8 recherche sur le mot-clé 'Nicotine'

Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder / Gerrit I. VAN SCHALKWYK in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066 Titre : Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur Article en page(s) : p.3061-3066 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental disorder  Aggression  Irritability  Nicotine  Nicotine patch  Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder [texte imprimé] / Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur . - p.3061-3066. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066 Mots-clés : Autism spectrum disorder  Developmental disorder  Aggression  Irritability  Nicotine  Nicotine patch  Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder / Alan S. LEWIS in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Titre : An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; Marina R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.2748-2757 Langues : Anglais (eng) Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder [texte imprimé] / Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; Marina R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.2748-2757. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection / Edward D. LEVIN in Cognitive Brain Research, 1-3 (October 1993)

Public ISBD [article]  inCognitive Brain Research > 1-3 (October 1993) . - p.137-143 Titre : Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection Type de document : texte imprimé Auteurs : Edward D. LEVIN, Auteur ; N. Channelle CHRISTOPHER, Auteur ; Sandra J. BRIGGS, Auteur ; Jed E. ROSE, Auteur Année de publication : 1993 Article en page(s) : p.137-143 Langues : Anglais (eng) Mots-clés : Nicotine Chronic Lesion Fimbria Basalocortical-projection Memory Nicotinic-acetycholine Radial-arm-maze Index. décimale : PER Périodiques Résumé : Nicotine has been found in a variety of studies to improve performance in memory tasks. This study was conducted to determine if chronic nicotine administration is useful in counteracting the working memory deficits seen after lesions of the fimbria or the medial basalocortical projection. Rats were trained to asymptotic performance on a working memory version of the radial-arm maze. Then, they were given knife cut lesions of the fimbria or the medial basalocortical projection or underwent sham surgeries. At the time of surgery, rats in each treatment group were implanted with either nicotine-containing or placebo glass and Silastic pellets. Rats with fimbria or basalocortical lesions showed a significant decline in working memory performance. Chronic nicotine significantly improved choice accuracy in both lesioned and unlesioned rats. Nicotine treatment restored performance of the lesioned rats to control levels. These data show that in addition to improving memory performance in normal rats, nicotine can counteract lesion-induced memory impairments. Nicotine also may be useful for treatment of disease-related memory impairments such as seen in Alzheimer's disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781 [article] Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection [texte imprimé] / Edward D. LEVIN, Auteur ; N. Channelle CHRISTOPHER, Auteur ; Sandra J. BRIGGS, Auteur ; Jed E. ROSE, Auteur . - 1993 . - p.137-143. Langues : Anglais (eng) in Cognitive Brain Research > 1-3 (October 1993) . - p.137-143 Mots-clés : Nicotine Chronic Lesion Fimbria Basalocortical-projection Memory Nicotinic-acetycholine Radial-arm-maze Index. décimale : PER Périodiques Résumé : Nicotine has been found in a variety of studies to improve performance in memory tasks. This study was conducted to determine if chronic nicotine administration is useful in counteracting the working memory deficits seen after lesions of the fimbria or the medial basalocortical projection. Rats were trained to asymptotic performance on a working memory version of the radial-arm maze. Then, they were given knife cut lesions of the fimbria or the medial basalocortical projection or underwent sham surgeries. At the time of surgery, rats in each treatment group were implanted with either nicotine-containing or placebo glass and Silastic pellets. Rats with fimbria or basalocortical lesions showed a significant decline in working memory performance. Chronic nicotine significantly improved choice accuracy in both lesioned and unlesioned rats. Nicotine treatment restored performance of the lesioned rats to control levels. These data show that in addition to improving memory performance in normal rats, nicotine can counteract lesion-induced memory impairments. Nicotine also may be useful for treatment of disease-related memory impairments such as seen in Alzheimer's disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781

