions could further expand our knowledge regarding metabolic alterations in the AS brain. Furthermore, increasing the sample size could reveal the involvement of more significantly altered metabolites in the pathophysiology of the AS brain. CONCLUSIONS: Ube3a loss of function alters bioenergy-related metabolism in the AS brain during embryonic development. Furthermore, these neurochemical changes could be linked to the mitochondrial reactive oxygen species and oxidative stress that occurs during the AS embryonic development. En ligne : https://dx.doi.org/10.1186/s13229-024-00608-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

A 3D approach to understanding heterogeneity in early developing autisms / Veronica MANDELLI in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 41p. Titre : A 3D approach to understanding heterogeneity in early developing autisms Type de document : texte imprimé Auteurs : Veronica MANDELLI, Auteur ; Ines SEVERINO, Auteur ; Lisa T. EYLER, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur ; Michael V. LOMBARDO, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Humans  Child, Preschool  Autistic Disorder/diagnostic imaging/diagnosis  Female  Male  Child  Phenotype  Imaging, Three-Dimensional  Clustering  Gene expression  Stratification  Subtypes  fMRI  for the Collection in this journal entitled 'Neuroimaging in Autism Spectrum  Disorders'. All other authors have no competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Phenotypic heterogeneity in early language, intellectual, motor, and adaptive functioning (LIMA) features are amongst the most striking features that distinguish different types of autistic individuals. Yet the current diagnostic criteria uses a single label of autism and implicitly emphasizes what individuals have in common as core social-communicative and restricted repetitive behavior difficulties. Subtype labels based on the non-core LIMA features may help to more meaningfully distinguish types of autisms with differing developmental paths and differential underlying biology. METHODS: Unsupervised data-driven subtypes were identified using stability-based relative clustering validation on publicly available Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) data (n = 615; age = 24-68 months) from the National Institute of Mental Health Data Archive (NDA). Differential developmental trajectories between subtypes were tested on longitudinal data from NDA and from an independent in-house dataset from UCSD. A subset of the UCSD dataset was also tested for subtype differences in functional and structural neuroimaging phenotypes and relationships with blood gene expression. The current subtyping model was also compared to early language outcome subtypes derived from past work. RESULTS: Two autism subtypes can be identified based on early phenotypic LIMA features. These data-driven subtypes are robust in the population and can be identified in independent data with 98% accuracy. The subtypes can be described as Type I versus Type II autisms differentiated by relatively high versus low scores on LIMA features. These two types of autisms are also distinguished by different developmental trajectories over the first decade of life. Finally, these two types of autisms reveal striking differences in functional and structural neuroimaging phenotypes and their relationships with gene expression and may highlight unique biological mechanisms. LIMITATIONS: Sample sizes for the neuroimaging and gene expression dataset are relatively small and require further independent replication. The current work is also limited to subtyping based on MSEL and VABS phenotypic measures. CONCLUSIONS: This work emphasizes the potential importance of stratifying autism by a Type I versus Type II distinction focused on LIMA features and which may be of high prognostic and biological significance. En ligne : https://dx.doi.org/10.1186/s13229-024-00613-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] A 3D approach to understanding heterogeneity in early developing autisms [texte imprimé] / Veronica MANDELLI, Auteur ; Ines SEVERINO, Auteur ; Lisa T. EYLER, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur ; Michael V. LOMBARDO, Auteur . - 41p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 41p. Mots-clés : Humans  Child, Preschool  Autistic Disorder/diagnostic imaging/diagnosis  Female  Male  Child  Phenotype  Imaging, Three-Dimensional  Clustering  Gene expression  Stratification  Subtypes  fMRI  for the Collection in this journal entitled 'Neuroimaging in Autism Spectrum  Disorders'. All other authors have no competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Phenotypic heterogeneity in early language, intellectual, motor, and adaptive functioning (LIMA) features are amongst the most striking features that distinguish different types of autistic individuals. Yet the current diagnostic criteria uses a single label of autism and implicitly emphasizes what individuals have in common as core social-communicative and restricted repetitive behavior difficulties. Subtype labels based on the non-core LIMA features may help to more meaningfully distinguish types of autisms with differing developmental paths and differential underlying biology. METHODS: Unsupervised data-driven subtypes were identified using stability-based relative clustering validation on publicly available Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) data (n = 615; age = 24-68 months) from the National Institute of Mental Health Data Archive (NDA). Differential developmental trajectories between