12 recherche sur le mot-clé 'N400'

Auditory and Semantic Processing of Speech-in-Noise in Autism: A Behavioral and EEG Study / Jiayin LI in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2011-2030 Titre : Auditory and Semantic Processing of Speech-in-Noise in Autism: A Behavioral and EEG Study Type de document : texte imprimé Auteurs : Jiayin LI, Auteur ; Maleeha SUJAWAL, Auteur ; Zivile BERNOTAITE, Auteur ; Ian CUNNINGS, Auteur ; Fang LIU, Auteur Article en page(s) : p.2011-2030 Langues : Anglais (eng) Mots-clés : autism  N400  neural tracking  speech-in-noise  temporal response functions Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals often struggle to recognize speech in noisy environments, but the neural mechanisms behind these challenges remain unclear. Effective speech-in-noise (SiN) processing relies on auditory processing, which tracks target sounds amidst noise, and semantic processing, which further integrates relevant acoustic information to derive meaning. This study examined these two processes in autism. Thirty-one autistic and 31 non-autistic adults completed a sentence judgment task under three conditions: quiet, babble noise, and competing speech. Auditory processing was measured using EEG-derived temporal response functions (TRFs), which tracked how the brain follows speech sounds, while semantic processing was assessed via behavioral accuracy and the N400 component, a neural marker of semantic processing. Autistic participants showed reduced TRF responses and delayed N400 onset, indicating less efficient auditory processing and slower semantic processing, despite similar N400 amplitude and behavioral performance. Moreover, non-autistic participants demonstrated a trade-off between auditory and semantic processing resources. In the competing speech condition, they showed enhanced semantic integration but reduced neural tracking of auditory information when managing linguistic competition introduced by intelligible speech noise. In contrast, the autistic group showed no modulation of neural responses, suggesting reduced flexibility in adjusting auditory and semantic demands. These findings highlight distinct neural processing patterns in autistic individuals during SiN tasks, providing new insights into how atypical auditory and semantic processing shape SiN perception in autism. En ligne : https://doi.org/10.1002/aur.70097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Auditory and Semantic Processing of Speech-in-Noise in Autism: A Behavioral and EEG Study [texte imprimé] / Jiayin LI, Auteur ; Maleeha SUJAWAL, Auteur ; Zivile BERNOTAITE, Auteur ; Ian CUNNINGS, Auteur ; Fang LIU, Auteur . - p.2011-2030. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2011-2030 Mots-clés : autism  N400  neural tracking  speech-in-noise  temporal response functions Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals often struggle to recognize speech in noisy environments, but the neural mechanisms behind these challenges remain unclear. Effective speech-in-noise (SiN) processing relies on auditory processing, which tracks target sounds amidst noise, and semantic processing, which further integrates relevant acoustic information to derive meaning. This study examined these two processes in autism. Thirty-one autistic and 31 non-autistic adults completed a sentence judgment task under three conditions: quiet, babble noise, and competing speech. Auditory processing was measured using EEG-derived temporal response functions (TRFs), which tracked how the brain follows speech sounds, while semantic processing was assessed via behavioral accuracy and the N400 component, a neural marker of semantic processing. Autistic participants showed reduced TRF responses and delayed N400 onset, indicating less efficient auditory processing and slower semantic processing, despite similar N400 amplitude and behavioral performance. Moreover, non-autistic participants demonstrated a trade-off between auditory and semantic processing resources. In the competing speech condition, they showed enhanced semantic integration but reduced neural tracking of auditory information when managing linguistic competition introduced by intelligible speech noise. In contrast, the autistic group showed no modulation of neural responses, suggesting reduced flexibility in adjusting auditory and semantic demands. These findings highlight distinct neural processing patterns in autistic individuals during SiN tasks, providing new insights into how atypical auditory and semantic processing shape SiN perception in autism. En ligne : https://doi.org/10.1002/aur.70097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Autistic Adults are Not Impaired at Maintaining or Switching Between Counterfactual and Factual Worlds: An ERP Study / Heather J. FERGUSON in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.349-360 Titre : Autistic Adults are Not Impaired at Maintaining or Switching Between Counterfactual and Factual Worlds: An ERP Study Type de document : texte imprimé Auteurs : Heather J. FERGUSON, Auteur ; Lena WIMMER, Auteur ; Jo BLACK, Auteur ; Mahsa BARZY, Auteur ; David WILLIAMS, Auteur Article en page(s) : p.349-360 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Brain  Comprehension  Evoked Potentials  Humans  Reading  Autism  Counterfactuals  Event-related potentials  Language comprehension  N400 Index. décimale : PER Périodiques Résumé : We report an event-related brain potential (ERP) experiment that tests whether autistic