6 recherche sur le mot-clé 'Nicotinic-acetycholine'

Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection / Edward D. LEVIN in Cognitive Brain Research, 1-3 (October 1993)

Public ISBD [article]  inCognitive Brain Research > 1-3 (October 1993) . - p.137-143 Titre : Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection Type de document : texte imprimé Auteurs : Edward D. LEVIN, Auteur ; N. Channelle CHRISTOPHER, Auteur ; Sandra J. BRIGGS, Auteur ; Jed E. ROSE, Auteur Année de publication : 1993 Article en page(s) : p.137-143 Langues : Anglais (eng) Mots-clés : Nicotine Chronic Lesion Fimbria Basalocortical-projection Memory Nicotinic-acetycholine Radial-arm-maze Index. décimale : PER Périodiques Résumé : Nicotine has been found in a variety of studies to improve performance in memory tasks. This study was conducted to determine if chronic nicotine administration is useful in counteracting the working memory deficits seen after lesions of the fimbria or the medial basalocortical projection. Rats were trained to asymptotic performance on a working memory version of the radial-arm maze. Then, they were given knife cut lesions of the fimbria or the medial basalocortical projection or underwent sham surgeries. At the time of surgery, rats in each treatment group were implanted with either nicotine-containing or placebo glass and Silastic pellets. Rats with fimbria or basalocortical lesions showed a significant decline in working memory performance. Chronic nicotine significantly improved choice accuracy in both lesioned and unlesioned rats. Nicotine treatment restored performance of the lesioned rats to control levels. These data show that in addition to improving memory performance in normal rats, nicotine can counteract lesion-induced memory impairments. Nicotine also may be useful for treatment of disease-related memory impairments such as seen in Alzheimer's disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781 [article] Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection [texte imprimé] / Edward D. LEVIN, Auteur ; N. Channelle CHRISTOPHER, Auteur ; Sandra J. BRIGGS, Auteur ; Jed E. ROSE, Auteur . - 1993 . - p.137-143. Langues : Anglais (eng) in Cognitive Brain Research > 1-3 (October 1993) . - p.137-143 Mots-clés : Nicotine Chronic Lesion Fimbria Basalocortical-projection Memory Nicotinic-acetycholine Radial-arm-maze Index. décimale : PER Périodiques Résumé : Nicotine has been found in a variety of studies to improve performance in memory tasks. This study was conducted to determine if chronic nicotine administration is useful in counteracting the working memory deficits seen after lesions of the fimbria or the medial basalocortical projection. Rats were trained to asymptotic performance on a working memory version of the radial-arm maze. Then, they were given knife cut lesions of the fimbria or the medial basalocortical projection or underwent sham surgeries. At the time of surgery, rats in each treatment group were implanted with either nicotine-containing or placebo glass and Silastic pellets. Rats with fimbria or basalocortical lesions showed a significant decline in working memory performance. Chronic nicotine significantly improved choice accuracy in both lesioned and unlesioned rats. Nicotine treatment restored performance of the lesioned rats to control levels. These data show that in addition to improving memory performance in normal rats, nicotine can counteract lesion-induced memory impairments. Nicotine also may be useful for treatment of disease-related memory impairments such as seen in Alzheimer's disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781

An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder / Alan S. LEWIS in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Titre : An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; Marina R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.2748-2757 Langues : Anglais (eng) Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder [texte imprimé] / Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; Marina R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.2748-2757. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder / Ann OLINCY in Journal of Autism and Developmental Disorders, 46-12 (December 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3812-3817 Titre : Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Ann OLINCY, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Lynn JOHNSON, Auteur ; William R. KEM, Auteur ; Robert FREEDMAN, Auteur Article en page(s) : p.3812-3817 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Attention  Sensory gating  Receptors nicotinic Index. décimale : PER Périodiques Résumé : Abnormalities in CHRNA7, the alpha7-nicotinic receptor gene, have been reported in autism spectrum disorder. These genetic abnormalities potentially decrease the receptor’s expression and diminish its functional role. This double-blind, placebo-controlled crossover study in two adult patients investigated whether an investigational receptor-specific partial agonist drug would increase the inhibitory functions of the gene and thereby increase patients’ attention. An electrophysiological biomarker, P50 inhibition, verified the intended neurobiological effect of the agonist, and neuropsychological testing verified a primary cognitive effect. Both patients perceived increased attention in their self-ratings. Alpha7-nicotinic receptor agonists, currently the target of drug development in schizophrenia and Alzheimer Disease, may also have positive clinical effects in autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2890-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder [texte imprimé] / Ann OLINCY, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Lynn JOHNSON, Auteur ; William R. KEM, Auteur ; Robert FREEDMAN, Auteur . - p.3812-3817. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3812-3817 Mots-clés : Autism spectrum disorder  Attention  Sensory gating  Receptors nicotinic Index. décimale : PER Périodiques Résumé : Abnormalities in CHRNA7, the alpha7-nicotinic receptor gene, have been reported in autism spectrum disorder. These genetic abnormalities potentially decrease the receptor’s expression and diminish its functional role. This double-blind, placebo-controlled crossover study in two adult patients investigated whether an investigational receptor-specific partial agonist drug would increase the inhibitory functions of the gene and thereby increase patients’ attention. An electrophysiological biomarker, P50 inhibition, verified the intended neurobiological effect of the agonist, and neuropsychological testing verified a primary cognitive effect. Both patients perceived increased attention in their self-ratings. Alpha7-nicotinic receptor agonists, currently the target of drug development in schizophrenia and Alzheimer Disease, may also have positive clinical effects in autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2890-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Direct G Protein Activation of Ion Channels? / David E. CLAPHAM in Annual Review of Neuroscience, 17 (1994)

Public ISBD [article]  inAnnual Review of Neuroscience > 17 (1994) . - p.441-464 Titre : Direct G Protein Activation of Ion Channels? Type de document : texte imprimé Auteurs : David E. CLAPHAM, Auteur Année de publication : 1994 Article en page(s) : p.441-464 Langues : Anglais (eng) Mots-clés : Ion-channels Patch-clamp Muscarinic-gated-potassium-channel G-beta-gamma G-alpha Calcium-channels Acetycholine Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=375 [article] Direct G Protein Activation of Ion Channels? [texte imprimé] / David E. CLAPHAM, Auteur . - 1994 . - p.441-464. Langues : Anglais (eng) in Annual Review of Neuroscience > 17 (1994) . - p.441-464 Mots-clés : Ion-channels Patch-clamp Muscarinic-gated-potassium-channel G-beta-gamma G-alpha Calcium-channels Acetycholine Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=375

Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder / Gerrit I. VAN SCHALKWYK in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066 Titre : Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur Article en page(s) : p.3061-3066 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental disorder  Aggression  Irritability  Nicotine  Nicotine patch  Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder [texte imprimé] / Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur . - p.3061-3066. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066 Mots-clés : Autism spectrum disorder  Developmental disorder  Aggression  Irritability  Nicotine  Nicotine patch  Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model / Hafiz M. MAHMOOD in Autism Research, 13-8 (August 2020)  

Permalink