subtypes were tested on longitudinal data from NDA and from an independent in-house dataset from UCSD. A subset of the UCSD dataset was also tested for subtype differences in functional and structural neuroimaging phenotypes and relationships with blood gene expression. The current subtyping model was also compared to early language outcome subtypes derived from past work. RESULTS: Two autism subtypes can be identified based on early phenotypic LIMA features. These data-driven subtypes are robust in the population and can be identified in independent data with 98% accuracy. The subtypes can be described as Type I versus Type II autisms differentiated by relatively high versus low scores on LIMA features. These two types of autisms are also distinguished by different developmental trajectories over the first decade of life. Finally, these two types of autisms reveal striking differences in functional and structural neuroimaging phenotypes and their relationships with gene expression and may highlight unique biological mechanisms. LIMITATIONS: Sample sizes for the neuroimaging and gene expression dataset are relatively small and require further independent replication. The current work is also limited to subtyping based on MSEL and VABS phenotypic measures. CONCLUSIONS: This work emphasizes the potential importance of stratifying autism by a Type I versus Type II distinction focused on LIMA features and which may be of high prognostic and biological significance. En ligne : https://dx.doi.org/10.1186/s13229-024-00613-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children / Cynthia E. ROGERS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 38 p. Titre : Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children Type de document : texte imprimé Auteurs : Cynthia E. ROGERS, Auteur ; Rachel E. LEAN, Auteur ; Muriah D. WHEELOCK, Auteur ; Christopher D. SMYSER, Auteur Année de publication : 2018 Article en page(s) : 38 p. Langues : Anglais (eng) Mots-clés : Functional connectivity  Magnetic resonance imaging  Neurodevelopmental disorders  Prematurity  Structural connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite advances in antenatal and neonatal care, preterm birth remains a leading cause of neurological disabilities in children. Infants born prematurely, particularly those delivered at the earliest gestational ages, commonly demonstrate increased rates of impairment across multiple neurodevelopmental domains. Indeed, the current literature establishes that preterm birth is a leading risk factor for cerebral palsy, is associated with executive function deficits, increases risk for impaired receptive and expressive language skills, and is linked with higher rates of co-occurring attention deficit hyperactivity disorder, anxiety, and autism spectrum disorders. These same infants also demonstrate elevated rates of aberrant cerebral structural and functional connectivity, with persistent changes evident across advanced magnetic resonance imaging modalities as early as the neonatal period. Emerging findings from cross-sectional and longitudinal investigations increasingly suggest that aberrant connectivity within key functional networks and white matter tracts may underlie the neurodevelopmental impairments common in this population. MAIN BODY: This review begins by highlighting the elevated rates of neurodevelopmental disorders across domains in this clinical population, describes the patterns of aberrant structural and functional connectivity common in prematurely-born infants and children, and then reviews the increasingly established body of literature delineating the relationship between these brain abnormalities and adverse neurodevelopmental outcomes. We also detail important, typically understudied, clinical, and social variables that may influence these relationships among preterm children, including heritability and psychosocial risks. CONCLUSION: Future work in this domain should continue to leverage longitudinal evaluations of preterm infants which include both neuroimaging and detailed serial neurodevelopmental assessments to further characterize relationships between imaging measures and impairment, information necessary for advancing our understanding of modifiable risk factors underlying these disorders and best practices for improving neurodevelopmental trajectories in this high-risk clinical population. En ligne : http://dx.doi.org/10.1186/s11689-018-9253-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children [texte imprimé] / Cynthia E. ROGERS, Auteur ; Rachel E. LEAN, Auteur ; Muriah D. WHEELOCK, Auteur ; Christopher D. SMYSER, Auteur . - 2018 . - 38 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 38 p. Mots-clés : Functional connectivity  Magnetic resonance imaging  Neurodevelopmental disorders  Prematurity  Structural connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite advances in antenatal and neonatal care, preterm birth remains a leading cause of neurological disabilities in children. Infants born prematurely, particularly those delivered at the earliest gestational ages, commonly demonstrate increased rates of impairment across multiple neurodevelopmental domains. Indeed, the current literature establishes that preterm birth is a leading risk factor for cerebral palsy, is associated with executive function deficits, increases risk for impaired receptive and expressive language skills, and is linked with higher rates of co-occurring attention deficit hyperactivity disorder, anxiety, and autism spectrum disorders. These same infants also demonstrate