adults are able to maintain and switch between counterfactual and factual worlds. Participants (N = 48) read scenarios that set up a factual or counterfactual scenario, then either maintained the counterfactual world or switched back to the factual world. When the context maintained the world, participants showed appropriate detection of the inconsistent critical word. In contrast, when participants had to switch from a counterfactual to factual world, they initially experienced interference from the counterfactual context, then favoured the factual interpretation of events. None of these effects were modulated by group, despite group-level impairments in Theory of Mind and cognitive flexibility among the autistic adults. These results demonstrate that autistic adults can appropriately use complex contextual cues to maintain and/or update mental representations of counterfactual and factual events. En ligne : http://dx.doi.org/10.1007/s10803-021-04939-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Autistic Adults are Not Impaired at Maintaining or Switching Between Counterfactual and Factual Worlds: An ERP Study [texte imprimé] / Heather J. FERGUSON, Auteur ; Lena WIMMER, Auteur ; Jo BLACK, Auteur ; Mahsa BARZY, Auteur ; David WILLIAMS, Auteur . - p.349-360. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.349-360 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Brain  Comprehension  Evoked Potentials  Humans  Reading  Autism  Counterfactuals  Event-related potentials  Language comprehension  N400 Index. décimale : PER Périodiques Résumé : We report an event-related brain potential (ERP) experiment that tests whether autistic adults are able to maintain and switch between counterfactual and factual worlds. Participants (N = 48) read scenarios that set up a factual or counterfactual scenario, then either maintained the counterfactual world or switched back to the factual world. When the context maintained the world, participants showed appropriate detection of the inconsistent critical word. In contrast, when participants had to switch from a counterfactual to factual world, they initially experienced interference from the counterfactual context, then favoured the factual interpretation of events. None of these effects were modulated by group, despite group-level impairments in Theory of Mind and cognitive flexibility among the autistic adults. These results demonstrate that autistic adults can appropriately use complex contextual cues to maintain and/or update mental representations of counterfactual and factual events. En ligne : http://dx.doi.org/10.1007/s10803-021-04939-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Implicit Semantic Processing of Linguistic and Non-linguistic Stimuli in Adults with Autism Spectrum Disorder / Emme O'ROURKE in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2611-2630 Titre : Implicit Semantic Processing of Linguistic and Non-linguistic Stimuli in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Emme O'ROURKE, Auteur ; Emily L. CODERRE, Auteur Article en page(s) : p.2611-2630 Langues : Anglais (eng) Mots-clés : Acoustic Stimulation/psychology  Adolescent  Adult  Autism Spectrum Disorder/physiopathology/psychology  Autistic Disorder  Electroencephalography  Evoked Potentials/physiology  Humans  Language  Male  Semantics  Autism  Event-related potentials  N400  Semantic integration Index. décimale : PER Périodiques Résumé : While many individuals with autism spectrum disorder (ASD) experience difficulties with language processing, non-linguistic semantic processing may be intact. We examined neural responses to an implicit semantic priming task by comparing N400 responses-an event-related potential related to semantic processing-in response to semantically related or unrelated pairs of words or pictures. Adults with ASD showed larger N400 responses than typically developing adults for pictures, but no group differences occurred for words. However, we also observed complex modulations of N400 amplitude by age and by level of autistic traits. These results offer important implications for how groups are delineated and compared in autism research. En ligne : http://dx.doi.org/10.1007/s10803-020-04736-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Implicit Semantic Processing of Linguistic and Non-linguistic Stimuli in Adults with Autism Spectrum Disorder [texte imprimé] / Emme O'ROURKE, Auteur ; Emily L. CODERRE, Auteur . - p.2611-2630. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2611-2630 Mots-clés : Acoustic Stimulation/psychology  Adolescent  Adult  Autism Spectrum Disorder/physiopathology/psychology  Autistic Disorder  Electroencephalography  Evoked Potentials/physiology  Humans  Language  Male  Semantics  Autism  Event-related potentials  N400  Semantic integration Index. décimale : PER Périodiques Résumé : While many individuals with autism spectrum disorder (ASD) experience difficulties with language processing, non-linguistic semantic processing may be intact. We examined neural responses to an implicit semantic priming task by comparing N400 responses-an event-related potential related to semantic processing-in response to semantically related or unrelated pairs of words or pictures. Adults with ASD showed larger N400 responses than typically developing adults for pictures, but no group differences occurred for words. However, we also observed complex modulations of N400 amplitude by age and by level of autistic traits. These results