13 recherche sur le mot-clé 'Morris-water-maze'

Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 / Robert J. HAMM in Cognitive Brain Research, 1-4 (December 1993)

Public ISBD [article]  inCognitive Brain Research > 1-4 (December 1993) . - p.223-226 Titre : Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 Type de document : texte imprimé Auteurs : Robert J. HAMM, Auteur ; Dianne M. O'DELL, Auteur ; Brian R. PIKE, Auteur ; Bruce G. LYETH, Auteur Année de publication : 1993 Article en page(s) : p.223-226 Langues : Anglais (eng) Mots-clés : Traumatic-brain-injury Morris-water-maze Scopolamine;MK-801 Rat Index. décimale : PER Périodiques Résumé : In order to examine the effectiveness of pre- and post-injury administration of muscarinic cholinergic and NMDA antagonists in reducing cognitive deficits following traumatic brain injury (TBI), rats were injected with either scopolamine (1 mg/kg) or MK-801 (0.3 mg/kg) 15 min prior to or 15 min after fluid percussion TBI. Cognitive performance was assessed with the Morris water maze procedure on days 11–15 after TBI or sham injury. When scopolamine and MK-801 were injected 15 min before injury, Morris water maze deficits were significantly reduced (P < 0.01 and P < 0.05, respectively). When scopolamine and MK-801 were injected 15 min after TBI, neither drug was effective in attenuating Morris water maze deficits. Consistent with other research, these results suggest that the cognitive deficits produced by TBI are the consequence of a brief period of excessive excitation of cholinergic and NMDA receptor systems. The results of this experiment also suggest that the temporal therapeutic window for the treatment of cognitive dysfunction with receptor antagonist intervention appears to be quite brief ( < 15 min) in the rat. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782 [article] Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 [texte imprimé] / Robert J. HAMM, Auteur ; Dianne M. O'DELL, Auteur ; Brian R. PIKE, Auteur ; Bruce G. LYETH, Auteur . - 1993 . - p.223-226. Langues : Anglais (eng) in Cognitive Brain Research > 1-4 (December 1993) . - p.223-226 Mots-clés : Traumatic-brain-injury Morris-water-maze Scopolamine;MK-801 Rat Index. décimale : PER Périodiques Résumé : In order to examine the effectiveness of pre- and post-injury administration of muscarinic cholinergic and NMDA antagonists in reducing cognitive deficits following traumatic brain injury (TBI), rats were injected with either scopolamine (1 mg/kg) or MK-801 (0.3 mg/kg) 15 min prior to or 15 min after fluid percussion TBI. Cognitive performance was assessed with the Morris water maze procedure on days 11–15 after TBI or sham injury. When scopolamine and MK-801 were injected 15 min before injury, Morris water maze deficits were significantly reduced (P < 0.01 and P < 0.05, respectively). When scopolamine and MK-801 were injected 15 min after TBI, neither drug was effective in attenuating Morris water maze deficits. Consistent with other research, these results suggest that the cognitive deficits produced by TBI are the consequence of a brief period of excessive excitation of cholinergic and NMDA receptor systems. The results of this experiment also suggest that the temporal therapeutic window for the treatment of cognitive dysfunction with receptor antagonist intervention appears to be quite brief ( < 15 min) in the rat. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782

Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems / Erik S. CARLSON in Journal of Neurodevelopmental Disorders, 2-3 (September 2010)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43 Titre : Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems Type de document : texte imprimé Auteurs : Erik S. CARLSON, Auteur ; Stephanie J.B. FRETHAM, Auteur ; Erica UNGER, Auteur ; Michael O'CONNOR, Auteur ; Anna PETRYK, Auteur ; Timothy SCHALLERT, Auteur ; Raghavendra RAO, Auteur ; Ivan TKAC, Auteur ; Michael K. GEORGIEFF, Auteur Article en page(s) : p.133-43 Langues : Anglais (eng) Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy  Hippocampus  Iron deficiency  Memory systems  Morris water maze  Procedural memory  Spatial memory  Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems [texte imprimé] / Erik S. CARLSON, Auteur ; Stephanie J.B. FRETHAM, Auteur ; Erica UNGER, Auteur ; Michael O'CONNOR, Auteur ; Anna PETRYK, Auteur ; Timothy SCHALLERT, Auteur ; Raghavendra RAO, Auteur ; Ivan TKAC, Auteur ; Michael K. GEORGIEFF, Auteur . - p.133-43. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43 Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy  Hippocampus  Iron deficiency  Memory systems  Morris water maze  Procedural memory  Spatial memory  Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Impaired spatial navigation in pediatric anxiety / Sven C. MUELLER in Journal of Child Psychology and Psychiatry, 50-10 (October 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1227-1234 Titre : Impaired spatial navigation in pediatric anxiety Type de document : texte imprimé Auteurs : Sven C. MUELLER, Auteur ; Daniel S. PINE, Auteur ; Monique ERNST, Auteur ; Veronica TEMPLE, Auteur ; Brian CORNWELL, Auteur ; Christian GRILLON, Auteur Année de publication : 2009 Article en page(s) : p.1227-1234 Langues : Anglais (eng) Mots-clés : Pediatric anxiety hippocampus water-maze spatial-navigation Index. décimale : PER Périodiques Résumé : Background: Previous theories implicate hippocampal dysfunction in anxiety disorders. Most of the data supporting these theories stem from animal research, particularly lesion studies. The generalization of findings from rodent models to human function is hampered by fundamental inter-species differences. The present work uses a task of spatial orientation, which is known to rely on hippocampal function. Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders. Methods: Thirty-four treatment-naive children with an anxiety disorder (mean 11.00 years ± 2.54) are compared to 35 healthy age- and IQ-matched healthy children (mean 11.95 years ± 2.36) on a virtual, computer-based equivalent of the Morris Water Maze task. Results: Results indicate that children with anxiety disorder exhibit overall impaired performance relative to the comparison group. Anxious children made more heading direction errors and had worse accuracy in completing trials relative to controls. Conclusions: The results present novel evidence that spatial orientation deficits occur in pediatric anxiety. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02112.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=838 [article] Impaired spatial navigation in pediatric anxiety [texte imprimé] / Sven C. MUELLER, Auteur ; Daniel S. PINE, Auteur ; Monique ERNST, Auteur ; Veronica TEMPLE, Auteur ; Brian CORNWELL, Auteur ; Christian GRILLON, Auteur . - 2009 . - p.1227-1234. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1227-1234 Mots-clés : Pediatric anxiety hippocampus water-maze spatial-navigation Index. décimale : PER Périodiques Résumé : Background: Previous theories implicate hippocampal dysfunction in anxiety disorders. Most of the data supporting these theories stem from animal research, particularly lesion studies. The generalization of findings from rodent models to human function is hampered by fundamental inter-species differences. The present work uses a task of spatial orientation, which is known to rely on hippocampal function. Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders. Methods: Thirty-four treatment-naive children with an anxiety disorder (mean 11.00 years ± 2.54) are compared to 35 healthy age- and IQ-matched healthy children (mean 11.95 years ± 2.36) on a virtual, computer-based equivalent of the Morris Water Maze task. Results: Results indicate that children with anxiety disorder exhibit overall impaired performance relative to the comparison group. Anxious children made more heading direction errors and had worse accuracy in completing trials relative to controls. Conclusions: The results present novel evidence that spatial orientation deficits occur in pediatric anxiety. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02112.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=838

Brief Report: Speech and Language Therapy in Children with ASD in an Aquatic Environment: the ASLT (Aquatic Speech and Language Therapy) Program / Stamatis SOURVINOS in Journal of Autism and Developmental Disorders, 51-4 (April 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-4 (April 2021) . - p.1406-1416 Titre : Brief Report: Speech and Language Therapy in Children with ASD in an Aquatic Environment: the ASLT (Aquatic Speech and Language Therapy) Program Type de document : texte imprimé Auteurs : Stamatis SOURVINOS, Auteur ; Aris MAVROPOULOS, Auteur ; Dimitrios S. KASSELIMIS, Auteur ; Andriani KORASIDI, Auteur ; Alexandra-Labrini VOUKOUNI, Auteur ; Panagiotis PAPADOPOULOS, Auteur ; Spyridon VLASEROS, Auteur ; Georgios DAMIANOS, Auteur ; Constantin POTAGAS, Auteur ; Demosthenes DAMIANOS, Auteur Article en page(s) : p.1406-1416 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Expressive vocabulary  Receptive vocabulary  Speech and language therapy  Water-based intervention Index. décimale : PER Périodiques Résumé : Although water-based approaches have been shown to be beneficial for children with Autism Spectrum Disorder (ASD), no study thus far has directly investigated the effects of such intervention programs on language skills. The present study aims to evaluate the efficacy of the Aquatic Speech and Language Therapy (ASLT) program, which is a new, exclusively aquatic intervention program designed especially for children with ASD. The effects of ASLT were compared to the outcome of a similar classroom-based intervention, in two groups of children with ASD matched for age, gender, and expressive/receptive vocabulary. Our findings show that ASLT results in significantly greater improvement of vocabulary measures, thus providing direct evidence of water-based intervention's beneficial effects on language skills in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04629-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Brief Report: Speech and Language Therapy in Children with ASD in an Aquatic Environment: the ASLT (Aquatic Speech and Language Therapy) Program [texte imprimé] / Stamatis SOURVINOS, Auteur ; Aris MAVROPOULOS, Auteur ; Dimitrios S. KASSELIMIS, Auteur ; Andriani KORASIDI, Auteur ; Alexandra-Labrini VOUKOUNI, Auteur ; Panagiotis PAPADOPOULOS, Auteur ; Spyridon VLASEROS, Auteur ; Georgios DAMIANOS, Auteur ; Constantin POTAGAS, Auteur ; Demosthenes DAMIANOS, Auteur . - p.1406-1416. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-4 (April 2021) . - p.1406-1416 Mots-clés : Autism spectrum disorder  Expressive vocabulary  Receptive vocabulary  Speech and language therapy  Water-based intervention Index. décimale : PER Périodiques Résumé : Although water-based approaches have been shown to be beneficial for children with Autism Spectrum Disorder (ASD), no study thus far has directly investigated the effects of such intervention programs on language skills. The present study aims to evaluate the efficacy of the Aquatic Speech and Language Therapy (ASLT) program, which is a new, exclusively aquatic intervention program designed especially for children with ASD. The effects of ASLT were compared to the outcome of a similar classroom-based intervention, in two groups of children with ASD matched for age, gender, and expressive/receptive vocabulary. Our findings show that ASLT results in significantly greater improvement of vocabulary measures, thus providing direct evidence of water-based intervention's beneficial effects on language skills in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04629-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection / Edward D. LEVIN in Cognitive Brain Research, 1-3 (October 1993)