elevated rates of aberrant cerebral structural and functional connectivity, with persistent changes evident across advanced magnetic resonance imaging modalities as early as the neonatal period. Emerging findings from cross-sectional and longitudinal investigations increasingly suggest that aberrant connectivity within key functional networks and white matter tracts may underlie the neurodevelopmental impairments common in this population. MAIN BODY: This review begins by highlighting the elevated rates of neurodevelopmental disorders across domains in this clinical population, describes the patterns of aberrant structural and functional connectivity common in prematurely-born infants and children, and then reviews the increasingly established body of literature delineating the relationship between these brain abnormalities and adverse neurodevelopmental outcomes. We also detail important, typically understudied, clinical, and social variables that may influence these relationships among preterm children, including heritability and psychosocial risks. CONCLUSION: Future work in this domain should continue to leverage longitudinal evaluations of preterm infants which include both neuroimaging and detailed serial neurodevelopmental assessments to further characterize relationships between imaging measures and impairment, information necessary for advancing our understanding of modifiable risk factors underlying these disorders and best practices for improving neurodevelopmental trajectories in this high-risk clinical population. En ligne : http://dx.doi.org/10.1186/s11689-018-9253-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder / Junko MATSUZAKI in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1225-1235 Titre : Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder Type de document : texte imprimé Auteurs : Junko MATSUZAKI, Auteur ; Emily S. KUSCHNER, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; Mina KIM, Auteur ; Matthew KU, Auteur ; J. Christopher EDGAR, Auteur ; David EMBICK, Auteur ; Timothy P.L. ROBERTS, Auteur Article en page(s) : p.1225-1235 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  language and communication skill  magnetoencephalography  minimally verbal/non-verbal children  vowel mismatch fields Index. décimale : PER Périodiques Résumé : Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 +/- 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 +/- 1.21 years, ASD-LI: n = 21, 10.67 +/- 1.20 years) and TD: n = 27, 10.14 +/- 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain imaging showed abnormal auditory discrimination processes in minimally-verbal/non-verbal children (MVNV) who have autism spectrum disorder (ASD). Delays in auditory discrimination were associated with impaired language and communication skills. Findings suggest these auditory neural measures may be objective markers of language and communication skills in both verbal and, previously-understudied, MVNV children who have ASD. En ligne : http://dx.doi.org/10.1002/aur.2136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder [texte imprimé] / Junko MATSUZAKI, Auteur ; Emily S. KUSCHNER, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; Mina KIM, Auteur ; Matthew KU, Auteur ; J. Christopher EDGAR, Auteur ; David EMBICK, Auteur ; Timothy P.L. ROBERTS, Auteur . - p.1225-1235. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1225-1235 Mots-clés : autism spectrum disorder  language and communication skill  magnetoencephalography  minimally verbal/non-verbal children  vowel mismatch fields Index. décimale : PER Périodiques Résumé : Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 +/- 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 +/- 1.21 years, ASD-LI: n = 21, 10.67 +/- 1.20 years) and TD: n = 27, 10.14 +/- 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain imaging showed abnormal auditory discrimination processes in minimally-verbal/non-verbal children (MVNV) who have autism spectrum disorder (ASD). Delays in auditory discrimination were associated with impaired language and communication skills. Findings suggest these auditory neural measures may be objective markers of language and communication skills in both verbal and, previously-understudied, MVNV children who have ASD. En ligne : http://dx.doi.org/10.1002/aur.2136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Abnormal Corpus Callosum Connectivity, Socio-communicative Deficits, and Motor Deficits in Children with Autism Spectrum Disorder: A Diffusion Tensor Imaging Study / Ryuzo HANAIE in Journal of Autism and Developmental Disorders, 44-9 (September 2014)  

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Accelerating Motor Skill Acquisition for Bicycle Riding in Children with ASD: A Pilot Study / Zoe HAWKS in Journal of Autism and Developmental Disorders, 50-1 (January 2020)  

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Adaptive Behavior Moderates Health-Related Pathways in Children with Autism Spectrum Disorder / Emily BREMER in Journal of Autism and Developmental Disorders, 50-2 (February 2020)  

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ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD / Jeffery N. EPSTEIN in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)  

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Adolescents' neural reactivity to acute psychosocial stress: dysfunctional regulation habits are linked to temporal gyrus response / Sabrina GOLDE in Development and Psychopathology, 35-1 (February 2023)  

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