offer important implications for how groups are delineated and compared in autism research. En ligne : http://dx.doi.org/10.1007/s10803-020-04736-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Neural patterns elicited by lexical processing in adolescents with specific language impairment: support for the procedural deficit hypothesis? / Julia L. EVANS in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Neural patterns elicited by lexical processing in adolescents with specific language impairment: support for the procedural deficit hypothesis? Type de document : texte imprimé Auteurs : Julia L. EVANS, Auteur ; Mandy J. MAGUIRE, Auteur ; Marisa L. SIZEMORE, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Electroencephalography  Evoked Potentials  Female  Humans  Language Development Disorders  Language Tests  Male  Specific Language Disorder  Developmental language disorder (DLD)  Event-related potentials  Imageability  N400  N700  Procedural deficit hypothesis  Procedural memory  Semantic processing  Specific language impairment (SLI)  Spoken word processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in procedural memory have been proposed to account for the language deficits in specific language impairment (SLI). A key aspect of the procedural deficit hypothesis (PDH) account of SLI is that declarative memory is intact and functions as a compensatory mechanism in the acquisition of language in individuals with SLI. The current study examined the neural correlates of lexical-phonological and lexical-semantic processing with respect to these predictions in a group of adolescents with SLI with procedural memory impairment and a group of chronologically age-matched (CA) normal controls. METHODS: Participants completed tasks designed to measure procedural and declarative memory and two ERP tasks designed to assess lexical-semantic and lexical-phonological processing in the auditory modality. Procedural memory was assessed using a statistical learning task. Lexical-semantic processing was assessed using a sentence judgment task modulating semantic congruency and lexical-phonological processing was assessed using a word/nonword decision task modulating word frequency. Behavioral performance on the tasks, mean amplitude of the cortical response, and animated topographs were examined. RESULTS: Performance on the statistical word-learning task was at chance for the adolescents with SLI, whereas declarative memory was no different from the CA controls. Behavioral accuracy on the lexical-semantic task was the same for the adolescents with SLI and CA controls but accuracy on the lexical-phonological task was significantly poorer for the adolescents with SLI as compared to the CA controls. An N400 component was elicited in response to semantic congruency on the lexical-semantic task for both groups but differences were noted in both the location and time course of the cortical response for the SLI and CA groups. An N400 component was elicited by word frequency on the lexical-phonological task for the CA controls not for the adolescents with SLI. In contrast, post hoc analysis revealed a cortical response based on imageability for the adolescents with SLI, but not CA controls. Statistical word learning was significantly correlated with speed of processing on the lexical decision task for the CA controls but not for the adolescents with SLI. In contrast, statistical word learning ability was not correlated with the modulation of the N400 on either task for either group. CONCLUSION: The behavioral data suggests intact semantic conceptual knowledge, but impaired lexical phonological processing for the adolescents with SLI, consistent with the PDH. The pattern of cortical activation in response to semantic congruency and word frequency suggests, however, that the processing of lexical-semantic and lexical-phonological information by adolescents with a history of SLI may be supported by both overlapping and nonoverlapping neural generators to those of CA controls, and a greater reliance on declarative memory strategies. Taken together, the findings from this study suggest that the underlying representations of words in the lexicons of adolescents with a history of SLI may differ qualitatively from those of their typical peers, but these differences may only be evident when behavioral data and neural cortical patterns of activation are examined together. En ligne : https://dx.doi.org/10.1186/s11689-022-09419-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Neural patterns elicited by lexical processing in adolescents with specific language impairment: support for the procedural deficit hypothesis? [texte imprimé] / Julia L. EVANS, Auteur ; Mandy J. MAGUIRE, Auteur ; Marisa L. SIZEMORE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Adolescent  Electroencephalography  Evoked Potentials  Female  Humans  Language Development Disorders  Language Tests  Male  Specific Language Disorder  Developmental language disorder (DLD)  Event-related potentials  Imageability  N400  N700  Procedural deficit hypothesis  Procedural memory  Semantic processing  Specific language impairment (SLI)  Spoken word processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in procedural memory have been proposed to account for the language deficits in specific language impairment (SLI). A key aspect of the procedural deficit hypothesis (PDH) account of SLI is that declarative memory is intact and functions as a compensatory mechanism in