Do traumatic events and substance use co-occur during adolescence? Testing three causal etiologic hypotheses / Susan F. TAPERT ; Sandra A. BROWN ; Sonya B. NORMAN ; William E. PELHAM III in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1388-1397 Titre : Do traumatic events and substance use co-occur during adolescence? Testing three causal etiologic hypotheses Type de document : texte imprimé Auteurs : Susan F. TAPERT, Auteur ; Sandra A. BROWN, Auteur ; Sonya B. NORMAN, Auteur ; William E. PELHAM III, Auteur Article en page(s) : p.1388-1397 Langues : Anglais (eng) Mots-clés : Trauma  childhood  adolescence  alcohol  cannabis  nicotine  etiology  self-medication  susceptibility  shared liability Index. décimale : PER Périodiques Résumé : Background Why do potentially traumatic events (PTEs) and substance use (SU) so commonly co-occur during adolescence? Causal hypotheses developed from the study of posttraumatic stress disorder (PTSD) and substance use disorder (SUD) among adults have not yet been subject to rigorous theoretical analysis or empirical tests among adolescents with the precursors to these disorders: PTEs and SU. Establishing causality demands accounting for various factors (e.g. genetics, parent education, race/ethnicity) that distinguish youth endorsing PTEs and SU from those who do not, a step often overlooked in previous research. Methods We leveraged nationwide data from a sociodemographically diverse sample of youth (N 11,468) in the Adolescent Brain and Cognitive Development Study. PTEs and substance use prevalence were assessed annually. To account for the many pre-existing differences between youth with and without PTE/SU (i.e. confounding bias) and provide rigorous tests of causal hypotheses, we linked within-person changes in PTEs and SU (alcohol, cannabis, nicotine) across repeated measurements and adjusted for time-varying factors (e.g. age, internalizing symptoms, externalizing symptoms, and friends' use of substances). Results Before adjusting for confounding using within-person modeling, PTEs and SU exhibited significant concurrent associations (?s .46 1.26, ps < .05) and PTEs prospectively predicted greater SU (?s .55 1.43, ps < .05) but not vice versa. After adjustment for confounding, the PTEs exhibited significant concurrent associations for alcohol (?s .14 .23, ps < .05) and nicotine (?s .16, ps < .05) but not cannabis (?s -.01, ps > .05) and PTEs prospectively predicted greater SU (?s .28 .55, ps > .05) but not vice versa. Conclusions When tested rigorously in a nationwide sample of adolescents, we find support for a model in which PTEs are followed by SU but not for a model in which SU is followed by PTEs. Explanations for why PTSD and SUD co-occur in adults may need further theoretical analysis and adaptation before extension to adolescents. En ligne : https://doi.org/10.1111/jcpp.13985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Do traumatic events and substance use co-occur during adolescence? Testing three causal etiologic hypotheses [texte imprimé] / Susan F. TAPERT, Auteur ; Sandra A. BROWN, Auteur ; Sonya B. NORMAN, Auteur ; William E. PELHAM III, Auteur . - p.1388-1397. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1388-1397 Mots-clés : Trauma  childhood  adolescence  alcohol  cannabis  nicotine  etiology  self-medication  susceptibility  shared liability Index. décimale : PER Périodiques Résumé : Background Why do potentially traumatic events (PTEs) and substance use (SU) so commonly co-occur during adolescence? Causal hypotheses developed from the study of posttraumatic stress disorder (PTSD) and substance use disorder (SUD) among adults have not yet been subject to rigorous theoretical analysis or empirical tests among adolescents with the precursors to these disorders: PTEs and SU. Establishing causality demands accounting for various factors (e.g. genetics, parent education, race/ethnicity) that distinguish youth endorsing PTEs and SU from those who do not, a step often overlooked in previous research. Methods We leveraged nationwide data from a sociodemographically diverse sample of youth (N 11,468) in the Adolescent Brain and Cognitive Development Study. PTEs and substance use prevalence were assessed annually. To account for the many pre-existing differences between youth with and without PTE/SU (i.e. confounding bias) and provide rigorous tests of causal hypotheses, we linked within-person changes in PTEs and SU (alcohol, cannabis, nicotine) across repeated measurements and adjusted for time-varying factors (e.g. age, internalizing symptoms, externalizing symptoms, and friends' use of substances). Results Before adjusting for confounding using within-person modeling, PTEs and SU exhibited significant concurrent associations (?s .46 1.26, ps < .05) and PTEs prospectively predicted greater SU (?s .55 1.43, ps < .05) but not vice versa. After adjustment for confounding, the PTEs exhibited significant concurrent associations for alcohol (?s .14 .23, ps < .05) and nicotine (?s .16, ps < .05) but not cannabis (?s -.01, ps > .05) and PTEs prospectively predicted greater SU (?s .28 .55, ps > .05) but not vice versa. Conclusions When tested rigorously in a nationwide sample of adolescents, we find support for a model in which PTEs are followed by SU but not for a model in which SU is followed