Public ISBD [article]  inCognitive Brain Research > 1-3 (October 1993) . - p.137-143 Titre : Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection Type de document : texte imprimé Auteurs : Edward D. LEVIN, Auteur ; N. Channelle CHRISTOPHER, Auteur ; Sandra J. BRIGGS, Auteur ; Jed E. ROSE, Auteur Année de publication : 1993 Article en page(s) : p.137-143 Langues : Anglais (eng) Mots-clés : Nicotine Chronic Lesion Fimbria Basalocortical-projection Memory Nicotinic-acetycholine Radial-arm-maze Index. décimale : PER Périodiques Résumé : Nicotine has been found in a variety of studies to improve performance in memory tasks. This study was conducted to determine if chronic nicotine administration is useful in counteracting the working memory deficits seen after lesions of the fimbria or the medial basalocortical projection. Rats were trained to asymptotic performance on a working memory version of the radial-arm maze. Then, they were given knife cut lesions of the fimbria or the medial basalocortical projection or underwent sham surgeries. At the time of surgery, rats in each treatment group were implanted with either nicotine-containing or placebo glass and Silastic pellets. Rats with fimbria or basalocortical lesions showed a significant decline in working memory performance. Chronic nicotine significantly improved choice accuracy in both lesioned and unlesioned rats. Nicotine treatment restored performance of the lesioned rats to control levels. These data show that in addition to improving memory performance in normal rats, nicotine can counteract lesion-induced memory impairments. Nicotine also may be useful for treatment of disease-related memory impairments such as seen in Alzheimer's disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781 [article] Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection [texte imprimé] / Edward D. LEVIN, Auteur ; N. Channelle CHRISTOPHER, Auteur ; Sandra J. BRIGGS, Auteur ; Jed E. ROSE, Auteur . - 1993 . - p.137-143. Langues : Anglais (eng) in Cognitive Brain Research > 1-3 (October 1993) . - p.137-143 Mots-clés : Nicotine Chronic Lesion Fimbria Basalocortical-projection Memory Nicotinic-acetycholine Radial-arm-maze Index. décimale : PER Périodiques Résumé : Nicotine has been found in a variety of studies to improve performance in memory tasks. This study was conducted to determine if chronic nicotine administration is useful in counteracting the working memory deficits seen after lesions of the fimbria or the medial basalocortical projection. Rats were trained to asymptotic performance on a working memory version of the radial-arm maze. Then, they were given knife cut lesions of the fimbria or the medial basalocortical projection or underwent sham surgeries. At the time of surgery, rats in each treatment group were implanted with either nicotine-containing or placebo glass and Silastic pellets. Rats with fimbria or basalocortical lesions showed a significant decline in working memory performance. Chronic nicotine significantly improved choice accuracy in both lesioned and unlesioned rats. Nicotine treatment restored performance of the lesioned rats to control levels. These data show that in addition to improving memory performance in normal rats, nicotine can counteract lesion-induced memory impairments. Nicotine also may be useful for treatment of disease-related memory impairments such as seen in Alzheimer's disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781

Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder / Bradley J. WILKES in Molecular Autism, 15 (2024)  

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Enhanced fear limits behavioral flexibility in Shank2-deficient mice / Miru YUN in Molecular Autism, 13 (2022)  

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Improving Beverage Choice in Adults with Developmental Disabilities: Implementation of a Token Reinforcement System in a Community Residential Setting / Brandon K. MAY in Journal of Autism and Developmental Disorders, 52-4 (April 2022)  

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Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis / Shuting ZHENG in Journal of Neurodevelopmental Disorders, 13 (2021)  

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Prediction of social behavior in autism spectrum disorders: Explicit versus implicit social cognition / Cara M. KEIFER in Autism, 24-7 (October 2020)  

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