the acquisition of language in individuals with SLI. The current study examined the neural correlates of lexical-phonological and lexical-semantic processing with respect to these predictions in a group of adolescents with SLI with procedural memory impairment and a group of chronologically age-matched (CA) normal controls. METHODS: Participants completed tasks designed to measure procedural and declarative memory and two ERP tasks designed to assess lexical-semantic and lexical-phonological processing in the auditory modality. Procedural memory was assessed using a statistical learning task. Lexical-semantic processing was assessed using a sentence judgment task modulating semantic congruency and lexical-phonological processing was assessed using a word/nonword decision task modulating word frequency. Behavioral performance on the tasks, mean amplitude of the cortical response, and animated topographs were examined. RESULTS: Performance on the statistical word-learning task was at chance for the adolescents with SLI, whereas declarative memory was no different from the CA controls. Behavioral accuracy on the lexical-semantic task was the same for the adolescents with SLI and CA controls but accuracy on the lexical-phonological task was significantly poorer for the adolescents with SLI as compared to the CA controls. An N400 component was elicited in response to semantic congruency on the lexical-semantic task for both groups but differences were noted in both the location and time course of the cortical response for the SLI and CA groups. An N400 component was elicited by word frequency on the lexical-phonological task for the CA controls not for the adolescents with SLI. In contrast, post hoc analysis revealed a cortical response based on imageability for the adolescents with SLI, but not CA controls. Statistical word learning was significantly correlated with speed of processing on the lexical decision task for the CA controls but not for the adolescents with SLI. In contrast, statistical word learning ability was not correlated with the modulation of the N400 on either task for either group. CONCLUSION: The behavioral data suggests intact semantic conceptual knowledge, but impaired lexical phonological processing for the adolescents with SLI, consistent with the PDH. The pattern of cortical activation in response to semantic congruency and word frequency suggests, however, that the processing of lexical-semantic and lexical-phonological information by adolescents with a history of SLI may be supported by both overlapping and nonoverlapping neural generators to those of CA controls, and a greater reliance on declarative memory strategies. Taken together, the findings from this study suggest that the underlying representations of words in the lexicons of adolescents with a history of SLI may differ qualitatively from those of their typical peers, but these differences may only be evident when behavioral data and neural cortical patterns of activation are examined together. En ligne : https://dx.doi.org/10.1186/s11689-022-09419-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Neural patterns elicited by sentence processing uniquely characterize typical development, SLI recovery, and SLI persistence / Eileen HAEBIG in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.22 Titre : Neural patterns elicited by sentence processing uniquely characterize typical development, SLI recovery, and SLI persistence Type de document : texte imprimé Auteurs : Eileen HAEBIG, Auteur ; Christine WEBER, Auteur ; Laurence B. LEONARD, Auteur ; Patricia DEEVY, Auteur ; J. Bruce TOMBLIN, Auteur Année de publication : 2017 Article en page(s) : p.22 Langues : Anglais (eng) Mots-clés : Event-related brain potentials  Language trajectories  N400  P600  Sentence processing  Specific language impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: A substantial amount of work has examined language abilities in young children with specific language impairment (SLI); however, our understanding of the developmental trajectory of language impairment is limited. Along with studying the behavioral changes that occur across development, it is important to examine the neural indices of language processing for children with different language trajectories. The current study sought to examine behavioral and neural bases of language processing in adolescents showing three different trajectories: those with normal language development (NL), those exhibiting persistent SLI (SLI-Persistent), and those with a history of SLI who appear to have recovered (SLI-Recovered). METHODS: Through a sentence judgment task, we examined semantic and syntactic processing. Adolescents judged whether or not each sentence was semantically and syntactically correct. Stimuli consisted of naturally spoken sentences that were either correct, contained a semantic verb error, or contained a syntactic verb agreement error. Verb agreement errors consisted of omission and commission violations of the third-person singular -s. Behavioral button-press responses and electroencephalographic recordings were collected. Behavioral judgments and mean amplitude of the N400 and P600 components were examined. RESULTS: Adolescents in the SLI-Persistent group had lower sentence judgment accuracy overall, relative to the NL and SLI-Recovered groups. Accuracy in judging omission and commission syntactic errors were marginally different, with marginally lower accuracy for commission errors. All