by PTEs. Explanations for why PTSD and SUD co-occur in adults may need further theoretical analysis and adaptation before extension to adolescents. En ligne : https://doi.org/10.1111/jcpp.13985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Neurocognitive predictors of substance use disorders and nicotine dependence in ADHD probands, their unaffected siblings, and controls: a 4-year prospective follow-up / Annabeth P. GROENMAN in Journal of Child Psychology and Psychiatry, 56-5 (May 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.521-529 Titre : Neurocognitive predictors of substance use disorders and nicotine dependence in ADHD probands, their unaffected siblings, and controls: a 4-year prospective follow-up Type de document : texte imprimé Auteurs : Annabeth P. GROENMAN, Auteur ; Jaap OOSTERLAAN, Auteur ; Corina U. GREVEN, Auteur ; Pieter Jelle VUIJK, Auteur ; Nanda N. ROMMELSE, Auteur ; Barbara FRANKE, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Joseph SERGEANT, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.521-529 Langues : Anglais (eng) Mots-clés : Attention-deficit/Hyperactivity disorder  substance use disorder  nicotine dependence  neurocognitive functions Index. décimale : PER Périodiques Résumé : Background Attention-Deficit/Hyperactivity Disorder (ADHD) is a risk factor for substance use disorders (SUDs) and nicotine dependence (ND). Neurocognitive deficits may predict the increased risk of developing SUDs and nicotine dependence. Methods This study comprised three groups derived from the Dutch part of the International Multicenter ADHD Genetics (IMAGE) study: ADHD probands (n = 294), unaffected siblings (n = 161), and controls (n = 214). At baseline (age = 12.2), a range of neurocognitive functions was assessed including executive functions (inhibition, working memory, timing), measures of motor functioning (motor timing and tracking) and IQ. After a mean follow-up of 4.2 years, SUDs and ND were assessed. Results None of the neurocognitive functions predicted later SUDs or ND in ADHD probands, even after controlling for medication use and conduct disorder. Slower response inhibition predicted later nicotine dependence in unaffected siblings (OR = 2.06, 95% CI = 1.22–3.48), and lower IQ predicted increased risk for SUDs in controls (OR = 1.96, 95% CI = 1.12–3.44). Conclusions Cold executive functions, motor functioning, and IQ did not predict the elevated risk of SUDs and ND in ADHD. Future studies should target ‘hot’ executive functions such as reward processing as risk factors for SUDs or ND. En ligne : http://dx.doi.org/10.1111/jcpp.12315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Neurocognitive predictors of substance use disorders and nicotine dependence in ADHD probands, their unaffected siblings, and controls: a 4-year prospective follow-up [texte imprimé] / Annabeth P. GROENMAN, Auteur ; Jaap OOSTERLAAN, Auteur ; Corina U. GREVEN, Auteur ; Pieter Jelle VUIJK, Auteur ; Nanda N. ROMMELSE, Auteur ; Barbara FRANKE, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Joseph SERGEANT, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur . - p.521-529. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.521-529 Mots-clés : Attention-deficit/Hyperactivity disorder  substance use disorder  nicotine dependence  neurocognitive functions Index. décimale : PER Périodiques Résumé : Background Attention-Deficit/Hyperactivity Disorder (ADHD) is a risk factor for substance use disorders (SUDs) and nicotine dependence (ND). Neurocognitive deficits may predict the increased risk of developing SUDs and nicotine dependence. Methods This study comprised three groups derived from the Dutch part of the International Multicenter ADHD Genetics (IMAGE) study: ADHD probands (n = 294), unaffected siblings (n = 161), and controls (n = 214). At baseline (age = 12.2), a range of neurocognitive functions was assessed including executive functions (inhibition, working memory, timing), measures of motor functioning (motor timing and tracking) and IQ. After a mean follow-up of 4.2 years, SUDs and ND were assessed. Results None of the neurocognitive functions predicted later SUDs or ND in ADHD probands, even after controlling for medication use and conduct disorder. Slower response inhibition predicted later nicotine dependence in unaffected siblings (OR = 2.06, 95% CI = 1.22–3.48), and lower IQ predicted increased risk for SUDs in controls (OR = 1.96, 95% CI = 1.12–3.44). Conclusions Cold executive functions, motor functioning, and IQ did not predict the elevated risk of SUDs and ND in ADHD. Future studies should target ‘hot’ executive functions such as reward processing as risk factors for SUDs or ND. En ligne : http://dx.doi.org/10.1111/jcpp.12315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Substance use and nicotine dependence in persistent, remittent, and late-onset ADHD: a 10-year longitudinal study from childhood to young adulthood / Shahrzad ILBEGI in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model / Hafiz M. MAHMOOD in Autism Research, 13-8 (August 2020)  

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Risk and protective factors for nicotine dependence in adolescence / Mei-Chen HU in Journal of Child Psychology and Psychiatry, 52-10 (October 2011)  

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