groups demonstrated an N400 component elicited by semantic violations. However, adolescents in the SLI-Persistent group demonstrated a less robust P600 component for syntactic violations. Furthermore, adolescents in the SLI-Recovered group exhibited a similar neural profile to the NL group for the semantic and syntactic omission violations. However, a unique profile with initial negativity was observed in the SLI-Recovered group in the commission violation condition. CONCLUSIONS: Adolescents with persistent language impairment continue to demonstrate delays in language processing at the behavioral and neural levels. Conversely, the adolescents in the SLI-Recovered group appear to have made gains in language processing skills to overcome their initial impairments. However, our findings suggest that the adolescents in the SLI-Recovered group may have compensatory processing strategies for some aspects of language, as evidenced by a unique event-related potential profile. En ligne : http://dx.doi.org/10.1186/s11689-017-9201-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Neural patterns elicited by sentence processing uniquely characterize typical development, SLI recovery, and SLI persistence [texte imprimé] / Eileen HAEBIG, Auteur ; Christine WEBER, Auteur ; Laurence B. LEONARD, Auteur ; Patricia DEEVY, Auteur ; J. Bruce TOMBLIN, Auteur . - 2017 . - p.22. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.22 Mots-clés : Event-related brain potentials  Language trajectories  N400  P600  Sentence processing  Specific language impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: A substantial amount of work has examined language abilities in young children with specific language impairment (SLI); however, our understanding of the developmental trajectory of language impairment is limited. Along with studying the behavioral changes that occur across development, it is important to examine the neural indices of language processing for children with different language trajectories. The current study sought to examine behavioral and neural bases of language processing in adolescents showing three different trajectories: those with normal language development (NL), those exhibiting persistent SLI (SLI-Persistent), and those with a history of SLI who appear to have recovered (SLI-Recovered). METHODS: Through a sentence judgment task, we examined semantic and syntactic processing. Adolescents judged whether or not each sentence was semantically and syntactically correct. Stimuli consisted of naturally spoken sentences that were either correct, contained a semantic verb error, or contained a syntactic verb agreement error. Verb agreement errors consisted of omission and commission violations of the third-person singular -s. Behavioral button-press responses and electroencephalographic recordings were collected. Behavioral judgments and mean amplitude of the N400 and P600 components were examined. RESULTS: Adolescents in the SLI-Persistent group had lower sentence judgment accuracy overall, relative to the NL and SLI-Recovered groups. Accuracy in judging omission and commission syntactic errors were marginally different, with marginally lower accuracy for commission errors. All groups demonstrated an N400 component elicited by semantic violations. However, adolescents in the SLI-Persistent group demonstrated a less robust P600 component for syntactic violations. Furthermore, adolescents in the SLI-Recovered group exhibited a similar neural profile to the NL group for the semantic and syntactic omission violations. However, a unique profile with initial negativity was observed in the SLI-Recovered group in the commission violation condition. CONCLUSIONS: Adolescents with persistent language impairment continue to demonstrate delays in language processing at the behavioral and neural levels. Conversely, the adolescents in the SLI-Recovered group appear to have made gains in language processing skills to overcome their initial impairments. However, our findings suggest that the adolescents in the SLI-Recovered group may have compensatory processing strategies for some aspects of language, as evidenced by a unique event-related potential profile. En ligne : http://dx.doi.org/10.1186/s11689-017-9201-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Neural systems mediating processing of sound units of language distinguish recovery versus persistence in stuttering / Ranjini MOHAN in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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Neurodevelopment for syntactic processing distinguishes childhood stuttering recovery versus persistence / Evan USLER in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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Visual and Verbal Narrative Comprehension in Children and Adolescents with Autism Spectrum Disorders: An ERP Study / Mirella MANFREDI in Journal of Autism and Developmental Disorders, 50-8 (August 2020)  

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Event-related brain potentials during natural speech processing: effects of semantic, morphological and syntactic violations / Angela D. FRIEDERICI in Cognitive Brain Research, 1-3 (October 1993)

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Event-related potentials and repetition priming in young, middle-aged and elderly normal subjects / Frini KARAYANIDIS in Cognitive Brain Research, 1-2 (April 1993)

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